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P59901

- LIRA4_HUMAN

UniProt

P59901 - LIRA4_HUMAN

Protein

Leukocyte immunoglobulin-like receptor subfamily A member 4

Gene

LILRA4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    May act as receptor for class I MHC antigens. Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. immune system process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 4
    Alternative name(s):
    CD85 antigen-like family member G
    Immunoglobulin-like transcript 7
    Short name:
    ILT-7
    CD_antigen: CD85g
    Gene namesi
    Name:LILRA4
    Synonyms:ILT7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:15503. LILRA4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671546.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 499476Leukocyte immunoglobulin-like receptor subfamily A member 4PRO_0000014819Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi143 ↔ 195PROSITE-ProRule annotation
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi244 ↔ 295PROSITE-ProRule annotation
    Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi344 ↔ 395PROSITE-ProRule annotation
    Modified residuei404 – 4041Nitrated tyrosine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Nitration

    Proteomic databases

    PaxDbiP59901.
    PRIDEiP59901.

    PTM databases

    PhosphoSiteiP59901.

    Expressioni

    Tissue specificityi

    Detected in eosinophils, neutrophils and monocytes.1 Publication

    Gene expression databases

    BgeeiP59901.
    CleanExiHS_LILRA4.
    GenevestigatoriP59901.

    Organism-specific databases

    HPAiHPA048255.
    HPA049418.

    Interactioni

    Subunit structurei

    Interacts with BST2.1 Publication

    Protein-protein interaction databases

    IntActiP59901. 1 interaction.
    STRINGi9606.ENSP00000291759.

    Structurei

    3D structure databases

    ProteinModelPortaliP59901.
    SMRiP59901. Positions 26-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 446423ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini468 – 49932CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei447 – 46721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 11895Ig-like C2-type 1Add
    BLAST
    Domaini123 – 21391Ig-like C2-type 2Add
    BLAST
    Domaini224 – 31390Ig-like C2-type 3Add
    BLAST
    Domaini324 – 41390Ig-like C2-type 4Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG25855.
    HOGENOMiHOG000234395.
    HOVERGENiHBG074353.
    InParanoidiP59901.
    KOiK06512.
    OMAiIHEVTIV.
    OrthoDBiEOG7R56S3.
    PhylomeDBiP59901.
    TreeFamiTF336644.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
    SMARTiSM00409. IG. 3 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P59901-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTLILTSLLF FGLSLGPRTR VQAENLPKPI LWAEPGPVIT WHNPVTIWCQ    50
    GTLEAQGYRL DKEGNSMSRH ILKTLESENK VKLSIPSMMW EHAGRYHCYY 100
    QSPAGWSEPS DPLELVVTAY SRPTLSALPS PVVTSGVNVT LRCASRLGLG 150
    RFTLIEEGDH RLSWTLNSHQ HNHGKFQALF PMGPLTFSNR GTFRCYGYEN 200
    NTPYVWSEPS DPLQLLVSGV SRKPSLLTLQ GPVVTPGENL TLQCGSDVGY 250
    IRYTLYKEGA DGLPQRPGRQ PQAGLSQANF TLSPVSRSYG GQYRCYGAHN 300
    VSSEWSAPSD PLDILIAGQI SDRPSLSVQP GPTVTSGEKV TLLCQSWDPM 350
    FTFLLTKEGA AHPPLRLRSM YGAHKYQAEF PMSPVTSAHA GTYRCYGSRS 400
    SNPYLLSHPS EPLELVVSGA TETLNPAQKK SDSKTAPHLQ DYTVENLIRM 450
    GVAGLVLLFL GILLFEAQHS QRSPPRCSQE ANSRKDNAPF RVVEPWEQI 499
    Length:499
    Mass (Da):55,165
    Last modified:February 9, 2010 - v2
    Checksum:i16FDB2A6C458F53B
    GO
    Isoform 2 (identifier: P59901-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-66: Missing.

    Show »
    Length:433
    Mass (Da):47,806
    Checksum:i52A2EF57AA9CA775
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31L → P in AAD02203. 1 PublicationCurated
    Sequence conflicti7 – 71S → V in AAD02203. 1 PublicationCurated
    Sequence conflicti9 – 113LFF → ICL in AAD02203. 1 PublicationCurated
    Sequence conflicti235 – 2351T → N in BI834924. 1 PublicationCurated
    Sequence conflicti398 – 3981S → T in AAD02203. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271P → L.
    Corresponds to variant rs2241384 [ dbSNP | Ensembl ].
    VAR_056054
    Natural varianti155 – 1551I → V.
    Corresponds to variant rs10419832 [ dbSNP | Ensembl ].
    VAR_056055

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6666Missing in isoform 2. 1 PublicationVSP_038694Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041261 mRNA. Translation: AAD02203.1.
    AC008746 Genomic DNA. No translation available.
    AC008984 Genomic DNA. No translation available.
    BC109198 mRNA. Translation: AAI09199.1.
    BI834924 mRNA. No translation available.
    AF283989 mRNA. Translation: AAL36993.1.
    CCDSiCCDS12890.1. [P59901-1]
    RefSeqiNP_036408.3. NM_012276.3. [P59901-1]
    UniGeneiHs.406708.

    Genome annotation databases

    EnsembliENST00000291759; ENSP00000291759; ENSG00000239961. [P59901-1]
    GeneIDi23547.
    KEGGihsa:23547.
    UCSCiuc002qfi.3. human. [P59901-1]

    Polymorphism databases

    DMDMi288558815.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041261 mRNA. Translation: AAD02203.1 .
    AC008746 Genomic DNA. No translation available.
    AC008984 Genomic DNA. No translation available.
    BC109198 mRNA. Translation: AAI09199.1 .
    BI834924 mRNA. No translation available.
    AF283989 mRNA. Translation: AAL36993.1 .
    CCDSi CCDS12890.1. [P59901-1 ]
    RefSeqi NP_036408.3. NM_012276.3. [P59901-1 ]
    UniGenei Hs.406708.

    3D structure databases

    ProteinModelPortali P59901.
    SMRi P59901. Positions 26-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P59901. 1 interaction.
    STRINGi 9606.ENSP00000291759.

    PTM databases

    PhosphoSitei P59901.

    Polymorphism databases

    DMDMi 288558815.

    Proteomic databases

    PaxDbi P59901.
    PRIDEi P59901.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000291759 ; ENSP00000291759 ; ENSG00000239961 . [P59901-1 ]
    GeneIDi 23547.
    KEGGi hsa:23547.
    UCSCi uc002qfi.3. human. [P59901-1 ]

    Organism-specific databases

    CTDi 23547.
    GeneCardsi GC19M054844.
    HGNCi HGNC:15503. LILRA4.
    HPAi HPA048255.
    HPA049418.
    MIMi 607517. gene.
    neXtProti NX_P59901.
    PharmGKBi PA142671546.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25855.
    HOGENOMi HOG000234395.
    HOVERGENi HBG074353.
    InParanoidi P59901.
    KOi K06512.
    OMAi IHEVTIV.
    OrthoDBi EOG7R56S3.
    PhylomeDBi P59901.
    TreeFami TF336644.

    Miscellaneous databases

    GeneWikii LILRA4.
    GenomeRNAii 23547.
    NextBioi 46084.
    PROi P59901.
    SOURCEi Search...

    Gene expression databases

    Bgeei P59901.
    CleanExi HS_LILRA4.
    Genevestigatori P59901.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR016332. A1B_glyco/leuk_Ig-like_rcpt.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    PIRSFi PIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
    SMARTi SM00409. IG. 3 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Immunoglobulin-like transcript 7."
      Colonna M.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-235 (ISOFORM 1).
      Tissue: Pancreas and Spleen.
    4. Canavez F.C.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-494 (ISOFORM 1).
    5. Cited for: FUNCTION, TISSUE SPECIFICITY.
    6. "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry."
      Zhan X., Desiderio D.M.
      Anal. Biochem. 354:279-289(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-404, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Pituitary adenoma.
    7. "Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction."
      Cao W., Bover L., Cho M., Wen X., Hanabuchi S., Bao M., Rosen D.B., Wang Y.H., Shaw J.L., Du Q., Li C., Arai N., Yao Z., Lanier L.L., Liu Y.J.
      J. Exp. Med. 206:1603-1614(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BST2.

    Entry informationi

    Entry nameiLIRA4_HUMAN
    AccessioniPrimary (citable) accession number: P59901
    Secondary accession number(s): Q32MC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3