ID   DJB13_HUMAN             Reviewed;         316 AA.
AC   P59910; Q8IZW5;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2003, sequence version 1.
DT   25-JAN-2012, entry version 67.
DE   RecName: Full=DnaJ homolog subfamily B member 13;
DE   AltName: Full=Testis and spermatogenesis cell-related protein 6;
DE   AltName: Full=Testis spermatocyte apoptosis-related gene 6 protein;
DE   AltName: Full=Testis spermatogenesis apoptosis-related gene 3 protein;
DE   AltName: Full=Testis spermatogenesis apoptosis-related gene 6 protein;
GN   Name=DNAJB13; Synonyms=TSARG3, TSARG6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RA   Liu G., Lu G., Fu J., Liu S., Xing X., Li L.;
RT   "Molecular cloning of Homo sapiens testis spermatogenesis apoptosis
RT   related gene 5 (TSARG5).";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RA   Liu G., Lu G., Fu J.;
RT   "Molecular cloning of Homo sapiens testis spermatogenesis apoptosis
RT   related gene 6 (TSARG6).";
RL   Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 112-316.
RC   TISSUE=Testis;
RX   MEDLINE=22561371; PubMed=12673577;
RA   Liu G., Lu G.-X., Fu J.-J., Liu S.-F., Xing X.-W., Li L.;
RT   "Molecular cloning of TSARG3 gene related to apoptosis in human
RT   spermatogenic cells.";
RL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:107-110(2003).
CC   -!- FUNCTION: May be involved in inhibiting testis spermatogenesis
CC       apoptosis.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P59910-1; Sequence=Displayed;
CC       Name=2; Synonyms=TSARG5;
CC         IsoId=P59910-2; Sequence=VSP_008519, VSP_008520;
CC   -!- TISSUE SPECIFICITY: Specifically expressed in testis.
CC   -!- SIMILARITY: Contains 1 J domain.
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DR   EMBL; AF516185; AAP47195.1; -; mRNA.
DR   EMBL; AY138810; AAN15929.1; -; mRNA.
DR   EMBL; AF419291; AAN32702.1; ALT_SEQ; mRNA.
DR   IPI; IPI00374262; -.
DR   IPI; IPI00374263; -.
DR   RefSeq; NP_705842.2; NM_153614.2.
DR   UniGene; Hs.567888; -.
DR   ProteinModelPortal; P59910; -.
DR   SMR; P59910; 1-74, 109-316.
DR   STRING; P59910; -.
DR   DMDM; 41704179; -.
DR   PRIDE; P59910; -.
DR   Ensembl; ENST00000339764; ENSP00000344431; ENSG00000187726.
DR   GeneID; 374407; -.
DR   KEGG; hsa:374407; -.
DR   UCSC; uc001ouo.1; human.
DR   CTD; 374407; -.
DR   GeneCards; GC11P073661; -.
DR   H-InvDB; HIX0009925; -.
DR   HGNC; HGNC:30718; DNAJB13.
DR   MIM; 610263; gene.
DR   neXtProt; NX_P59910; -.
DR   eggNOG; prNOG18951; -.
DR   GeneTree; ENSGT00600000084029; -.
DR   HOGENOM; HBG635315; -.
DR   HOVERGEN; HBG066727; -.
DR   InParanoid; P59910; -.
DR   OMA; ITRNAED; -.
DR   OrthoDB; EOG4PVP07; -.
DR   PhylomeDB; P59910; -.
DR   NextBio; 100185; -.
DR   ArrayExpress; P59910; -.
DR   Bgee; P59910; -.
DR   CleanEx; HS_DNAJB13; -.
DR   Genevestigator; P59910; -.
DR   GermOnline; ENSG00000187726; Homo sapiens.
DR   GO; GO:0031072; F:heat shock protein binding; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEP:UniProtKB.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; IEP:UniProtKB.
DR   InterPro; IPR002939; DnaJ_C.
DR   InterPro; IPR001623; DnaJ_N.
DR   InterPro; IPR018253; Heat_shock_DnaJ_CS.
DR   InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR   InterPro; IPR003095; Hsp_DnaJ.
DR   Gene3D; G3DSA:1.10.287.110; DnaJ_N; 1.
DR   KO; K09519; -.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF01556; DnaJ_C; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; DnaJ_N; 1.
DR   SUPFAM; SSF49493; HSP40_DnaJ_pep; 2.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Chaperone; Complete proteome;
KW   Reference proteome.
FT   CHAIN         1    316       DnaJ homolog subfamily B member 13.
FT                                /FTId=PRO_0000071039.
FT   DOMAIN        4     68       J.
FT   VAR_SEQ       1    175       Missing (in isoform 2).
FT                                /FTId=VSP_008519.
FT   VAR_SEQ     176    201       KDKILTIDVKPGWRQGTRITFEKEGD -> METSRGRNLAK
FT                                VTRPTSPCHLLASPA (in isoform 2).
FT                                /FTId=VSP_008520.
SQ   SEQUENCE   316 AA;  36118 MW;  8251CB720724B7E5 CRC64;
     MGQDYYSVLG ITRNSEDAQI KQAYRRLALK HHPLKSNEPS SAEIFRQIAE AYDVLSDPMK
     RGIYDKFGEE GLKGGIPLEF GSQTPWTTGY VFHGKPEKVF HEFFGGNNPF SEFFDAEGSE
     VDLNFGGLQG RGVKKQDPQV ERDLYLSLED LFFGCTKKIK ISRRVLNEDG YSSTIKDKIL
     TIDVKPGWRQ GTRITFEKEG DQGPNIIPAD IIFIVKEKLH PRFRRENDNL FFVNPIPLGK
     ALTCCTVEVR TLDDRLLNIP INDIIHPKYF KKVPGEGMPL PEDPTKKGDL FIFFDIQFPT
     RLTPQKKQML RQALLT
//