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P59861 (DB131_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 131
Alternative name(s):
Beta-defensin 31
Short name=DEFB-31
Defensin, beta 131
Gene names
Name:DEFB131
Synonyms:DEFB31
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length70 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has antibacterial activity Potential.

Subcellular location

Secreted Potential.

Tissue specificity

Highly expressed in testis. Is moderately expressed in the prostate and small intestine. Ref.1

Sequence similarities

Belongs to the beta-defensin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Peptide23 – 7048Beta-defensin 131
PRO_0000007006

Amino acid modifications

Disulfide bond29 ↔ 56 By similarity
Disulfide bond36 ↔ 50 By similarity
Disulfide bond40 ↔ 57 By similarity

Experimental info

Sequence conflict201A → G in AAQ09523. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P59861 [UniParc].

Last modified February 9, 2010. Version 2.
Checksum: 2A3DC536A4924F14

FASTA708,199
        10         20         30         40         50         60 
MRVLFFVFGV LSLMFTVPPA RSFISNDECP SEYYHCRLKC NADEHAIRYC ADFSICCKLK 

        70 
IIEIDGQKKW 

« Hide

References

« Hide 'large scale' references
[1]"ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes."
Kao C.Y., Chen Y., Zhao Y.H., Wu R.
Am. J. Respir. Cell Mol. Biol. 29:71-80(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF529414 mRNA. Translation: AAQ09523.1.
AC116655 Genomic DNA. No translation available.
BC160155 mRNA. Translation: AAI60155.1.
CCDSCCDS43213.1.
RefSeqNP_001035538.2. NM_001040448.2.
UniGeneHs.590200.

3D structure databases

ProteinModelPortalP59861.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000335538.

Polymorphism databases

DMDM288558809.

Proteomic databases

PRIDEP59861.

Protocols and materials databases

DNASU644414.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334879; ENSP00000335538; ENSG00000186146.
GeneID644414.
KEGGhsa:644414.
UCSCuc011bwt.2. human.

Organism-specific databases

CTD644414.
GeneCardsGC04P009446.
H-InvDBHIX0031394.
HGNCHGNC:18108. DEFB131.
HPAHPA052257.
neXtProtNX_P59861.
PharmGKBPA38504.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG79710.
HOGENOMHOG000112162.
HOVERGENHBG051313.
InParanoidP59861.
OMAADFIERC.
OrthoDBEOG7NGQF7.
PhylomeDBP59861.
TreeFamTF341399.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

CleanExHS_DEFB131.
GenevestigatorP59861.

Family and domain databases

InterProIPR025933. Beta_defensin.
[Graphical view]
PfamPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio116219.
PROP59861.

Entry information

Entry nameDB131_HUMAN
AccessionPrimary (citable) accession number: P59861
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: February 9, 2010
Last modified: July 9, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM