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Protein

Sensor histidine kinase MtrB

Gene

mtrB

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system MtrA/MtrB. Seems to function as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor histidine kinase MtrB (EC:2.7.13.3)
Gene namesi
Name:mtrB
Ordered Locus Names:Mb3273c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Sensor histidine kinase MtrBPRO_0000074806Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei305 – 3051Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP59963.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 28753HAMPPROSITE-ProRule annotationAdd
BLAST
Domaini302 – 519218Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HAMP domain.PROSITE-ProRule annotation
Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000247709.
KOiK07654.
OMAiQEDARLH.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59963-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFGSRRRIR GRRGRSGPMT RGLSALSRAV AVAWRRSLQL RVVALTLGLS
60 70 80 90 100
LAVILALGFV LTSQVTNRVL DIKVRAAIDQ IERARTTVSG IVNGEETRSL
110 120 130 140 150
DSSLQLARNT LTSKTDPASG AGLAGAFDAV LMVPGDGPRA ASTAGPVDQV
160 170 180 190 200
PNALRGFVKA GQAAYQYATV QTEGFSGPAL IIGTPTLSRV ANLELYLIFP
210 220 230 240 250
LASEQATITL VRGTMATGGL VLLVLLAGIA LLVSRQVVVP VRSASRIAER
260 270 280 290 300
FAEGHLSERM PVRGEDDMAR LAVSFNDMAE SLSRQIAQLE EFGNLQRRFT
310 320 330 340 350
SDVSHELRTP LTTVRMAADL IYDHSADLDP TLRRSTELMV SELDRFETLL
360 370 380 390 400
NDLLEISRHD AGVAELSVEA VDLRTTVNNA LGNVGHLAEE AGIELLVDLP
410 420 430 440 450
AEQVIAEVDA RRVERILRNL IANAIDHAEH KPVRIRMAAD EDTVAVTVRD
460 470 480 490 500
YGVGLRPGEE KLVFSRFWRS DPSRVRRSGG TGLGLAISVE DARLHQGRLE
510 520 530 540 550
AWGEPGEGAC FRLTLPLVRG HKVTTSPLPM KPIPQPVLQP VAQPNPQPMP
560
PEYKERQRPR EHAEWSG
Length:567
Mass (Da):61,619
Last modified:October 31, 2003 - v1
Checksum:iB4C73DF5D69D064E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44545.1.
RefSeqiNP_856918.1. NC_002945.3.
WP_003416988.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO44545; CDO44545; Mb3273c.
GeneIDi1093997.
KEGGimbo:Mb3273c.
PATRICi18008944. VBIMycBov88188_3600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44545.1.
RefSeqiNP_856918.1. NC_002945.3.
WP_003416988.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP59963.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO44545; CDO44545; Mb3273c.
GeneIDi1093997.
KEGGimbo:Mb3273c.
PATRICi18008944. VBIMycBov88188_3600.

Phylogenomic databases

HOGENOMiHOG000247709.
KOiK07654.
OMAiQEDARLH.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiMTRB_MYCBO
AccessioniPrimary (citable) accession number: P59963
Secondary accession number(s): X2BNF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: December 9, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.