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P59915

- HAGA1_PORGI

UniProt

P59915 - HAGA1_PORGI

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Protein
Hemagglutinin A
Gene
hagA, PG_1837
Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Agglutinates erythrocytes By similarity.

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciPGIN242619:GHX8-1660-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin A
Gene namesi
Name:hagA
Ordered Locus Names:PG_1837
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000000588: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 21642139Hemagglutinin A
PRO_0000026537Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi242619.PG1837.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1139 – 11413
Beta strandi1156 – 11594
Beta strandi1168 – 11714
Turni1172 – 11743
Beta strandi1181 – 119616
Beta strandi1200 – 12045
Beta strandi1213 – 12208
Beta strandi1229 – 12368
Helixi1240 – 12423
Beta strandi1243 – 12497
Beta strandi1263 – 12653
Beta strandi1277 – 12826
Beta strandi1289 – 12968
Beta strandi1302 – 131110

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KM5X-ray1.40A/B1137-1314[»]

Miscellaneous databases

EvolutionaryTraceiP59915.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 539514Peptidase C25-like 1
Add
BLAST
Regioni540 – 991452Peptidase C25-like 2
Add
BLAST
Regioni992 – 1443452Peptidase C25-like 3
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C25 family.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

OMAiAFRHFGC.
OrthoDBiEOG6T7N3B.

Family and domain databases

InterProiIPR011628. Cleaved_adhesin.
IPR003961. Fibronectin_type3.
IPR018832. Pept_C25_gingipain_C.
[Graphical view]
PfamiPF07675. Cleaved_Adhesin. 8 hits.
PF10365. DUF2436. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59915-1 [UniParc]FASTAAdd to Basket

