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Protein

Cation-transporting P-type ATPase B

Gene

ctpB

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26PROSITE-ProRule annotation1
Metal bindingi29PROSITE-ProRule annotation1
Active sitei4464-aspartylphosphate intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-transporting P-type ATPase B (EC:3.6.3.-)
Gene namesi
Name:ctpB
Ordered Locus Names:Mb0106c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Transmembranei714 – 734HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461661 – 752Cation-transporting P-type ATPase BAdd BLAST752

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP59947.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 79HMAPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Contains 1 HMA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000250397.
KOiK12949.
OMAiAWEALRY.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR000579. Cation-trans_P-type_ATPase_A/B.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00940. CATPATPASEA.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPVVGDAD LQSVRRIRLD VSGMSCAACA SRVETKLNKI PGVRASVNFA
60 70 80 90 100
TRVATIDAVG MAADELCGVV EKAGYHAAPH TETTVLDKRT KDPDGAHARR
110 120 130 140 150
LLRRLLVAAV LFVPLADLST LFAIVPSARV PGWGYILTAL AAPVVTWAAW
160 170 180 190 200
PFHSVALRNA RHRTTSMETL ISVGIVAATA WSLSSVFGDQ PPREGSGIWR
210 220 230 240 250
AILNSDSIYL EVAAGVTVFV LAGRYFEARA KSKAGSALRA LAELGAKNVA
260 270 280 290 300
VLLPDGAELV IPASELKKRQ RFVTRPGETI AADGVVVDGS AAIDMSAMTG
310 320 330 340 350
EAKPVRAYPA ASVVGGTVVM DGRLVIEATA VGADTQFAAM VRLVEQAQTQ
360 370 380 390 400
KARAQRLADH IAGVFVPVVF VIAGLAGAAW LVSGAGADRA FSVTLGVLVI
410 420 430 440 450
ACPCALGLAT PTAMMVASGR GAQLGIFIKG YRALETIRSI DTVVFDKTGT
460 470 480 490 500
LTVGQLAVST VTMAGSGTSE RDREEVLGLA AAVESASEHA MAAAIVAASP
510 520 530 540 550
DPGPVNGFVA VAGCGVSGEV GGHHVEVGKP SWITRTTPCH DAALVSARLD
560 570 580 590 600
GESRGETVVF VSVDGVVRAA LTIADTLKDS AAAAVAALRS RGLRTILLTG
610 620 630 640 650
DNRAAADAVA AQVGIDSAVA DMLPEGKVDV IQRLREEGHT VAMVGDGIND
660 670 680 690 700
GPALVGADLG LAIGRGTDVA LGAADIILVR DDLNTVPQAL DLARATMRTI
710 720 730 740 750
RMNMIWAFGY NVAAIPIAAA GLLNPLIAGA AMAFSSFFVV SNSLRLRNFG

AQ
Length:752
Mass (Da):77,483
Last modified:October 31, 2003 - v1
Checksum:iD5247986C5132626
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO41341.1.
RefSeqiNP_853774.1. NC_002945.3.
WP_003400797.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO41341; CDO41341; Mb0106c.
GeneIDi1090789.
KEGGimbo:Mb0106c.
PATRICi18001900. VBIMycBov88188_0118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO41341.1.
RefSeqiNP_853774.1. NC_002945.3.
WP_003400797.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP59947.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO41341; CDO41341; Mb0106c.
GeneIDi1090789.
KEGGimbo:Mb0106c.
PATRICi18001900. VBIMycBov88188_0118.

Phylogenomic databases

HOGENOMiHOG000250397.
KOiK12949.
OMAiAWEALRY.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR000579. Cation-trans_P-type_ATPase_A/B.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00940. CATPATPASEA.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTPB_MYCBO
AccessioniPrimary (citable) accession number: P59947
Secondary accession number(s): X2BE13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.