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P59886

- KAX38_HOTTS

UniProt

P59886 - KAX38_HOTTS

Protein

Potassium channel toxin alpha-KTx 3.8

Gene
N/A
Organism
Hottentotta tamulus sindicus (Scorpion) (Buthus sindicus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Potassium channel inhibitor.By similarity

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. defense response Source: InterPro
    2. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 3.8
    Alternative name(s):
    Charybdotoxin-like peptide Bs 6
    Short name:
    Bs6
    OrganismiHottentotta tamulus sindicus (Scorpion) (Buthus sindicus)
    Taxonomic identifieri42519 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3838Potassium channel toxin alpha-KTx 3.8PRO_0000044900Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi8 ↔ 28By similarity
    Disulfide bondi14 ↔ 33By similarity
    Disulfide bondi18 ↔ 35By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliP59886.
    SMRiP59886. Positions 1-38.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 338Interaction with Ca(2+)-activated K(+) channelsBy similarity

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.30.30.10. 1 hit.
    InterProiIPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view]
    PfamiPF00451. Toxin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00286. CHARYBDTOXIN.
    ProDomiPD003586. Scorpion_toxinS. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF57095. SSF57095. 1 hit.
    PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59886-1 [UniParc]FASTAAdd to Basket

    « Hide

    GVPINVKCRG SPQCIQPCRD AGMRFGKCMN GKCHCTPQ                38
    Length:38
    Mass (Da):4,122
    Last modified:September 26, 2003 - v1
    Checksum:i1F2505014F8D2174
    GO

    Mass spectrometryi

    Molecular mass is 4121.4 Da from positions 1 - 38. Determined by MALDI. 1 Publication

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P59886.
    SMRi P59886. Positions 1-38.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.30.10. 1 hit.
    InterProi IPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view ]
    Pfami PF00451. Toxin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00286. CHARYBDTOXIN.
    ProDomi PD003586. Scorpion_toxinS. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF57095. SSF57095. 1 hit.
    PROSITEi PS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification and primary structure of low molecular mass peptides from scorpion (Buthus sindicus) venom."
      Ali S.A., Stoeva S., Schuetz J., Kayed R., Abbasi A., Zaidi Z.H., Voelter W.
      Comp. Biochem. Physiol. 121A:323-332(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY.
      Tissue: Venom.

    Entry informationi

    Entry nameiKAX38_HOTTS
    AccessioniPrimary (citable) accession number: P59886
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: September 26, 2003
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3