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Protein

Transcription elongation factor 1 homolog

Gene

Elof1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi26 – 261ZincCombined sources
Metal bindingi29 – 291ZincCombined sources
Metal bindingi50 – 501ZincCombined sources
Metal bindingi53 – 531ZincCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor 1 homolog
Gene namesi
Name:Elof1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1913376. Elof1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8383Transcription elongation factor 1 homologPRO_0000120942Add
BLAST

Proteomic databases

EPDiP60003.
PaxDbiP60003.
PRIDEiP60003.

PTM databases

PhosphoSiteiP60003.

Expressioni

Gene expression databases

BgeeiP60003.
CleanExiMM_ELOF1.
ExpressionAtlasiP60003. baseline and differential.
GenevisibleiP60003. MM.

Interactioni

Protein-protein interaction databases

IntActiP60003. 1 interaction.
MINTiMINT-4139023.
STRINGi10090.ENSMUSP00000013966.

Structurei

Secondary structure

1
83
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni27 – 293Combined sources
Beta strandi35 – 406Combined sources
Turni41 – 444Combined sources
Beta strandi45 – 539Combined sources
Beta strandi56 – 605Combined sources
Helixi69 – 7911Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WIINMR-A8-79[»]
ProteinModelPortaliP60003.
SMRiP60003. Positions 6-81.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60003.

Family & Domainsi

Sequence similaritiesi

Belongs to the ELOF1 family.Curated

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3214. Eukaryota.
COG4888. LUCA.
HOVERGENiHBG024628.
InParanoidiP60003.
OMAiSSRKPMG.
OrthoDBiEOG7GN2Q8.
PhylomeDBiP60003.
TreeFamiTF313731.

Family and domain databases

InterProiIPR007808. Elf1.
[Graphical view]
PANTHERiPTHR20934. PTHR20934. 1 hit.
PfamiPF05129. Elf1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRKSKRKP PPKKKMTGTL ETQFTCPFCN HEKSCDVKMD RARNTGVISC
60 70 80
TVCLEEFQTP ITYLSEPVDV YSDWIDACEA ANQ
Length:83
Mass (Da):9,462
Last modified:November 14, 2003 - v1
Checksum:i77F11EFBEC72AC6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019870 mRNA. Translation: AAH19870.3.
BC024488 mRNA. Translation: AAH24488.3.
BC056225 mRNA. Translation: AAH56225.1.
CCDSiCCDS40559.1.
RefSeqiNP_740747.1. NM_170777.3.
UniGeneiMm.29801.

Genome annotation databases

EnsembliENSMUST00000013966; ENSMUSP00000013966; ENSMUSG00000013822.
ENSMUST00000166335; ENSMUSP00000128173; ENSMUSG00000013822.
GeneIDi66126.
KEGGimmu:66126.
UCSCiuc009onw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019870 mRNA. Translation: AAH19870.3.
BC024488 mRNA. Translation: AAH24488.3.
BC056225 mRNA. Translation: AAH56225.1.
CCDSiCCDS40559.1.
RefSeqiNP_740747.1. NM_170777.3.
UniGeneiMm.29801.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WIINMR-A8-79[»]
ProteinModelPortaliP60003.
SMRiP60003. Positions 6-81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP60003. 1 interaction.
MINTiMINT-4139023.
STRINGi10090.ENSMUSP00000013966.

PTM databases

PhosphoSiteiP60003.

Proteomic databases

EPDiP60003.
PaxDbiP60003.
PRIDEiP60003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013966; ENSMUSP00000013966; ENSMUSG00000013822.
ENSMUST00000166335; ENSMUSP00000128173; ENSMUSG00000013822.
GeneIDi66126.
KEGGimmu:66126.
UCSCiuc009onw.1. mouse.

Organism-specific databases

CTDi84337.
MGIiMGI:1913376. Elof1.

Phylogenomic databases

eggNOGiKOG3214. Eukaryota.
COG4888. LUCA.
HOVERGENiHBG024628.
InParanoidiP60003.
OMAiSSRKPMG.
OrthoDBiEOG7GN2Q8.
PhylomeDBiP60003.
TreeFamiTF313731.

Miscellaneous databases

ChiTaRSiElof1. mouse.
EvolutionaryTraceiP60003.
NextBioi320710.
PROiP60003.
SOURCEiSearch...

Gene expression databases

BgeeiP60003.
CleanExiMM_ELOF1.
ExpressionAtlasiP60003. baseline and differential.
GenevisibleiP60003. MM.

Family and domain databases

InterProiIPR007808. Elf1.
[Graphical view]
PANTHERiPTHR20934. PTHR20934. 1 hit.
PfamiPF05129. Elf1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Colon, Liver and Mammary gland.
  2. "Solution structure of RSGI RUH-025, a DUF701 domain from mouse cDNA."
    RIKEN structural genomics initiative (RSGI)
    Submitted (MAY-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 8-79 IN COMPLEX WITH ZINC, ZINC-BINDING SITES.

Entry informationi

Entry nameiELOF1_MOUSE
AccessioniPrimary (citable) accession number: P60003
Secondary accession number(s): Q8R1J7, Q96II4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: March 16, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.