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Protein

Beta-defensin 1

Gene

DEFB1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has bactericidal activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 1
Short name:
BD-1
Alternative name(s):
Defensin, beta 1
cBD1
Gene namesi
Name:DEFB1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 3211By similarityPRO_0000006911Add
BLAST
Peptidei33 – 6836Beta-defensin 1PRO_0000006912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 66By similarity
Disulfide bondi44 ↔ 59By similarity
Disulfide bondi49 ↔ 67By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP60023.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000034184.

Structurei

3D structure databases

ProteinModelPortaliP60023.
SMRiP60023. Positions 33-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7H1. Eukaryota.
ENOG41119QC. LUCA.
GeneTreeiENSGT00390000017014.
HOGENOMiHOG000112188.
HOVERGENiHBG084156.
InParanoidiP60023.
OMAiKIQGTCY.
OrthoDBiEOG77WWGH.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTSYLLLFT LCLLLSEMAS GGNFLTGLGH RSDHYNCVSS GGQCLYSACP
60
IFTKIQGTCY GGKAKCCK
Length:68
Mass (Da):7,321
Last modified:May 29, 2007 - v2
Checksum:iF1AB76DEC3B14F88
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611G → R in AAF04110 (PubMed:11168821).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188607 mRNA. Translation: AAF04110.1.
AY033749, AY033735 Genomic DNA. Translation: AAK61462.1.
AM410097 Genomic DNA. Translation: CAL68980.1.
RefSeqiNP_001009151.1. NM_001009151.1.
UniGeneiPtr.6153.

Genome annotation databases

EnsembliENSPTRT00000036989; ENSPTRP00000034184; ENSPTRG00000019951.
GeneIDi450100.
KEGGiptr:450100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188607 mRNA. Translation: AAF04110.1.
AY033749, AY033735 Genomic DNA. Translation: AAK61462.1.
AM410097 Genomic DNA. Translation: CAL68980.1.
RefSeqiNP_001009151.1. NM_001009151.1.
UniGeneiPtr.6153.

3D structure databases

ProteinModelPortaliP60023.
SMRiP60023. Positions 33-68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000034184.

Proteomic databases

PaxDbiP60023.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000036989; ENSPTRP00000034184; ENSPTRG00000019951.
GeneIDi450100.
KEGGiptr:450100.

Organism-specific databases

CTDi1672.

Phylogenomic databases

eggNOGiENOG410J7H1. Eukaryota.
ENOG41119QC. LUCA.
GeneTreeiENSGT00390000017014.
HOGENOMiHOG000112188.
HOVERGENiHBG084156.
InParanoidiP60023.
OMAiKIQGTCY.
OrthoDBiEOG77WWGH.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Evolution and sequence variation of human beta-defensin genes."
    Hollox E.J., Armour J.A.L.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDEFB1_PANTR
AccessioniPrimary (citable) accession number: P60023
Secondary accession number(s): A4H1Z2, Q09753, Q95M69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: May 29, 2007
Last modified: June 8, 2016
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.