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P59870

- KAX55_MESTA

UniProt

P59870 - KAX55_MESTA

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Protein

Potassium channel toxin alpha-KTx 5.5

Gene
N/A
Organism
Mesobuthus tamulus (Eastern Indian scorpion) (Buthus tamulus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Blocks small conductance calcium-activated potassium channels.1 Publication

GO - Molecular functioni

  1. ion channel inhibitor activity Source: InterPro

GO - Biological processi

  1. defense response Source: InterPro
  2. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Calcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 5.5
Alternative name(s):
Tamapin-2
OrganismiMesobuthus tamulus (Eastern Indian scorpion) (Buthus tamulus)
Taxonomic identifieri34647 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3131Potassium channel toxin alpha-KTx 5.5PRO_0000044931Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi3 ↔ 21By similarity
Disulfide bondi8 ↔ 26By similarity
Disulfide bondi12 ↔ 28By similarity
Modified residuei31 – 311Histidine amideCurated

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP59870.
SMRiP59870. Positions 2-31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamiPF00451. Toxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59870-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30
AFCNLRRCEL SCRSLGLLGK CIGEECKCVP H
Length:31
Mass (Da):3,439
Last modified:September 26, 2003 - v1
Checksum:iE4D43CDC54CA415C
GO

Mass spectrometryi

Molecular mass is 3431.4±0.2 Da from positions 1 - 31. Determined by ESI. 1 Publication

Cross-referencesi

3D structure databases

ProteinModelPortali P59870.
SMRi P59870. Positions 2-31.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view ]
Pfami PF00451. Toxin_2. 1 hit.
[Graphical view ]
SUPFAMi SSF57095. SSF57095. 1 hit.
PROSITEi PS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons."
    Pedarzani P., D'hoedt D., Doorty K.B., Wadsworth J.D.F., Joseph J.S., Jeyaseelan K., Kini R.M., Gadre S.V., Sapatnekar S.M., Stocker M., Strong P.N.
    J. Biol. Chem. 277:46101-46109(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, FUNCTION.
    Tissue: Venom.

Entry informationi

Entry nameiKAX55_MESTA
AccessioniPrimary (citable) accession number: P59870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3