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Protein

Anaphase-promoting complex subunit 15

Gene

ANAPC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-176412 Phosphorylation of the APC/C
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 15
Short name:
APC15
Gene namesi
Name:ANAPC15
Synonyms:C11orf51
ORF Names:HSPC020
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110200.8
HGNCiHGNC:24531 ANAPC15
MIMi614717 gene
neXtProtiNX_P60006

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110200
PharmGKBiPA143485346

Polymorphism and mutation databases

BioMutaiANAPC15
DMDMi38372627

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000840721 – 121Anaphase-promoting complex subunit 15Add BLAST121

Proteomic databases

MaxQBiP60006
PaxDbiP60006
PeptideAtlasiP60006
PRIDEiP60006

Expressioni

Gene expression databases

BgeeiENSG00000110200
CleanExiHS_C11orf51
ExpressionAtlasiP60006 baseline and differential
GenevisibleiP60006 HS

Organism-specific databases

HPAiHPA036596

Interactioni

Subunit structurei

The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.2 Publications

Protein-protein interaction databases

BioGridi117412, 50 interactors
DIPiDIP-61021N
IntActiP60006, 45 interactors
STRINGi9606.ENSP00000227618

Structurei

Secondary structure

1121
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi27 – 45Combined sources19
Turni46 – 48Combined sources3
Beta strandi49 – 51Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UI9electron microscopy3.60D1-121[»]
5A31electron microscopy4.30D6-121[»]
5G04electron microscopy4.00D1-121[»]
5G05electron microscopy3.40D1-121[»]
5L9Telectron microscopy6.40D1-121[»]
5L9Uelectron microscopy6.40D1-121[»]
5LCWelectron microscopy4.00D1-121[»]
ProteinModelPortaliP60006
SMRiP60006
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 117Asp-richAdd BLAST55

Sequence similaritiesi

Belongs to the APC15 family.Curated

Phylogenomic databases

eggNOGiENOG410J0F5 Eukaryota
ENOG410Y01T LUCA
GeneTreeiENSGT00390000000938
HOGENOMiHOG000026787
HOVERGENiHBG002951
InParanoidiP60006
OMAiIDMEVSY
PhylomeDBiP60006

Family and domain databases

InterProiView protein in InterPro
IPR026182 ANAPC15
PANTHERiPTHR22526 PTHR22526, 1 hit
PfamiView protein in Pfam
PF15243 ANAPC15, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P60006-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTLFPSLFP RVTETLWFNL DRPCVEETEL QQQEQQHQAW LQSIAEKDNN
60 70 80 90 100
LVPIGKPASE HYDDEEEEDD EDDEDSEEDS EDDEDMQDMD EMNDYNESPD
110 120
DGEVNEVDME GNEQDQDQWM I
Length:121
Mass (Da):14,281
Last modified:November 14, 2003 - v1
Checksum:i2C889607C3013A82
GO
Isoform 2 (identifier: P60006-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-106: E → EPPLQ

Note: No experimental confimation available.
Show »
Length:125
Mass (Da):14,716
Checksum:iBCDB1E98984878D3
GO

Sequence cautioni

The sequence EAW74842 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73D → G in AK222622 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055048106E → EPPLQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077206 mRNA Translation: AAD27001.1
AL080071 mRNA Translation: CAB45698.1
AK222622 mRNA No translation available.
AP000812 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74842.1 Sequence problems.
BC005156 mRNA Translation: AAH05156.1
BC005393 mRNA Translation: AAH05393.1
CCDSiCCDS60880.1 [P60006-2]
CCDS8210.1 [P60006-1]
PIRiT12467
RefSeqiNP_001265414.1, NM_001278485.1 [P60006-2]
NP_001265415.1, NM_001278486.1 [P60006-2]
NP_001265416.1, NM_001278487.1 [P60006-1]
NP_001265417.1, NM_001278488.1 [P60006-1]
NP_001265418.1, NM_001278489.1 [P60006-1]
NP_001265419.1, NM_001278490.1 [P60006-1]
NP_001265420.1, NM_001278491.1 [P60006-1]
NP_001265421.1, NM_001278492.1 [P60006-1]
NP_001265422.1, NM_001278493.1 [P60006-1]
NP_001265423.1, NM_001278494.1 [P60006-1]
NP_054761.1, NM_014042.2 [P60006-1]
XP_016872985.1, XM_017017496.1 [P60006-1]
XP_016872986.1, XM_017017497.1 [P60006-1]
UniGeneiHs.38044

Genome annotation databases

EnsembliENST00000227618; ENSP00000227618; ENSG00000110200 [P60006-1]
ENST00000535234; ENSP00000446412; ENSG00000110200 [P60006-1]
ENST00000535503; ENSP00000443383; ENSG00000110200 [P60006-1]
ENST00000538393; ENSP00000440002; ENSG00000110200 [P60006-1]
ENST00000538919; ENSP00000440983; ENSG00000110200 [P60006-1]
ENST00000542531; ENSP00000443911; ENSG00000110200 [P60006-1]
ENST00000543587; ENSP00000439403; ENSG00000110200 [P60006-2]
ENST00000545680; ENSP00000443645; ENSG00000110200 [P60006-2]
ENST00000545944; ENSP00000446383; ENSG00000110200 [P60006-1]
GeneIDi25906
KEGGihsa:25906
UCSCiuc001orv.5 human [P60006-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAPC15_HUMAN
AccessioniPrimary (citable) accession number: P60006
Secondary accession number(s): G3V1Q3, Q9CXK2, Q9Y269
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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