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Reviewed, UniProtKB/Swiss-Prot P59910 (DJB13_HUMAN)

Last modified March 2, 2010. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
DnaJ homolog subfamily B member 13
Alternative name(s):
Testis spermatocyte apoptosis-related gene 6 protein
Testis and spermatogenesis cell-related protein 6
Testis spermatogenesis apoptosis-related gene 6 protein
Testis spermatogenesis apoptosis-related gene 3 protein
Gene names
Name:DNAJB13
Synonyms:TSARG3, TSARG6
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

May be involved in inhibiting testis spermatogenesis apoptosis.

Tissue specificity

Specifically expressed in testis.

Sequence similarities

Contains 1 J domain.

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Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processapoptosis Ref.3

Inferred from expression pattern. Source: UniProtKB

protein folding

Inferred from electronic annotation. Source: InterPro

spermatogenesis Ref.3

Inferred from expression pattern. Source: UniProtKB

   Molecular functionheat shock protein binding

Inferred from electronic annotation. Source: InterPro

unfolded protein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P59910-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P59910-2)

Also known as: TSARG5;

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.
     176-201: KDKILTIDVKPGWRQGTRITFEKEGD → METSRGRNLAKVTRPTSPCHLLASPA

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316DnaJ homolog subfamily B member 13
PRO_0000071039

Regions

Domain4 – 6865J

Natural variations

Alternative sequence1 – 175175Missing in isoform 2.
VSP_008519
Alternative sequence176 – 20126KDKIL…EKEGD → METSRGRNLAKVTRPTSPCH LLASPA in isoform 2.
VSP_008520

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 10, 2003. Version 1.
Checksum: 8251CB720724B7E5

FASTA31636,118
        10         20         30         40         50         60 
MGQDYYSVLG ITRNSEDAQI KQAYRRLALK HHPLKSNEPS SAEIFRQIAE AYDVLSDPMK 

        70         80         90        100        110        120 
RGIYDKFGEE GLKGGIPLEF GSQTPWTTGY VFHGKPEKVF HEFFGGNNPF SEFFDAEGSE 

       130        140        150        160        170        180 
VDLNFGGLQG RGVKKQDPQV ERDLYLSLED LFFGCTKKIK ISRRVLNEDG YSSTIKDKIL 

       190        200        210        220        230        240 
TIDVKPGWRQ GTRITFEKEG DQGPNIIPAD IIFIVKEKLH PRFRRENDNL FFVNPIPLGK 

       250        260        270        280        290        300 
ALTCCTVEVR TLDDRLLNIP INDIIHPKYF KKVPGEGMPL PEDPTKKGDL FIFFDIQFPT 

       310 
RLTPQKKQML RQALLT

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Isoform 2 (TSARG5).

Checksum: 8E9BCD598D26A1DC
Show »

FASTA14116,085

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References

[1]"Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 5 (TSARG5)."
Liu G., Lu G., Fu J., Liu S., Xing X., Li L.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Testis.
[2]"Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 6 (TSARG6)."
Liu G., Lu G., Fu J.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Testis.
[3]"Molecular cloning of TSARG3 gene related to apoptosis in human spermatogenic cells."
Liu G., Lu G.-X., Fu J.-J., Liu S.-F., Xing X.-W., Li L.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:107-110(2003) [PubMed: 12673577] [Abstract]
Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 112-316.
Tissue: Testis.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF516185 mRNA. Translation: AAP47195.1.
AY138810 mRNA. Translation: AAN15929.1.
AF419291 mRNA. Translation: AAN32702.1. Sequence problems.
IPIIPI00374262.
IPI00374263.
RefSeqNP_705842.2.
UniGeneHs.567888

3D structure databases

SMRP59910. Positions 1-74, 138-310.
ModBaseSearch...

Protein-protein interaction databases

STRINGP59910.

Proteomic databases

PRIDEP59910.

Genome annotation databases

EnsemblENST00000339764; ENSP00000344431; ENSG00000187726; Homo sapiens. [Genome view]
GeneID374407.
KEGGhsa:374407.
UCSCuc001ouo.1. human.

Organism-specific databases

CTD374407.
GeneCardsGC11P073340.
H-InvDBHIX0009925.
HGNCHGNC:30718. DNAJB13.
MIM610263. gene.
PharmGKBPA142671972.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18951.
HOGENOMHBG635315.
HOVERGENHBG066727.
InParanoidP59910.
OMALTIDVRP.
OrthoDBEOG9KD95F.
PhylomeDBP59910.

Gene expression databases

ArrayExpressP59910.
BgeeP59910.
CleanExHS_DNAJB13.
GenevestigatorP59910.
GermOnlineENSG00000187726. Homo sapiens.

Family and domain databases

InterProIPR002939. DnaJ_C.
IPR001623. DnaJ_N.
IPR018253. Heat_shock_DnaJ_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR015609. Hsp40/DnaJ_Rel.
IPR003095. Hsp_DnaJ.
[Graphical view]
Gene3DG3DSA:1.10.287.110. DnaJ_N. 1 hit.
PANTHERPTHR11821. Hsp40/DnaJ_Rel. 1 hit.
PfamPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
[Graphical view]
PRINTSPR00625. DNAJPROTEIN.
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMSSF46565. DnaJ_N. 1 hit.
SSF49493. HSP40_DnaJ_pep. 2 hits.
PROSITEPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio100185.
SOURCESearch...

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Entry information

Entry nameDJB13_HUMAN
AccessionPrimary (citable) accession number: P59910
Secondary accession number(s): Q8IZW5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: March 2, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents