SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P60018

- HFE_PANTR

UniProt

P60018 - HFE_PANTR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Hereditary hemochromatosis protein homolog
Gene
HFE, Patr-H
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin By similarity.

GO - Molecular functioni

  1. peptide antigen binding Source: InterPro

GO - Biological processi

  1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
  2. hormone biosynthetic process Source: Ensembl
  3. immune response Source: InterPro
  4. iron ion import into cell Source: Ensembl
  5. multicellular organismal iron ion homeostasis Source: Ensembl
  6. positive regulation of T cell mediated cytotoxicity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity, Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Hereditary hemochromatosis protein homolog
Gene namesi
Name:HFE
Synonyms:Patr-H
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 306284Extracellular Reviewed prediction
Add
BLAST
Transmembranei307 – 33024Helical; Reviewed prediction
Add
BLAST
Topological domaini331 – 34818Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. MHC class I protein complex Source: UniProtKB-KW
  2. apical part of cell Source: Ensembl
  3. basal part of cell Source: Ensembl
  4. cytoplasmic vesicle Source: Ensembl
  5. early endosome Source: Ensembl
  6. integral component of membrane Source: UniProtKB-KW
  7. perinuclear region of cytoplasm Source: Ensembl
  8. recycling endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarity
Add
BLAST
Chaini23 – 348326Hereditary hemochromatosis protein homolog
PRO_0000018893Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi124 ↔ 187 By similarity
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi225 ↔ 282 By similarity
Glycosylationi234 – 2341N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP60018.

Interactioni

Subunit structurei

Binds TFR through the extracellular domain.

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000050508.

Structurei

3D structure databases

ProteinModelPortaliP60018.
SMRiP60018. Positions 26-297.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 29892Ig-like C1-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 11492Alpha-1
Add
BLAST
Regioni115 – 20591Alpha-2
Add
BLAST
Regioni206 – 29792Alpha-3
Add
BLAST
Regioni298 – 3069Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41118.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiP60018.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60018-1 [UniParc]FASTAAdd to Basket

« Hide

MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL    50
GYVDDQLFVF YDHESRRVEP RTPWVSSRIS SQMWLQLSQS LKGWDHMFTV 100
DFWTIMENHN HSKESHTLQV ILGCEMQEDN STEGYWKYGY DGQDHLEFCP 150
DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPAQ LQQLLELGRG 200
VLDQQVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL KDKQPMDAKE 250
FEPKDVLPNG DGTYQGWITL AVPPGEEQRY TCQVEHPGLD QPLIVIWEPS 300
PSGTLVIGVI SGIAVFVVIL FIGILFIILR KRQGSRGAMG HYVLAERE 348
Length:348
Mass (Da):40,108
Last modified:November 21, 2003 - v1
Checksum:i432EB9A314A55BEA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF447807 Genomic DNA. Translation: AAN09793.1.
RefSeqiNP_001009101.1. NM_001009101.1.
UniGeneiPtr.6185.

Genome annotation databases

GeneIDi462489.
KEGGiptr:462489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF447807 Genomic DNA. Translation: AAN09793.1 .
RefSeqi NP_001009101.1. NM_001009101.1.
UniGenei Ptr.6185.

3D structure databases

ProteinModelPortali P60018.
SMRi P60018. Positions 26-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000050508.

Proteomic databases

PRIDEi P60018.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 462489.
KEGGi ptr:462489.

Organism-specific databases

CTDi 3077.

Phylogenomic databases

eggNOGi NOG41118.
HOGENOMi HOG000296917.
HOVERGENi HBG016709.
InParanoidi P60018.

Miscellaneous databases

NextBioi 20841754.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence variation and haplotype structure at the Human HFE Locus."
    Toomajian C., Kreitman M.
    Genetics 161:1609-1623(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHFE_PANTR
AccessioniPrimary (citable) accession number: P60018
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi