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Protein

Leukocyte immunoglobulin-like receptor subfamily A member 4

Gene

LILRA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as receptor for class I MHC antigens. Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 4
Alternative name(s):
CD85 antigen-like family member G
Immunoglobulin-like transcript 7
Short name:
ILT-7
CD_antigen: CD85g
Gene namesi
Name:LILRA4
Synonyms:ILT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15503. LILRA4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 446ExtracellularSequence analysisAdd BLAST423
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Topological domaini468 – 499CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23547.
OpenTargetsiENSG00000274185.
ENSG00000276798.
ENSG00000277092.
PharmGKBiPA142671546.

Polymorphism and mutation databases

BioMutaiLILRA4.
DMDMi288558815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001481924 – 499Leukocyte immunoglobulin-like receptor subfamily A member 4Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi143 ↔ 195PROSITE-ProRule annotation
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi244 ↔ 295PROSITE-ProRule annotation
Glycosylationi279N-linked (GlcNAc...)Sequence analysis1
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi344 ↔ 395PROSITE-ProRule annotation
Modified residuei404Nitrated tyrosineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Nitration

Proteomic databases

PaxDbiP59901.
PeptideAtlasiP59901.
PRIDEiP59901.
TopDownProteomicsiP59901-1. [P59901-1]

PTM databases

iPTMnetiP59901.
PhosphoSitePlusiP59901.

Expressioni

Tissue specificityi

Detected in eosinophils, neutrophils and monocytes.1 Publication

Gene expression databases

BgeeiENSG00000239961.
CleanExiHS_LILRA4.
ExpressionAtlasiP59901. baseline and differential.
GenevisibleiP59901. HS.

Organism-specific databases

HPAiHPA048255.
HPA049418.

Interactioni

Subunit structurei

Interacts with BST2.1 Publication

Protein-protein interaction databases

IntActiP59901. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP59901.
SMRiP59901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 118Ig-like C2-type 1Add BLAST95
Domaini123 – 213Ig-like C2-type 2Add BLAST91
Domaini224 – 313Ig-like C2-type 3Add BLAST90
Domaini324 – 413Ig-like C2-type 4Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiP59901.
KOiK06512.
OMAiPESAAPH.
OrthoDBiEOG091G0D6W.
PhylomeDBiP59901.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 2 hits.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P59901-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLILTSLLF FGLSLGPRTR VQAENLPKPI LWAEPGPVIT WHNPVTIWCQ
60 70 80 90 100
GTLEAQGYRL DKEGNSMSRH ILKTLESENK VKLSIPSMMW EHAGRYHCYY
110 120 130 140 150
QSPAGWSEPS DPLELVVTAY SRPTLSALPS PVVTSGVNVT LRCASRLGLG
160 170 180 190 200
RFTLIEEGDH RLSWTLNSHQ HNHGKFQALF PMGPLTFSNR GTFRCYGYEN
210 220 230 240 250
NTPYVWSEPS DPLQLLVSGV SRKPSLLTLQ GPVVTPGENL TLQCGSDVGY
260 270 280 290 300
IRYTLYKEGA DGLPQRPGRQ PQAGLSQANF TLSPVSRSYG GQYRCYGAHN
310 320 330 340 350
VSSEWSAPSD PLDILIAGQI SDRPSLSVQP GPTVTSGEKV TLLCQSWDPM
360 370 380 390 400
FTFLLTKEGA AHPPLRLRSM YGAHKYQAEF PMSPVTSAHA GTYRCYGSRS
410 420 430 440 450
SNPYLLSHPS EPLELVVSGA TETLNPAQKK SDSKTAPHLQ DYTVENLIRM
460 470 480 490
GVAGLVLLFL GILLFEAQHS QRSPPRCSQE ANSRKDNAPF RVVEPWEQI
Length:499
Mass (Da):55,165
Last modified:February 9, 2010 - v2
Checksum:i16FDB2A6C458F53B
GO
Isoform 2 (identifier: P59901-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Show »
Length:433
Mass (Da):47,806
Checksum:i52A2EF57AA9CA775
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3L → P in AAD02203 (Ref. 1) Curated1
Sequence conflicti7S → V in AAD02203 (Ref. 1) Curated1
Sequence conflicti9 – 11LFF → ICL in AAD02203 (Ref. 1) Curated3
Sequence conflicti235T → N in BI834924 (Ref. 4) Curated1
Sequence conflicti398S → T in AAD02203 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05605427P → L.Corresponds to variant rs2241384dbSNPEnsembl.1
Natural variantiVAR_056055155I → V.Corresponds to variant rs10419832dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0386941 – 66Missing in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041261 mRNA. Translation: AAD02203.1.
AC008746 Genomic DNA. No translation available.
AC008984 Genomic DNA. No translation available.
BC109198 mRNA. Translation: AAI09199.1.
BI834924 mRNA. No translation available.
AF283989 mRNA. Translation: AAL36993.1.
CCDSiCCDS12890.1. [P59901-1]
RefSeqiNP_036408.4. NM_012276.4.
UniGeneiHs.406708.

