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P59870

- KAX55_MESTA

UniProt

P59870 - KAX55_MESTA

Protein

Potassium channel toxin alpha-KTx 5.5

Gene
N/A
Organism
Mesobuthus tamulus (Eastern Indian scorpion) (Buthus tamulus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Blocks small conductance calcium-activated potassium channels.1 Publication

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. defense response Source: InterPro
    2. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin alpha-KTx 5.5
    Alternative name(s):
    Tamapin-2
    OrganismiMesobuthus tamulus (Eastern Indian scorpion) (Buthus tamulus)
    Taxonomic identifieri34647 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 3131Potassium channel toxin alpha-KTx 5.5PRO_0000044931Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi3 ↔ 21By similarity
    Disulfide bondi8 ↔ 26By similarity
    Disulfide bondi12 ↔ 28By similarity
    Modified residuei31 – 311Histidine amideCurated

    Keywords - PTMi

    Amidation, Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliP59870.
    SMRiP59870. Positions 2-31.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view]
    PfamiPF00451. Toxin_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF57095. SSF57095. 1 hit.
    PROSITEiPS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59870-1 [UniParc]FASTAAdd to Basket

    « Hide

    AFCNLRRCEL SCRSLGLLGK CIGEECKCVP H                       31
    Length:31
    Mass (Da):3,439
    Last modified:September 26, 2003 - v1
    Checksum:iE4D43CDC54CA415C
    GO

    Mass spectrometryi

    Molecular mass is 3431.4±0.2 Da from positions 1 - 31. Determined by ESI. 1 Publication

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P59870.
    SMRi P59870. Positions 2-31.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR003614. Scorpion_toxin-like.
    IPR001947. Scorpion_toxinS_K_inh.
    [Graphical view ]
    Pfami PF00451. Toxin_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57095. SSF57095. 1 hit.
    PROSITEi PS01138. SCORP_SHORT_TOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons."
      Pedarzani P., D'hoedt D., Doorty K.B., Wadsworth J.D.F., Joseph J.S., Jeyaseelan K., Kini R.M., Gadre S.V., Sapatnekar S.M., Stocker M., Strong P.N.
      J. Biol. Chem. 277:46101-46109(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, FUNCTION.
      Tissue: Venom.

    Entry informationi

    Entry nameiKAX55_MESTA
    AccessioniPrimary (citable) accession number: P59870
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: September 26, 2003
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3