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Protein

P2Y purinoceptor 1

Gene

P2RY1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for extracellular adenine nucleotides such as ATP and ADP.By similarity

GO - Molecular functioni

  • ATP-activated adenosine receptor activity Source: BHF-UCL
  • G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  • neurotransmitter receptor activity Source: BHF-UCL

GO - Biological processi

  • cellular response to ATP Source: BHF-UCL
  • neuronal signal transduction Source: BHF-UCL
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: InterPro
  • platelet activation Source: InterPro
  • positive regulation of ion transport Source: Ensembl
  • relaxation of muscle Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 1
Short name:
P2Y1
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2RY1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
Transmembranei58 – 78Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini79 – 89CytoplasmicSequence analysisAdd BLAST11
Transmembranei90 – 110Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini111 – 128ExtracellularSequence analysisAdd BLAST18
Transmembranei129 – 149Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini150 – 167CytoplasmicSequence analysisAdd BLAST18
Transmembranei168 – 188Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini189 – 220ExtracellularSequence analysisAdd BLAST32
Transmembranei221 – 241Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini242 – 258CytoplasmicSequence analysisAdd BLAST17
Transmembranei259 – 279Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini280 – 310ExtracellularSequence analysisAdd BLAST31
Transmembranei311 – 331Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini332 – 373CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • cell surface Source: Ensembl
  • integral component of plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700051 – 373P2Y purinoceptor 1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi124 ↔ 202PROSITE-ProRule annotation
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000014399.

Structurei

3D structure databases

ProteinModelPortaliP59902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEMX. Eukaryota.
ENOG410Z2ZK. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP59902.
OMAiDYLRSYF.
OrthoDBiEOG091G093Y.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEVLWPAAP NGTDAAFLAS PGFHWGNSTA TSTAAAAAPF RCALTKTGFQ
60 70 80 90 100
FYYLPAVYIV VFIIGFLGNS IAIWMFVFHM KPWSGISVYM FNLALADFLY
110 120 130 140 150
VLTLPALIFY YFNKTNWIFG DAMCKLQRFI FHVNLYGSIL FLTCISAHRY
160 170 180 190 200
SGVVYPLKSL GRLKKKNAVY ISVLVWLIVV VAISPILFYS GTGIRKNKTI
210 220 230 240 250
TCYDTTSDEY LRSYFIYSMC TTVAMFCVPL VLILGCYGLI VRALIYKDLD
260 270 280 290 300
NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPEMCTFND
310 320 330 340 350
RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL
360 370
QSKSEDMTLN ILSEFKQNGD TSL
Length:373
Mass (Da):42,301
Last modified:October 3, 2003 - v1
Checksum:i2BD66543FFE3F341
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048684 mRNA. Translation: AAL05953.1.
RefSeqiNP_001166465.1. NM_001172994.1.
XP_005006594.1. XM_005006537.2.

Genome annotation databases

EnsembliENSCPOT00000015697; ENSCPOP00000014399; ENSCPOG00000015545.
GeneIDi100135592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048684 mRNA. Translation: AAL05953.1.
RefSeqiNP_001166465.1. NM_001172994.1.
XP_005006594.1. XM_005006537.2.

3D structure databases

ProteinModelPortaliP59902.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000014399.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000015697; ENSCPOP00000014399; ENSCPOG00000015545.
GeneIDi100135592.

Organism-specific databases

CTDi5028.

Phylogenomic databases

eggNOGiENOG410IEMX. Eukaryota.
ENOG410Z2ZK. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiP59902.
OMAiDYLRSYF.
OrthoDBiEOG091G093Y.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000142. P2Y1_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF2. PTHR24231:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00595. P2Y1PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2RY1_CAVPO
AccessioniPrimary (citable) accession number: P59902
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: October 5, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.