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Protein

Transcription elongation factor 1 homolog

Gene

Elof1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26ZincCombined sources1
Metal bindingi29ZincCombined sources1
Metal bindingi50ZincCombined sources1
Metal bindingi53ZincCombined sources1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor 1 homolog
Gene namesi
Name:Elof1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1913376. Elof1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001209421 – 83Transcription elongation factor 1 homologAdd BLAST83

Proteomic databases

EPDiP60003.
PaxDbiP60003.
PeptideAtlasiP60003.
PRIDEiP60003.

PTM databases

PhosphoSitePlusiP60003.

Expressioni

Gene expression databases

BgeeiENSMUSG00000013822.
CleanExiMM_ELOF1.
ExpressionAtlasiP60003. baseline and differential.
GenevisibleiP60003. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP60003. 1 interactor.
MINTiMINT-4139023.
STRINGi10090.ENSMUSP00000013966.

Structurei

Secondary structure

183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni27 – 29Combined sources3
Beta strandi35 – 40Combined sources6
Turni41 – 44Combined sources4
Beta strandi45 – 53Combined sources9
Beta strandi56 – 60Combined sources5
Helixi69 – 79Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WIINMR-A8-79[»]
ProteinModelPortaliP60003.
SMRiP60003.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60003.

Family & Domainsi

Sequence similaritiesi

Belongs to the ELOF1 family.Curated

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3214. Eukaryota.
COG4888. LUCA.
GeneTreeiENSGT00390000000053.
HOVERGENiHBG024628.
InParanoidiP60003.
OMAiSSRKPMG.
OrthoDBiEOG091G14AQ.
PhylomeDBiP60003.
TreeFamiTF313731.

Family and domain databases

InterProiIPR007808. Elf1.
[Graphical view]
PANTHERiPTHR20934. PTHR20934. 1 hit.
PfamiPF05129. Elf1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRKSKRKP PPKKKMTGTL ETQFTCPFCN HEKSCDVKMD RARNTGVISC
60 70 80
TVCLEEFQTP ITYLSEPVDV YSDWIDACEA ANQ
Length:83
Mass (Da):9,462
Last modified:November 14, 2003 - v1
Checksum:i77F11EFBEC72AC6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019870 mRNA. Translation: AAH19870.3.
BC024488 mRNA. Translation: AAH24488.3.
BC056225 mRNA. Translation: AAH56225.1.
CCDSiCCDS40559.1.
RefSeqiNP_740747.1. NM_170777.3.
XP_017168995.1. XM_017313506.1.
XP_017168996.1. XM_017313507.1.
XP_017168997.1. XM_017313508.1.
UniGeneiMm.29801.

Genome annotation databases

EnsembliENSMUST00000013966; ENSMUSP00000013966; ENSMUSG00000013822.
ENSMUST00000166335; ENSMUSP00000128173; ENSMUSG00000013822.
GeneIDi66126.
KEGGimmu:66126.
UCSCiuc009onw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019870 mRNA. Translation: AAH19870.3.
BC024488 mRNA. Translation: AAH24488.3.
BC056225 mRNA. Translation: AAH56225.1.
CCDSiCCDS40559.1.
RefSeqiNP_740747.1. NM_170777.3.
XP_017168995.1. XM_017313506.1.
XP_017168996.1. XM_017313507.1.
XP_017168997.1. XM_017313508.1.
UniGeneiMm.29801.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WIINMR-A8-79[»]
ProteinModelPortaliP60003.
SMRiP60003.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP60003. 1 interactor.
MINTiMINT-4139023.
STRINGi10090.ENSMUSP00000013966.

PTM databases

PhosphoSitePlusiP60003.

Proteomic databases

EPDiP60003.
PaxDbiP60003.
PeptideAtlasiP60003.
PRIDEiP60003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013966; ENSMUSP00000013966; ENSMUSG00000013822.
ENSMUST00000166335; ENSMUSP00000128173; ENSMUSG00000013822.
GeneIDi66126.
KEGGimmu:66126.
UCSCiuc009onw.1. mouse.

Organism-specific databases

CTDi84337.
MGIiMGI:1913376. Elof1.

Phylogenomic databases

eggNOGiKOG3214. Eukaryota.
COG4888. LUCA.
GeneTreeiENSGT00390000000053.
HOVERGENiHBG024628.
InParanoidiP60003.
OMAiSSRKPMG.
OrthoDBiEOG091G14AQ.
PhylomeDBiP60003.
TreeFamiTF313731.

Miscellaneous databases

ChiTaRSiElof1. mouse.
EvolutionaryTraceiP60003.
PROiP60003.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000013822.
CleanExiMM_ELOF1.
ExpressionAtlasiP60003. baseline and differential.
GenevisibleiP60003. MM.

Family and domain databases

InterProiIPR007808. Elf1.
[Graphical view]
PANTHERiPTHR20934. PTHR20934. 1 hit.
PfamiPF05129. Elf1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELOF1_MOUSE
AccessioniPrimary (citable) accession number: P60003
Secondary accession number(s): Q8R1J7, Q96II4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.