ID   D131A_HUMAN             Reviewed;          70 AA.
AC   P59861;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 2.
DT   24-JAN-2024, entry version 128.
DE   RecName: Full=Beta-defensin 131A {ECO:0000305};
DE   AltName: Full=Beta-defensin 31;
DE            Short=DEFB-31;
DE   AltName: Full=Defensin, beta 131 {ECO:0000312|HGNC:HGNC:18108};
DE   Flags: Precursor;
GN   Name=DEFB131A {ECO:0000312|HGNC:HGNC:18108};
GN   Synonyms=DEFB131 {ECO:0000303|PubMed:12600824}, DEFB31;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=12600824; DOI=10.1165/rcmb.2002-0205oc;
RA   Kao C.Y., Chen Y., Zhao Y.H., Wu R.;
RT   "ORFeome-based search of airway epithelial cell-specific novel human beta-
RT   defensin genes.";
RL   Am. J. Respir. Cell Mol. Biol. 29:71-80(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=26649771; DOI=10.1371/journal.pone.0144776;
RA   Kim J.H., Kim K.H., Kim H.J., Lee J., Myung S.C.;
RT   "Expression of Beta-Defensin 131 Promotes an Innate Immune Response in
RT   Human Prostate Epithelial Cells.";
RL   PLoS ONE 10:E0144776-E0144776(2015).
CC   -!- FUNCTION: Has antibacterial activity (Probable). Upon stimulation with
CC       lipoteichoic acid, promotes cytokines and chemokines production and
CC       secretion (PubMed:26649771). {ECO:0000269|PubMed:26649771,
CC       ECO:0000305}.
CC   -!- INTERACTION:
CC       P59861; O43765: SGTA; NbExp=5; IntAct=EBI-12304807, EBI-347996;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in testis. Is moderately expressed
CC       in the prostate and small intestine. {ECO:0000269|PubMed:12600824}.
CC   -!- INDUCTION: Up-regulated upon stimulation with lipoteichoic acid.
CC       {ECO:0000269|PubMed:26649771}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AF529414; AAQ09523.1; -; mRNA.
DR   EMBL; AC116655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC160155; AAI60155.1; -; mRNA.
DR   CCDS; CCDS43213.1; -.
DR   RefSeq; NP_001035538.2; NM_001040448.2.
DR   AlphaFoldDB; P59861; -.
DR   SMR; P59861; -.
DR   BioGRID; 569591; 5.
DR   IntAct; P59861; 1.
DR   STRING; 9606.ENSP00000335538; -.
DR   BioMuta; DEFB131A; -.
DR   DMDM; 288558809; -.
DR   MassIVE; P59861; -.
DR   PaxDb; 9606-ENSP00000335538; -.
DR   PeptideAtlas; P59861; -.
DR   ProteomicsDB; 57165; -.
DR   Antibodypedia; 57939; 6 antibodies from 3 providers.
DR   DNASU; 644414; -.
DR   Ensembl; ENST00000334879.2; ENSP00000335538.1; ENSG00000186146.2.
DR   GeneID; 644414; -.
DR   KEGG; hsa:644414; -.
DR   MANE-Select; ENST00000334879.2; ENSP00000335538.1; NM_001040448.3; NP_001035538.2.
DR   UCSC; uc011bwt.2; human.
DR   AGR; HGNC:18108; -.
DR   CTD; 644414; -.
DR   GeneCards; DEFB131A; -.
DR   HGNC; HGNC:18108; DEFB131A.
DR   HPA; ENSG00000186146; Tissue enriched (epididymis).
DR   neXtProt; NX_P59861; -.
DR   OpenTargets; ENSG00000186146; -.
DR   PharmGKB; PA38504; -.
DR   VEuPathDB; HostDB:ENSG00000186146; -.
DR   eggNOG; ENOG502TEDN; Eukaryota.
DR   GeneTree; ENSGT00390000001538; -.
DR   HOGENOM; CLU_203372_0_0_1; -.
DR   InParanoid; P59861; -.
DR   OMA; ICCKLKY; -.
DR   OrthoDB; 4822456at2759; -.
DR   PhylomeDB; P59861; -.
DR   TreeFam; TF341399; -.
DR   PathwayCommons; P59861; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   Reactome; R-HSA-1461973; Defensins.
DR   SignaLink; P59861; -.
DR   BioGRID-ORCS; 644414; 7 hits in 626 CRISPR screens.
DR   ChiTaRS; DEFB131; human.
DR   GenomeRNAi; 644414; -.
DR   Pharos; P59861; Tbio.
DR   PRO; PR:P59861; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; P59861; Protein.
DR   Bgee; ENSG00000186146; Expressed in duodenum and 66 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   PANTHER; PTHR47900; BETA-DEFENSIN 131A; 1.
DR   PANTHER; PTHR47900:SF1; BETA-DEFENSIN 131A; 1.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..70
FT                   /note="Beta-defensin 131A"
FT                   /id="PRO_0000007006"
FT   DISULFID        29..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..50
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..57
FT                   /evidence="ECO:0000250"
FT   CONFLICT        20
FT                   /note="A -> G (in Ref. 1; AAQ09523)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   70 AA;  8199 MW;  2A3DC536A4924F14 CRC64;
     MRVLFFVFGV LSLMFTVPPA RSFISNDECP SEYYHCRLKC NADEHAIRYC ADFSICCKLK
     IIEIDGQKKW
//