Reviewed,
UniProtKB/Swiss-Prot P60033 (CD81_HUMAN)
Last modified
November 4, 2008.
Version 52.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: CD81 antigen Alternative name(s): 26 kDa cell surface protein TAPA-1 Target of the antiproliferative antibody 1 Tetraspanin-28 Short name=Tspan-28 CD_antigen=CD81 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 236 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May acts a the viral receptor for HCV. |
| Subunit structure | Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. Interacts directly with IGSF8. |
| Subcellular location | |
| Tissue specificity | Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines. |
| Post-translational modification | Not glycosylated Probable. |
| Sequence similarities | Belongs to the tetraspanin (TM4SF) family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||
Molecule processing | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 236 | 236 | CD81 antigen | PRO_0000219221 | ||||||||||||||||
Regions | ||||||||||||||||||||
| Topological domain | 1 – 12 | 12 | Cytoplasmic Potential | |||||||||||||||||
| Transmembrane | 13 – 33 | 21 | Potential | |||||||||||||||||
| Topological domain | 34 – 63 | 30 | Extracellular Potential | |||||||||||||||||
| Transmembrane | 64 – 84 | 21 | Potential | |||||||||||||||||
| Topological domain | 85 – 89 | 5 | Cytoplasmic Potential | |||||||||||||||||
| Transmembrane | 90 – 112 | 23 | Potential | |||||||||||||||||
| Topological domain | 113 – 201 | 89 | Extracellular Potential | |||||||||||||||||
| Transmembrane | 202 – 224 | 23 | Potential | |||||||||||||||||
| Topological domain | 225 – 236 | 12 | Cytoplasmic Potential | |||||||||||||||||
Amino acid modifications | ||||||||||||||||||||
| Disulfide bond | 156 ↔ 190 | |||||||||||||||||||
| Disulfide bond | 157 ↔ 175 | |||||||||||||||||||
Secondary structure | ||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||
| Helix | 116 – 136 | 21 | ||||||||||||||||||
| Helix | 141 – 154 | 14 | ||||||||||||||||||
| Helix | 163 – 165 | 3 | ||||||||||||||||||
| Helix | 166 – 171 | 6 | ||||||||||||||||||
| Helix | 181 – 185 | 5 | ||||||||||||||||||
| Helix | 190 – 199 | 10 | ||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins." Oren R., Takahashi S., Doss C., Levy R., Levy S. Mol. Cell. Biol. 10:4007-4015(1990) [PubMed: 1695320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [5] | "Structure and membrane topology of TAPA-1." Levy S., Nguyen V.Q., Andria M.L., Takahashi S. J. Biol. Chem. 266:14597-14602(1991) [PubMed: 1860863] [Abstract] Cited for: TOPOLOGY. |
| [6] | "CD81-dependent binding of hepatitis C virus E1E2 heterodimers." Cocquerel L., Kuo C.-C., Dubuisson J., Levy S. J. Virol. 77:10677-10683(2003) [PubMed: 12970454] [Abstract] Cited for: INTERACTION WITH HCV E1/E2 ENVELOPE HETERODIMER. |
| [7] | "Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor." Bartosch B., Vitelli A., Granier C., Goujon C., Dubuisson J., Pascale S., Scarselli E., Cortese R., Nicosia A., Cosset F.-L. J. Biol. Chem. 278:41624-41630(2003) [PubMed: 12913001] [Abstract] Cited for: INTERACTION WITH HCV E1/E2 ENVELOPE HETERODIMER. |
| [8] | "CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs." Kitadokoro K., Bordo D., Galli G., Petracca R., Falugi F., Abrignani S., Grandi G., Bolognesi M. EMBO J. 20:12-18(2001) [PubMed: 11226150] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 113-202. |
| [9] | "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily." Stipp C.S., Kolesnikova T.V., Hemler M.E. J. Biol. Chem. 276:40545-40554(2001) [PubMed: 11504738] [Abstract] Cited for: INTERACTION WITH IGSF8. |
| [10] | "Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop." Kitadokoro K., Ponassi M., Galli G., Petracca R., Falugi F., Grandi G., Bolognesi M. Biol. Chem. 383:1447-1452(2002) [PubMed: 12437138] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 113-201. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M33680 mRNA. Translation: AAA36663.1. BT019507 mRNA. Translation: AAV38314.1. BT019508 mRNA. Translation: AAV38315.1. EF064749 Genomic DNA. Translation: ABK41932.1. BC002978 mRNA. Translation: AAH02978.1. BC093047 mRNA. Translation: AAH93047.1. | |||||||||||||||||||||||||
| PIR | A35649. | ||||||||||||||||||||||||
| RefSeq | NP_004347.1. | ||||||||||||||||||||||||
| UniGene | Hs.54457 | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
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| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| IntAct | P60033. | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENSG00000110651. Homo sapiens. [Contig view] | ||||||||||||||||||||||||
| GeneID | 975. | ||||||||||||||||||||||||
| KEGG | hsa:975. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| H-InvDB | HIX0009363. | ||||||||||||||||||||||||
| HGNC | HGNC:1701. CD81. | ||||||||||||||||||||||||
| HPA | CAB002507. HPA007234. | ||||||||||||||||||||||||
| MIM | 186845. gene. | ||||||||||||||||||||||||
| PharmGKB | PA26240. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
| GeneCards | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| HOVERGEN | P60033. | ||||||||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||||||||
| Reactome | REACT_6900. Signaling in Immune System. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | P60033. | ||||||||||||||||||||||||
| CleanEx | HS_CD81. | ||||||||||||||||||||||||
| GermOnline | ENSG00000110651. Homo sapiens. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR000301. Transmem_4. [Graphical view] | ||||||||||||||||||||||||
| Pfam | PF00335. Tetraspannin. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| PRINTS | PR00259. TMFOUR. | ||||||||||||||||||||||||
| PROSITE | PS00421. TM4_1. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||
| LinkHub | P60033. | ||||||||||||||||||||||||
| NextBio | 4090. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | CD81_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P60033 Secondary accession number(s): P18582, Q5U0J6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


