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P60018 (HFE_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hereditary hemochromatosis protein homolog
Gene names
Name:HFE
Synonyms:Patr-H
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin By similarity.

Subunit structure

Binds TFR through the extracellular domain.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processImmunity
Ion transport
Iron transport
Transport
   Cellular componentMembrane
MHC I
   DomainSignal
Transmembrane
Transmembrane helix
   LigandIron
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation of peptide antigen via MHC class I

Inferred from electronic annotation. Source: UniProtKB-KW

hormone biosynthetic process

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

iron ion import into cell

Inferred from electronic annotation. Source: Ensembl

multicellular organismal iron ion homeostasis

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: InterPro

   Cellular_componentMHC class I protein complex

Inferred from electronic annotation. Source: UniProtKB-KW

apical part of cell

Inferred from electronic annotation. Source: Ensembl

basal part of cell

Inferred from electronic annotation. Source: Ensembl

cytoplasmic vesicle

Inferred from electronic annotation. Source: Ensembl

early endosome

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

recycling endosome

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionpeptide antigen binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 348326Hereditary hemochromatosis protein homolog
PRO_0000018893

Regions

Topological domain23 – 306284Extracellular Potential
Transmembrane307 – 33024Helical; Potential
Topological domain331 – 34818Cytoplasmic Potential
Domain207 – 29892Ig-like C1-type
Region23 – 11492Alpha-1
Region115 – 20591Alpha-2
Region206 – 29792Alpha-3
Region298 – 3069Connecting peptide

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation2341N-linked (GlcNAc...) Potential
Disulfide bond124 ↔ 187 By similarity
Disulfide bond225 ↔ 282 By similarity

Sequences

Sequence LengthMass (Da)Tools
P60018 [UniParc].

Last modified November 21, 2003. Version 1.
Checksum: 432EB9A314A55BEA

FASTA34840,108
        10         20         30         40         50         60 
MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF 

        70         80         90        100        110        120 
YDHESRRVEP RTPWVSSRIS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV 

       130        140        150        160        170        180 
ILGCEMQEDN STEGYWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR 

       190        200        210        220        230        240 
AYLERDCPAQ LQQLLELGRG VLDQQVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL 

       250        260        270        280        290        300 
KDKQPMDAKE FEPKDVLPNG DGTYQGWITL AVPPGEEQRY TCQVEHPGLD QPLIVIWEPS 

       310        320        330        340 
PSGTLVIGVI SGIAVFVVIL FIGILFIILR KRQGSRGAMG HYVLAERE 

« Hide

References

[1]"Sequence variation and haplotype structure at the Human HFE Locus."
Toomajian C., Kreitman M.
Genetics 161:1609-1623(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF447807 Genomic DNA. Translation: AAN09793.1.
RefSeqNP_001009101.1. NM_001009101.1.
UniGenePtr.6185.

3D structure databases

ProteinModelPortalP60018.
SMRP60018. Positions 26-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9598.ENSPTRP00000050508.

Proteomic databases

PRIDEP60018.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID462489.
KEGGptr:462489.

Organism-specific databases

CTD3077.

Phylogenomic databases

eggNOGNOG41118.
HOGENOMHOG000296917.
HOVERGENHBG016709.
InParanoidP60018.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20841754.

Entry information

Entry nameHFE_PANTR
AccessionPrimary (citable) accession number: P60018
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families