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Reviewed, UniProtKB/Swiss-Prot P59962 (NUOG_MYCBO)

Last modified June 16, 2009. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADH-quinone oxidoreductase subunit G
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit G
    NDH-1 subunit G
Gene names
Name: nuoG
Ordered Locus Names: Mb3175
OrganismMycobacterium bovis [Complete proteome] [HAMAP]
Taxonomic identifier1765 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length806 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD+ + quinol.

Cofactor

Binds 1 2Fe-2S cluster per subunit By similarity.

Binds 3 4Fe-4S clusters per subunit By similarity.

Sequence similarities

Belongs to the complex I 75 kDa subunit family.

Contains 1 2Fe-2S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 806806NADH-quinone oxidoreductase subunit G
PRO_0000118558

Regions

Domain15 – 93792Fe-2S ferredoxin-type

Sites

Metal binding491Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding601Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding631Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding771Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1111Iron-sulfur 2 (4Fe-4S); via pros nitrogen By similarity
Metal binding1151Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1181Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1241Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1641Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1671Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1701Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding2141Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding2401Iron-sulfur 4 (4Fe-4S) Potential
Metal binding2431Iron-sulfur 4 (4Fe-4S) Potential
Metal binding2471Iron-sulfur 4 (4Fe-4S) Potential
Metal binding2751Iron-sulfur 4 (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
P59962-1 [UniParc].

Last modified October 31, 2003. Version 1.
Checksum: D674D74FA6FF3E81

FASTA80685,412
        10         20         30         40         50         60 
MTQAADTDIR VGQPEMVTLT IDGVEISVPK GTLVIRAAEL MGIQIPRFCD HPLLEPVGAC 

        70         80         90        100        110        120 
RQCLVEVEGQ RKPLASCTTV ATDDMVVRTQ LTSEIADKAQ HGVMELLLIN HPLDCPMCDK 

       130        140        150        160        170        180 
GGECPLQNQA MSNGRTDSRF TEAKRTFAKP INISAQVLLD RERCILCARC TRFSDQIAGD 

       190        200        210        220        230        240 
PFIDMQERGA LQQVGIYADE PFESYFSGNT VQICPVGALT GTAYRFRARP FDLVSSPSVC 

       250        260        270        280        290        300 
EHCASGCAQR TDHRRGKVLR RLAGDDPEVN EEWNCDKGRW AFTYATQPDV ITTPLIRDGG 

       310        320        330        340        350        360 
DPKGALVPTS WSHAMAVAAQ GLAAARGRTG VLVGGRVTWE DAYAYAKFAR ITLGTNDIDF 

       370        380        390        400        410        420 
RARPHSAEEA DFLAARIAGR HMAVSYADLE SAPVVLLVGF EPEDESPIVF LRLRKAARRH 

       430        440        450        460        470        480 
RVPVYTIAPF ATGGLHKMSG RLIKTVPGGE PAALDDLATG AVGDLLATPG AVIMVGERLA 

       490        500        510        520        530        540 
TVPGGLSAAA RLADTTGARL AWVPRRAGER GALEAGALPT LLPGGRPLAD EVARAQVCAA 

       550        560        570        580        590        600 
WHIAELPAAA GRDADGILAA AADETLAALL VGGIEPADFA DPDAVLAALD ATGFVVSLEL 

       610        620        630        640        650        660 
RHSAVTERAD VVFPVAPTTQ KAGAFVNWEG RYRTFEPALR GSTLQAGQSD HRVLDALADD 

       670        680        690        700        710        720 
MGVHLGVPTV EAAREELAAL GIWDGKHAAG PHIAATGPTQ PEAGEAILTG WRMLLDEGRL 

       730        740        750        760        770        780 
QDGEPYLAGT ARTPVVRLSP DTAAEIGAAD GEAVTVSTSR GSITLPCSVT DMPDRVVWLP 

       790        800 
LNSAGSTVHR QLRVTIGSIV KIGAGS 

« Hide

Cross-references

Sequence databases

BX248345 Genomic DNA. Translation: CAD95267.1.
RefSeqNP_856820.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1093502.
GenomeReviewsGene locus Mb3175 in contig BX248333_GR.
KEGGmbo:Mb3175.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP59962.
OMAP59962. LKQGGQW.

Enzyme and pathway databases

BRENDA1.6.99.5. 3091.

Family and domain databases

InterProIPR006058. 2Fe2S_fd_BS.
IPR009010. Asp_de-COase-like_fold.
IPR001041. Ferredoxin.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_Fe4S4.
IPR006657. MPT_dinuc_bd.
IPR000283. NADH_UbQ_OxRdtase_75KDa_su_CS.
IPR010228. NADH_UbQ_OxRdtase_Gsu.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
Gene3DG3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
PfamPF00111. Fer2. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
TIGRFAMsTIGR01973. NuoG. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. False negative.
PS51085. 2FE2S_FER_2. 1 hit.
PS00641. COMPLEX1_75K_1. 1 hit.
PS00642. COMPLEX1_75K_2. 1 hit.
PS00643. COMPLEX1_75K_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOG_MYCBO
AccessionPrimary (citable) accession number: P59962
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents