P59901 (LIRA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 4

Alternative name(s):
CD85 antigen-like family member G
Immunoglobulin-like transcript 7
Short name=ILT-7
CD_antigen=CD85g

Gene names

Name:	LILRA4
Synonyms:	ILT7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as receptor for class I MHC antigens. Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4. Ref.5
Subunit structure	Interacts with BST2. Ref.7
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Detected in eosinophils, neutrophils and monocytes. Ref.5
Sequence similarities	Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Biological process	Adaptive immunity Immunity
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Nitration
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P59901-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P59901-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 499	476	Leukocyte immunoglobulin-like receptor subfamily A member 4		PRO_0000014819
Regions
	Topological domain	24 – 446	423	Extracellular Potential
	Transmembrane	447 – 467	21	Helical; Potential
	Topological domain	468 – 499	32	Cytoplasmic Potential
	Domain	24 – 118	95	Ig-like C2-type 1
	Domain	123 – 213	91	Ig-like C2-type 2
	Domain	224 – 313	90	Ig-like C2-type 3
	Domain	324 – 413	90	Ig-like C2-type 4
Amino acid modifications
	Modified residue	404	1	Nitrated tyrosine Ref.6
	Glycosylation	138	1	N-linked (GlcNAc...) Potential
	Glycosylation	239	1	N-linked (GlcNAc...) Potential
	Glycosylation	279	1	N-linked (GlcNAc...) Potential
	Glycosylation	300	1	N-linked (GlcNAc...) Potential
	Disulfide bond	49 ↔ 98		By similarity
	Disulfide bond	143 ↔ 195		By similarity
	Disulfide bond	244 ↔ 295		Potential
	Disulfide bond	344 ↔ 395		Potential
Natural variations
	Alternative sequence	1 – 66	66	Missing in isoform 2.		VSP_038694
	Natural variant	27	1	P → L. Corresponds to variant rs2241384 [ dbSNP | Ensembl ].		VAR_056054
	Natural variant	155	1	I → V. Corresponds to variant rs10419832 [ dbSNP | Ensembl ].		VAR_056055
Experimental info
	Sequence conflict	3	1	L → P in AAD02203. Ref.1
	Sequence conflict	7	1	S → V in AAD02203. Ref.1
	Sequence conflict	9 – 11	3	LFF → ICL in AAD02203. Ref.1
	Sequence conflict	235	1	T → N in BI834924. Ref.4
	Sequence conflict	398	1	S → T in AAD02203. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 9, 2010. Version 2. Checksum: 16FDB2A6C458F53B	FASTA	499	55,165
	10 20 30 40 50 60 MTLILTSLLF FGLSLGPRTR VQAENLPKPI LWAEPGPVIT WHNPVTIWCQ GTLEAQGYRL 70 80 90 100 110 120 DKEGNSMSRH ILKTLESENK VKLSIPSMMW EHAGRYHCYY QSPAGWSEPS DPLELVVTAY 130 140 150 160 170 180 SRPTLSALPS PVVTSGVNVT LRCASRLGLG RFTLIEEGDH RLSWTLNSHQ HNHGKFQALF 190 200 210 220 230 240 PMGPLTFSNR GTFRCYGYEN NTPYVWSEPS DPLQLLVSGV SRKPSLLTLQ GPVVTPGENL 250 260 270 280 290 300 TLQCGSDVGY IRYTLYKEGA DGLPQRPGRQ PQAGLSQANF TLSPVSRSYG GQYRCYGAHN 310 320 330 340 350 360 VSSEWSAPSD PLDILIAGQI SDRPSLSVQP GPTVTSGEKV TLLCQSWDPM FTFLLTKEGA 370 380 390 400 410 420 AHPPLRLRSM YGAHKYQAEF PMSPVTSAHA GTYRCYGSRS SNPYLLSHPS EPLELVVSGA 430 440 450 460 470 480 TETLNPAQKK SDSKTAPHLQ DYTVENLIRM GVAGLVLLFL GILLFEAQHS QRSPPRCSQE 490 ANSRKDNAPF RVVEPWEQI
	Isoform 2 [UniParc]. Checksum: 52A2EF57AA9CA775	FASTA	433	47,806
