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Protein

5-hydroxytryptamine receptor 1B

Gene

HTR1B

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).By similarity

Miscellaneous

A residue in the 7th transmembrane region ('Thr-355' in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei355Important for species-specific agonist sensitivityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBehavior

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1B
Short name:
5-HT-1B
Short name:
5-HT1B
Alternative name(s):
Serotonin receptor 1B
Gene namesi
Name:HTR1B
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:7894 HTR1B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49ExtracellularBy similarityAdd BLAST49
Transmembranei50 – 75Helical; Name=1By similarityAdd BLAST26
Topological domaini76 – 84CytoplasmicBy similarity9
Transmembranei85 – 110Helical; Name=2By similarityAdd BLAST26
Topological domaini111 – 123ExtracellularBy similarityAdd BLAST13
Transmembranei124 – 145Helical; Name=3By similarityAdd BLAST22
Topological domaini146 – 165CytoplasmicBy similarityAdd BLAST20
Transmembranei166 – 187Helical; Name=4By similarityAdd BLAST22
Topological domaini188 – 205ExtracellularBy similarityAdd BLAST18
Transmembranei206 – 228Helical; Name=5By similarityAdd BLAST23
Topological domaini229 – 315CytoplasmicBy similarityAdd BLAST87
Transmembranei316 – 336Helical; Name=6By similarityAdd BLAST21
Topological domaini337 – 349ExtracellularBy similarityAdd BLAST13
Transmembranei350 – 371Helical; Name=7By similarityAdd BLAST22
Topological domaini372 – 390CytoplasmicBy similarityAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689181 – 3905-hydroxytryptamine receptor 1BAdd BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi122 ↔ 199PROSITE-ProRule annotation
Lipidationi388S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

Phosphorylated.By similarity
Palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP60020

Expressioni

Gene expression databases

BgeeiENSPTRG00000018361

Interactioni

Subunit structurei

Homodimer. Heterodimer with HTR1D (By similarity).By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000031384

Structurei

3D structure databases

ProteinModelPortaliP60020
SMRiP60020
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 134Agonist bindingBy similarity10
Regioni327 – 331Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi146 – 148DRY motif; important for ligand-induced conformation changes and signalingBy similarity3
Motifi365 – 369NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

Domaini

Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP60020
KOiK04153
OMAiVNTDHVL
OrthoDBiEOG091G06VI
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR002147 5HT1B_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF16 PTHR24247:SF16, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00513 5HT1BRECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P60020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV
60 70 80 90 100
LLVMLLALIT LATTLSNAFV IATVYRTRKL HTPANYLIAS LAVTDLLVSI
110 120 130 140 150
LVMPISTMYT VTGRWTLGQV VCDFWLSSDI TCCTASILHL CVIALDRYWA
160 170 180 190 200
ITDAVEYSAK RTPKRAAVMI ALVWVFSISI SLPPFFWRQA KAEEEVSECV
210 220 230 240 250
VNTDHILYTV YSTVGAFYFP TLLLIALYGR IYVEARSRIL KQTPNRTGKR
260 270 280 290 300
LTRAQLITDS PGSTSSVTSI NSRVPDVPSE SGSPVYVNQV KVRVSDALLE
310 320 330 340 350
KKKLMAARER KATKTLGIIL GAFIVCWLPF FIISLVMPIC KDACWFHLAI
360 370 380 390
FDFFTWLGYL NSLINPIIYT MSNEDFKQAF HKLIRFKCTS
Length:390
Mass (Da):43,568
Last modified:November 21, 2003 - v1
Checksum:iCD874DC7EB44CF12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041371 Genomic DNA Translation: BAA94456.1
RefSeqiNP_001009102.1, NM_001009102.1
UniGeneiPtr.6397

Genome annotation databases

EnsembliENSPTRT00000033962; ENSPTRP00000031384; ENSPTRG00000018361
GeneIDi462833
KEGGiptr:462833

Similar proteinsi

Entry informationi

Entry namei5HT1B_PANTR
AccessioniPrimary (citable) accession number: P60020
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health