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Protein

Transcription elongation factor 1 homolog

Gene

ELOF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26ZincBy similarity1
Metal bindingi29ZincBy similarity1
Metal bindingi50ZincBy similarity1
Metal bindingi53ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130165-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor 1 homolog
Gene namesi
Name:ELOF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28691. ELOF1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84337.
OpenTargetsiENSG00000130165.
PharmGKBiPA142671911.

Polymorphism and mutation databases

BioMutaiELOF1.
DMDMi38372864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001209411 – 83Transcription elongation factor 1 homologAdd BLAST83

Proteomic databases

EPDiP60002.
MaxQBiP60002.
PaxDbiP60002.
PeptideAtlasiP60002.
PRIDEiP60002.

PTM databases

iPTMnetiP60002.
PhosphoSitePlusiP60002.

Expressioni

Gene expression databases

BgeeiENSG00000130165.
CleanExiHS_ELOF1.
ExpressionAtlasiP60002. baseline and differential.
GenevisibleiP60002. HS.

Organism-specific databases

HPAiHPA045606.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124061. 8 interactors.
IntActiP60002. 7 interactors.
MINTiMINT-2804664.
STRINGi9606.ENSP00000252445.

Structurei

3D structure databases

ProteinModelPortaliP60002.
SMRiP60002.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELOF1 family.Curated

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3214. Eukaryota.
COG4888. LUCA.
GeneTreeiENSGT00390000000053.
HOVERGENiHBG024628.
InParanoidiP60002.
PhylomeDBiP60002.
TreeFamiTF313731.

Family and domain databases

InterProiIPR007808. Elf1.
[Graphical view]
PANTHERiPTHR20934. PTHR20934. 1 hit.
PfamiPF05129. Elf1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRKSKRKP PPKKKMTGTL ETQFTCPFCN HEKSCDVKMD RARNTGVISC
60 70 80
TVCLEEFQTP ITYLSEPVDV YSDWIDACEA ANQ
Length:83
Mass (Da):9,462
Last modified:November 14, 2003 - v1
Checksum:i77F11EFBEC72AC6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007516 mRNA. Translation: AAH07516.1.
CCDSiCCDS12264.1.
RefSeqiNP_115753.1. NM_032377.3.
XP_016882847.1. XM_017027358.1.
XP_016882848.1. XM_017027359.1.
UniGeneiHs.631633.

Genome annotation databases

EnsembliENST00000252445; ENSP00000252445; ENSG00000130165.
ENST00000586120; ENSP00000467914; ENSG00000130165.
ENST00000590700; ENSP00000467264; ENSG00000130165.
GeneIDi84337.
KEGGihsa:84337.
UCSCiuc002mse.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007516 mRNA. Translation: AAH07516.1.
CCDSiCCDS12264.1.
RefSeqiNP_115753.1. NM_032377.3.
XP_016882847.1. XM_017027358.1.
XP_016882848.1. XM_017027359.1.
UniGeneiHs.631633.

3D structure databases

ProteinModelPortaliP60002.
SMRiP60002.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124061. 8 interactors.
IntActiP60002. 7 interactors.
MINTiMINT-2804664.
STRINGi9606.ENSP00000252445.

PTM databases

iPTMnetiP60002.
PhosphoSitePlusiP60002.

Polymorphism and mutation databases

BioMutaiELOF1.
DMDMi38372864.

Proteomic databases

EPDiP60002.
MaxQBiP60002.
PaxDbiP60002.
PeptideAtlasiP60002.
PRIDEiP60002.

Protocols and materials databases

DNASUi84337.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252445; ENSP00000252445; ENSG00000130165.
ENST00000586120; ENSP00000467914; ENSG00000130165.
ENST00000590700; ENSP00000467264; ENSG00000130165.
GeneIDi84337.
KEGGihsa:84337.
UCSCiuc002mse.1. human.

Organism-specific databases

CTDi84337.
DisGeNETi84337.
GeneCardsiELOF1.
HGNCiHGNC:28691. ELOF1.
HPAiHPA045606.
neXtProtiNX_P60002.
OpenTargetsiENSG00000130165.
PharmGKBiPA142671911.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3214. Eukaryota.
COG4888. LUCA.
GeneTreeiENSGT00390000000053.
HOVERGENiHBG024628.
InParanoidiP60002.
PhylomeDBiP60002.
TreeFamiTF313731.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130165-MONOMER.

Miscellaneous databases

ChiTaRSiELOF1. human.
GenomeRNAii84337.
PROiP60002.

Gene expression databases

BgeeiENSG00000130165.
CleanExiHS_ELOF1.
ExpressionAtlasiP60002. baseline and differential.
GenevisibleiP60002. HS.

Family and domain databases

InterProiIPR007808. Elf1.
[Graphical view]
PANTHERiPTHR20934. PTHR20934. 1 hit.
PfamiPF05129. Elf1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELOF1_HUMAN
AccessioniPrimary (citable) accession number: P60002
Secondary accession number(s): Q8R1J7, Q96II4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.