P59861 (DB131_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 131

Alternative name(s):
Beta-defensin 31
Short name=DEFB-31
Defensin, beta 131

Gene names

Name:	DEFB131
Synonyms:	DEFB31

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	70 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antibacterial activity Potential.
Subcellular location	Secreted Potential.
Tissue specificity	Highly expressed in testis. Is moderately expressed in the prostate and small intestine. Ref.1
Sequence similarities	Belongs to the beta-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Peptide	23 – 70	48	Beta-defensin 131		PRO_0000007006
Amino acid modifications
	Disulfide bond	29 ↔ 56		By similarity
	Disulfide bond	36 ↔ 50		By similarity
	Disulfide bond	40 ↔ 57		By similarity
Experimental info
	Sequence conflict	20	1	A → G in AAQ09523. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P59861 [UniParc]. Last modified February 9, 2010. Version 2. Checksum: 2A3DC536A4924F14	FASTA	70	8,199
	10 20 30 40 50 60 MRVLFFVFGV LSLMFTVPPA RSFISNDECP SEYYHCRLKC NADEHAIRYC ADFSICCKLK 70 IIEIDGQKKW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes." Kao C.Y., Chen Y., Zhao Y.H., Wu R. Am. J. Respir. Cell Mol. Biol. 29:71-80(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF529414 mRNA. Translation: AAQ09523.1. AC116655 Genomic DNA. No translation available. BC160155 mRNA. Translation: AAI60155.1.
IPI	IPI00739683.
RefSeq	NP_001035538.2. NM_001040448.2.
UniGene	Hs.590200.
3D structure databases
ProteinModelPortal	P59861.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000335538.
Polymorphism databases
DMDM	288558809.
Proteomic databases
PRIDE	P59861.
Protocols and materials databases
DNASU	644414.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334879; ENSP00000335538; ENSG00000186146.
GeneID	644414.
KEGG	hsa:644414.
UCSC	uc011bwt.2. human.
Organism-specific databases
CTD	644414.
GeneCards	GC04P009446.
H-InvDB	HIX0031394.
HGNC	HGNC:18108. DEFB131.
HPA	HPA052257.
neXtProt	NX_P59861.
PharmGKB	PA38504.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG79710.
HOGENOM	HOG000112162.
HOVERGEN	HBG051313.
InParanoid	P59861.
OMA	DEYSVRY.
OrthoDB	EOG4QFWFX.
PhylomeDB	P59861.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
CleanEx	HS_DEFB131.
Genevestigator	P59861.
Family and domain databases
InterPro	IPR025933. Beta_defensin. [Graphical view]
Pfam	PF13841. Defensin_beta_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	116219.

Entry information

Entry name

DB131_HUMAN

Accession

Primary (citable) accession number: P59861

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	February 9, 2010
Last modified:	April 3, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.