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Protein

Zinc finger protein 445

Gene

ZNF445

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri485 – 507C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 619C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri625 – 647C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri681 – 703C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri709 – 731C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri840 – 862C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri868 – 890C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri896 – 918C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri978 – 1000C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1006 – 1028C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32067-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 445
Alternative name(s):
Zinc finger protein 168
Zinc finger protein with KRAB and SCAN domains 15
Gene namesi
Name:ZNF445
Synonyms:ZKSCAN15, ZNF168
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:21018. ZNF445.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi353274.
OpenTargetsiENSG00000185219.
ENSG00000283034.
PharmGKBiPA134904986.

Polymorphism and mutation databases

BioMutaiZNF445.
DMDMi45593854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475941 – 1031Zinc finger protein 445Add BLAST1031

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki938Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP59923.
MaxQBiP59923.
PaxDbiP59923.
PeptideAtlasiP59923.
PRIDEiP59923.

PTM databases

iPTMnetiP59923.
PhosphoSitePlusiP59923.

Expressioni

Gene expression databases

BgeeiENSG00000185219.
CleanExiHS_ZNF445.
ExpressionAtlasiP59923. baseline and differential.
GenevisibleiP59923. HS.

Organism-specific databases

HPAiHPA006678.

Interactioni

Protein-protein interaction databases

BioGridi131672. 19 interactors.
IntActiP59923. 3 interactors.
STRINGi9606.ENSP00000379387.

Structurei

3D structure databases

ProteinModelPortaliP59923.
SMRiP59923.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 137SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini234 – 304KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri485 – 507C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 619C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri625 – 647C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri681 – 703C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri709 – 731C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri840 – 862C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri868 – 890C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri896 – 918C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri978 – 1000C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1006 – 1028C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00570000079264.
HOGENOMiHOG000234619.
HOVERGENiHBG106583.
InParanoidiP59923.
KOiK09229.
OMAiRHMKNHI.
OrthoDBiEOG091G02KC.
PhylomeDBiP59923.
TreeFamiTF350827.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPGRWHAAY PAQAQSSRER GRLQTVKKEE EDESYTPVQA ARPQTLNRPG
60 70 80 90 100
QELFRQLFRQ LRYHESSGPL ETLSRLRELC RWWLRPDVLS KAQILELLVL
110 120 130 140 150
EQFLSILPGE LRVWVQLHNP ESGEEAVALL EELQRDLDGT SWRDPGPAQS
160 170 180 190 200
PDVHWMGTGA LRSAQIWSLA SPLRSSSALG DHLEPPYEIE ARDFLAGQSD
210 220 230 240 250
TPAAQMPALF PREGCPGDQV TPTRSLTAQL QETMTFKDVE VTFSQDEWGW
260 270 280 290 300
LDSAQRNLYR DVMLENYRNM ASLVGPFTKP ALISWLEARE PWGLNMQAAQ
310 320 330 340 350
PKGNPVAAPT GDDLQSKTNK FILNQEPLEE AETLAVSSGC PATSVSEGIG
360 370 380 390 400
LRESFQQKSR QKDQCENPIQ VRVKKEETNF SHRTGKDSEV SGSNSLDLKH
410 420 430 440 450
VTYLRVSGRK ESLKHGCGKH FRMSSHHYDY KKYGKGLRHM IGGFSLHQRI
460 470 480 490 500
HSGLKGNKKD VCGKDFSLSS HHQRGQSLHT VGVSFKCSDC GRTFSHSSHL
510 520 530 540 550
AYHQRLHTQE KAFKCRVCGK AFRWSSNCAR HEKIHTGVKP YKCDLCEKAF
560 570 580 590 600
RRLSAYRLHR ETHAKKKFLE LNQYRAALTY SSGFDHHLGD QSGEKLFDCS
610 620 630 640 650
QCRKSFHCKS YVLEHQRIHT QEKPYKCTKC RKTFRWRSNF TRHMRLHEEE
660 670 680 690 700
KFYKQDECRE GFRQSPDCSQ PQGAPAVEKT FLCQQCGKTF TRKKTLVDHQ
710 720 730 740 750
RIHTGEKPYQ CSDCGKDFAY RSAFIVHKKK HAMKRKPEGG PSFSQDTVFQ
760 770 780 790 800
VPQSSHSKEE PYKCSQCGKA FRNHSFLLIH QRVHTGEKPY KCRECGKAFR
810 820 830 840 850
WSSNLYRHQR IHSLQKQYDC HESEKTPNVE PKILTGEKRF WCQECGKTFT
860 870 880 890 900
RKRTLLDHKG IHSGEKRYKC NLCGKSYDRN YRLVNHQRIH STERPFKCQW
910 920 930 940 950
CGKEFIGRHT LSSHQRKHTR AAQAERSPPA RSSSQDTKLR LQKLKPSEEM
960 970 980 990 1000
PLEDCKEACS QSSRLTGLQD ISIGKKCHKC SICGKTFNKS SQLISHKRFH
1010 1020 1030
TRERPFKCSK CGKTFRWSSN LARHMKNHIR D
Length:1,031
Mass (Da):118,963
Last modified:October 10, 2003 - v1
Checksum:i39C288802894006E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052832428Y → C.Corresponds to variant rs11710965dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262260 mRNA. Translation: AAP36990.1.
AY295873 mRNA. Translation: AAP50258.1.
BC101486 mRNA. Translation: AAI01487.1.
CCDSiCCDS2713.1.
RefSeqiNP_852466.1. NM_181489.5.
XP_005265159.1. XM_005265102.2.
XP_011531976.1. XM_011533674.2.
UniGeneiHs.250481.