« Hide

MRKLNSLFSL AVLLSLLCWG QTAAAQGGPK TAPSVTHQAV QKGIRTSKAK     50
DLRDPIPAGM ARIILEAHDV WEDGTGYQML WDADHNQYGA SIPEESFWFA 100
NGTIPAGLYD PFEYKVPVNA DASFSPTNFV LDGTASADIP AGTYDYVIIN 150
PNPGIIYIVG EGVSKGNDYV VEAGKTYHFT VQRQGPGDAA SVVVTGEGGN 200
EFAPVQNLQW SVSGQTVTLT WQAPASDKRT YVLNESFDTQ TLPNGWTMID 250
ADGDGHNWLS TINVYNTATH TGDGAMFSKS WTASSGAKID LSPDNYLVTP 300
KFTVPENGKL SYWVSSQEPW TNEHYGVFLS TTGNEAANFT IKLLEETLGS 350
GKPAPMNLVK SEGVKAPAPY QERTIDLSAY AGQQVYLAFR HFGCTGIFRL 400
YLDDVAVSGE GSSNDYTYTV YRDNVVIAQN LTATTFNQEN VAPGQYNYCV 450
EVKYTAGVSP KVCKDVTVEG SNEFAPVQNL TGSAVGQKVT LKWDAPNGTP 500
NPNPGTTTLS ESFENGIPAS WKTIDADGDG NNWTTTPPPG GSSFAGHNSA 550
ICVSSASYIN FEGPQNPDNY LVTPELSLPN GGTLTFWVCA QDANYASEHY 600
AVYASSTGND ASNFANALLE EVLTAKTVVT APEAIRGTRV QGTWYQKTVQ 650
LPAGTKYVAF RHFGCTDFFW INLDDVEIKA NGKRADFTET FESSTHGEAP 700
AEWTTIDADG DGQGWLCLSS GQLGWLTAHG GTNVVASFSW NGMALNPDNY 750
LISKDVTGAT KVKYYYAVND GFPGDHYAVM ISKTGTNAGD FTVVFEETPN 800
GINKGGARFG LSTEANGAKP QSVWIERTVD LPAGTKYVAF RHYNCSDLNY 850
ILLDDIQFTM GGSPTPTDYT YTVYRDGTKI KEGLTETTFE EDGVATGNHE 900
YCVEVKYTAG VSPKECVNVT VDPVQFNPVQ NLTGSAVGQK VTLKWDAPNG 950
TPNPNPGTTT LSESFENGIP ASWKTIDADG DGNNWTTTPP PGGTSFAGHN 1000
SAICVSSASY INFEGPQNPD NYLVTPELSL PNGGTLTFWV CAQDANYASE 1050
HYAVYASSTG NDASNFANAL LEEVLTAKTV VTAPEAIRGT RVQGTWYQKT 1100
VQLPAGTKYV AFRHFGCTDF FWINLDDVEI KANGKRADFT ETFESSTHGE 1150
APAEWTTIDA DGDGQGWLCL SSGQLDWLTA HGGTNVVASF SWNGMALNPD 1200
NYLISKDVTG ATKVKYYYAV NDGFPGDHYA VMISKTGTNA GDFTVVFEET 1250
PNGINKGGAR FGLSTEANGA KPQSVWIERT VDLPAGTKYV AFRHYNCSDL 1300
NYILLDDIQF TMGGSPTPTD YTYTVYRDGT KIKEGLTETT FEEDGVATGN 1350
HEYCVEVKYT AGVSPKECVN VTVDPVQFNP VQNLTGSAVG QKVTLKWDAP 1400
NGTPNPNPGT TTLSESFENG IPASWKTIDA DGDGNNWTTT PPPGGTSFAG 1450
HNSAICVSSA SYINFEGPQN PDNYLVTPEL SLPNGGTLTF WVCAQDANYA 1500
SEHYAVYASS TGNDASNFAN ALLEEVLTAK TVVTAPEAIR GTRVQGTWYQ 1550
KTVQLPAGTK YVAFRHFGCT DFFWINLDDV EIKANGKRAD FTETFESSTH 1600
GEAPAEWTTI DADGDGQGWL CLSSGQLGWL TAHGGTNVVA SFSWNGMALN 1650
PDNYLISKDV TGATKVKYYY AVNDGFPGDH YAVMISKTGT NAGDFTVVFE 1700
ETPNGINKGG ARFGLSTEAN GAKPQSVWIE RTVDLPAGTK YVAFRHYNCS 1750
DLNYILLDDI QFTMGGSPTP TDYTYTVYRD GTKIKEGLTE TTFEEDGVAT 1800
GNHEYCVEVK YTAGVSPKEC VNVTINPTQF NPVQNLTAEQ APNSMDAILK 1850
WNAPASKRAE VLNEDFENGI PASWKTIDAD GDGNNWTTTP PPGGSSFAGH 1900
NSAICVSSAS YINFEGPQNP DNYLVTPELS LPGGGTLTFW VCAQDANYAS 1950
EHYAVYASST GNDASNFANA LLEEVLTAKT VVTAPEAIRG TRVQGTWYQK 2000
TVQLPAGTKY VAFRHFGCTD FFWINLDDVV ITSGNAPSYT YTIYRNNTQI 2050
ASGVTETTYR DPDLATGFYT YGVKVVYPNG ESAIETATLN ITSLADVTAQ 2100
KPYTLTVVGK TITVTCQGEA MIYDMNGRRL AAGRNTVVYT AQGGHYAVMV 2150
VVDGKSYVEK LAVK 2164
Length:2,164
Mass (Da):233,389
Last modified:October 10, 2003 - v1
Checksum:i6DFAB22832586C63
GO

Sequence cautioni

The sequence AAQ66831.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ66831.1. Different initiation.
RefSeqiNP_905932.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ66831; AAQ66831; PG_1837.
GeneIDi2551934.
KEGGipgi:PG1837.
PATRICi22980654. VBIPorGin134034_1698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015924 Genomic DNA. Translation: AAQ66831.1 . Different initiation.
RefSeqi NP_905932.1. NC_002950.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KM5 X-ray 1.40 A/B 1137-1314 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 242619.PG1837.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ66831 ; AAQ66831 ; PG_1837 .
GeneIDi 2551934.
KEGGi pgi:PG1837.
PATRICi 22980654. VBIPorGin134034_1698.

Phylogenomic databases

OMAi AFRHFGC.
OrthoDBi EOG6T7N3B.

Enzyme and pathway databases

BioCyci PGIN242619:GHX8-1660-MONOMER.

Miscellaneous databases

EvolutionaryTracei P59915.

Family and domain databases

InterProi IPR011628. Cleaved_adhesin.
IPR003961. Fibronectin_type3.
IPR018832. Pept_C25_gingipain_C.
[Graphical view ]
Pfami PF07675. Cleaved_Adhesin. 8 hits.
PF10365. DUF2436. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.

Entry informationi

Entry nameiHAGA1_PORGI
AccessioniPrimary (citable) accession number: P59915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi