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Protein

DnaJ homolog subfamily B member 13

Gene

DNAJB13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in inhibiting testis spermatogenesis apoptosis.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 13
Alternative name(s):
Testis and spermatogenesis cell-related protein 6
Testis spermatocyte apoptosis-related gene 6 protein
Testis spermatogenesis apoptosis-related gene 3 protein
Testis spermatogenesis apoptosis-related gene 6 protein
Gene namesi
Name:DNAJB13
Synonyms:TSARG3, TSARG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:30718. DNAJB13.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671972.

Polymorphism and mutation databases

BioMutaiDNAJB13.
DMDMi41704179.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316DnaJ homolog subfamily B member 13PRO_0000071039Add
BLAST

Proteomic databases

PaxDbiP59910.
PRIDEiP59910.

PTM databases

PhosphoSiteiP59910.

Expressioni

Tissue specificityi

Specifically expressed in testis.

Gene expression databases

BgeeiP59910.
CleanExiHS_DNAJB13.
ExpressionAtlasiP59910. baseline and differential.
GenevisibleiP59910. HS.

Organism-specific databases

HPAiHPA052465.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344431.

Structurei

3D structure databases

ProteinModelPortaliP59910.
SMRiP59910. Positions 1-104, 134-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 6865JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiP59910.
KOiK09519.
OMAiDNPFGEF.
OrthoDBiEOG7TF79F.
PhylomeDBiP59910.
TreeFamiTF105141.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
[Graphical view]
PfamiPF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P59910-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQDYYSVLG ITRNSEDAQI KQAYRRLALK HHPLKSNEPS SAEIFRQIAE
60 70 80 90 100
AYDVLSDPMK RGIYDKFGEE GLKGGIPLEF GSQTPWTTGY VFHGKPEKVF
110 120 130 140 150
HEFFGGNNPF SEFFDAEGSE VDLNFGGLQG RGVKKQDPQV ERDLYLSLED
160 170 180 190 200
LFFGCTKKIK ISRRVLNEDG YSSTIKDKIL TIDVKPGWRQ GTRITFEKEG
210 220 230 240 250
DQGPNIIPAD IIFIVKEKLH PRFRRENDNL FFVNPIPLGK ALTCCTVEVR
260 270 280 290 300
TLDDRLLNIP INDIIHPKYF KKVPGEGMPL PEDPTKKGDL FIFFDIQFPT
310
RLTPQKKQML RQALLT
Length:316
Mass (Da):36,118
Last modified:October 10, 2003 - v1
Checksum:i8251CB720724B7E5
GO
Isoform 2 (identifier: P59910-2) [UniParc]FASTAAdd to basket

Also known as: TSARG5

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.
     176-201: KDKILTIDVKPGWRQGTRITFEKEGD → METSRGRNLAKVTRPTSPCHLLASPA

Show »
Length:141
Mass (Da):16,085
Checksum:i8E9BCD598D26A1DC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 175175Missing in isoform 2. 1 PublicationVSP_008519Add
BLAST
Alternative sequencei176 – 20126KDKIL…EKEGD → METSRGRNLAKVTRPTSPCH LLASPA in isoform 2. 1 PublicationVSP_008520Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF516185 mRNA. Translation: AAP47195.1.
AY138810 mRNA. Translation: AAN15929.1.
AY325766 mRNA. Translation: AAQ17190.1.
AF419291 mRNA. Translation: AAN32702.1. Sequence problems.
CH471076 Genomic DNA. Translation: EAW74920.1.
CCDSiCCDS8227.1. [P59910-1]
RefSeqiNP_705842.2. NM_153614.3. [P59910-1]
UniGeneiHs.567888.

Genome annotation databases

EnsembliENST00000339764; ENSP00000344431; ENSG00000187726. [P59910-1]
ENST00000537753; ENSP00000439711; ENSG00000187726. [P59910-2]
ENST00000543947; ENSP00000438576; ENSG00000187726. [P59910-2]
GeneIDi374407.
KEGGihsa:374407.
UCSCiuc001ouo.3. human. [P59910-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF516185 mRNA. Translation: AAP47195.1.
AY138810 mRNA. Translation: AAN15929.1.
AY325766 mRNA. Translation: AAQ17190.1.
AF419291 mRNA. Translation: AAN32702.1. Sequence problems.
CH471076 Genomic DNA. Translation: EAW74920.1.
CCDSiCCDS8227.1. [P59910-1]
RefSeqiNP_705842.2. NM_153614.3. [P59910-1]
UniGeneiHs.567888.

3D structure databases

ProteinModelPortaliP59910.
SMRiP59910. Positions 1-104, 134-314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344431.

PTM databases

PhosphoSiteiP59910.

Polymorphism and mutation databases

BioMutaiDNAJB13.
DMDMi41704179.

Proteomic databases

PaxDbiP59910.
PRIDEiP59910.

Protocols and materials databases

DNASUi374407.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339764; ENSP00000344431; ENSG00000187726. [P59910-1]
ENST00000537753; ENSP00000439711; ENSG00000187726. [P59910-2]
ENST00000543947; ENSP00000438576; ENSG00000187726. [P59910-2]
GeneIDi374407.
KEGGihsa:374407.
UCSCiuc001ouo.3. human. [P59910-1]

Organism-specific databases

CTDi374407.
GeneCardsiGC11P073661.
H-InvDBHIX0171374.
HGNCiHGNC:30718. DNAJB13.
HPAiHPA052465.
MIMi610263. gene.
neXtProtiNX_P59910.
PharmGKBiPA142671972.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiP59910.
KOiK09519.
OMAiDNPFGEF.
OrthoDBiEOG7TF79F.
PhylomeDBiP59910.
TreeFamiTF105141.

Miscellaneous databases

GenomeRNAii374407.
NextBioi100185.
PROiP59910.
SOURCEiSearch...

Gene expression databases

BgeeiP59910.
CleanExiHS_DNAJB13.
ExpressionAtlasiP59910. baseline and differential.
GenevisibleiP59910. HS.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
[Graphical view]
PfamiPF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 5 (TSARG5)."
    Liu G., Lu G., Fu J., Liu S., Xing X., Li L.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 6 (TSARG6)."
    Liu G., Lu G., Fu J.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "Cloning and characterization of a novel human and rat DnaJ gene."
    Shan Y.X., Huang C.Q., Yu L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Molecular cloning of TSARG3 gene related to apoptosis in human spermatogenic cells."
    Liu G., Lu G.-X., Fu J.-J., Liu S.-F., Xing X.-W., Li L.
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:107-110(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 112-316.
    Tissue: Testis.

Entry informationi

Entry nameiDJB13_HUMAN
AccessioniPrimary (citable) accession number: P59910
Secondary accession number(s): B3LEP4, Q8IZW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 24, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.