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Protein

General transcription factor IIH subunit 4

Gene

GTF2H4

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4
Alternative name(s):
Basic transcription factor 2 52 kDa subunit
Short name:
BTF2 p52
General transcription factor IIH polypeptide 4
TFIIH basal transcription factor complex p52 subunit
Gene namesi
Name:GTF2H4
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462General transcription factor IIH subunit 4PRO_0000119255Add
BLAST

Proteomic databases

PaxDbiP60027.
PRIDEiP60027.

Interactioni

Subunit structurei

One of the six subunits forming the core-TFIIH basal transcription factor.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000030616.

Structurei

3D structure databases

ProteinModelPortaliP60027.
SMRiP60027. Positions 382-457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.Curated

Phylogenomic databases

eggNOGiKOG3471. Eukaryota.
COG5144. LUCA.
GeneTreeiENSGT00390000014159.
HOGENOMiHOG000170529.
HOVERGENiHBG054205.
InParanoidiP60027.
KOiK03144.
OMAiVVQKNGH.
OrthoDBiEOG71VSST.
TreeFamiTF300879.

Family and domain databases

InterProiIPR004598. TFIIH_p52/Tfb2.
[Graphical view]
PANTHERiPTHR13152. PTHR13152. 1 hit.
PfamiPF03849. Tfb2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00625. tfb2. 1 hit.

Sequencei

Sequence statusi: Complete.

P60027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTPSRGLN RVHLQCRNLQ EFLGGLSPGV LDRLYGHPAT CLAVFRELPS
60 70 80 90 100
LAKNWVMRML FLEQPLPQAA VALWVKKEFS KAQEESTGLL SGLRIWHTQL
110 120 130 140 150
LPGGLQGLIL NPIFRQNLRI ALLGGGKAWS DDTSQLGPDK HARDVPSLDK
160 170 180 190 200
YAEERWEVVL HFMVGSPSAA VSQDLAQLLS QAGLMKSTEP GEPPCITSAG
210 220 230 240 250
FQFLLLDTPA QLWYFMLQYL QTAQSRGMDL VEILSFLFQL SFSTLGKDYS
260 270 280 290 300
VEGMSDSLLN FLQHLREFGL VFQRKRKSRR YYPTRLAINL SSGVSGAGGT
310 320 330 340 350
VHQPGFIVVE TNYRLYAYTE SELQIALIAL FSEMLYRFPN MVVAQVTRES
360 370 380 390 400
VQQAIASGIT AQQIIHFLRT RAHPVMLKQT PVLPPTITDQ IRLWELERDR
410 420 430 440 450
LRFTEGVLYN QFLSQVDFEL LLAHARELGV LVFENSAKRL MVVTPAGHSD
460
VKRFWKRQKH SS
Length:462
Mass (Da):52,186
Last modified:November 21, 2003 - v1
Checksum:i5532DAD617CA743C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000041 Genomic DNA. Translation: BAC78171.1.
AB210199 Genomic DNA. Translation: BAE92819.1.
AB210200 Genomic DNA. Translation: BAE92820.1.
RefSeqiNP_001038968.1. NM_001045503.1.
UniGeneiPtr.6202.

Genome annotation databases

EnsembliENSPTRT00000033136; ENSPTRP00000030616; ENSPTRG00000017943.
GeneIDi462549.
KEGGiptr:462549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000041 Genomic DNA. Translation: BAC78171.1.
AB210199 Genomic DNA. Translation: BAE92819.1.
AB210200 Genomic DNA. Translation: BAE92820.1.
RefSeqiNP_001038968.1. NM_001045503.1.
UniGeneiPtr.6202.

3D structure databases

ProteinModelPortaliP60027.
SMRiP60027. Positions 382-457.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000030616.

Proteomic databases

PaxDbiP60027.
PRIDEiP60027.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000033136; ENSPTRP00000030616; ENSPTRG00000017943.
GeneIDi462549.
KEGGiptr:462549.

Organism-specific databases

CTDi2968.

Phylogenomic databases

eggNOGiKOG3471. Eukaryota.
COG5144. LUCA.
GeneTreeiENSGT00390000014159.
HOGENOMiHOG000170529.
HOVERGENiHBG054205.
InParanoidiP60027.
KOiK03144.
OMAiVVQKNGH.
OrthoDBiEOG71VSST.
TreeFamiTF300879.

Family and domain databases

InterProiIPR004598. TFIIH_p52/Tfb2.
[Graphical view]
PANTHERiPTHR13152. PTHR13152. 1 hit.
PfamiPF03849. Tfb2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00625. tfb2. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence."
    Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A., Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y., Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T., Meyer A., Ikeo K.
    , Gojobori T., Bahram S., Inoko H.
    Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
    Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
    , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
    Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTF2H4_PANTR
AccessioniPrimary (citable) accession number: P60027
Secondary accession number(s): Q1XHV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.