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P59910 (DJB13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DnaJ homolog subfamily B member 13
Alternative name(s):
Testis and spermatogenesis cell-related protein 6
Testis spermatocyte apoptosis-related gene 6 protein
Testis spermatogenesis apoptosis-related gene 3 protein
Testis spermatogenesis apoptosis-related gene 6 protein
Gene names
Name:DNAJB13
Synonyms:TSARG3, TSARG6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in inhibiting testis spermatogenesis apoptosis.

Tissue specificity

Specifically expressed in testis.

Sequence similarities

Contains 1 J domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Molecular functionChaperone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P59910-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P59910-2)

Also known as: TSARG5;

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.
     176-201: KDKILTIDVKPGWRQGTRITFEKEGD → METSRGRNLAKVTRPTSPCHLLASPA

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316DnaJ homolog subfamily B member 13
PRO_0000071039

Regions

Domain4 – 6865J

Natural variations

Alternative sequence1 – 175175Missing in isoform 2.
VSP_008519
Alternative sequence176 – 20126KDKIL…EKEGD → METSRGRNLAKVTRPTSPCH LLASPA in isoform 2.
VSP_008520

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 10, 2003. Version 1.
Checksum: 8251CB720724B7E5

FASTA31636,118
        10         20         30         40         50         60 
MGQDYYSVLG ITRNSEDAQI KQAYRRLALK HHPLKSNEPS SAEIFRQIAE AYDVLSDPMK 

        70         80         90        100        110        120 
RGIYDKFGEE GLKGGIPLEF GSQTPWTTGY VFHGKPEKVF HEFFGGNNPF SEFFDAEGSE 

       130        140        150        160        170        180 
VDLNFGGLQG RGVKKQDPQV ERDLYLSLED LFFGCTKKIK ISRRVLNEDG YSSTIKDKIL 

       190        200        210        220        230        240 
TIDVKPGWRQ GTRITFEKEG DQGPNIIPAD IIFIVKEKLH PRFRRENDNL FFVNPIPLGK 

       250        260        270        280        290        300 
ALTCCTVEVR TLDDRLLNIP INDIIHPKYF KKVPGEGMPL PEDPTKKGDL FIFFDIQFPT 

       310 
RLTPQKKQML RQALLT 

« Hide

Isoform 2 (TSARG5) [UniParc].

Checksum: 8E9BCD598D26A1DC
Show »

FASTA14116,085

References

« Hide 'large scale' references
[1]"Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 5 (TSARG5)."
Liu G., Lu G., Fu J., Liu S., Xing X., Li L.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Testis.
[2]"Molecular cloning of Homo sapiens testis spermatogenesis apoptosis related gene 6 (TSARG6)."
Liu G., Lu G., Fu J.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Testis.
[3]"Cloning and characterization of a novel human and rat DnaJ gene."
Shan Y.X., Huang C.Q., Yu L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Molecular cloning of TSARG3 gene related to apoptosis in human spermatogenic cells."
Liu G., Lu G.-X., Fu J.-J., Liu S.-F., Xing X.-W., Li L.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:107-110(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA] OF 112-316.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF516185 mRNA. Translation: AAP47195.1.
AY138810 mRNA. Translation: AAN15929.1.
AY325766 mRNA. Translation: AAQ17190.1.
AF419291 mRNA. Translation: AAN32702.1. Sequence problems.
CH471076 Genomic DNA. Translation: EAW74920.1.
CCDSCCDS8227.1. [P59910-1]
RefSeqNP_705842.2. NM_153614.2. [P59910-1]
XP_005274040.1. XM_005273983.1. [P59910-1]
UniGeneHs.567888.

3D structure databases

ProteinModelPortalP59910.
SMRP59910. Positions 1-104, 134-314.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000344431.

PTM databases

PhosphoSiteP59910.

Polymorphism databases

DMDM41704179.

Proteomic databases

PaxDbP59910.
PRIDEP59910.

Protocols and materials databases

DNASU374407.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339764; ENSP00000344431; ENSG00000187726. [P59910-1]
ENST00000537753; ENSP00000439711; ENSG00000187726. [P59910-2]
ENST00000543947; ENSP00000438576; ENSG00000187726. [P59910-2]
GeneID374407.
KEGGhsa:374407.
UCSCuc001ouo.3. human. [P59910-1]

Organism-specific databases

CTD374407.
GeneCardsGC11P073661.
H-InvDBHIX0171374.
HGNCHGNC:30718. DNAJB13.
HPAHPA052465.
MIM610263. gene.
neXtProtNX_P59910.
PharmGKBPA142671972.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0484.
HOGENOMHOG000226718.
HOVERGENHBG066727.
InParanoidP59910.
KOK09519.
OMADNPFGEF.
OrthoDBEOG7TF79F.
PhylomeDBP59910.
TreeFamTF105141.

Gene expression databases

BgeeP59910.
CleanExHS_DNAJB13.
GenevestigatorP59910.

Family and domain databases

Gene3D1.10.287.110. 1 hit.
InterProIPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
[Graphical view]
PfamPF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSPR00625. JDOMAIN.
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi374407.
NextBio100185.
PROP59910.
SOURCESearch...

Entry information

Entry nameDJB13_HUMAN
AccessionPrimary (citable) accession number: P59910
Secondary accession number(s): B3LEP4, Q8IZW5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM