Potassium channel toxin gamma-KTx 3.1

Functionⁱ

Blocks Kv11/ERG potassium channels (tested in MMQ lactotroph cells that contain the three ERG channels: rKv11.1/KCNH2/ERG1, rKv11.2/KCNH6/ERG2 and rKv11.3/KCNH7/ERG3). This toxin can be used to distinguish slow deactivating components (ERGS) from fast deactivating components (ERGF) currents, since it specifically blocks ERGS.1 Publication

GO - Molecular functionⁱ

potassium channel inhibitor activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

defense response Source: InterPro
pathogenesis Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Molecular function

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium channel toxin gamma-KTx 3.11 Publication Alternative name(s): CnErgTx21 Publication Short name: CnErg21 Publication Ergtoxin-21 Publication Short name: ErgTx21 Publication Ergtoxin-like protein1 Publication
Organismⁱ	Centruroides noxius (Mexican scorpion)
Taxonomic identifierⁱ	6878 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides

Subcellular locationⁱ

Secreted
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "A large number of novel Ergtoxin-like genes and ERG K+-channels blocking peptides from scorpions of the genus Centruroides."
  Corona M., Gurrola G.B., Merino E., Cassulini R.R., Valdez-Cruz N.A., Garcia B., Ramirez-Dominguez M.E., Coronas F.I., Zamudio F.Z., Wanke E., Possani L.D.
  FEBS Lett. 532:121-126(2002) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, NOMENCLATURE.

GO - Cellular componentⁱ

extracellular region Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000066840	1 – 43	Potassium channel toxin gamma-KTx 3.11 PublicationAdd BLAST		43

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	5 ↔ 23	By similarity
Disulfide bondⁱ	11 ↔ 34	By similarity
Disulfide bondⁱ	20 ↔ 39	By similarity
Disulfide bondⁱ	24 ↔ 41	By similarity

Keywords - PTMⁱ

Disulfide bond

Expressionⁱ

Tissue specificityⁱ

Expressed by the venom gland.Curated

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P59939.
SMRⁱ	P59939.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Has the CSalpha/beta fold, which comprises one or two short alpha helices connected to anti-parallel beta-sheets stabilized by three or four disulfide bonds.By similarity

Sequence similaritiesⁱ

Belongs to the ergtoxin family. Gamma-KTx 3 subfamily.Curated

Keywords - Domainⁱ

Knottin

Family and domain databases

Gene3Dⁱ	3.30.30.10. 1 hit.
InterProⁱ	View protein in InterPro IPR012622. Ergtoxin. IPR003614. Scorpion_toxin-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08086. Toxin_17. 1 hit.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD736966. Ergtoxin. 1 hit.
SUPFAMⁱ	SSF57095. SSF57095. 1 hit.
PROSITEⁱ	View protein in PROSITE PS60026. ERGTX. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P59939-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40 
GRDSCVNKSR CAKYGYYSQC EVCCKKAGHK GGTCDFFKCK CKV

Length:43

Mass (Da):4,791

Last modified:October 31, 2003 - v1

Checksum:ⁱ76851224D563EBC1

GO

Mass spectrometryⁱ

Molecular mass is 4783 Da from positions 1 - 43. 1 Publication

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

3D structure databases

ProteinModelPortalⁱ	P59939.
SMRⁱ	P59939.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

Gene3Dⁱ	3.30.30.10. 1 hit.
InterProⁱ	View protein in InterPro IPR012622. Ergtoxin. IPR003614. Scorpion_toxin-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08086. Toxin_17. 1 hit.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD736966. Ergtoxin. 1 hit.
SUPFAMⁱ	SSF57095. SSF57095. 1 hit.
PROSITEⁱ	View protein in PROSITE PS60026. ERGTX. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KGX31_CENNO
Accessionⁱ	P59939Primary (citable) accession number: P59939
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
	Last sequence update:	October 31, 2003
	Last modified:	January 18, 2017
	This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Animal Toxin Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Direct protein sequencing

Documents

Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries
SIMILARITY comments
Index of protein domains and families

UniProtKB - P59939 (KGX31_CENNO)

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Expressionⁱ

Tissue specificityⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domainⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Family and domain databases

Sequenceⁱ

Mass spectrometryⁱ

Similar proteinsⁱ

Cross-referencesⁱ

3D structure databases

Protocols and materials databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P59939 (KGX31_CENNO)

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Potassium channel toxin gamma-KTx 3.1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Mass spectrometryⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