P59910 (DJB13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DnaJ homolog subfamily B member 13

Alternative name(s):
Testis and spermatogenesis cell-related protein 6
Testis spermatocyte apoptosis-related gene 6 protein
Testis spermatogenesis apoptosis-related gene 3 protein
Testis spermatogenesis apoptosis-related gene 6 protein

Gene names

Name:	DNAJB13
Synonyms:	TSARG3, TSARG6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in inhibiting testis spermatogenesis apoptosis.
Tissue specificity	Specifically expressed in testis.
Sequence similarities	Contains 1 J domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from expression pattern Ref.3. Source: UniProtKB protein folding Inferred from electronic annotation. Source: InterPro spermatogenesis Inferred from expression pattern Ref.3. Source: UniProtKB
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P59910-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P59910-2)

Also known as: TSARG5;

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.
     176-201: KDKILTIDVKPGWRQGTRITFEKEGD → METSRGRNLAKVTRPTSPCHLLASPA

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	DnaJ homolog subfamily B member 13		PRO_0000071039
Regions
	Domain	4 – 68	65	J
Natural variations
	Alternative sequence	1 – 175	175	Missing in isoform 2.		VSP_008519
	Alternative sequence	176 – 201	26	KDKIL…EKEGD → METSRGRNLAKVTRPTSPCH LLASPA in isoform 2.		VSP_008520

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 10, 2003. Version 1. Checksum: 8251CB720724B7E5	FASTA	316	36,118
	10 20 30 40 50 60 MGQDYYSVLG ITRNSEDAQI KQAYRRLALK HHPLKSNEPS SAEIFRQIAE AYDVLSDPMK 70 80 90 100 110 120 RGIYDKFGEE GLKGGIPLEF GSQTPWTTGY VFHGKPEKVF HEFFGGNNPF SEFFDAEGSE 130 140 150 160 170 180 VDLNFGGLQG RGVKKQDPQV ERDLYLSLED LFFGCTKKIK ISRRVLNEDG YSSTIKDKIL 190 200 210 220 230 240 TIDVKPGWRQ GTRITFEKEG DQGPNIIPAD IIFIVKEKLH PRFRRENDNL FFVNPIPLGK 250 260 270 280 290 300 ALTCCTVEVR TLDDRLLNIP INDIIHPKYF KKVPGEGMPL PEDPTKKGDL FIFFDIQFPT 310 RLTPQKKQML RQALLT
	Isoform 2 (TSARG5) [UniParc]. Checksum: 8E9BCD598D26A1DC	FASTA	141	16,085
	10 20 30 40 50 60 METSRGRNLA KVTRPTSPCH LLASPAQGPN IIPADIIFIV KEKLHPRFRR ENDNLFFVNP 70 80 90 100 110 120 IPLGKALTCC TVEVRTLDDR LLNIPINDII HPKYFKKVPG EGMPLPEDPT KKGDLFIFFD 130 140 IQFPTRLTPQ KKQMLRQALL T

References

[1]	"Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 5 (TSARG5)." Liu G., Lu G., Fu J., Liu S., Xing X., Li L. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Testis.
[2]	"Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 6 (TSARG6)." Liu G., Lu G., Fu J. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[3]	"Molecular cloning of TSARG3 gene related to apoptosis in human spermatogenic cells." Liu G., Lu G.-X., Fu J.-J., Liu S.-F., Xing X.-W., Li L. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:107-110(2003) [PubMed: 12673577] [Abstract] Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 112-316. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF516185 mRNA. Translation: AAP47195.1. AY138810 mRNA. Translation: AAN15929.1. AF419291 mRNA. Translation: AAN32702.1. Sequence problems.
IPI	IPI00374262. IPI00374263.
RefSeq	NP_705842.2. NM_153614.2.
UniGene	Hs.567888.
3D structure databases
ProteinModelPortal	P59910.
SMR	P59910. Positions 1-74, 109-316.
ModBase	Search...
Protein-protein interaction databases
STRING	P59910.
Polymorphism databases
DMDM	41704179.
Proteomic databases
PRIDE	P59910.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339764; ENSP00000344431; ENSG00000187726.
GeneID	374407.
KEGG	hsa:374407.
UCSC	uc001ouo.1. human.
Organism-specific databases
CTD	374407.
GeneCards	GC11P073661.
H-InvDB	HIX0009925.
HGNC	HGNC:30718. DNAJB13.
MIM	610263. gene.
neXtProt	NX_P59910.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18951.
GeneTree	ENSGT00600000084029.
HOGENOM	HBG635315.
HOVERGEN	HBG066727.
InParanoid	P59910.
OMA	ITRNAED.
OrthoDB	EOG4PVP07.
PhylomeDB	P59910.
Gene expression databases
ArrayExpress	P59910.
Bgee	P59910.
CleanEx	HS_DNAJB13.
Genevestigator	P59910.
GermOnline	ENSG00000187726. Homo sapiens.
Family and domain databases
InterPro	IPR002939. DnaJ_C. IPR001623. DnaJ_N. IPR018253. Heat_shock_DnaJ_CS. IPR008971. HSP40/DnaJ_pept-bd. IPR003095. Hsp_DnaJ. [Graphical view]
Gene3D	G3DSA:1.10.287.110. DnaJ_N. 1 hit.
KO	K09519.
Pfam	PF00226. DnaJ. 1 hit. PF01556. DnaJ_C. 1 hit. [Graphical view]
PRINTS	PR00625. JDOMAIN.
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
SUPFAM	SSF46565. DnaJ_N. 1 hit. SSF49493. HSP40_DnaJ_pep. 2 hits.
PROSITE	PS00636. DNAJ_1. 1 hit. PS50076. DNAJ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	100185.
SOURCE	Search...

Entry information

Entry name

DJB13_HUMAN

Accession

Primary (citable) accession number: P59910
Secondary accession number(s): Q8IZW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 10, 2003
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.