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Protein

Beta-defensin 131

Gene

DEFB131

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.Curated

GO - Biological processi

  1. defense response to bacterium Source: GO_Central
  2. innate immune response Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 131
Alternative name(s):
Beta-defensin 31
Short name:
DEFB-31
Defensin, beta 131
Gene namesi
Name:DEFB131
Synonyms:DEFB31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:18108. DEFB131.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. cell surface Source: GO_Central
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Peptidei23 – 7048Beta-defensin 131PRO_0000007006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 56By similarity
Disulfide bondi36 ↔ 50By similarity
Disulfide bondi40 ↔ 57By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP59861.

Expressioni

Tissue specificityi

Highly expressed in testis. Is moderately expressed in the prostate and small intestine.1 Publication

Gene expression databases

CleanExiHS_DEFB131.
GenevestigatoriP59861.

Organism-specific databases

HPAiHPA052257.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335538.

Structurei

3D structure databases

ProteinModelPortaliP59861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG79710.
GeneTreeiENSGT00390000001538.
HOGENOMiHOG000112162.
HOVERGENiHBG051313.
InParanoidiP59861.
OMAiDEYSVRY.
OrthoDBiEOG7NGQF7.
PhylomeDBiP59861.
TreeFamiTF341399.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLFFVFGV LSLMFTVPPA RSFISNDECP SEYYHCRLKC NADEHAIRYC
60 70
ADFSICCKLK IIEIDGQKKW
Length:70
Mass (Da):8,199
Last modified:February 9, 2010 - v2
Checksum:i2A3DC536A4924F14
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201A → G in AAQ09523 (PubMed:12600824).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529414 mRNA. Translation: AAQ09523.1.
AC116655 Genomic DNA. No translation available.
BC160155 mRNA. Translation: AAI60155.1.
CCDSiCCDS43213.1.
RefSeqiNP_001035538.2. NM_001040448.2.
UniGeneiHs.590200.

Genome annotation databases

EnsembliENST00000334879; ENSP00000335538; ENSG00000186146.
GeneIDi644414.
KEGGihsa:644414.
UCSCiuc011bwt.2. human.

Polymorphism databases

DMDMi288558809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529414 mRNA. Translation: AAQ09523.1.
AC116655 Genomic DNA. No translation available.
BC160155 mRNA. Translation: AAI60155.1.
CCDSiCCDS43213.1.
RefSeqiNP_001035538.2. NM_001040448.2.
UniGeneiHs.590200.

3D structure databases

ProteinModelPortaliP59861.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000335538.

Polymorphism databases

DMDMi288558809.

Proteomic databases

PRIDEiP59861.

Protocols and materials databases

DNASUi644414.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334879; ENSP00000335538; ENSG00000186146.
GeneIDi644414.
KEGGihsa:644414.
UCSCiuc011bwt.2. human.

Organism-specific databases

CTDi644414.
GeneCardsiGC04P009446.
H-InvDBHIX0031394.
HGNCiHGNC:18108. DEFB131.
HPAiHPA052257.
neXtProtiNX_P59861.
PharmGKBiPA38504.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG79710.
GeneTreeiENSGT00390000001538.
HOGENOMiHOG000112162.
HOVERGENiHBG051313.
InParanoidiP59861.
OMAiDEYSVRY.
OrthoDBiEOG7NGQF7.
PhylomeDBiP59861.
TreeFamiTF341399.

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii644414.
NextBioi116219.
PROiP59861.

Gene expression databases

CleanExiHS_DEFB131.
GenevestigatoriP59861.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes."
    Kao C.Y., Chen Y., Zhao Y.H., Wu R.
    Am. J. Respir. Cell Mol. Biol. 29:71-80(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiDB131_HUMAN
AccessioniPrimary (citable) accession number: P59861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: February 9, 2010
Last modified: February 4, 2015
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.