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Protein

Doublecortin domain-containing protein 1

Gene

DCDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Doublecortin domain-containing protein 1
Gene namesi
Name:DCDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000170959.14
HGNCiHGNC:20625 DCDC1
MIMi608062 gene
neXtProtiNX_P59894

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170959
PharmGKBiPA134970075

Polymorphism and mutation databases

BioMutaiDCDC1
DMDMi160332323

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000798031 – 354Doublecortin domain-containing protein 1Add BLAST354

Proteomic databases

PaxDbiP59894
PeptideAtlasiP59894
PRIDEiP59894
ProteomicsDBi57166

PTM databases

iPTMnetiP59894
PhosphoSitePlusiP59894

Expressioni

Tissue specificityi

Highly expressed in testis. Lower levels of expression in lung, kidney, and pancreas. Higher expression in fetal brain than in adult brain.1 Publication

Gene expression databases

BgeeiENSG00000170959
CleanExiHS_DCDC1
ExpressionAtlasiP59894 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi131112, 1 interactor
STRINGi9606.ENSP00000389792

Structurei

3D structure databases

ProteinModelPortaliP59894
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 252DoublecortinPROSITE-ProRule annotationAdd BLAST85

Phylogenomic databases

eggNOGiENOG410KDIP Eukaryota
ENOG41122B9 LUCA
GeneTreeiENSGT00390000012809
HOGENOMiHOG000112174
HOVERGENiHBG051318
InParanoidiP59894
PhylomeDBiP59894
TreeFamiTF329467

Family and domain databases

Gene3Di3.10.20.230, 1 hit
InterProiView protein in InterPro
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
SUPFAMiSSF89837 SSF89837, 2 hits
PROSITEiView protein in PROSITE
PS50309 DC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P59894-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKTGAEDHR EALSQSSLSL LTEAMEVLQQ SSPEGTLDGN TVNPIYKYIL
60 70 80 90 100
NDLPREFMSS QAKAVIKTTD DYLQSQFGPN RLVHSAAVSE GSGLQDCSTH
110 120 130 140 150
QTASDHSHDE ISDLDSYKSN SKNNSCSISA SKRNRPVSAP VGQLRVAEFS
160 170 180 190 200
SLKFQSARNW QKLSQRHKLQ PRVIKVTAYK NGSRTVFARV TVPTITLLLE
210 220 230 240 250
ECTEKLNLNM AARRVFLADG KEALEPEDIP HEADVYVSTG EPFLNPFKKI
260 270 280 290 300
KDHLLLIKKV TWTMNGLMLP TDIKRRKTKP VLSIRMKKLT ERTSVRILFF
310 320 330 340 350
KNGMGQDGHE ITVGKETMKK VLDTCTIRMN LNLPARYFYD LYGRKIEDIS

KGKH
Length:354
Mass (Da):39,859
Last modified:November 13, 2007 - v2
Checksum:i4C30ED8D93F7FBEE
GO
Isoform 2 (identifier: P59894-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-270: DHLLLIKKVTWTMNGLMLP → GFRYLYNKNESKFTSQIFL
     271-354: Missing.

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):30,149
Checksum:iEACDF63FAE8B4D19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192V → A in AAP75563 (PubMed:12820024).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0372847E → G. Corresponds to variant dbSNP:rs11031357Ensembl.1
Natural variantiVAR_03376783V → M. Corresponds to variant dbSNP:rs2761591Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056951252 – 270DHLLL…GLMLP → GFRYLYNKNESKFTSQIFL in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_056952271 – 354Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY247970 mRNA Translation: AAP75563.1
AK126066 mRNA Translation: BAC86423.2
AL133296 Genomic DNA No translation available.
AL133349 Genomic DNA No translation available.
AL133376 Genomic DNA No translation available.
AL135932 Genomic DNA No translation available.
AL137160 Genomic DNA No translation available.
AL162614 Genomic DNA No translation available.
AL137804 Genomic DNA No translation available.
CCDSiCCDS7872.1 [P59894-1]
RefSeqiNP_861523.2, NM_181807.3 [P59894-1]
UniGeneiHs.127405
Hs.530438
Hs.592000
Hs.729691
Hs.730375

Genome annotation databases

EnsembliENST00000342355; ENSP00000343496; ENSG00000170959 [P59894-2]
ENST00000452803; ENSP00000389792; ENSG00000170959 [P59894-1]
GeneIDi341019
KEGGihsa:341019
UCSCiuc001msu.3 human [P59894-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDCDC1_HUMAN
AccessioniPrimary (citable) accession number: P59894
Secondary accession number(s): A6PVL6, B7WNX6, Q6ZU04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 13, 2007
Last modified: June 20, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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