Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 445

Gene

ZNF445

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri485 – 507C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 619C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri625 – 647C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri681 – 703C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri709 – 731C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri840 – 862C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri868 – 890C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri896 – 918C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri978 – 1000C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1006 – 1028C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 445
Alternative name(s):
Zinc finger protein 168
Zinc finger protein with KRAB and SCAN domains 15
Gene namesi
Name:ZNF445
Synonyms:ZKSCAN15, ZNF168
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000185219.16
HGNCiHGNC:21018 ZNF445
neXtProtiNX_P59923

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi353274
OpenTargetsiENSG00000185219
PharmGKBiPA134904986

Polymorphism and mutation databases

BioMutaiZNF445
DMDMi45593854

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475941 – 1031Zinc finger protein 445Add BLAST1031

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki374Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki375Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki567Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki654Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki736Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki758Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki938Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki956Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki975Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP59923
MaxQBiP59923
PaxDbiP59923
PeptideAtlasiP59923
PRIDEiP59923
ProteomicsDBi57172

PTM databases

iPTMnetiP59923
PhosphoSitePlusiP59923

Expressioni

Gene expression databases

BgeeiENSG00000185219
CleanExiHS_ZNF445
ExpressionAtlasiP59923 baseline and differential
GenevisibleiP59923 HS

Organism-specific databases

HPAiHPA006678

Interactioni

Protein-protein interaction databases

BioGridi131672, 25 interactors
IntActiP59923, 3 interactors
STRINGi9606.ENSP00000379387

Structurei

3D structure databases

ProteinModelPortaliP59923
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 137SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini234 – 304KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri485 – 507C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 619C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri625 – 647C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri681 – 703C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri709 – 731C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri840 – 862C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri868 – 890C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri896 – 918C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri978 – 1000C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1006 – 1028C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000141186
HOGENOMiHOG000234619
HOVERGENiHBG106583
InParanoidiP59923
KOiK09229
OMAiRHMKNHI
OrthoDBiEOG091G02KC
PhylomeDBiP59923
TreeFamiTF350827

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequencei

Sequence statusi: Complete.

P59923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPGRWHAAY PAQAQSSRER GRLQTVKKEE EDESYTPVQA ARPQTLNRPG
60 70 80 90 100
QELFRQLFRQ LRYHESSGPL ETLSRLRELC RWWLRPDVLS KAQILELLVL
110 120 130 140 150
EQFLSILPGE LRVWVQLHNP ESGEEAVALL EELQRDLDGT SWRDPGPAQS
160 170 180 190 200
PDVHWMGTGA LRSAQIWSLA SPLRSSSALG DHLEPPYEIE ARDFLAGQSD
210 220 230 240 250
TPAAQMPALF PREGCPGDQV TPTRSLTAQL QETMTFKDVE VTFSQDEWGW
260 270 280 290 300
LDSAQRNLYR DVMLENYRNM ASLVGPFTKP ALISWLEARE PWGLNMQAAQ
310 320 330 340 350
PKGNPVAAPT GDDLQSKTNK FILNQEPLEE AETLAVSSGC PATSVSEGIG
360 370 380 390 400
LRESFQQKSR QKDQCENPIQ VRVKKEETNF SHRTGKDSEV SGSNSLDLKH
410 420 430 440 450
VTYLRVSGRK ESLKHGCGKH FRMSSHHYDY KKYGKGLRHM IGGFSLHQRI
460 470 480 490 500
HSGLKGNKKD VCGKDFSLSS HHQRGQSLHT VGVSFKCSDC GRTFSHSSHL
510 520 530 540 550
AYHQRLHTQE KAFKCRVCGK AFRWSSNCAR HEKIHTGVKP YKCDLCEKAF
560 570 580 590 600
RRLSAYRLHR ETHAKKKFLE LNQYRAALTY SSGFDHHLGD QSGEKLFDCS
610 620 630 640 650
QCRKSFHCKS YVLEHQRIHT QEKPYKCTKC RKTFRWRSNF TRHMRLHEEE
660 670 680 690 700
KFYKQDECRE GFRQSPDCSQ PQGAPAVEKT FLCQQCGKTF TRKKTLVDHQ
710 720 730 740 750
RIHTGEKPYQ CSDCGKDFAY RSAFIVHKKK HAMKRKPEGG PSFSQDTVFQ
760 770 780 790 800
VPQSSHSKEE PYKCSQCGKA FRNHSFLLIH QRVHTGEKPY KCRECGKAFR
810 820 830 840 850
WSSNLYRHQR IHSLQKQYDC HESEKTPNVE PKILTGEKRF WCQECGKTFT
860 870 880 890 900
RKRTLLDHKG IHSGEKRYKC NLCGKSYDRN YRLVNHQRIH STERPFKCQW
910 920 930 940 950
CGKEFIGRHT LSSHQRKHTR AAQAERSPPA RSSSQDTKLR LQKLKPSEEM
960 970 980 990 1000
PLEDCKEACS QSSRLTGLQD ISIGKKCHKC SICGKTFNKS SQLISHKRFH
1010 1020 1030
TRERPFKCSK CGKTFRWSSN LARHMKNHIR D
Length:1,031
Mass (Da):118,963
Last modified:October 10, 2003 - v1
Checksum:i39C288802894006E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052832428Y → C. Corresponds to variant dbSNP:rs11710965Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262260 mRNA Translation: AAP36990.1
AY295873 mRNA Translation: AAP50258.1
BC101486 mRNA Translation: AAI01487.1
CCDSiCCDS2713.1
RefSeqiNP_852466.1, NM_181489.5
XP_005265159.1, XM_005265102.2
XP_011531976.1, XM_011533674.2
UniGeneiHs.250481

Genome annotation databases

EnsembliENST00000396077; ENSP00000379387; ENSG00000185219
ENST00000425708; ENSP00000413073; ENSG00000185219
ENST00000634579; ENSP00000489139; ENSG00000283034
ENST00000635479; ENSP00000489368; ENSG00000283034
GeneIDi353274
KEGGihsa:353274
UCSCiuc003cnf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN445_HUMAN
AccessioniPrimary (citable) accession number: P59923
Secondary accession number(s): Q3MJD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 20, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health