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Protein

Actin-related protein 2/3 complex subunit 4

Gene

Arpc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 4
Alternative name(s):
Arp2/3 complex 20 kDa subunit
Short name:
p20-ARC
Gene namesi
Name:Arpc4
Synonyms:Arc20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1915339 Arpc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001240502 – 168Actin-related protein 2/3 complex subunit 4Add BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP59999
MaxQBiP59999
PaxDbiP59999
PeptideAtlasiP59999
PRIDEiP59999
TopDownProteomicsiP59999

PTM databases

iPTMnetiP59999
PhosphoSitePlusiP59999

Expressioni

Gene expression databases

BgeeiENSMUSG00000079426
CleanExiMM_ARPC4
ExpressionAtlasiP59999 baseline and differential
GenevisibleiP59999 MM

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212649, 6 interactors
IntActiP59999, 7 interactors
MINTiP59999
STRINGi10090.ENSMUSP00000114839

Structurei

3D structure databases

ProteinModelPortaliP59999
SMRiP59999
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC4 family.Curated

Phylogenomic databases

eggNOGiKOG1876 Eukaryota
ENOG4111G2F LUCA
GeneTreeiENSGT00390000016233
HOGENOMiHOG000202303
HOVERGENiHBG050582
InParanoidiP59999
KOiK05755
OMAiMLKHKIV
OrthoDBiEOG091G0OI8
PhylomeDBiP59999
TreeFamiTF105621

Family and domain databases

Gene3Di3.30.1460.20, 1 hit
InterProiView protein in InterPro
IPR034666 ARPC2/4
IPR008384 ARPC4
PANTHERiPTHR22629 PTHR22629, 1 hit
PfamiView protein in Pfam
PF05856 ARPC4, 1 hit
PIRSFiPIRSF039100 ARPC4, 1 hit
SUPFAMiSSF69645 SSF69645, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59999-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP
60 70 80 90 100
VTISRNEKEK VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN
110 120 130 140 150
FFILRRKPVE GYDISFLITN FHTEQMYKHK LVDFVIHFME EIDKEISEMK
160
LSVNARARIV AEEFLKNF
Length:168
Mass (Da):19,667
Last modified:January 23, 2007 - v3
Checksum:i273CCB230AC703DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278129 mRNA Translation: CAC34583.1
AK017993 mRNA Translation: BAB31026.1
AK039215 mRNA Translation: BAC30279.1
AK077325 mRNA Translation: BAC36751.1
AK133626 mRNA Translation: BAE21755.1
AK136082 mRNA Translation: BAE22810.1
AK150690 mRNA Translation: BAE29769.1
AK153380 mRNA Translation: BAE31946.1
AK166440 mRNA Translation: BAE38777.1
BC015280 mRNA No translation available.
CCDSiCCDS20417.1
RefSeqiNP_001163956.1, NM_001170485.1
NP_001163957.1, NM_001170486.1
NP_080828.1, NM_026552.3
UniGeneiMm.289306
Mm.472172

Genome annotation databases

EnsembliENSMUST00000156898; ENSMUSP00000114839; ENSMUSG00000079426
GeneIDi68089
KEGGimmu:68089
UCSCiuc009dfs.2 mouse

Similar proteinsi

Entry informationi

Entry nameiARPC4_MOUSE
AccessioniPrimary (citable) accession number: P59999
Secondary accession number(s): O15509, Q3UWV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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