	10 20 30 40 50 60 MSRHILKTLE SENKVKLSIP SMMWEHAGRY HCYYQSPAGW SEPSDPLELV VTAYSRPTLS 70 80 90 100 110 120 ALPSPVVTSG VNVTLRCASR LGLGRFTLIE EGDHRLSWTL NSHQHNHGKF QALFPMGPLT 130 140 150 160 170 180 FSNRGTFRCY GYENNTPYVW SEPSDPLQLL VSGVSRKPSL LTLQGPVVTP GENLTLQCGS 190 200 210 220 230 240 DVGYIRYTLY KEGADGLPQR PGRQPQAGLS QANFTLSPVS RSYGGQYRCY GAHNVSSEWS 250 260 270 280 290 300 APSDPLDILI AGQISDRPSL SVQPGPTVTS GEKVTLLCQS WDPMFTFLLT KEGAAHPPLR 310 320 330 340 350 360 LRSMYGAHKY QAEFPMSPVT SAHAGTYRCY GSRSSNPYLL SHPSEPLELV VSGATETLNP 370 380 390 400 410 420 AQKKSDSKTA PHLQDYTVEN LIRMGVAGLV LLFLGILLFE AQHSQRSPPR CSQEANSRKD 430 NAPFRVVEPW EQI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Immunoglobulin-like transcript 7." Colonna M. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-235 (ISOFORM 1). Tissue: Pancreas and Spleen.
[4]	Canavez F.C. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-494 (ISOFORM 1).
[5]	"Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7." Tedla N., Bandeira-Melo C., Tassinari P., Sloane D.E., Samplaski M., Cosman D., Borges L., Weller P.F., Arm J.P. Proc. Natl. Acad. Sci. U.S.A. 100:1174-1179(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[6]	"Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry." Zhan X., Desiderio D.M. Anal. Biochem. 354:279-289(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-404, MASS SPECTROMETRY. Tissue: Pituitary adenoma.
[7]	"Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction." Cao W., Bover L., Cho M., Wen X., Hanabuchi S., Bao M., Rosen D.B., Wang Y.H., Shaw J.L., Du Q., Li C., Arai N., Yao Z., Lanier L.L., Liu Y.J. J. Exp. Med. 206:1603-1614(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH BST2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF041261 mRNA. Translation: AAD02203.1. AC008746 Genomic DNA. No translation available. AC008984 Genomic DNA. No translation available. BC109198 mRNA. Translation: AAI09199.1. BI834924 mRNA. No translation available. AF283989 mRNA. Translation: AAL36993.1.
IPI	IPI00017501. IPI00954845.
RefSeq	NP_036408.3. NM_012276.3.
UniGene	Hs.406708.
3D structure databases
ProteinModelPortal	P59901.
SMR	P59901. Positions 26-418.
ModBase	Search...
Protein-protein interaction databases
IntAct	P59901. 1 interaction.
STRING	9606.ENSP00000291759.
PTM databases
PhosphoSite	P59901.
Polymorphism databases
DMDM	288558815.
Proteomic databases
PaxDb	P59901.
PRIDE	P59901.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000291759; ENSP00000291759; ENSG00000239961. ENST00000574300; ENSP00000461142; ENSG00000261929. ENST00000576301; ENSP00000461412; ENSG00000262284.
GeneID	23547.
KEGG	hsa:23547.
UCSC	uc002qfi.3. human.
Organism-specific databases
CTD	23547.
GeneCards	GC19M054844.
HGNC	HGNC:15503. LILRA4.
HPA	HPA048255. HPA049418.
MIM	607517. gene.
neXtProt	NX_P59901.
PharmGKB	PA142671546.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG25855.
HOGENOM	HOG000234395.
HOVERGEN	HBG074353.
InParanoid	P59901.
KO	K06512.
OMA	NNTPYVW.
OrthoDB	EOG43R3MG.
PhylomeDB	P59901.
Gene expression databases
Bgee	P59901.
CleanEx	HS_LILRA4.
Genevestigator	P59901.
GermOnline	ENSG00000170858. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR016332. A1B_glyco/leuk_Ig-like_rcpt. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
PIRSF	PIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMART	SM00409. IG. 3 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23547.
NextBio	46084.
SOURCE	Search...

Entry information

Entry name

LIRA4_HUMAN

Accession

Primary (citable) accession number: P59901
Secondary accession number(s): Q32MC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	February 9, 2010
Last modified:	May 1, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.