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P59910

- DJB13_HUMAN

UniProt

P59910 - DJB13_HUMAN

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Protein

DnaJ homolog subfamily B member 13

Gene

DNAJB13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in inhibiting testis spermatogenesis apoptosis.

GO - Biological processi

  1. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 13
Alternative name(s):
Testis and spermatogenesis cell-related protein 6
Testis spermatocyte apoptosis-related gene 6 protein
Testis spermatogenesis apoptosis-related gene 3 protein
Testis spermatogenesis apoptosis-related gene 6 protein
Gene namesi
Name:DNAJB13
Synonyms:TSARG3, TSARG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:30718. DNAJB13.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671972.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316DnaJ homolog subfamily B member 13PRO_0000071039Add
BLAST

Proteomic databases

PaxDbiP59910.
PRIDEiP59910.

PTM databases

PhosphoSiteiP59910.

Expressioni

Tissue specificityi

Specifically expressed in testis.

Gene expression databases

BgeeiP59910.
CleanExiHS_DNAJB13.
GenevestigatoriP59910.

Organism-specific databases

HPAiHPA052465.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344431.

Structurei

3D structure databases

ProteinModelPortaliP59910.
SMRiP59910. Positions 1-104, 134-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 6865JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiP59910.
KOiK09519.
OMAiDNPFGEF.
OrthoDBiEOG7TF79F.
PhylomeDBiP59910.
TreeFamiTF105141.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
[Graphical view]
PfamiPF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P59910-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQDYYSVLG ITRNSEDAQI KQAYRRLALK HHPLKSNEPS SAEIFRQIAE
60 70 80 90 100
AYDVLSDPMK RGIYDKFGEE GLKGGIPLEF GSQTPWTTGY VFHGKPEKVF
110 120 130 140 150
HEFFGGNNPF SEFFDAEGSE VDLNFGGLQG RGVKKQDPQV ERDLYLSLED
160 170 180 190 200
LFFGCTKKIK ISRRVLNEDG YSSTIKDKIL TIDVKPGWRQ GTRITFEKEG
210 220 230 240 250
DQGPNIIPAD IIFIVKEKLH PRFRRENDNL FFVNPIPLGK ALTCCTVEVR
260 270 280 290 300
TLDDRLLNIP INDIIHPKYF KKVPGEGMPL PEDPTKKGDL FIFFDIQFPT
310
RLTPQKKQML RQALLT
Length:316
Mass (Da):36,118
Last modified:October 10, 2003 - v1
Checksum:i8251CB720724B7E5
GO
Isoform 2 (identifier: P59910-2) [UniParc]FASTAAdd to Basket

Also known as: TSARG5

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.
     176-201: KDKILTIDVKPGWRQGTRITFEKEGD → METSRGRNLAKVTRPTSPCHLLASPA

Show »
Length:141
Mass (Da):16,085
Checksum:i8E9BCD598D26A1DC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 175175Missing in isoform 2. 1 PublicationVSP_008519Add
BLAST
Alternative sequencei176 – 20126KDKIL…EKEGD → METSRGRNLAKVTRPTSPCH LLASPA in isoform 2. 1 PublicationVSP_008520Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF516185 mRNA. Translation: AAP47195.1.
AY138810 mRNA. Translation: AAN15929.1.
AY325766 mRNA. Translation: AAQ17190.1.
AF419291 mRNA. Translation: AAN32702.1. Sequence problems.
CH471076 Genomic DNA. Translation: EAW74920.1.
CCDSiCCDS8227.1. [P59910-1]
RefSeqiNP_705842.2. NM_153614.2. [P59910-1]
XP_005274040.1. XM_005273983.1. [P59910-1]
UniGeneiHs.567888.

Genome annotation databases

EnsembliENST00000339764; ENSP00000344431; ENSG00000187726. [P59910-1]
ENST00000537753; ENSP00000439711; ENSG00000187726. [P59910-2]
ENST00000543947; ENSP00000438576; ENSG00000187726. [P59910-2]
GeneIDi374407.
KEGGihsa:374407.
UCSCiuc001ouo.3. human. [P59910-1]

Polymorphism databases

DMDMi41704179.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF516185 mRNA. Translation: AAP47195.1 .
AY138810 mRNA. Translation: AAN15929.1 .
AY325766 mRNA. Translation: AAQ17190.1 .
AF419291 mRNA. Translation: AAN32702.1 . Sequence problems.
CH471076 Genomic DNA. Translation: EAW74920.1 .
CCDSi CCDS8227.1. [P59910-1 ]
RefSeqi NP_705842.2. NM_153614.2. [P59910-1 ]
XP_005274040.1. XM_005273983.1. [P59910-1 ]
UniGenei Hs.567888.

3D structure databases

ProteinModelPortali P59910.
SMRi P59910. Positions 1-104, 134-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000344431.

PTM databases

PhosphoSitei P59910.

Polymorphism databases

DMDMi 41704179.

Proteomic databases

PaxDbi P59910.
PRIDEi P59910.

Protocols and materials databases

DNASUi 374407.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339764 ; ENSP00000344431 ; ENSG00000187726 . [P59910-1 ]
ENST00000537753 ; ENSP00000439711 ; ENSG00000187726 . [P59910-2 ]
ENST00000543947 ; ENSP00000438576 ; ENSG00000187726 . [P59910-2 ]
GeneIDi 374407.
KEGGi hsa:374407.
UCSCi uc001ouo.3. human. [P59910-1 ]

Organism-specific databases

CTDi 374407.
GeneCardsi GC11P073661.
H-InvDB HIX0171374.
HGNCi HGNC:30718. DNAJB13.
HPAi HPA052465.
MIMi 610263. gene.
neXtProti NX_P59910.
PharmGKBi PA142671972.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0484.
GeneTreei ENSGT00760000118947.
HOGENOMi HOG000226718.
HOVERGENi HBG066727.
InParanoidi P59910.
KOi K09519.
OMAi DNPFGEF.
OrthoDBi EOG7TF79F.
PhylomeDBi P59910.
TreeFami TF105141.

Miscellaneous databases

GenomeRNAii 374407.
NextBioi 100185.
PROi P59910.
SOURCEi Search...

Gene expression databases

Bgeei P59910.
CleanExi HS_DNAJB13.
Genevestigatori P59910.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
InterProi IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
[Graphical view ]
Pfami PF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
[Graphical view ]
PRINTSi PR00625. JDOMAIN.
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEi PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 5 (TSARG5)."
    Liu G., Lu G., Fu J., Liu S., Xing X., Li L.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 6 (TSARG6)."
    Liu G., Lu G., Fu J.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "Cloning and characterization of a novel human and rat DnaJ gene."
    Shan Y.X., Huang C.Q., Yu L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Molecular cloning of TSARG3 gene related to apoptosis in human spermatogenic cells."
    Liu G., Lu G.-X., Fu J.-J., Liu S.-F., Xing X.-W., Li L.
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:107-110(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 112-316.
    Tissue: Testis.

Entry informationi

Entry nameiDJB13_HUMAN
AccessioniPrimary (citable) accession number: P59910
Secondary accession number(s): B3LEP4, Q8IZW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3