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P59944 (KAX1D_LEIQH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 1.13
Alternative name(s):
Charybdotoxin c
Short name=ChTx-c
OrganismLeiurus quinquestriatus hebraeus (Yellow scorpion)
Taxonomic identifier6884 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeLeiurus

Protein attributes

Sequence length37 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Blocks calcium-activated potassium channels By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3737Potassium channel toxin alpha-KTx 1.13
PRO_0000044892

Regions

Region26 – 338Interaction with Ca(2+)-activated K(+) channels Potential

Sites

Site271Basic residue of the functional dyad By similarity
Site361Aromatic residue of the functional dyad By similarity

Amino acid modifications

Modified residue11Pyrrolidone carboxylic acid
Disulfide bond7 ↔ 28 By similarity
Disulfide bond13 ↔ 33 By similarity
Disulfide bond17 ↔ 35 By similarity

Sequences

Sequence LengthMass (Da)Tools
P59944 [UniParc].

Last modified October 31, 2003. Version 1.
Checksum: 29319BCB43994EE2

FASTA374,318
        10         20         30 
QFTNVSCTTS KECWSVCEKL YNTSRGKCMN KKCRCYS 

« Hide

References

[1]"Dynamic diversification from a putative common ancestor of scorpion toxins affecting sodium, potassium, and chloride channels."
Froy O., Sagiv T., Poreh M., Urbach D., Zilberberg N., Gurevitz M.
J. Mol. Evol. 48:187-196(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.

Cross-references

3D structure databases

ProteinModelPortalP59944.
SMRP59944. Positions 1-37.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSPR00286. CHARYBDTOXIN.
ProDomPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKAX1D_LEIQH
AccessionPrimary (citable) accession number: P59944
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: October 16, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries