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P59910

- DJB13_HUMAN

UniProt

P59910 - DJB13_HUMAN

Protein

DnaJ homolog subfamily B member 13

Gene

DNAJB13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (10 Oct 2003)
      Previous versions | rss
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    Functioni

    May be involved in inhibiting testis spermatogenesis apoptosis.

    GO - Biological processi

    1. protein folding Source: InterPro

    Keywords - Molecular functioni

    Chaperone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DnaJ homolog subfamily B member 13
    Alternative name(s):
    Testis and spermatogenesis cell-related protein 6
    Testis spermatocyte apoptosis-related gene 6 protein
    Testis spermatogenesis apoptosis-related gene 3 protein
    Testis spermatogenesis apoptosis-related gene 6 protein
    Gene namesi
    Name:DNAJB13
    Synonyms:TSARG3, TSARG6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:30718. DNAJB13.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671972.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316DnaJ homolog subfamily B member 13PRO_0000071039Add
    BLAST

    Proteomic databases

    PaxDbiP59910.
    PRIDEiP59910.

    PTM databases

    PhosphoSiteiP59910.

    Expressioni

    Tissue specificityi

    Specifically expressed in testis.

    Gene expression databases

    BgeeiP59910.
    CleanExiHS_DNAJB13.
    GenevestigatoriP59910.

    Organism-specific databases

    HPAiHPA052465.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000344431.

    Structurei

    3D structure databases

    ProteinModelPortaliP59910.
    SMRiP59910. Positions 1-104, 134-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 6865JPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 J domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0484.
    HOGENOMiHOG000226718.
    HOVERGENiHBG066727.
    InParanoidiP59910.
    KOiK09519.
    OMAiDNPFGEF.
    OrthoDBiEOG7TF79F.
    PhylomeDBiP59910.
    TreeFamiTF105141.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    InterProiIPR002939. DnaJ_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    IPR008971. HSP40/DnaJ_pept-bd.
    [Graphical view]
    PfamiPF01556. CTDII. 1 hit.
    PF00226. DnaJ. 1 hit.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    SSF49493. SSF49493. 2 hits.
    PROSITEiPS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P59910-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGQDYYSVLG ITRNSEDAQI KQAYRRLALK HHPLKSNEPS SAEIFRQIAE    50
    AYDVLSDPMK RGIYDKFGEE GLKGGIPLEF GSQTPWTTGY VFHGKPEKVF 100
    HEFFGGNNPF SEFFDAEGSE VDLNFGGLQG RGVKKQDPQV ERDLYLSLED 150
    LFFGCTKKIK ISRRVLNEDG YSSTIKDKIL TIDVKPGWRQ GTRITFEKEG 200
    DQGPNIIPAD IIFIVKEKLH PRFRRENDNL FFVNPIPLGK ALTCCTVEVR 250
    TLDDRLLNIP INDIIHPKYF KKVPGEGMPL PEDPTKKGDL FIFFDIQFPT 300
    RLTPQKKQML RQALLT 316
    Length:316
    Mass (Da):36,118
    Last modified:October 10, 2003 - v1
    Checksum:i8251CB720724B7E5
    GO
    Isoform 2 (identifier: P59910-2) [UniParc]FASTAAdd to Basket

    Also known as: TSARG5

    The sequence of this isoform differs from the canonical sequence as follows:
         1-175: Missing.
         176-201: KDKILTIDVKPGWRQGTRITFEKEGD → METSRGRNLAKVTRPTSPCHLLASPA

    Show »
    Length:141
    Mass (Da):16,085
    Checksum:i8E9BCD598D26A1DC
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 175175Missing in isoform 2. 1 PublicationVSP_008519Add
    BLAST
    Alternative sequencei176 – 20126KDKIL…EKEGD → METSRGRNLAKVTRPTSPCH LLASPA in isoform 2. 1 PublicationVSP_008520Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF516185 mRNA. Translation: AAP47195.1.
    AY138810 mRNA. Translation: AAN15929.1.
    AY325766 mRNA. Translation: AAQ17190.1.
    AF419291 mRNA. Translation: AAN32702.1. Sequence problems.
    CH471076 Genomic DNA. Translation: EAW74920.1.
    CCDSiCCDS8227.1. [P59910-1]
    RefSeqiNP_705842.2. NM_153614.2. [P59910-1]
    XP_005274040.1. XM_005273983.1. [P59910-1]
    UniGeneiHs.567888.

