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P59915

- HAGA1_PORGI

UniProt

P59915 - HAGA1_PORGI

Protein

Hemagglutinin A

Gene

hagA

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (10 Oct 2003)
      Previous versions | rss
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    Functioni

    Agglutinates erythrocytes.By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Virulence

    Enzyme and pathway databases

    BioCyciPGIN242619:GHX8-1660-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin A
    Gene namesi
    Name:hagA
    Ordered Locus Names:PG_1837
    OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
    Taxonomic identifieri242619 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
    ProteomesiUP000000588: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 21642139Hemagglutinin APRO_0000026537Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi242619.PG1837.

    Structurei

    Secondary structure

    1
    2164
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1139 – 11413
    Beta strandi1156 – 11594
    Beta strandi1168 – 11714
    Turni1172 – 11743
    Beta strandi1181 – 119616
    Beta strandi1200 – 12045
    Beta strandi1213 – 12208
    Beta strandi1229 – 12368
    Helixi1240 – 12423
    Beta strandi1243 – 12497
    Beta strandi1263 – 12653
    Beta strandi1277 – 12826
    Beta strandi1289 – 12968
    Beta strandi1302 – 131110

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3KM5X-ray1.40A/B1137-1314[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP59915.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 539514Peptidase C25-like 1Add
    BLAST
    Regioni540 – 991452Peptidase C25-like 2Add
    BLAST
    Regioni992 – 1443452Peptidase C25-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C25 family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    OMAiAFRHFGC.
    OrthoDBiEOG6T7N3B.

