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P59870 (KAX55_MESTA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 5.5
Alternative name(s):
Tamapin-2
OrganismMesobuthus tamulus (Eastern Indian scorpion) (Buthus tamulus)
Taxonomic identifier34647 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

Protein attributes

Sequence length31 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Blocks small conductance calcium-activated potassium channels. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 5 subfamily.

Mass spectrometry

Molecular mass is 3431.4±0.2 Da from positions 1 - 31. Determined by ESI. Ref.1

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMAmidation
Disulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: InterPro

pathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionion channel inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3131Potassium channel toxin alpha-KTx 5.5
PRO_0000044931

Amino acid modifications

Modified residue311Histidine amide Probable
Disulfide bond3 ↔ 21 By similarity
Disulfide bond8 ↔ 26 By similarity
Disulfide bond12 ↔ 28 By similarity

Sequences

Sequence LengthMass (Da)Tools
P59870 [UniParc].

Last modified September 26, 2003. Version 1.
Checksum: E4D43CDC54CA415C

FASTA313,439
        10         20         30 
AFCNLRRCEL SCRSLGLLGK CIGEECKCVP H 

« Hide

References

[1]"Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons."
Pedarzani P., D'hoedt D., Doorty K.B., Wadsworth J.D.F., Joseph J.S., Jeyaseelan K., Kini R.M., Gadre S.V., Sapatnekar S.M., Stocker M., Strong P.N.
J. Biol. Chem. 277:46101-46109(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, FUNCTION.
Tissue: Venom.

Cross-references

3D structure databases

ProteinModelPortalP59870.
SMRP59870. Positions 2-31.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKAX55_MESTA
AccessionPrimary (citable) accession number: P59870
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: October 16, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries