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Protein

Beta-defensin 131A

Gene

DEFB131A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Has antibacterial activity (Probable). Upon stimulation with lipoteichoic acid, promotes cytokines and chemokines production and secretion (PubMed:26649771).Curated1 Publication

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • cellular response to lipoteichoic acid Source: UniProtKB
  • defense response to bacterium Source: GO_Central
  • innate immune response Source: UniProtKB
  • positive regulation of chemokine production Source: UniProtKB
  • positive regulation of cytokine secretion involved in immune response Source: UniProtKB
  • positive regulation of monocyte chemotaxis Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 131ACurated
Alternative name(s):
Beta-defensin 31
Short name:
DEFB-31
Defensin, beta 131Imported
Gene namesi
Name:DEFB131AImported
Synonyms:DEFB1311 Publication, DEFB31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000186146.1.
HGNCiHGNC:18108. DEFB131.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186146.
PharmGKBiPA38504.

Polymorphism and mutation databases

BioMutaiDEFB131.
DMDMi288558809.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PeptideiPRO_000000700623 – 70Beta-defensin 131AAdd BLAST48

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 56By similarity
Disulfide bondi36 ↔ 50By similarity
Disulfide bondi40 ↔ 57By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP59861.
PeptideAtlasiP59861.
PRIDEiP59861.

Expressioni

Tissue specificityi

Highly expressed in testis. Is moderately expressed in the prostate and small intestine.1 Publication

Inductioni

Up-regulated upon stimulation with lipoteichoic acid.1 Publication

Gene expression databases

BgeeiENSG00000186146.
CleanExiHS_DEFB131.

Interactioni

Protein-protein interaction databases

IntActiP59861. 2 interactors.
STRINGi9606.ENSP00000335538.

Structurei

3D structure databases

ProteinModelPortaliP59861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JJYR. Eukaryota.
ENOG411131M. LUCA.
GeneTreeiENSGT00390000001538.
HOGENOMiHOG000112162.
HOVERGENiHBG051313.
InParanoidiP59861.
OMAiTICCKEK.
OrthoDBiEOG091G1ARV.
PhylomeDBiP59861.
TreeFamiTF341399.

Family and domain databases

InterProiView protein in InterPro
IPR025933. Beta_defensin.
PANTHERiPTHR15001. PTHR15001. 1 hit.
PfamiView protein in Pfam
PF13841. Defensin_beta_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLFFVFGV LSLMFTVPPA RSFISNDECP SEYYHCRLKC NADEHAIRYC
60 70
ADFSICCKLK IIEIDGQKKW
Length:70
Mass (Da):8,199
Last modified:February 9, 2010 - v2
Checksum:i2A3DC536A4924F14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20A → G in AAQ09523 (PubMed:12600824).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529414 mRNA. Translation: AAQ09523.1.
AC116655 Genomic DNA. No translation available.
BC160155 mRNA. Translation: AAI60155.1.
CCDSiCCDS43213.1.
RefSeqiNP_001035538.2. NM_001040448.2.
UniGeneiHs.590200.

Genome annotation databases

EnsembliENST00000334879; ENSP00000335538; ENSG00000186146.
GeneIDi644414.
KEGGihsa:644414.
UCSCiuc011bwt.2. human.

Similar proteinsi

Entry informationi

Entry nameiD131A_HUMAN
AccessioniPrimary (citable) accession number: P59861
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: February 9, 2010
Last modified: September 27, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families