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P59861

- DB131_HUMAN

UniProt

P59861 - DB131_HUMAN

Protein

Beta-defensin 131

Gene

DEFB131

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has antibacterial activity.Curated

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 131
    Alternative name(s):
    Beta-defensin 31
    Short name:
    DEFB-31
    Defensin, beta 131
    Gene namesi
    Name:DEFB131
    Synonyms:DEFB31
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:18108. DEFB131.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38504.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Peptidei23 – 7048Beta-defensin 131PRO_0000007006Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 56By similarity
    Disulfide bondi36 ↔ 50By similarity
    Disulfide bondi40 ↔ 57By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP59861.

    Expressioni

    Tissue specificityi

    Highly expressed in testis. Is moderately expressed in the prostate and small intestine.1 Publication

    Gene expression databases

    CleanExiHS_DEFB131.
    GenevestigatoriP59861.

    Organism-specific databases

    HPAiHPA052257.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000335538.

    Structurei

    3D structure databases

    ProteinModelPortaliP59861.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG79710.
    HOGENOMiHOG000112162.
    HOVERGENiHBG051313.
    InParanoidiP59861.
    OMAiADFIERC.
    OrthoDBiEOG7NGQF7.
    PhylomeDBiP59861.
    TreeFamiTF341399.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P59861-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVLFFVFGV LSLMFTVPPA RSFISNDECP SEYYHCRLKC NADEHAIRYC   50
    ADFSICCKLK IIEIDGQKKW 70
    Length:70
    Mass (Da):8,199
    Last modified:February 9, 2010 - v2
    Checksum:i2A3DC536A4924F14
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201A → G in AAQ09523. (PubMed:12600824)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF529414 mRNA. Translation: AAQ09523.1.
    AC116655 Genomic DNA. No translation available.
    BC160155 mRNA. Translation: AAI60155.1.
    CCDSiCCDS43213.1.
    RefSeqiNP_001035538.2. NM_001040448.2.
    UniGeneiHs.590200.

    Genome annotation databases

    EnsembliENST00000334879; ENSP00000335538; ENSG00000186146.
    GeneIDi644414.
    KEGGihsa:644414.
    UCSCiuc011bwt.2. human.

    Polymorphism databases

    DMDMi288558809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF529414 mRNA. Translation: AAQ09523.1 .
    AC116655 Genomic DNA. No translation available.
    BC160155 mRNA. Translation: AAI60155.1 .
    CCDSi CCDS43213.1.
    RefSeqi NP_001035538.2. NM_001040448.2.
    UniGenei Hs.590200.

    3D structure databases

    ProteinModelPortali P59861.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000335538.

    Polymorphism databases

    DMDMi 288558809.

    Proteomic databases

    PRIDEi P59861.

    Protocols and materials databases

    DNASUi 644414.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334879 ; ENSP00000335538 ; ENSG00000186146 .
    GeneIDi 644414.
    KEGGi hsa:644414.
    UCSCi uc011bwt.2. human.

    Organism-specific databases

    CTDi 644414.
    GeneCardsi GC04P009446.
    H-InvDB HIX0031394.
    HGNCi HGNC:18108. DEFB131.
    HPAi HPA052257.
    neXtProti NX_P59861.
    PharmGKBi PA38504.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79710.
    HOGENOMi HOG000112162.
    HOVERGENi HBG051313.
    InParanoidi P59861.
    OMAi ADFIERC.
    OrthoDBi EOG7NGQF7.
    PhylomeDBi P59861.
    TreeFami TF341399.

    Enzyme and pathway databases

    Reactomei REACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Miscellaneous databases

    NextBioi 116219.
    PROi P59861.

    Gene expression databases

    CleanExi HS_DEFB131.
    Genevestigatori P59861.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes."
      Kao C.Y., Chen Y., Zhao Y.H., Wu R.
      Am. J. Respir. Cell Mol. Biol. 29:71-80(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiDB131_HUMAN
    AccessioniPrimary (citable) accession number: P59861
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3