    Genome annotation databases

    EnsembliENST00000339764; ENSP00000344431; ENSG00000187726. [P59910-1]
    ENST00000537753; ENSP00000439711; ENSG00000187726. [P59910-2]
    ENST00000543947; ENSP00000438576; ENSG00000187726. [P59910-2]
    GeneIDi374407.
    KEGGihsa:374407.
    UCSCiuc001ouo.3. human. [P59910-1]

    Polymorphism databases

    DMDMi41704179.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF516185 mRNA. Translation: AAP47195.1 .
    AY138810 mRNA. Translation: AAN15929.1 .
    AY325766 mRNA. Translation: AAQ17190.1 .
    AF419291 mRNA. Translation: AAN32702.1 . Sequence problems.
    CH471076 Genomic DNA. Translation: EAW74920.1 .
    CCDSi CCDS8227.1. [P59910-1 ]
    RefSeqi NP_705842.2. NM_153614.2. [P59910-1 ]
    XP_005274040.1. XM_005273983.1. [P59910-1 ]
    UniGenei Hs.567888.

    3D structure databases

    ProteinModelPortali P59910.
    SMRi P59910. Positions 1-104, 134-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000344431.

    PTM databases

    PhosphoSitei P59910.

    Polymorphism databases

    DMDMi 41704179.

    Proteomic databases

    PaxDbi P59910.
    PRIDEi P59910.

    Protocols and materials databases

    DNASUi 374407.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339764 ; ENSP00000344431 ; ENSG00000187726 . [P59910-1 ]
    ENST00000537753 ; ENSP00000439711 ; ENSG00000187726 . [P59910-2 ]
    ENST00000543947 ; ENSP00000438576 ; ENSG00000187726 . [P59910-2 ]
    GeneIDi 374407.
    KEGGi hsa:374407.
    UCSCi uc001ouo.3. human. [P59910-1 ]

    Organism-specific databases

    CTDi 374407.
    GeneCardsi GC11P073661.
    H-InvDB HIX0171374.
    HGNCi HGNC:30718. DNAJB13.
    HPAi HPA052465.
    MIMi 610263. gene.
    neXtProti NX_P59910.
    PharmGKBi PA142671972.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0484.
    HOGENOMi HOG000226718.
    HOVERGENi HBG066727.
    InParanoidi P59910.
    KOi K09519.
    OMAi DNPFGEF.
    OrthoDBi EOG7TF79F.
    PhylomeDBi P59910.
    TreeFami TF105141.

    Miscellaneous databases

    GenomeRNAii 374407.
    NextBioi 100185.
    PROi P59910.
    SOURCEi Search...

    Gene expression databases

    Bgeei P59910.
    CleanExi HS_DNAJB13.
    Genevestigatori P59910.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    InterProi IPR002939. DnaJ_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    IPR008971. HSP40/DnaJ_pept-bd.
    [Graphical view ]
    Pfami PF01556. CTDII. 1 hit.
    PF00226. DnaJ. 1 hit.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    SSF49493. SSF49493. 2 hits.
    PROSITEi PS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 5 (TSARG5)."
      Liu G., Lu G., Fu J., Liu S., Xing X., Li L.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. "Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 6 (TSARG6)."
      Liu G., Lu G., Fu J.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. "Cloning and characterization of a novel human and rat DnaJ gene."
      Shan Y.X., Huang C.Q., Yu L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Molecular cloning of TSARG3 gene related to apoptosis in human spermatogenic cells."
      Liu G., Lu G.-X., Fu J.-J., Liu S.-F., Xing X.-W., Li L.
      Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:107-110(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 112-316.
      Tissue: Testis.

    Entry informationi

    Entry nameiDJB13_HUMAN
    AccessioniPrimary (citable) accession number: P59910
    Secondary accession number(s): B3LEP4, Q8IZW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 10, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3