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P59901

- LIRA4_HUMAN

UniProt

P59901 - LIRA4_HUMAN

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Protein

Leukocyte immunoglobulin-like receptor subfamily A member 4

Gene

LILRA4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May act as receptor for class I MHC antigens. Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4.1 Publication

GO - Biological processi

  1. immune system process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 4
Alternative name(s):
CD85 antigen-like family member G
Immunoglobulin-like transcript 7
Short name:
ILT-7
CD_antigen: CD85g
Gene namesi
Name:LILRA4
Synonyms:ILT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:15503. LILRA4.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 499476Leukocyte immunoglobulin-like receptor subfamily A member 4PRO_0000014819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi143 ↔ 195PROSITE-ProRule annotation
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi244 ↔ 295PROSITE-ProRule annotation
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi344 ↔ 395PROSITE-ProRule annotation
Modified residuei404 – 4041Nitrated tyrosine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Nitration

Proteomic databases

PaxDbiP59901.
PRIDEiP59901.

PTM databases

PhosphoSiteiP59901.

Expressioni

Tissue specificityi

Detected in eosinophils, neutrophils and monocytes.1 Publication

Gene expression databases

BgeeiP59901.
CleanExiHS_LILRA4.
GenevestigatoriP59901.

Organism-specific databases

HPAiHPA048255.
HPA049418.

Interactioni

Subunit structurei

Interacts with BST2.1 Publication

Protein-protein interaction databases

IntActiP59901. 1 interaction.
STRINGi9606.ENSP00000291759.

Structurei

3D structure databases

ProteinModelPortaliP59901.
SMRiP59901. Positions 26-418.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 446423ExtracellularSequence AnalysisAdd
BLAST
Topological domaini468 – 49932CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei447 – 46721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 11895Ig-like C2-type 1Add
BLAST
Domaini123 – 21391Ig-like C2-type 2Add
BLAST
Domaini224 – 31390Ig-like C2-type 3Add
BLAST
Domaini324 – 41390Ig-like C2-type 4Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25855.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiP59901.
KOiK06512.
OMAiIHEVTIV.
OrthoDBiEOG7R56S3.
PhylomeDBiP59901.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 3 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P59901-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLILTSLLF FGLSLGPRTR VQAENLPKPI LWAEPGPVIT WHNPVTIWCQ
60 70 80 90 100
GTLEAQGYRL DKEGNSMSRH ILKTLESENK VKLSIPSMMW EHAGRYHCYY
110 120 130 140 150
QSPAGWSEPS DPLELVVTAY SRPTLSALPS PVVTSGVNVT LRCASRLGLG
160 170 180 190 200
RFTLIEEGDH RLSWTLNSHQ HNHGKFQALF PMGPLTFSNR GTFRCYGYEN
210 220 230 240 250
NTPYVWSEPS DPLQLLVSGV SRKPSLLTLQ GPVVTPGENL TLQCGSDVGY
260 270 280 290 300
IRYTLYKEGA DGLPQRPGRQ PQAGLSQANF TLSPVSRSYG GQYRCYGAHN
310 320 330 340 350
VSSEWSAPSD PLDILIAGQI SDRPSLSVQP GPTVTSGEKV TLLCQSWDPM
360 370 380 390 400
FTFLLTKEGA AHPPLRLRSM YGAHKYQAEF PMSPVTSAHA GTYRCYGSRS
410 420 430 440 450
SNPYLLSHPS EPLELVVSGA TETLNPAQKK SDSKTAPHLQ DYTVENLIRM
460 470 480 490
GVAGLVLLFL GILLFEAQHS QRSPPRCSQE ANSRKDNAPF RVVEPWEQI
Length:499
Mass (Da):55,165
Last modified:February 9, 2010 - v2
Checksum:i16FDB2A6C458F53B
GO
Isoform 2 (identifier: P59901-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Show »
Length:433
Mass (Da):47,806
Checksum:i52A2EF57AA9CA775
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31L → P in AAD02203. 1 PublicationCurated
Sequence conflicti7 – 71S → V in AAD02203. 1 PublicationCurated
Sequence conflicti9 – 113LFF → ICL in AAD02203. 1 PublicationCurated
Sequence conflicti235 – 2351T → N in BI834924. 1 PublicationCurated
Sequence conflicti398 – 3981S → T in AAD02203. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271P → L.
Corresponds to variant rs2241384 [ dbSNP | Ensembl ].
VAR_056054
Natural varianti155 – 1551I → V.
Corresponds to variant rs10419832 [ dbSNP | Ensembl ].
VAR_056055