Genome annotation databases

EnsembliENST00000396077; ENSP00000379387; ENSG00000185219.
ENST00000425708; ENSP00000413073; ENSG00000185219.
ENST00000634579; ENSP00000489139; ENSG00000283034.
ENST00000635479; ENSP00000489368; ENSG00000283034.
GeneIDi353274.
KEGGihsa:353274.
UCSCiuc003cnf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262260 mRNA. Translation: AAP36990.1.
AY295873 mRNA. Translation: AAP50258.1.
BC101486 mRNA. Translation: AAI01487.1.
CCDSiCCDS2713.1.
RefSeqiNP_852466.1. NM_181489.5.
XP_005265159.1. XM_005265102.2.
XP_011531976.1. XM_011533674.2.
UniGeneiHs.250481.

3D structure databases

ProteinModelPortaliP59923.
SMRiP59923.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131672. 19 interactors.
IntActiP59923. 3 interactors.
STRINGi9606.ENSP00000379387.

PTM databases

iPTMnetiP59923.
PhosphoSitePlusiP59923.

Polymorphism and mutation databases

BioMutaiZNF445.
DMDMi45593854.

Proteomic databases

EPDiP59923.
MaxQBiP59923.
PaxDbiP59923.
PeptideAtlasiP59923.
PRIDEiP59923.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396077; ENSP00000379387; ENSG00000185219.
ENST00000425708; ENSP00000413073; ENSG00000185219.
ENST00000634579; ENSP00000489139; ENSG00000283034.
ENST00000635479; ENSP00000489368; ENSG00000283034.
GeneIDi353274.
KEGGihsa:353274.
UCSCiuc003cnf.3. human.

Organism-specific databases

CTDi353274.
DisGeNETi353274.
GeneCardsiZNF445.
HGNCiHGNC:21018. ZNF445.
HPAiHPA006678.
neXtProtiNX_P59923.
OpenTargetsiENSG00000185219.
ENSG00000283034.
PharmGKBiPA134904986.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00570000079264.
HOGENOMiHOG000234619.
HOVERGENiHBG106583.
InParanoidiP59923.
KOiK09229.
OMAiRHMKNHI.
OrthoDBiEOG091G02KC.
PhylomeDBiP59923.
TreeFamiTF350827.

Enzyme and pathway databases

BioCyciZFISH:G66-32067-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF445. human.
GenomeRNAii353274.
PROiP59923.

Gene expression databases

BgeeiENSG00000185219.
CleanExiHS_ZNF445.
ExpressionAtlasiP59923. baseline and differential.
GenevisibleiP59923. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN445_HUMAN
AccessioniPrimary (citable) accession number: P59923
Secondary accession number(s): Q3MJD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.