Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P60018

- HFE_PANTR

UniProt

P60018 - HFE_PANTR

Protein

Hereditary hemochromatosis protein homolog

Gene

HFE

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (21 Nov 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.By similarity

    GO - Molecular functioni

    1. peptide antigen binding Source: InterPro

    GO - Biological processi

    1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
    2. hormone biosynthetic process Source: Ensembl
    3. immune response Source: InterPro
    4. iron ion import into cell Source: Ensembl
    5. multicellular organismal iron ion homeostasis Source: Ensembl
    6. positive regulation of T cell mediated cytotoxicity Source: InterPro

    Keywords - Biological processi

    Immunity, Ion transport, Iron transport, Transport

    Keywords - Ligandi

    Iron

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hereditary hemochromatosis protein homolog
    Gene namesi
    Name:HFE
    Synonyms:Patr-H
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. basal part of cell Source: Ensembl
    3. cytoplasmic vesicle Source: Ensembl
    4. early endosome Source: Ensembl
    5. integral component of membrane Source: UniProtKB-KW
    6. MHC class I protein complex Source: UniProtKB-KW
    7. perinuclear region of cytoplasm Source: Ensembl
    8. recycling endosome Source: Ensembl

    Keywords - Cellular componenti

    Membrane, MHC I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 348326Hereditary hemochromatosis protein homologPRO_0000018893Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi124 ↔ 187PROSITE-ProRule annotation
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi225 ↔ 282PROSITE-ProRule annotation
    Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP60018.

    Interactioni

    Subunit structurei

    Binds TFR through the extracellular domain.

    Protein-protein interaction databases

    STRINGi9598.ENSPTRP00000050508.

    Structurei

    3D structure databases

    ProteinModelPortaliP60018.
    SMRiP60018. Positions 26-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 306284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini331 – 34818CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei307 – 33024HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini207 – 29892Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 11492Alpha-1Add
    BLAST
    Regioni115 – 20591Alpha-2Add
    BLAST
    Regioni206 – 29792Alpha-3Add
    BLAST
    Regioni298 – 3069Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41118.
    HOGENOMiHOG000296917.
    HOVERGENiHBG016709.
    InParanoidiP60018.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P60018-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL    50
    GYVDDQLFVF YDHESRRVEP RTPWVSSRIS SQMWLQLSQS LKGWDHMFTV 100
    DFWTIMENHN HSKESHTLQV ILGCEMQEDN STEGYWKYGY DGQDHLEFCP 150
    DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPAQ LQQLLELGRG 200
    VLDQQVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL KDKQPMDAKE 250
    FEPKDVLPNG DGTYQGWITL AVPPGEEQRY TCQVEHPGLD QPLIVIWEPS 300
    PSGTLVIGVI SGIAVFVVIL FIGILFIILR KRQGSRGAMG HYVLAERE 348
    Length:348
    Mass (Da):40,108
    Last modified:November 21, 2003 - v1
    Checksum:i432EB9A314A55BEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF447807 Genomic DNA. Translation: AAN09793.1.
    RefSeqiNP_001009101.1. NM_001009101.1.
    UniGeneiPtr.6185.

    Genome annotation databases

    GeneIDi462489.
    KEGGiptr:462489.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF447807 Genomic DNA. Translation: AAN09793.1 .
    RefSeqi NP_001009101.1. NM_001009101.1.
    UniGenei Ptr.6185.

    3D structure databases

    ProteinModelPortali P60018.
    SMRi P60018. Positions 26-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9598.ENSPTRP00000050508.

    Proteomic databases

    PRIDEi P60018.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 462489.
    KEGGi ptr:462489.

    Organism-specific databases

    CTDi 3077.

    Phylogenomic databases

    eggNOGi NOG41118.
    HOGENOMi HOG000296917.
    HOVERGENi HBG016709.
    InParanoidi P60018.

    Miscellaneous databases

    NextBioi 20841754.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence variation and haplotype structure at the Human HFE Locus."
      Toomajian C., Kreitman M.
      Genetics 161:1609-1623(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHFE_PANTR
    AccessioniPrimary (citable) accession number: P60018
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: November 21, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3