UniProtKB - P60033 (CD81_HUMAN)
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Protein
CD81 antigen
Gene
CD81
Organism
Homo sapiens (Human)
Status
Functioni
May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.2 Publications
GO - Molecular functioni
- MHC class II protein complex binding Source: UniProtKB
- transferrin receptor binding Source: BHF-UCL
- virus receptor activity Source: UniProtKB
GO - Biological processi
- activation of MAPK activity Source: UniProtKB
- cell proliferation Source: ProtInc
- cell surface receptor signaling pathway Source: GO_Central
- cellular response to low-density lipoprotein particle stimulus Source: UniProtKB
- positive regulation of 1-phosphatidylinositol 4-kinase activity Source: UniProtKB
- positive regulation of B cell proliferation Source: AgBase
- positive regulation of cell proliferation Source: UniProtKB
- positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of protein catabolic process in the vacuole Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- protein localization Source: UniProtKB
- protein localization to lysosome Source: BHF-UCL
- receptor internalization Source: UniProtKB
- receptor-mediated virion attachment to host cell Source: UniProtKB
- regulation of cell motility Source: Ensembl
- regulation of complement activation Source: Reactome
- regulation of immune response Source: Reactome
- regulation of protein stability Source: BHF-UCL
- viral entry into host cell Source: UniProtKB
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor |
Biological process | Host-virus interaction |
Enzyme and pathway databases
Reactomei | R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. R-HSA-977606. Regulation of Complement cascade. |
SignaLinki | P60033. |
Protein family/group databases
TCDBi | 8.A.40.1.1. the tetraspanin (tetraspanin) family. |
Names & Taxonomyi
Protein namesi | Recommended name: CD81 antigenAlternative name(s): 26 kDa cell surface protein TAPA-1 Target of the antiproliferative antibody 1 Tetraspanin-28 Short name: Tspan-28 CD_antigen: CD81 |
Gene namesi | Name:CD81 Synonyms:TAPA1, TSPAN28 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000110651.11. |
HGNCi | HGNC:1701. CD81. |
MIMi | 186845. gene. |
neXtProti | NX_P60033. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 12 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 13 – 33 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 34 – 63 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 64 – 84 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 85 – 89 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 90 – 112 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 113 – 201 | ExtracellularSequence analysisAdd BLAST | 89 | |
Transmembranei | 202 – 224 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 225 – 236 | CytoplasmicSequence analysisAdd BLAST | 12 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Immunodeficiency, common variable, 6 (CVID6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
See also OMIM:613496Organism-specific databases
DisGeNETi | 975. |
MalaCardsi | CD81. |
MIMi | 613496. phenotype. |
OpenTargetsi | ENSG00000110651. |
Orphaneti | 1572. Common variable immunodeficiency. |
PharmGKBi | PA26240. |
Chemistry databases
ChEMBLi | CHEMBL1075180. |
Polymorphism and mutation databases
BioMutai | CD81. |
DMDMi | 38503376. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219221 | 1 – 236 | CD81 antigenAdd BLAST | 236 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 156 ↔ 190 | |||
Disulfide bondi | 157 ↔ 175 |
Post-translational modificationi
Not glycosylated.Curated
Keywords - PTMi
Disulfide bondProteomic databases
EPDi | P60033. |
MaxQBi | P60033. |
PaxDbi | P60033. |
PeptideAtlasi | P60033. |
PRIDEi | P60033. |
PTM databases
iPTMneti | P60033. |
PhosphoSitePlusi | P60033. |
SwissPalmi | P60033. |
Expressioni
Tissue specificityi
Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.
Gene expression databases
Bgeei | ENSG00000110651. |
CleanExi | HS_CD81. |
ExpressionAtlasi | P60033. baseline and differential. |
Genevisiblei | P60033. HS. |
Organism-specific databases
HPAi | CAB002507. HPA007234. |
Interactioni
Subunit structurei
Homodimer (PubMed:20375010). Interacts directly with IGSF8 (PubMed:11504738). Interacts with CD53 and SCIMP (PubMed:21930792). Interacts with IFITM1 (PubMed:2398277). Interacts with IFITM2 and IFITM3 (By similarity). Part of a GPCR-tetraspanin complex consisting at least of ADGRG1, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of ADGRG1 with GNA11 (PubMed:15004227). Interacts with CLDN1 (PubMed:20375010, PubMed:21516087). Interacts with CLDN6 and CLDN9 (PubMed:20375010).By similarity6 Publications
(Microbial infection) Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer.2 Publications
Binary interactionsi
GO - Molecular functioni
- MHC class II protein complex binding Source: UniProtKB
- transferrin receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGridi | 107413. 200 interactors. |
CORUMi | P60033. |
IntActi | P60033. 43 interactors. |
MINTi | P60033. |
STRINGi | 9606.ENSP00000263645. |
Chemistry databases
BindingDBi | P60033. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 10 – 36 | Combined sources | 27 | |
Helixi | 57 – 80 | Combined sources | 24 | |
Helixi | 81 – 84 | Combined sources | 4 | |
Helixi | 89 – 114 | Combined sources | 26 | |
Helixi | 116 – 136 | Combined sources | 21 | |
Helixi | 141 – 154 | Combined sources | 14 | |
Beta strandi | 158 – 160 | Combined sources | 3 | |
Helixi | 163 – 165 | Combined sources | 3 | |
Helixi | 166 – 171 | Combined sources | 6 | |
Helixi | 172 – 174 | Combined sources | 3 | |
Helixi | 181 – 185 | Combined sources | 5 | |
Helixi | 190 – 199 | Combined sources | 10 | |
Helixi | 202 – 230 | Combined sources | 29 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1G8Q | X-ray | 1.60 | A/B | 113-201 | [»] | |
1IV5 | X-ray | 2.60 | A/B | 113-201 | [»] | |
2AVZ | model | - | A | 1-236 | [»] | |
3X0E | X-ray | 1.84 | A/B | 113-202 | [»] | |
5DFV | X-ray | 2.80 | A/B | 112-201 | [»] | |
5DFW | X-ray | 2.33 | A | 112-201 | [»] | |
5M2C | X-ray | 1.96 | A/B | 112-201 | [»] | |
5M33 | X-ray | 1.28 | A/B | 113-201 | [»] | |
5M3D | X-ray | 2.38 | A/B/C/D | 112-201 | [»] | |
5M3T | X-ray | 2.02 | A/B | 112-201 | [»] | |
5M4R | X-ray | 3.10 | A/B/C/D/E | 112-201 | [»] | |
5TCX | X-ray | 2.96 | A | 2-236 | [»] | |
ProteinModelPortali | P60033. | |||||
SMRi | P60033. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P60033. |
Family & Domainsi
Sequence similaritiesi
Belongs to the tetraspanin (TM4SF) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3882. Eukaryota. ENOG4111IRY. LUCA. |
GeneTreei | ENSGT00880000137858. |
HOGENOMi | HOG000230651. |
HOVERGENi | HBG002324. |
InParanoidi | P60033. |
KOi | K06508. |
PhylomeDBi | P60033. |
TreeFami | TF352895. |
Family and domain databases
Gene3Di | 1.10.1450.10. 1 hit. |
InterProi | View protein in InterPro IPR000301. Tetraspanin. IPR018499. Tetraspanin/Peripherin. IPR018503. Tetraspanin_CS. IPR008952. Tetraspanin_EC2_sf. |
Pfami | View protein in Pfam PF00335. Tetraspannin. 1 hit. |
PIRSFi | PIRSF002419. Tetraspanin. 1 hit. |
PRINTSi | PR00259. TMFOUR. |
SUPFAMi | SSF48652. SSF48652. 1 hit. |
PROSITEi | View protein in PROSITE PS00421. TM4_1. 1 hit. |
i Sequence
Sequence statusi: Complete.
P60033-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTNLLYLELG
60 70 80 90 100
DKPAPNTFYV GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI
110 120 130 140 150
LFACEVAAGI WGFVNKDQIA KDVKQFYDQA LQQAVVDDDA NNAKAVVKTF
160 170 180 190 200
HETLDCCGSS TLTALTTSVL KNNLCPSGSN IISNLFKEDC HQKIDDLFSG
210 220 230
KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M33680 mRNA. Translation: AAA36663.1. BT019507 mRNA. Translation: AAV38314.1. BT019508 mRNA. Translation: AAV38315.1. EF064749 Genomic DNA. Translation: ABK41932.1. AC129929 Genomic DNA. No translation available. AC124057 Genomic DNA. No translation available. BC002978 mRNA. Translation: AAH02978.1. BC093047 mRNA. Translation: AAH93047.1. |
CCDSi | CCDS7734.1. |
PIRi | A35649. |
RefSeqi | NP_001284578.1. NM_001297649.1. NP_004347.1. NM_004356.3. |
UniGenei | Hs.54457. |
Genome annotation databases
Ensembli | ENST00000263645; ENSP00000263645; ENSG00000110651. |
GeneIDi | 975. |
KEGGi | hsa:975. |
UCSCi | uc001lwf.2. human. |
Similar proteinsi
Entry informationi
Entry namei | CD81_HUMAN | |
Accessioni | P60033Primary (citable) accession number: P60033 Secondary accession number(s): P18582, Q5U0J6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 21, 2003 |
Last sequence update: | November 21, 2003 | |
Last modified: | March 28, 2018 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |