Reviewed, UniProtKB/Swiss-Prot P59848 (KAX19_CENLM)

Names and origin

Protein names	Recommended name:     Potassium channel toxin alpha-KTx 1.9 Alternative name(s):     Hongotoxin-2       Short name=HgTX2
Organism	Centruroides limbatus (Bark scorpion)
Taxonomic identifier	244936 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides

Protein attributes

Sequence length	36 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Potent selective inhibitor of Kv1 voltage-gated potassium channels By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 1 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ionic channel inhibitor Neurotoxin Potassium channel inhibitor Toxin
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›36	›36	Potassium channel toxin alpha-KTx 1.9		PRO_0000066833
Experimental info
	Non-terminal residue	36	1

Sequences

	Sequence		Length	Mass (Da)
	P59848-1 [UniParc]. Last modified September 19, 2003. Version 1. Checksum: A9D585FC06312E16	FASTA	36	3,946
	10 20 30 HFIDVKCTTS KECWPPCKAA TGKAAGKCMN KKCKCQ

References

[1]

"Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom." Koschak A., Bugianesi R.M., Mitterdorfer J., Kaczorowski G.J., Garcia M.L., Knaus H.-G. J. Biol. Chem. 273:2639-2644(1998) [PubMed: 9446567] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR001947. Scorpion_toxinS. [Graphical view]
Pfam	PF00451. Toxin_2. 1 hit. [Graphical view]
PRINTS	PR00286. CHARYBDTOXIN.
PROSITE	PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAX19_CENLM

Accession

Primary (citable) accession number: P59848

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	September 19, 2003
Last modified:	November 24, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)