Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable vesicular acetylcholine transporter-B

Gene

slc18a3b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in acetylcholine transport into synaptic vesicles.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Probable vesicular acetylcholine transporter-B
Short name:
VAChT-B
Alternative name(s):
Solute carrier family 18 member 3-B
Gene namesi
Name:slc18a3b
Synonyms:slc18a3, vacht
ORF Names:zgc:64220
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1410. slc18a3b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939CytoplasmicSequence analysisAdd
BLAST
Transmembranei40 – 6021HelicalSequence analysisAdd
BLAST
Topological domaini61 – 8626Lumenal, vesicleSequence analysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST
Topological domaini108 – 1136CytoplasmicSequence analysis
Transmembranei114 – 13421HelicalSequence analysisAdd
BLAST
Topological domaini135 – 1439Lumenal, vesicleSequence analysis
Transmembranei144 – 16421HelicalSequence analysisAdd
BLAST
Topological domaini165 – 17410CytoplasmicSequence analysis
Transmembranei175 – 19521HelicalSequence analysisAdd
BLAST
Topological domaini196 – 2038Lumenal, vesicleSequence analysis
Transmembranei204 – 22421HelicalSequence analysisAdd
BLAST
Topological domaini225 – 24723CytoplasmicSequence analysisAdd
BLAST
Transmembranei248 – 26821HelicalSequence analysisAdd
BLAST
Topological domaini269 – 28416Lumenal, vesicleSequence analysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence analysisAdd
BLAST
Topological domaini306 – 31510CytoplasmicSequence analysis
Transmembranei316 – 33621HelicalSequence analysisAdd
BLAST
Topological domaini337 – 34711Lumenal, vesicleSequence analysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Topological domaini369 – 37810CytoplasmicSequence analysis
Transmembranei379 – 39921HelicalSequence analysisAdd
BLAST
Topological domaini400 – 4067Lumenal, vesicleSequence analysis
Transmembranei407 – 42721HelicalSequence analysisAdd
BLAST
Topological domaini428 – 49366CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Probable vesicular acetylcholine transporter-BPRO_0000127521Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP59845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG055082.
InParanoidiP59845.
PhylomeDBiP59845.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004734. Multidrug-R.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00880. 2_A_01_02. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSTGAPGLA QSAVLQLSAM GERSRELGGA LREPERKRRL LLVVVCVALL
60 70 80 90 100
LDNMLYMVIV PIIPDYLADL RGERGNSSAD LDIQIGVLFA SKALLQLLVN
110 120 130 140 150
PLSGTFIDRV GYDLPLLIGL LVMFLSTCIF AFAENYGTLF AARSLQGLGS
160 170 180 190 200
AFADTSGIAM IADKFTEEAE RSRALGIALA FISFGSLVAP PFGGILYEFA
210 220 230 240 250
GKRVPFIVLA CVCLADGVLL LTVVKPFSDR TRENMPVGTP IHRLMVDPYI
260 270 280 290 300
AVVAGALTVC NIPLAFLEPT IANWMESTMD ASKWQMGLVW LPAFLPHVLG
310 320 330 340 350
VYITVRLAAR YPERQWFYGA LGMVIIGASS CTVPACKTFG ELVFPLCGIC
360 370 380 390 400
FGIALVDTAL LPTLAFLVDV RHVSVYGSVY AIADISYSVA YAMGPVVAGQ
410 420 430 440 450
IVHNLGFVQL NLGMGLVNVL YAPALLLLRP VCQIKPSFSE RNVLLEEGPS
460 470 480 490
GLYDSIRLEE RALRRKGLSA GAGTEHGLRG RSEEEEESGP ESA
Length:493
Mass (Da):53,052
Last modified:September 19, 2003 - v1
Checksum:iD3A450870750B842
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054646 mRNA. Translation: AAH54646.1.
RefSeqiNP_957401.1. NM_201107.1.
UniGeneiDr.87876.

Genome annotation databases

GeneIDi394082.
KEGGidre:394082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054646 mRNA. Translation: AAH54646.1.
RefSeqiNP_957401.1. NM_201107.1.
UniGeneiDr.87876.

3D structure databases

ProteinModelPortaliP59845.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi394082.
KEGGidre:394082.

Organism-specific databases

CTDi394082.
ZFINiZDB-GENE-040426-1410. slc18a3b.

Phylogenomic databases

HOVERGENiHBG055082.
InParanoidiP59845.
PhylomeDBiP59845.

Miscellaneous databases

PROiP59845.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004734. Multidrug-R.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00880. 2_A_01_02. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiVACHB_DANRE
AccessioniPrimary (citable) accession number: P59845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: September 19, 2003
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.