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Protein

Spermatid-specific linker histone H1-like protein

Gene

HILS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • histone binding Source: UniProtKB
  • nucleic acid binding Source: UniProtKB

GO - Biological processi

  • chromatin remodeling Source: UniProtKB
  • chromatin silencing Source: UniProtKB
  • chromosome condensation Source: UniProtKB
  • germ cell development Source: UniProtKB
  • multicellular organism development Source: UniProtKB-KW
  • nucleosome assembly Source: InterPro
  • regulation of transcription, DNA-templated Source: UniProtKB
  • spermatogenesis Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid-specific linker histone H1-like protein
Gene namesi
Name:HILS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:30616. HILS1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Chromosome PROSITE-ProRule annotation

GO - Cellular componenti

  • male germ cell nucleus Source: UniProtKB
  • nucleosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi38372285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Spermatid-specific linker histone H1-like proteinPRO_0000196014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei135 – 1351PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP60008.

PTM databases

iPTMnetiP60008.
PhosphoSiteiP60008.

Expressioni

Tissue specificityi

Expressed exclusively in the testis.

Gene expression databases

CleanExiHS_HILS1.

Interactioni

GO - Molecular functioni

  • histone binding Source: UniProtKB

Structurei

3D structure databases

ProteinModelPortaliP60008.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 17765H15PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000112898.
InParanoidiP60008.
PhylomeDBiP60008.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHASTIWHL RSTPPRRKQW GHCDPHRILV ASEVTTEITS PTPAPRAQVC
60 70 80 90 100
GGQPWVTVLD PLSGHTGREA ERHFATVSIS AVELKYCHGW RPAGQRVPSK
110 120 130 140 150
TATGQRTCAK PCQKPSTSKV ILRAVADKGT CKYVSLATLK KAVSTTGYDM
160 170 180 190 200
ARNAYHFKRV LKGLVDKGSA GSFTLGKKQA SKSKLKVKRQ RQQRWRSGQR
210 220 230
PFGQHRSLLG SKQGHKRLIK GVRRVAKCHC N
Length:231
Mass (Da):25,632
Last modified:November 14, 2003 - v1
Checksum:iDF3612D213CB406F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY286318 mRNA. Translation: AAQ23050.1.
UniGeneiHs.25934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY286318 mRNA. Translation: AAQ23050.1.
UniGeneiHs.25934.

3D structure databases

ProteinModelPortaliP60008.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP60008.
PhosphoSiteiP60008.

Polymorphism and mutation databases

DMDMi38372285.

Proteomic databases

PRIDEiP60008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiHILS1.
H-InvDBHIX0039133.
HGNCiHGNC:30616. HILS1.
MIMi608101. gene.
neXtProtiNX_P60008.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000112898.
InParanoidiP60008.
PhylomeDBiP60008.

Miscellaneous databases

PROiP60008.
SOURCEiSearch...

Gene expression databases

CleanExiHS_HILS1.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHILS1_HUMAN
AccessioniPrimary (citable) accession number: P60008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.