P59999 (ARPC4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin-related protein 2/3 complex subunit 4

Alternative name(s):
Arp2/3 complex 20 kDa subunit
Short name=p20-ARC

Gene names

Name:	Arpc4
Synonyms:	Arc20

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament By similarity.
Subunit structure	Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity. Cell projection By similarity.
Sequence similarities	Belongs to the ARPC4 family.

Ontologies

Keywords
Cellular component	Cell projection Cytoplasm Cytoskeleton
Ligand	Actin-binding
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	actin filament polymerization Inferred from electronic annotation. Source: InterPro
Cellular component	Arp2/3 protein complex Traceable author statement. Source: MGI cell projection Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	actin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.4
	Chain	2 – 168	167	Actin-related protein 2/3 complex subunit 4		PRO_0000124050
Amino acid modifications
	Modified residue	2	1	N-acetylthreonine Ref.4
	Modified residue	35	1	N6-acetyllysine By similarity
	Modified residue	89	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P59999 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 273CCB230AC703DF	FASTA	168	19,667
	10 20 30 40 50 60 MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP VTISRNEKEK 70 80 90 100 110 120 VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN FFILRRKPVE GYDISFLITN 130 140 150 160 FHTEQMYKHK LVDFVIHFME EIDKEISEMK LSVNARARIV AEEFLKNF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Full-length sequencing of some human and murine muscular transcripts (Telethon Italy project B41)." Ievolella C., Campagna D., Lanfranchi G. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Bone marrow, Egg, Hypothalamus, Mammary gland, Pituitary and Thymus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[4]	Sumpton D.P., Sandilands E., Frame M.C., Bienvenut W.V. Submitted (MAR-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-41; 45-55; 61-71; 98-105; 107-128; 131-150 AND 159-166, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
[5]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 98-105, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ278129 mRNA. Translation: CAC34583.1. AK017993 mRNA. Translation: BAB31026.1. AK039215 mRNA. Translation: BAC30279.1. AK077325 mRNA. Translation: BAC36751.1. AK133626 mRNA. Translation: BAE21755.1. AK136082 mRNA. Translation: BAE22810.1. AK150690 mRNA. Translation: BAE29769.1. AK153380 mRNA. Translation: BAE31946.1. AK166440 mRNA. Translation: BAE38777.1. BC015280 mRNA. No translation available.
IPI	IPI00138691.
RefSeq	NP_001163956.1. NM_001170485.1. NP_001163957.1. NM_001170486.1. NP_080828.1. NM_026552.3.
UniGene	Mm.289306. Mm.472172.
3D structure databases
ProteinModelPortal	P59999.
SMR	P59999. Positions 2-168.
ModBase	Search...
Protein-protein interaction databases
IntAct	P59999. 3 interactions.
STRING	P59999.
PTM databases
PhosphoSite	P59999.
Proteomic databases
PRIDE	P59999.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000156898; ENSMUSP00000114839; ENSMUSG00000079426.
GeneID	68089.
KEGG	mmu:68089.
UCSC	uc009dfs.2. mouse.
Organism-specific databases
CTD	10093.
MGI	MGI:1915339. Arpc4.
Phylogenomic databases
eggNOG	roNOG04263.
HOGENOM	HBG314395.
HOVERGEN	HBG050582.
InParanoid	P59999.
OMA	PVQGYDI.
PhylomeDB	P59999.
Gene expression databases
ArrayExpress	P59999.
Bgee	P59999.
CleanEx	MM_ARPC4.
Genevestigator	P59999.
GermOnline	ENSMUSG00000072846. Mus musculus.
Family and domain databases
InterPro	IPR008384. ARPC4. [Graphical view]
KO	K05755.
PANTHER	PTHR22629. ARPC4. 1 hit.
Pfam	PF05856. ARPC4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	326392.
SOURCE	Search...

Entry information

Entry name

ARPC4_MOUSE

Accession

Primary (citable) accession number: P59999
Secondary accession number(s): O15509, Q3UWV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 73 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program