SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P59861

- DB131_HUMAN

UniProt

P59861 - DB131_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Beta-defensin 131
Gene
DEFB131, DEFB31
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Has antibacterial activity Reviewed prediction.

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 131
Alternative name(s):
Beta-defensin 31
Short name:
DEFB-31
Defensin, beta 131
Gene namesi
Name:DEFB131
Synonyms:DEFB31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:18108. DEFB131.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Peptidei23 – 7048Beta-defensin 131
PRO_0000007006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 56 By similarity
Disulfide bondi36 ↔ 50 By similarity
Disulfide bondi40 ↔ 57 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP59861.

Expressioni

Tissue specificityi

Highly expressed in testis. Is moderately expressed in the prostate and small intestine.1 Publication

Gene expression databases

CleanExiHS_DEFB131.
GenevestigatoriP59861.

Organism-specific databases

HPAiHPA052257.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335538.

Structurei

3D structure databases

ProteinModelPortaliP59861.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG79710.
HOGENOMiHOG000112162.
HOVERGENiHBG051313.
InParanoidiP59861.
OMAiADFIERC.
OrthoDBiEOG7NGQF7.
PhylomeDBiP59861.
TreeFamiTF341399.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59861-1 [UniParc]FASTAAdd to Basket

« Hide

MRVLFFVFGV LSLMFTVPPA RSFISNDECP SEYYHCRLKC NADEHAIRYC   50
ADFSICCKLK IIEIDGQKKW 70
Length:70
Mass (Da):8,199
Last modified:February 9, 2010 - v2
Checksum:i2A3DC536A4924F14
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201A → G in AAQ09523. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF529414 mRNA. Translation: AAQ09523.1.
AC116655 Genomic DNA. No translation available.
BC160155 mRNA. Translation: AAI60155.1.
CCDSiCCDS43213.1.
RefSeqiNP_001035538.2. NM_001040448.2.
UniGeneiHs.590200.

Genome annotation databases

EnsembliENST00000334879; ENSP00000335538; ENSG00000186146.
GeneIDi644414.
KEGGihsa:644414.
UCSCiuc011bwt.2. human.

Polymorphism databases

DMDMi288558809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF529414 mRNA. Translation: AAQ09523.1 .
AC116655 Genomic DNA. No translation available.
BC160155 mRNA. Translation: AAI60155.1 .
CCDSi CCDS43213.1.
RefSeqi NP_001035538.2. NM_001040448.2.
UniGenei Hs.590200.

3D structure databases

ProteinModelPortali P59861.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000335538.

Polymorphism databases

DMDMi 288558809.

Proteomic databases

PRIDEi P59861.

Protocols and materials databases

DNASUi 644414.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334879 ; ENSP00000335538 ; ENSG00000186146 .
GeneIDi 644414.
KEGGi hsa:644414.
UCSCi uc011bwt.2. human.

Organism-specific databases

CTDi 644414.
GeneCardsi GC04P009446.
H-InvDB HIX0031394.
HGNCi HGNC:18108. DEFB131.
HPAi HPA052257.
neXtProti NX_P59861.
PharmGKBi PA38504.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79710.
HOGENOMi HOG000112162.
HOVERGENi HBG051313.
InParanoidi P59861.
OMAi ADFIERC.
OrthoDBi EOG7NGQF7.
PhylomeDBi P59861.
TreeFami TF341399.

Enzyme and pathway databases

Reactomei REACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

NextBioi 116219.
PROi P59861.

Gene expression databases

CleanExi HS_DEFB131.
Genevestigatori P59861.

Family and domain databases

InterProi IPR025933. Beta_defensin.
[Graphical view ]
Pfami PF13841. Defensin_beta_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ORFeome-based search of airway epithelial cell-specific novel human beta-defensin genes."
    Kao C.Y., Chen Y., Zhao Y.H., Wu R.
    Am. J. Respir. Cell Mol. Biol. 29:71-80(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiDB131_HUMAN
AccessioniPrimary (citable) accession number: P59861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: February 9, 2010
Last modified: September 3, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi