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UniProtKB - P60033 (CD81_HUMAN)

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Protein

CD81 antigen

Gene

CD81

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.2 Publications

GO - Molecular functioni

  • MHC class II protein complex binding Source: UniProtKB
  • transferrin receptor binding Source: BHF-UCL
  • virus receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • cell proliferation Source: ProtInc
  • cell surface receptor signaling pathway Source: GO_Central
  • cellular response to low-density lipoprotein particle stimulus Source: UniProtKB
  • positive regulation of 1-phosphatidylinositol 4-kinase activity Source: UniProtKB
  • positive regulation of B cell proliferation Source: AgBase
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  • positive regulation of protein catabolic process in the vacuole Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • protein localization Source: UniProtKB
  • protein localization to lysosome Source: BHF-UCL
  • receptor internalization Source: UniProtKB
  • receptor-mediated virion attachment to host cell Source: UniProtKB
  • regulation of cell motility Source: Ensembl
  • regulation of complement activation Source: Reactome
  • regulation of immune response Source: Reactome
  • regulation of protein stability Source: BHF-UCL
  • viral entry into host cell Source: UniProtKB
Complete GO annotation...

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-977606. Regulation of Complement cascade.
SignaLinkiP60033.

Protein family/group databases

TCDBi8.A.40.1.1. the tetraspanin (tetraspanin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
CD81 antigen
Alternative name(s):
26 kDa cell surface protein TAPA-1
Target of the antiproliferative antibody 1
Tetraspanin-28
Short name:
Tspan-28
CD_antigen: CD81
Gene namesi
Name:CD81
Synonyms:TAPA1, TSPAN28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1701. CD81.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 63ExtracellularSequence analysisAdd BLAST30
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 89CytoplasmicSequence analysis5
Transmembranei90 – 112HelicalSequence analysisAdd BLAST23
Topological domaini113 – 201ExtracellularSequence analysisAdd BLAST89
Transmembranei202 – 224HelicalSequence analysisAdd BLAST23
Topological domaini225 – 236CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • basolateral plasma membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • immunological synapse Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency, common variable, 6 (CVID6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
See also OMIM:613496

Organism-specific databases

DisGeNETi975.
MalaCardsiCD81.
MIMi613496. phenotype.
OpenTargetsiENSG00000110651.
Orphaneti1572. Common variable immunodeficiency.
PharmGKBiPA26240.

Chemistry databases

ChEMBLiCHEMBL1075180.

Polymorphism and mutation databases

BioMutaiCD81.
DMDMi38503376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192211 – 236CD81 antigenAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi156 ↔ 190
Disulfide bondi157 ↔ 175

Post-translational modificationi

Not glycosylated.Curated

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP60033.
MaxQBiP60033.
PaxDbiP60033.
PeptideAtlasiP60033.
PRIDEiP60033.

PTM databases

iPTMnetiP60033.
PhosphoSitePlusiP60033.
SwissPalmiP60033.

Expressioni

Tissue specificityi

Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.

Gene expression databases

BgeeiENSG00000110651.
CleanExiHS_CD81.
ExpressionAtlasiP60033. baseline and differential.
GenevisibleiP60033. HS.

Organism-specific databases

HPAiCAB002507.
HPA007234.

Interactioni

Subunit structurei

Homodimer (PubMed:20375010). Interacts directly with IGSF8 (PubMed:11504738). Interacts with CD53 and SCIMP (PubMed:21930792). Interacts with IFITM1 (PubMed:2398277). Interacts with IFITM2 and IFITM3 (By similarity). Part of a GPCR-tetraspanin complex consisting at least of ADGRG1, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of ADGRG1 with GNA11 (PubMed:15004227). Interacts with CLDN1 (PubMed:20375010, PubMed:21516087). Interacts with CLDN6 and CLDN9 (PubMed:20375010).By similarity6 Publications
(Microbial infection) Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • MHC class II protein complex binding Source: UniProtKB
  • transferrin receptor binding Source: BHF-UCL
Complete GO annotation...

Protein-protein interaction databases

BioGridi107413. 199 interactors.
IntActiP60033. 41 interactors.
MINTiMINT-5001104.
STRINGi9606.ENSP00000263645.

Chemistry databases

BindingDBiP60033.

Structurei

Secondary structure

1236
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 36Combined sources27
Helixi57 – 80Combined sources24
Helixi81 – 84Combined sources4
Helixi89 – 114Combined sources26
Helixi116 – 136Combined sources21
Helixi141 – 154Combined sources14
Beta strandi158 – 160Combined sources3
Helixi163 – 165Combined sources3
Helixi166 – 171Combined sources6
Helixi172 – 174Combined sources3
Helixi181 – 185Combined sources5
Helixi190 – 199Combined sources10
Helixi202 – 230Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G8QX-ray1.60A/B113-201[»]
1IV5X-ray2.60A/B113-201[»]
2AVZmodel-A1-236[»]
3X0EX-ray1.84A/B113-202[»]
5DFVX-ray2.80A/B112-201[»]
5DFWX-ray2.33A112-201[»]
5M2CX-ray1.96A/B112-201[»]
5M33X-ray1.28A/B113-201[»]
5M3DX-ray2.38A/B/C/D112-201[»]
5M3TX-ray2.02A/B112-201[»]
5M4RX-ray3.10A/B/C/D/E112-201[»]
5TCXX-ray2.96A2-236[»]
ProteinModelPortaliP60033.
SMRiP60033.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60033.

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00880000137858.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP60033.
KOiK06508.
PhylomeDBiP60033.
TreeFamiTF352895.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiView protein in InterPro
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
PfamiView protein in Pfam
PF00335. Tetraspannin. 1 hit.
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiView protein in PROSITE
PS00421. TM4_1. 1 hit.

Sequencei

Sequence statusi: Complete.

P60033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTNLLYLELG 
        60         70         80         90        100
DKPAPNTFYV GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI 
       110        120        130        140        150
LFACEVAAGI WGFVNKDQIA KDVKQFYDQA LQQAVVDDDA NNAKAVVKTF 
       160        170        180        190        200
HETLDCCGSS TLTALTTSVL KNNLCPSGSN IISNLFKEDC HQKIDDLFSG 
       210        220        230 
KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY
Length:236
Mass (Da):25,809
Last modified:November 21, 2003 - v1
Checksum:iEB9BD7671AC91B4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33680 mRNA. Translation: AAA36663.1.
BT019507 mRNA. Translation: AAV38314.1.
BT019508 mRNA. Translation: AAV38315.1.
EF064749 Genomic DNA. Translation: ABK41932.1.
AC129929 Genomic DNA. No translation available.
AC124057 Genomic DNA. No translation available.
BC002978 mRNA. Translation: AAH02978.1.
BC093047 mRNA. Translation: AAH93047.1.
CCDSiCCDS7734.1.
PIRiA35649.
RefSeqiNP_001284578.1. NM_001297649.1.
NP_004347.1. NM_004356.3.
UniGeneiHs.54457.

Genome annotation databases

EnsembliENST00000263645; ENSP00000263645; ENSG00000110651.
GeneIDi975.
KEGGihsa:975.
UCSCiuc001lwf.2. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCD81_HUMAN
AccessioniPrimary (citable) accession number: P60033
Secondary accession number(s): P18582, Q5U0J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: July 5, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families