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P59915

- HAGA1_PORGI

UniProt

P59915 - HAGA1_PORGI

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Protein

Hemagglutinin A

Gene

hagA

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Agglutinates erythrocytes.By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciPGIN242619:GHX8-1660-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin A
Gene namesi
Name:hagA
Ordered Locus Names:PG_1837
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000000588: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 21642139Hemagglutinin APRO_0000026537Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi242619.PG1837.

Structurei

Secondary structure

1
2164
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1139 – 11413Combined sources
Beta strandi1156 – 11594Combined sources
Beta strandi1168 – 11714Combined sources
Turni1172 – 11743Combined sources
Beta strandi1181 – 119616Combined sources
Beta strandi1200 – 12045Combined sources
Beta strandi1213 – 12208Combined sources
Beta strandi1229 – 12368Combined sources
Helixi1240 – 12423Combined sources
Beta strandi1243 – 12497Combined sources
Beta strandi1263 – 12653Combined sources
Beta strandi1277 – 12826Combined sources
Beta strandi1289 – 12968Combined sources
Beta strandi1302 – 131110Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KM5X-ray1.40A/B1137-1314[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP59915.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 539514Peptidase C25-like 1Add
BLAST
Regioni540 – 991452Peptidase C25-like 2Add
BLAST
Regioni992 – 1443452Peptidase C25-like 3Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C25 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

OMAiAFRHFGC.
OrthoDBiEOG6T7N3B.

