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P59894

- DCDC1_HUMAN

UniProt

P59894 - DCDC1_HUMAN

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Protein

Doublecortin domain-containing protein 1

Gene

DCDC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Doublecortin domain-containing protein 1
Gene namesi
Name:DCDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:20625. DCDC1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134970075.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Doublecortin domain-containing protein 1PRO_0000079803Add
BLAST

Proteomic databases

PaxDbiP59894.
PRIDEiP59894.

PTM databases

PhosphoSiteiP59894.

Expressioni

Tissue specificityi

Highly expressed in testis. Lower levels of expression in lung, kidney, and pancreas. Higher expression in fetal brain than in adult brain.1 Publication

Gene expression databases

BgeeiP59894.
CleanExiHS_DCDC1.
ExpressionAtlasiP59894. baseline and differential.
GenevestigatoriP59894.

Organism-specific databases

HPAiHPA032084.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000389792.

Structurei

3D structure databases

ProteinModelPortaliP59894.
SMRiP59894. Positions 170-245, 294-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 25285DoublecortinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 doublecortin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG84268.
GeneTreeiENSGT00390000012809.
HOGENOMiHOG000112174.
HOVERGENiHBG051318.
InParanoidiP59894.
PhylomeDBiP59894.
TreeFamiTF329467.

Family and domain databases

Gene3Di3.10.20.230. 2 hits.
InterProiIPR003533. Doublecortin_dom.
[Graphical view]
PROSITEiPS50309. DC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P59894-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKTGAEDHR EALSQSSLSL LTEAMEVLQQ SSPEGTLDGN TVNPIYKYIL
60 70 80 90 100
NDLPREFMSS QAKAVIKTTD DYLQSQFGPN RLVHSAAVSE GSGLQDCSTH
110 120 130 140 150
QTASDHSHDE ISDLDSYKSN SKNNSCSISA SKRNRPVSAP VGQLRVAEFS
160 170 180 190 200
SLKFQSARNW QKLSQRHKLQ PRVIKVTAYK NGSRTVFARV TVPTITLLLE
210 220 230 240 250
ECTEKLNLNM AARRVFLADG KEALEPEDIP HEADVYVSTG EPFLNPFKKI
260 270 280 290 300
KDHLLLIKKV TWTMNGLMLP TDIKRRKTKP VLSIRMKKLT ERTSVRILFF
310 320 330 340 350
KNGMGQDGHE ITVGKETMKK VLDTCTIRMN LNLPARYFYD LYGRKIEDIS

KGKH
Length:354
Mass (Da):39,859
Last modified:November 13, 2007 - v2
Checksum:i4C30ED8D93F7FBEE
GO
Isoform 2 (identifier: P59894-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-270: DHLLLIKKVTWTMNGLMLP → GFRYLYNKNESKFTSQIFL
     271-354: Missing.

Note: No experimental confirmation available

Show »
Length:270
Mass (Da):30,149
Checksum:iEACDF63FAE8B4D19
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921V → A in AAP75563. (PubMed:12820024)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71E → G.
Corresponds to variant rs11031357 [ dbSNP | Ensembl ].
VAR_037284
Natural varianti83 – 831V → M.
Corresponds to variant rs2761591 [ dbSNP | Ensembl ].
VAR_033767

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei252 – 27019DHLLL…GLMLP → GFRYLYNKNESKFTSQIFL in isoform 2. 1 PublicationVSP_056951Add
BLAST
Alternative sequencei271 – 35484Missing in isoform 2. 1 PublicationVSP_056952Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY247970 mRNA. Translation: AAP75563.1.
AK126066 mRNA. Translation: BAC86423.2.
AL133296 Genomic DNA. No translation available.
AL133349 Genomic DNA. No translation available.
AL133376 Genomic DNA. No translation available.
AL135932 Genomic DNA. No translation available.
AL137160 Genomic DNA. No translation available.
AL162614, AL137804 Genomic DNA. Translation: CAO03494.1.
AL137804, AL162614 Genomic DNA. Translation: CAO03548.1.
CCDSiCCDS7872.1.
RefSeqiNP_861523.2. NM_181807.3.
UniGeneiHs.127405.
Hs.592000.

Genome annotation databases

EnsembliENST00000342355; ENSP00000343496; ENSG00000170959. [P59894-2]
ENST00000452803; ENSP00000389792; ENSG00000170959. [P59894-1]
GeneIDi341019.
KEGGihsa:341019.
UCSCiuc001msv.3. human. [P59894-1]

Polymorphism databases

DMDMi160332323.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY247970 mRNA. Translation: AAP75563.1 .
AK126066 mRNA. Translation: BAC86423.2 .
AL133296 Genomic DNA. No translation available.
AL133349 Genomic DNA. No translation available.
AL133376 Genomic DNA. No translation available.
AL135932 Genomic DNA. No translation available.
AL137160 Genomic DNA. No translation available.
AL162614 , AL137804 Genomic DNA. Translation: CAO03494.1 .
AL137804 , AL162614 Genomic DNA. Translation: CAO03548.1 .
CCDSi CCDS7872.1.
RefSeqi NP_861523.2. NM_181807.3.
UniGenei Hs.127405.
Hs.592000.

3D structure databases

ProteinModelPortali P59894.
SMRi P59894. Positions 170-245, 294-351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000389792.

PTM databases

PhosphoSitei P59894.

Polymorphism databases

DMDMi 160332323.

Proteomic databases

PaxDbi P59894.
PRIDEi P59894.

Protocols and materials databases

DNASUi 341019.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342355 ; ENSP00000343496 ; ENSG00000170959 . [P59894-2 ]
ENST00000452803 ; ENSP00000389792 ; ENSG00000170959 . [P59894-1 ]
GeneIDi 341019.
KEGGi hsa:341019.
UCSCi uc001msv.3. human. [P59894-1 ]

Organism-specific databases

CTDi 341019.
GeneCardsi GC11M030851.
H-InvDB HIX0009525.
HGNCi HGNC:20625. DCDC1.
HPAi HPA032084.
MIMi 608062. gene.
neXtProti NX_P59894.
PharmGKBi PA134970075.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG84268.
GeneTreei ENSGT00390000012809.
HOGENOMi HOG000112174.
HOVERGENi HBG051318.
InParanoidi P59894.
PhylomeDBi P59894.
TreeFami TF329467.

Miscellaneous databases

GenomeRNAii 341019.
NextBioi 98060.
PROi P59894.
SOURCEi Search...

Gene expression databases

Bgeei P59894.
CleanExi HS_DCDC1.
ExpressionAtlasi P59894. baseline and differential.
Genevestigatori P59894.

Family and domain databases

Gene3Di 3.10.20.230. 2 hits.
InterProi IPR003533. Doublecortin_dom.
[Graphical view ]
PROSITEi PS50309. DC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human doublecortin-domain-containing gene (DCDC1) expressed mainly in testis."
    Zeng L., Gu S., Li Y., Zhao E., Xu J., Ye X., Wu Q., Wang L., Xie Y., Mao Y.
    J. Hum. Genet. 48:393-396(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDCDC1_HUMAN
AccessioniPrimary (citable) accession number: P59894
Secondary accession number(s): A6PVL6, B7WNX6, Q6ZU04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3