    Family and domain databases

    InterProiIPR011628. Cleaved_adhesin.
    IPR003961. Fibronectin_type3.
    IPR018832. Pept_C25_gingipain_C.
    [Graphical view]
    PfamiPF07675. Cleaved_Adhesin. 8 hits.
    PF10365. DUF2436. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P59915-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKLNSLFSL AVLLSLLCWG QTAAAQGGPK TAPSVTHQAV QKGIRTSKAK     50
    DLRDPIPAGM ARIILEAHDV WEDGTGYQML WDADHNQYGA SIPEESFWFA 100
    NGTIPAGLYD PFEYKVPVNA DASFSPTNFV LDGTASADIP AGTYDYVIIN 150
    PNPGIIYIVG EGVSKGNDYV VEAGKTYHFT VQRQGPGDAA SVVVTGEGGN 200
    EFAPVQNLQW SVSGQTVTLT WQAPASDKRT YVLNESFDTQ TLPNGWTMID 250
    ADGDGHNWLS TINVYNTATH TGDGAMFSKS WTASSGAKID LSPDNYLVTP 300
    KFTVPENGKL SYWVSSQEPW TNEHYGVFLS TTGNEAANFT IKLLEETLGS 350
    GKPAPMNLVK SEGVKAPAPY QERTIDLSAY AGQQVYLAFR HFGCTGIFRL 400
    YLDDVAVSGE GSSNDYTYTV YRDNVVIAQN LTATTFNQEN VAPGQYNYCV 450
    EVKYTAGVSP KVCKDVTVEG SNEFAPVQNL TGSAVGQKVT LKWDAPNGTP 500
    NPNPGTTTLS ESFENGIPAS WKTIDADGDG NNWTTTPPPG GSSFAGHNSA 550
    ICVSSASYIN FEGPQNPDNY LVTPELSLPN GGTLTFWVCA QDANYASEHY 600
    AVYASSTGND ASNFANALLE EVLTAKTVVT APEAIRGTRV QGTWYQKTVQ 650
    LPAGTKYVAF RHFGCTDFFW INLDDVEIKA NGKRADFTET FESSTHGEAP 700
    AEWTTIDADG DGQGWLCLSS GQLGWLTAHG GTNVVASFSW NGMALNPDNY 750
    LISKDVTGAT KVKYYYAVND GFPGDHYAVM ISKTGTNAGD FTVVFEETPN 800
    GINKGGARFG LSTEANGAKP QSVWIERTVD LPAGTKYVAF RHYNCSDLNY 850
    ILLDDIQFTM GGSPTPTDYT YTVYRDGTKI KEGLTETTFE EDGVATGNHE 900
    YCVEVKYTAG VSPKECVNVT VDPVQFNPVQ NLTGSAVGQK VTLKWDAPNG 950
    TPNPNPGTTT LSESFENGIP ASWKTIDADG DGNNWTTTPP PGGTSFAGHN 1000
    SAICVSSASY INFEGPQNPD NYLVTPELSL PNGGTLTFWV CAQDANYASE 1050
    HYAVYASSTG NDASNFANAL LEEVLTAKTV VTAPEAIRGT RVQGTWYQKT 1100
    VQLPAGTKYV AFRHFGCTDF FWINLDDVEI KANGKRADFT ETFESSTHGE 1150
    APAEWTTIDA DGDGQGWLCL SSGQLDWLTA HGGTNVVASF SWNGMALNPD 1200
    NYLISKDVTG ATKVKYYYAV NDGFPGDHYA VMISKTGTNA GDFTVVFEET 1250
    PNGINKGGAR FGLSTEANGA KPQSVWIERT VDLPAGTKYV AFRHYNCSDL 1300
    NYILLDDIQF TMGGSPTPTD YTYTVYRDGT KIKEGLTETT FEEDGVATGN 1350
    HEYCVEVKYT AGVSPKECVN VTVDPVQFNP VQNLTGSAVG QKVTLKWDAP 1400
    NGTPNPNPGT TTLSESFENG IPASWKTIDA DGDGNNWTTT PPPGGTSFAG 1450
    HNSAICVSSA SYINFEGPQN PDNYLVTPEL SLPNGGTLTF WVCAQDANYA 1500
    SEHYAVYASS TGNDASNFAN ALLEEVLTAK TVVTAPEAIR GTRVQGTWYQ 1550
    KTVQLPAGTK YVAFRHFGCT DFFWINLDDV EIKANGKRAD FTETFESSTH 1600
    GEAPAEWTTI DADGDGQGWL CLSSGQLGWL TAHGGTNVVA SFSWNGMALN 1650
    PDNYLISKDV TGATKVKYYY AVNDGFPGDH YAVMISKTGT NAGDFTVVFE 1700
    ETPNGINKGG ARFGLSTEAN GAKPQSVWIE RTVDLPAGTK YVAFRHYNCS 1750
    DLNYILLDDI QFTMGGSPTP TDYTYTVYRD GTKIKEGLTE TTFEEDGVAT 1800
    GNHEYCVEVK YTAGVSPKEC VNVTINPTQF NPVQNLTAEQ APNSMDAILK 1850
    WNAPASKRAE VLNEDFENGI PASWKTIDAD GDGNNWTTTP PPGGSSFAGH 1900
    NSAICVSSAS YINFEGPQNP DNYLVTPELS LPGGGTLTFW VCAQDANYAS 1950
    EHYAVYASST GNDASNFANA LLEEVLTAKT VVTAPEAIRG TRVQGTWYQK 2000
    TVQLPAGTKY VAFRHFGCTD FFWINLDDVV ITSGNAPSYT YTIYRNNTQI 2050
    ASGVTETTYR DPDLATGFYT YGVKVVYPNG ESAIETATLN ITSLADVTAQ 2100
    KPYTLTVVGK TITVTCQGEA MIYDMNGRRL AAGRNTVVYT AQGGHYAVMV 2150
    VVDGKSYVEK LAVK 2164
    Length:2,164
    Mass (Da):233,389
    Last modified:October 10, 2003 - v1
    Checksum:i6DFAB22832586C63
    GO

    Sequence cautioni

    The sequence AAQ66831.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015924 Genomic DNA. Translation: AAQ66831.1. Different initiation.
    RefSeqiNP_905932.1. NC_002950.2.

    Genome annotation databases

    EnsemblBacteriaiAAQ66831; AAQ66831; PG_1837.
    GeneIDi2551934.
    KEGGipgi:PG1837.
    PATRICi22980654. VBIPorGin134034_1698.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015924 Genomic DNA. Translation: AAQ66831.1 . Different initiation.
    RefSeqi NP_905932.1. NC_002950.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3KM5 X-ray 1.40 A/B 1137-1314 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 242619.PG1837.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAQ66831 ; AAQ66831 ; PG_1837 .
    GeneIDi 2551934.
    KEGGi pgi:PG1837.
    PATRICi 22980654. VBIPorGin134034_1698.

    Phylogenomic databases

    OMAi AFRHFGC.
    OrthoDBi EOG6T7N3B.

    Enzyme and pathway databases

    BioCyci PGIN242619:GHX8-1660-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P59915.

    Family and domain databases

    InterProi IPR011628. Cleaved_adhesin.
    IPR003961. Fibronectin_type3.
    IPR018832. Pept_C25_gingipain_C.
    [Graphical view ]
    Pfami PF07675. Cleaved_Adhesin. 8 hits.
    PF10365. DUF2436. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-308 / W83.

    Entry informationi

    Entry nameiHAGA1_PORGI
    AccessioniPrimary (citable) accession number: P59915
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 10, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3