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Protein

Spermatid-specific linker histone H1-like protein

Gene

HILS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • histone binding Source: UniProtKB
  • nucleic acid binding Source: UniProtKB

GO - Biological processi

  • chromatin remodeling Source: UniProtKB
  • chromatin silencing Source: UniProtKB
  • chromosome condensation Source: UniProtKB
  • germ cell development Source: UniProtKB
  • multicellular organism development Source: UniProtKB-KW
  • nucleosome assembly Source: InterPro
  • regulation of transcription, DNA-templated Source: UniProtKB
  • spermatogenesis Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Developmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid-specific linker histone H1-like protein
Gene namesi
Name:HILS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:30616 HILS1
MIMi608101 gene
neXtProtiNX_P60008

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi38372285

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001960141 – 231Spermatid-specific linker histone H1-like proteinAdd BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP60008

PTM databases

iPTMnetiP60008
PhosphoSitePlusiP60008

Expressioni

Tissue specificityi

Expressed exclusively in the testis.

Gene expression databases

CleanExiHS_HILS1

Interactioni

GO - Molecular functioni

  • histone binding Source: UniProtKB

Structurei

3D structure databases

ProteinModelPortaliP60008
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 177H15PROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000112898
InParanoidiP60008
PhylomeDBiP60008

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

Sequencei

Sequence statusi: Complete.

P60008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHASTIWHL RSTPPRRKQW GHCDPHRILV ASEVTTEITS PTPAPRAQVC
60 70 80 90 100
GGQPWVTVLD PLSGHTGREA ERHFATVSIS AVELKYCHGW RPAGQRVPSK
110 120 130 140 150
TATGQRTCAK PCQKPSTSKV ILRAVADKGT CKYVSLATLK KAVSTTGYDM
160 170 180 190 200
ARNAYHFKRV LKGLVDKGSA GSFTLGKKQA SKSKLKVKRQ RQQRWRSGQR
210 220 230
PFGQHRSLLG SKQGHKRLIK GVRRVAKCHC N
Length:231
Mass (Da):25,632
Last modified:November 14, 2003 - v1
Checksum:iDF3612D213CB406F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY286318 mRNA Translation: AAQ23050.1
UniGeneiHs.25934

Similar proteinsi

Entry informationi

Entry nameiHILS1_HUMAN
AccessioniPrimary (citable) accession number: P60008
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: April 25, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health