P59894 (DCDC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Doublecortin domain-containing protein 1

Gene names

Name:

DCDC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Highly expressed in testis. Lower levels of expression in lung, kidney, and pancreas. Higher expression in fetal brain than in adult brain. Ref.1
Sequence similarities	Contains 1 doublecortin domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Doublecortin domain-containing protein 1		PRO_0000079803
Regions
	Domain	168 – 252	85	Doublecortin
Natural variations
	Natural variant	7	1	E → G. Corresponds to variant rs11031357 [ dbSNP | Ensembl ].		VAR_037284
	Natural variant	83	1	V → M. Corresponds to variant rs2761591 [ dbSNP | Ensembl ].		VAR_033767
Experimental info
	Sequence conflict	192	1	V → A in AAP75563. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P59894 [UniParc]. Last modified November 13, 2007. Version 2. Checksum: 4C30ED8D93F7FBEE	FASTA	354	39,859
	10 20 30 40 50 60 MAKTGAEDHR EALSQSSLSL LTEAMEVLQQ SSPEGTLDGN TVNPIYKYIL NDLPREFMSS 70 80 90 100 110 120 QAKAVIKTTD DYLQSQFGPN RLVHSAAVSE GSGLQDCSTH QTASDHSHDE ISDLDSYKSN 130 140 150 160 170 180 SKNNSCSISA SKRNRPVSAP VGQLRVAEFS SLKFQSARNW QKLSQRHKLQ PRVIKVTAYK 190 200 210 220 230 240 NGSRTVFARV TVPTITLLLE ECTEKLNLNM AARRVFLADG KEALEPEDIP HEADVYVSTG 250 260 270 280 290 300 EPFLNPFKKI KDHLLLIKKV TWTMNGLMLP TDIKRRKTKP VLSIRMKKLT ERTSVRILFF 310 320 330 340 350 KNGMGQDGHE ITVGKETMKK VLDTCTIRMN LNLPARYFYD LYGRKIEDIS KGKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel human doublecortin-domain-containing gene (DCDC1) expressed mainly in testis." Zeng L., Gu S., Li Y., Zhao E., Xu J., Ye X., Wu Q., Wang L., Xie Y., Mao Y. J. Hum. Genet. 48:393-396(2003) [PubMed: 12820024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY247970 mRNA. Translation: AAP75563.1. AL162614, AL137804 Genomic DNA. Translation: CAO03494.1. AL137804, AL162614 Genomic DNA. Translation: CAO03548.1.
IPI	IPI00377096.
RefSeq	NP_861523.2. NM_181807.3.
UniGene	Hs.127405. Hs.592000.
3D structure databases
ProteinModelPortal	P59894.
SMR	P59894. Positions 171-245.
ModBase	Search...
Protein-protein interaction databases
STRING	P59894.
Polymorphism databases
DMDM	160332323.
Proteomic databases
PRIDE	P59894.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000452803; ENSP00000389792; ENSG00000188682.
GeneID	341019.
KEGG	hsa:341019.
UCSC	uc001msv.1. human.
Organism-specific databases
CTD	341019.
GeneCards	GC11M030964.
H-InvDB	HIX0009525.
HGNC	HGNC:20625. DCDC1.
HPA	HPA032083.
MIM	608062. gene.
neXtProt	NX_P59894.
PharmGKB	PA134970075.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18133.
GeneTree	ENSGT00390000016867.
HOVERGEN	HBG051318.
InParanoid	P59894.
OMA	NGMGQDG.
PhylomeDB	P59894.
Gene expression databases
ArrayExpress	P59894.
Bgee	P59894.
CleanEx	HS_DCDC1.
Genevestigator	P59894.
Family and domain databases
InterPro	IPR003533. Doublecortin_dom. [Graphical view]
Gene3D	G3DSA:3.10.20.230. Doublecortin_dom. 2 hits.
SUPFAM	SSF89837. Doublecortin_dom. 2 hits.
PROSITE	PS50309. DC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	98060.
SOURCE	Search...

Entry information

Entry name

DCDC1_HUMAN

Accession

Primary (citable) accession number: P59894
Secondary accession number(s): A6PVL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	November 13, 2007
Last modified:	December 14, 2011
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.