Genome annotation databases

EnsembliENST00000291759; ENSP00000291759; ENSG00000239961.
ENST00000613813; ENSP00000479979; ENSG00000277092. [P59901-1]
ENST00000616790; ENSP00000483846; ENSG00000274185. [P59901-1]
ENST00000619832; ENSP00000481073; ENSG00000276798. [P59901-1]
GeneIDi23547.
KEGGihsa:23547.
UCSCiuc002qfj.4. human. [P59901-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041261 mRNA. Translation: AAD02203.1.
AC008746 Genomic DNA. No translation available.
AC008984 Genomic DNA. No translation available.
BC109198 mRNA. Translation: AAI09199.1.
BI834924 mRNA. No translation available.
AF283989 mRNA. Translation: AAL36993.1.
CCDSiCCDS12890.1. [P59901-1]
RefSeqiNP_036408.4. NM_012276.4.
UniGeneiHs.406708.

3D structure databases

ProteinModelPortaliP59901.
SMRiP59901.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP59901. 1 interactor.

PTM databases

iPTMnetiP59901.
PhosphoSitePlusiP59901.

Polymorphism and mutation databases

BioMutaiLILRA4.
DMDMi288558815.

Proteomic databases

PaxDbiP59901.
PeptideAtlasiP59901.
PRIDEiP59901.
TopDownProteomicsiP59901-1. [P59901-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291759; ENSP00000291759; ENSG00000239961.
ENST00000613813; ENSP00000479979; ENSG00000277092. [P59901-1]
ENST00000616790; ENSP00000483846; ENSG00000274185. [P59901-1]
ENST00000619832; ENSP00000481073; ENSG00000276798. [P59901-1]
GeneIDi23547.
KEGGihsa:23547.
UCSCiuc002qfj.4. human. [P59901-1]

Organism-specific databases

CTDi23547.
DisGeNETi23547.
GeneCardsiLILRA4.
HGNCiHGNC:15503. LILRA4.
HPAiHPA048255.
HPA049418.
MIMi607517. gene.
neXtProtiNX_P59901.
OpenTargetsiENSG00000274185.
ENSG00000276798.
ENSG00000277092.
PharmGKBiPA142671546.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiP59901.
KOiK06512.
OMAiPESAAPH.
OrthoDBiEOG091G0D6W.
PhylomeDBiP59901.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiLILRA4.
GenomeRNAii23547.
PROiP59901.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000239961.
CleanExiHS_LILRA4.
ExpressionAtlasiP59901. baseline and differential.
GenevisibleiP59901. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 2 hits.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIRA4_HUMAN
AccessioniPrimary (citable) accession number: P59901
Secondary accession number(s): Q32MC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: February 9, 2010
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.