Family and domain databases

InterProiIPR011628. Cleaved_adhesin.
IPR003961. Fibronectin_type3.
IPR018832. Pept_C25_gingipain_C.
[Graphical view]
PfamiPF07675. Cleaved_Adhesin. 8 hits.
PF10365. DUF2436. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59915 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKLNSLFSL AVLLSLLCWG QTAAAQGGPK TAPSVTHQAV QKGIRTSKAK
60 70 80 90 100
DLRDPIPAGM ARIILEAHDV WEDGTGYQML WDADHNQYGA SIPEESFWFA
110 120 130 140 150
NGTIPAGLYD PFEYKVPVNA DASFSPTNFV LDGTASADIP AGTYDYVIIN
160 170 180 190 200
PNPGIIYIVG EGVSKGNDYV VEAGKTYHFT VQRQGPGDAA SVVVTGEGGN
210 220 230 240 250
EFAPVQNLQW SVSGQTVTLT WQAPASDKRT YVLNESFDTQ TLPNGWTMID
260 270 280 290 300
ADGDGHNWLS TINVYNTATH TGDGAMFSKS WTASSGAKID LSPDNYLVTP
310 320 330 340 350
KFTVPENGKL SYWVSSQEPW TNEHYGVFLS TTGNEAANFT IKLLEETLGS
360 370 380 390 400
GKPAPMNLVK SEGVKAPAPY QERTIDLSAY AGQQVYLAFR HFGCTGIFRL
410 420 430 440 450
YLDDVAVSGE GSSNDYTYTV YRDNVVIAQN LTATTFNQEN VAPGQYNYCV
460 470 480 490 500
EVKYTAGVSP KVCKDVTVEG SNEFAPVQNL TGSAVGQKVT LKWDAPNGTP
510 520 530 540 550
NPNPGTTTLS ESFENGIPAS WKTIDADGDG NNWTTTPPPG GSSFAGHNSA
560 570 580 590 600
ICVSSASYIN FEGPQNPDNY LVTPELSLPN GGTLTFWVCA QDANYASEHY
610 620 630 640 650
AVYASSTGND ASNFANALLE EVLTAKTVVT APEAIRGTRV QGTWYQKTVQ
660 670 680 690 700
LPAGTKYVAF RHFGCTDFFW INLDDVEIKA NGKRADFTET FESSTHGEAP
710 720 730 740 750
AEWTTIDADG DGQGWLCLSS GQLGWLTAHG GTNVVASFSW NGMALNPDNY
760 770 780 790 800
LISKDVTGAT KVKYYYAVND GFPGDHYAVM ISKTGTNAGD FTVVFEETPN
810 820 830 840 850
GINKGGARFG LSTEANGAKP QSVWIERTVD LPAGTKYVAF RHYNCSDLNY
860 870 880 890 900
ILLDDIQFTM GGSPTPTDYT YTVYRDGTKI KEGLTETTFE EDGVATGNHE
910 920 930 940 950
YCVEVKYTAG VSPKECVNVT VDPVQFNPVQ NLTGSAVGQK VTLKWDAPNG
960 970 980 990 1000
TPNPNPGTTT LSESFENGIP ASWKTIDADG DGNNWTTTPP PGGTSFAGHN
1010 1020 1030 1040 1050
SAICVSSASY INFEGPQNPD NYLVTPELSL PNGGTLTFWV CAQDANYASE
1060 1070 1080 1090 1100
HYAVYASSTG NDASNFANAL LEEVLTAKTV VTAPEAIRGT RVQGTWYQKT
1110 1120 1130 1140 1150
VQLPAGTKYV AFRHFGCTDF FWINLDDVEI KANGKRADFT ETFESSTHGE
1160 1170 1180 1190 1200
APAEWTTIDA DGDGQGWLCL SSGQLDWLTA HGGTNVVASF SWNGMALNPD
1210 1220 1230 1240 1250
NYLISKDVTG ATKVKYYYAV NDGFPGDHYA VMISKTGTNA GDFTVVFEET
1260 1270 1280 1290 1300
PNGINKGGAR FGLSTEANGA KPQSVWIERT VDLPAGTKYV AFRHYNCSDL
1310 1320 1330 1340 1350
NYILLDDIQF TMGGSPTPTD YTYTVYRDGT KIKEGLTETT FEEDGVATGN
1360 1370 1380 1390 1400
HEYCVEVKYT AGVSPKECVN VTVDPVQFNP VQNLTGSAVG QKVTLKWDAP
1410 1420 1430 1440 1450
NGTPNPNPGT TTLSESFENG IPASWKTIDA DGDGNNWTTT PPPGGTSFAG
1460 1470 1480 1490 1500
HNSAICVSSA SYINFEGPQN PDNYLVTPEL SLPNGGTLTF WVCAQDANYA
1510 1520 1530 1540 1550
SEHYAVYASS TGNDASNFAN ALLEEVLTAK TVVTAPEAIR GTRVQGTWYQ
1560 1570 1580 1590 1600
KTVQLPAGTK YVAFRHFGCT DFFWINLDDV EIKANGKRAD FTETFESSTH
1610 1620 1630 1640 1650
GEAPAEWTTI DADGDGQGWL CLSSGQLGWL TAHGGTNVVA SFSWNGMALN
1660 1670 1680 1690 1700
PDNYLISKDV TGATKVKYYY AVNDGFPGDH YAVMISKTGT NAGDFTVVFE
1710 1720 1730 1740 1750
ETPNGINKGG ARFGLSTEAN GAKPQSVWIE RTVDLPAGTK YVAFRHYNCS
1760 1770 1780 1790 1800
DLNYILLDDI QFTMGGSPTP TDYTYTVYRD GTKIKEGLTE TTFEEDGVAT
1810 1820 1830 1840 1850
GNHEYCVEVK YTAGVSPKEC VNVTINPTQF NPVQNLTAEQ APNSMDAILK
1860 1870 1880 1890 1900
WNAPASKRAE VLNEDFENGI PASWKTIDAD GDGNNWTTTP PPGGSSFAGH
1910 1920 1930 1940 1950
NSAICVSSAS YINFEGPQNP DNYLVTPELS LPGGGTLTFW VCAQDANYAS
1960 1970 1980 1990 2000
EHYAVYASST GNDASNFANA LLEEVLTAKT VVTAPEAIRG TRVQGTWYQK
2010 2020 2030 2040 2050
TVQLPAGTKY VAFRHFGCTD FFWINLDDVV ITSGNAPSYT YTIYRNNTQI
2060 2070 2080 2090 2100
ASGVTETTYR DPDLATGFYT YGVKVVYPNG ESAIETATLN ITSLADVTAQ
2110 2120 2130 2140 2150
KPYTLTVVGK TITVTCQGEA MIYDMNGRRL AAGRNTVVYT AQGGHYAVMV
2160
VVDGKSYVEK LAVK
Length:2,164
Mass (Da):233,389
Last modified:October 10, 2003 - v1
Checksum:i6DFAB22832586C63
GO

Sequence cautioni

The sequence AAQ66831.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ66831.1. Different initiation.
RefSeqiNP_905932.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ66831; AAQ66831; PG_1837.
GeneIDi2551934.
KEGGipgi:PG1837.
PATRICi22980654. VBIPorGin134034_1698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ66831.1 . Different initiation.
RefSeqi NP_905932.1. NC_002950.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KM5 X-ray 1.40 A/B 1137-1314 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 242619.PG1837.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ66831 ; AAQ66831 ; PG_1837 .
GeneIDi 2551934.
KEGGi pgi:PG1837.
PATRICi 22980654. VBIPorGin134034_1698.

Phylogenomic databases

OMAi AFRHFGC.
OrthoDBi EOG6T7N3B.

Enzyme and pathway databases

BioCyci PGIN242619:GHX8-1660-MONOMER.

Miscellaneous databases

EvolutionaryTracei P59915.

Family and domain databases

InterProi IPR011628. Cleaved_adhesin.
IPR003961. Fibronectin_type3.
IPR018832. Pept_C25_gingipain_C.
[Graphical view ]
Pfami PF07675. Cleaved_Adhesin. 8 hits.
PF10365. DUF2436. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.

Entry informationi

Entry nameiHAGA1_PORGI
AccessioniPrimary (citable) accession number: P59915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3