Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sensor histidine kinase MtrB

Gene

mtrB

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Member of the two-component regulatory system MtrA/MtrB. Seems to function as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-3441-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor histidine kinase MtrB (EC:2.7.13.3)
Gene namesi
Name:mtrB
Ordered Locus Names:BQ2027_MB3273C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000748061 – 567Sensor histidine kinase MtrBAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei305Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP59963
SMRiP59963
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 287HAMPPROSITE-ProRule annotationAdd BLAST53
Domaini302 – 519Histidine kinasePROSITE-ProRule annotationAdd BLAST218

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000247709
OMAiNRFWRSD

Family and domain databases

CDDicd06225 HAMP, 1 hit
cd00075 HATPase_c, 1 hit
cd00082 HisKA, 1 hit
Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003660 HAMP_dom
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR004358 Sig_transdc_His_kin-like_C
PfamiView protein in Pfam
PF00672 HAMP, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00304 HAMP, 1 hit
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SUPFAMiSSF47384 SSF47384, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50885 HAMP, 1 hit
PS50109 HIS_KIN, 1 hit

Sequencei

Sequence statusi: Complete.

P59963-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFGSRRRIR GRRGRSGPMT RGLSALSRAV AVAWRRSLQL RVVALTLGLS
60 70 80 90 100
LAVILALGFV LTSQVTNRVL DIKVRAAIDQ IERARTTVSG IVNGEETRSL
110 120 130 140 150
DSSLQLARNT LTSKTDPASG AGLAGAFDAV LMVPGDGPRA ASTAGPVDQV
160 170 180 190 200
PNALRGFVKA GQAAYQYATV QTEGFSGPAL IIGTPTLSRV ANLELYLIFP
210 220 230 240 250
LASEQATITL VRGTMATGGL VLLVLLAGIA LLVSRQVVVP VRSASRIAER
260 270 280 290 300
FAEGHLSERM PVRGEDDMAR LAVSFNDMAE SLSRQIAQLE EFGNLQRRFT
310 320 330 340 350
SDVSHELRTP LTTVRMAADL IYDHSADLDP TLRRSTELMV SELDRFETLL
360 370 380 390 400
NDLLEISRHD AGVAELSVEA VDLRTTVNNA LGNVGHLAEE AGIELLVDLP
410 420 430 440 450
AEQVIAEVDA RRVERILRNL IANAIDHAEH KPVRIRMAAD EDTVAVTVRD
460 470 480 490 500
YGVGLRPGEE KLVFSRFWRS DPSRVRRSGG TGLGLAISVE DARLHQGRLE
510 520 530 540 550
AWGEPGEGAC FRLTLPLVRG HKVTTSPLPM KPIPQPVLQP VAQPNPQPMP
560
PEYKERQRPR EHAEWSG
Length:567
Mass (Da):61,619
Last modified:October 31, 2003 - v1
Checksum:iB4C73DF5D69D064E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU01902.1
RefSeqiNP_856918.1, NC_002945.3
WP_003416988.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO44545; CDO44545; Mb3273c
PATRICifig|233413.5.peg.3600

Similar proteinsi

Entry informationi

Entry nameiMTRB_MYCBO
AccessioniPrimary (citable) accession number: P59963
Secondary accession number(s): A0A1R3Y3J3, X2BNF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health