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6666Missing in isoform 2. 1 PublicationVSP_038694Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041261 mRNA. Translation: AAD02203.1.
AC008746 Genomic DNA. No translation available.
AC008984 Genomic DNA. No translation available.
BC109198 mRNA. Translation: AAI09199.1.
BI834924 mRNA. No translation available.
AF283989 mRNA. Translation: AAL36993.1.
CCDSiCCDS12890.1. [P59901-1]
RefSeqiNP_036408.3. NM_012276.3. [P59901-1]
UniGeneiHs.406708.

Genome annotation databases

EnsembliENST00000291759; ENSP00000291759; ENSG00000239961.
ENST00000613813; ENSP00000479979; ENSG00000277092. [P59901-1]
ENST00000616790; ENSP00000483846; ENSG00000274185. [P59901-1]
ENST00000619832; ENSP00000481073; ENSG00000276798. [P59901-1]
GeneIDi23547.
KEGGihsa:23547.
UCSCiuc002qfi.3. human. [P59901-1]

Polymorphism databases

DMDMi288558815.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041261 mRNA. Translation: AAD02203.1 .
AC008746 Genomic DNA. No translation available.
AC008984 Genomic DNA. No translation available.
BC109198 mRNA. Translation: AAI09199.1 .
BI834924 mRNA. No translation available.
AF283989 mRNA. Translation: AAL36993.1 .
CCDSi CCDS12890.1. [P59901-1 ]
RefSeqi NP_036408.3. NM_012276.3. [P59901-1 ]
UniGenei Hs.406708.

3D structure databases

ProteinModelPortali P59901.
SMRi P59901. Positions 26-418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P59901. 1 interaction.
STRINGi 9606.ENSP00000291759.

PTM databases

PhosphoSitei P59901.

Polymorphism databases

DMDMi 288558815.

Proteomic databases

PaxDbi P59901.
PRIDEi P59901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000291759 ; ENSP00000291759 ; ENSG00000239961 .
ENST00000613813 ; ENSP00000479979 ; ENSG00000277092 . [P59901-1 ]
ENST00000616790 ; ENSP00000483846 ; ENSG00000274185 . [P59901-1 ]
ENST00000619832 ; ENSP00000481073 ; ENSG00000276798 . [P59901-1 ]
GeneIDi 23547.
KEGGi hsa:23547.
UCSCi uc002qfi.3. human. [P59901-1 ]

Organism-specific databases

CTDi 23547.
GeneCardsi GC19M054844.
HGNCi HGNC:15503. LILRA4.
HPAi HPA048255.
HPA049418.
MIMi 607517. gene.
neXtProti NX_P59901.
PharmGKBi PA142671546.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25855.
HOGENOMi HOG000234395.
HOVERGENi HBG074353.
InParanoidi P59901.
KOi K06512.
OMAi IHEVTIV.
OrthoDBi EOG7R56S3.
PhylomeDBi P59901.
TreeFami TF336644.

Miscellaneous databases

GeneWikii LILRA4.
GenomeRNAii 23547.
NextBioi 46084.
PROi P59901.
SOURCEi Search...

Gene expression databases

Bgeei P59901.
CleanExi HS_LILRA4.
Genevestigatori P59901.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
PIRSFi PIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTi SM00409. IG. 3 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Immunoglobulin-like transcript 7."
    Colonna M.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-235 (ISOFORM 1).
    Tissue: Pancreas and Spleen.
  4. Canavez F.C.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-494 (ISOFORM 1).
  5. Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry."
    Zhan X., Desiderio D.M.
    Anal. Biochem. 354:279-289(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-404, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pituitary adenoma.
  7. "Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction."
    Cao W., Bover L., Cho M., Wen X., Hanabuchi S., Bao M., Rosen D.B., Wang Y.H., Shaw J.L., Du Q., Li C., Arai N., Yao Z., Lanier L.L., Liu Y.J.
    J. Exp. Med. 206:1603-1614(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BST2.

Entry informationi

Entry nameiLIRA4_HUMAN
AccessioniPrimary (citable) accession number: P59901
Secondary accession number(s): Q32MC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: February 9, 2010
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3