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P59901 (LIRA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 4
Alternative name(s):
CD85 antigen-like family member G
Immunoglobulin-like transcript 7
Short name=ILT-7
CD_antigen=CD85g
Gene names
Name:LILRA4
Synonyms:ILT7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as receptor for class I MHC antigens. Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4. Ref.5

Subunit structure

Interacts with BST2. Ref.7

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Detected in eosinophils, neutrophils and monocytes. Ref.5

Sequence similarities

Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
   Biological processAdaptive immunity
Immunity
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Nitration
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processimmune system process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P59901-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P59901-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 499476Leukocyte immunoglobulin-like receptor subfamily A member 4
PRO_0000014819

Regions

Topological domain24 – 446423Extracellular Potential
Transmembrane447 – 46721Helical; Potential
Topological domain468 – 49932Cytoplasmic Potential
Domain24 – 11895Ig-like C2-type 1
Domain123 – 21391Ig-like C2-type 2
Domain224 – 31390Ig-like C2-type 3
Domain324 – 41390Ig-like C2-type 4

Amino acid modifications

Modified residue4041Nitrated tyrosine Ref.6
Glycosylation1381N-linked (GlcNAc...) Potential
Glycosylation2391N-linked (GlcNAc...) Potential
Glycosylation2791N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 98 By similarity
Disulfide bond143 ↔ 195 By similarity
Disulfide bond244 ↔ 295 Potential
Disulfide bond344 ↔ 395 Potential

Natural variations

Alternative sequence1 – 6666Missing in isoform 2.
VSP_038694
Natural variant271P → L.
Corresponds to variant rs2241384 [ dbSNP | Ensembl ].
VAR_056054
Natural variant1551I → V.
Corresponds to variant rs10419832 [ dbSNP | Ensembl ].
VAR_056055

Experimental info

Sequence conflict31L → P in AAD02203. Ref.1
Sequence conflict71S → V in AAD02203. Ref.1
Sequence conflict9 – 113LFF → ICL in AAD02203. Ref.1
Sequence conflict2351T → N in BI834924. Ref.4
Sequence conflict3981S → T in AAD02203. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 9, 2010. Version 2.
Checksum: 16FDB2A6C458F53B

FASTA49955,165
        10         20         30         40         50         60 
MTLILTSLLF FGLSLGPRTR VQAENLPKPI LWAEPGPVIT WHNPVTIWCQ GTLEAQGYRL 

        70         80         90        100        110        120 
DKEGNSMSRH ILKTLESENK VKLSIPSMMW EHAGRYHCYY QSPAGWSEPS DPLELVVTAY 

       130        140        150        160        170        180 
SRPTLSALPS PVVTSGVNVT LRCASRLGLG RFTLIEEGDH RLSWTLNSHQ HNHGKFQALF 

       190        200        210        220        230        240 
PMGPLTFSNR GTFRCYGYEN NTPYVWSEPS DPLQLLVSGV SRKPSLLTLQ GPVVTPGENL 

       250        260        270        280        290        300 
TLQCGSDVGY IRYTLYKEGA DGLPQRPGRQ PQAGLSQANF TLSPVSRSYG GQYRCYGAHN 

       310        320        330        340        350        360 
VSSEWSAPSD PLDILIAGQI SDRPSLSVQP GPTVTSGEKV TLLCQSWDPM FTFLLTKEGA 

       370        380        390        400        410        420 
AHPPLRLRSM YGAHKYQAEF PMSPVTSAHA GTYRCYGSRS SNPYLLSHPS EPLELVVSGA 

       430        440        450        460        470        480 
TETLNPAQKK SDSKTAPHLQ DYTVENLIRM GVAGLVLLFL GILLFEAQHS QRSPPRCSQE 

       490 
ANSRKDNAPF RVVEPWEQI 

« Hide

Isoform 2 [UniParc].

Checksum: 52A2EF57AA9CA775
Show »

FASTA43347,806

References

« Hide 'large scale' references
[1]"Immunoglobulin-like transcript 7."
Colonna M.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-235 (ISOFORM 1).
Tissue: Pancreas and Spleen.
[4]Canavez F.C.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-494 (ISOFORM 1).
[5]"Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7."
Tedla N., Bandeira-Melo C., Tassinari P., Sloane D.E., Samplaski M., Cosman D., Borges L., Weller P.F., Arm J.P.
Proc. Natl. Acad. Sci. U.S.A. 100:1174-1179(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[6]"Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry."
Zhan X., Desiderio D.M.
Anal. Biochem. 354:279-289(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-404, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Pituitary adenoma.
[7]"Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction."
Cao W., Bover L., Cho M., Wen X., Hanabuchi S., Bao M., Rosen D.B., Wang Y.H., Shaw J.L., Du Q., Li C., Arai N., Yao Z., Lanier L.L., Liu Y.J.
J. Exp. Med. 206:1603-1614(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BST2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF041261 mRNA. Translation: AAD02203.1.
AC008746 Genomic DNA. No translation available.
AC008984 Genomic DNA. No translation available.
BC109198 mRNA. Translation: AAI09199.1.
BI834924 mRNA. No translation available.
AF283989 mRNA. Translation: AAL36993.1.
RefSeqNP_036408.3. NM_012276.3.
UniGeneHs.406708.

3D structure databases

ProteinModelPortalP59901.
SMRP59901. Positions 26-418.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP59901. 1 interaction.
STRING9606.ENSP00000291759.

PTM databases

PhosphoSiteP59901.

Polymorphism databases

DMDM288558815.

Proteomic databases

PaxDbP59901.
PRIDEP59901.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000291759; ENSP00000291759; ENSG00000239961. [P59901-1]
ENST00000574300; ENSP00000461142; ENSG00000261929. [P59901-1]
ENST00000576301; ENSP00000461412; ENSG00000262284. [P59901-1]
GeneID23547.
KEGGhsa:23547.
UCSCuc002qfi.3. human. [P59901-1]

Organism-specific databases

CTD23547.
GeneCardsGC19M054844.
HGNCHGNC:15503. LILRA4.
HPAHPA048255.
HPA049418.
MIM607517. gene.
neXtProtNX_P59901.
PharmGKBPA142671546.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25855.
HOGENOMHOG000234395.
HOVERGENHBG074353.
InParanoidP59901.
KOK06512.
OMAYENNTPY.
OrthoDBEOG7R56S3.
PhylomeDBP59901.
TreeFamTF336644.

Gene expression databases

BgeeP59901.
CleanExHS_LILRA4.
GenevestigatorP59901.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PIRSFPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTSM00409. IG. 3 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiLILRA4.
GenomeRNAi23547.
NextBio46084.
PROP59901.
SOURCESearch...

Entry information

Entry nameLIRA4_HUMAN
AccessionPrimary (citable) accession number: P59901
Secondary accession number(s): Q32MC4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: February 9, 2010
Last modified: March 19, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries