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P59934 (COOS1_CARHZ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carbon monoxide dehydrogenase 1
Short name=CODH 1
EC=1.2.99.2
Gene names
Name:cooS1
Ordered Locus Names:CHY_1824
OrganismCarboxydothermus hydrogenoformans (strain Z-2901 / DSM 6008) [Complete proteome] [HAMAP]
Taxonomic identifier246194 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Carboxydothermus

Protein attributes

Sequence length636 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH) By similarity.

Catalytic activity

CO + H2O + A = CO2 + AH2.

Cofactor

Binds 3 4Fe-4S clusters per homodimer By similarity.

Binds 2 nickel-iron-sulfur clusters per homodimer By similarity.

Enzyme regulation

Inactivated by O2.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Loosely attached to the membrane, probably via CooF. Ref.2

Sequence similarities

Belongs to the Ni-containing carbon monoxide dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 636635Carbon monoxide dehydrogenase 1
PRO_0000157137

Sites

Metal binding381Iron-sulfur 1 (4Fe-4S); shared with dimeric partner By similarity
Metal binding461Iron-sulfur 1 (4Fe-4S); shared with dimeric partner By similarity
Metal binding471Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding501Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding551Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding691Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding2621Nickel-iron-sulfur By similarity
Metal binding2971Nickel-iron-sulfur By similarity
Metal binding3351Nickel-iron-sulfur By similarity
Metal binding4481Nickel-iron-sulfur By similarity
Metal binding4781Nickel-iron-sulfur By similarity
Metal binding5281Nickel-iron-sulfur By similarity

Experimental info

Sequence conflict101P → D AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P59934 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 78CDD333C2A296C7

FASTA63667,679
        10         20         30         40         50         60 
MSNWKNSVDP AVDYLLPIAK KAGIETAWDR YEAMQPQCGF GELGVCCRIC WKGPCRIDPF 

        70         80         90        100        110        120 
GNGPQRGVCG ADAHTIVARN LIRMIAAGAA AHSEHGRHIA LTLLEVGEGH APAYRIKDEQ 

       130        140        150        160        170        180 
KLRKIAEKLN LAPAGKDIRQ VAKEVALASL DDYSRQKRNV PCNWAKETLT AERVDKLAEL 

       190        200        210        220        230        240 
GVMPHNIDAV ITEIMGRTHV GCDADAVNLL LGGIKGALAD YTGMCLSTEL SDVIFGTPKP 

       250        260        270        280        290        300 
VITQANLGVL KEDAVNIAVH GHNPLLSEII CDVALKMNEE AKKAGAKEGI NVVGICCTGN 

       310        320        330        340        350        360 
EVMMRRGIPL ATNYLSQEMA IITGALDAMV VDVQCIMPAL TSVAECFHTE IITTMAENKI 

       370        380        390        400        410        420 
TGATHIEFRE DSAVESAKKI VEVAIEAFKK RDKRKVNIPD CKQTAITGFS AEAIMAVLSK 

       430        440        450        460        470        480 
LNANDPLKPL IDNIINGNIQ GIALFAGCNN PKAIHDNSFI TIAKELAKNN VLMLATGCGA 

       490        500        510        520        530        540 
GAFAKNGLMT QEATEAYAGE SLKAVLTALG KAAGLNGPLP LVLHMGSCVD NSRAVNVAVA 

       550        560        570        580        590        600 
IANKLGVDLD KLPLVASAPE FMSEKAVAIG TWAVTLGIPT HIGIVPQIMG SSVVVEFLTE 

       610        620        630 
KAKDLLGGYF IVETNPELAA AKLVAVIKER RRGLGI

« Hide

References

« Hide 'large scale' references
[1]"Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901."
Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J., Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.
PLoS Genet. 1:563-574(2005) [PubMed: 16311624] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Z-2901 / DSM 6008.
[2]"Two membrane-associated NiFeS-carbon monoxide dehydrogenases from the anaerobic carbon-monoxide-utilizing eubacterium Carboxydothermus hydrogenoformans."
Svetlitchnyi V., Peschel C., Acker G., Meyer O.
J. Bacteriol. 183:5134-5144(2001) [PubMed: 11489867] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-23, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000141 Genomic DNA. Translation: ABB14432.1.
RefSeqYP_360644.1. NC_007503.1.

3D structure databases

ProteinModelPortalP59934.
SMRP59934. Positions 25-634.
ModBaseSearch...

Protein-protein interaction databases

STRINGP59934.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3728783.
GenomeReviewsGene locus CHY_1824 in contig CP000141_GR.
KEGGchy:CHY_1824.
NMPDRfig|246194.3.peg.2363.
PATRIC21276751. VBICarHyd26463_1739.
TIGRCHY_1824.

Phylogenomic databases

eggNOGCOG1151.
HOGENOMHBG393174.
OMAHGRHIAL.
ProtClustDBCLSK862738.

Enzyme and pathway databases

BioCycCHYD246194:CHY_1824-MONOMER.

Family and domain databases

InterProIPR016101. CO_DH_a-bundle.
IPR010047. CO_DH_cat.
IPR004137. Prismane.
IPR011254. Prismane-like.
IPR016099. Prismane-like_a/b-sand.
[Graphical view]
Gene3DG3DSA:1.20.1270.30. CO_DH_a-bundle. 1 hit.
G3DSA:3.40.50.2030. Prismane-like_a/b-sand. 2 hits.
KOK00190.
PfamPF03063. Prismane. 1 hit.
[Graphical view]
PIRSFPIRSF005023. CODH. 1 hit.
SUPFAMSSF56821. Prismane_like. 1 hit.
TIGRFAMsTIGR01702. CO_DH_cata. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOOS1_CARHZ
AccessionPrimary (citable) accession number: P59934
Secondary accession number(s): Q3AB40
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 58 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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