Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable vesicular acetylcholine transporter-B

Gene

slc18a3b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in acetylcholine transport into synaptic vesicles.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Probable vesicular acetylcholine transporter-B
Short name:
VAChT-B
Alternative name(s):
Solute carrier family 18 member 3-B
Gene namesi
Name:slc18a3b
Synonyms:slc18a3, vacht
ORF Names:zgc:64220
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1410. slc18a3b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 86Lumenal, vesicleSequence analysisAdd BLAST26
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 113CytoplasmicSequence analysis6
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 143Lumenal, vesicleSequence analysis9
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 174CytoplasmicSequence analysis10
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 203Lumenal, vesicleSequence analysis8
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 247CytoplasmicSequence analysisAdd BLAST23
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Topological domaini269 – 284Lumenal, vesicleSequence analysisAdd BLAST16
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 315CytoplasmicSequence analysis10
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 347Lumenal, vesicleSequence analysisAdd BLAST11
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 378CytoplasmicSequence analysis10
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 406Lumenal, vesicleSequence analysis7
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 493CytoplasmicSequence analysisAdd BLAST66

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001275211 – 493Probable vesicular acetylcholine transporter-BAdd BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP59845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG055082.
InParanoidiP59845.
PhylomeDBiP59845.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004734. Multidrug-R.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00880. 2_A_01_02. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSTGAPGLA QSAVLQLSAM GERSRELGGA LREPERKRRL LLVVVCVALL
60 70 80 90 100
LDNMLYMVIV PIIPDYLADL RGERGNSSAD LDIQIGVLFA SKALLQLLVN
110 120 130 140 150
PLSGTFIDRV GYDLPLLIGL LVMFLSTCIF AFAENYGTLF AARSLQGLGS
160 170 180 190 200
AFADTSGIAM IADKFTEEAE RSRALGIALA FISFGSLVAP PFGGILYEFA
210 220 230 240 250
GKRVPFIVLA CVCLADGVLL LTVVKPFSDR TRENMPVGTP IHRLMVDPYI
260 270 280 290 300
AVVAGALTVC NIPLAFLEPT IANWMESTMD ASKWQMGLVW LPAFLPHVLG
310 320 330 340 350
VYITVRLAAR YPERQWFYGA LGMVIIGASS CTVPACKTFG ELVFPLCGIC
360 370 380 390 400
FGIALVDTAL LPTLAFLVDV RHVSVYGSVY AIADISYSVA YAMGPVVAGQ
410 420 430 440 450
IVHNLGFVQL NLGMGLVNVL YAPALLLLRP VCQIKPSFSE RNVLLEEGPS
460 470 480 490
GLYDSIRLEE RALRRKGLSA GAGTEHGLRG RSEEEEESGP ESA
Length:493
Mass (Da):53,052
Last modified:September 19, 2003 - v1
Checksum:iD3A450870750B842
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054646 mRNA. Translation: AAH54646.1.
RefSeqiNP_957401.1. NM_201107.1.
UniGeneiDr.87876.

Genome annotation databases

GeneIDi394082.
KEGGidre:394082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054646 mRNA. Translation: AAH54646.1.
RefSeqiNP_957401.1. NM_201107.1.
UniGeneiDr.87876.

3D structure databases

ProteinModelPortaliP59845.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi394082.
KEGGidre:394082.

Organism-specific databases

CTDi394082.
ZFINiZDB-GENE-040426-1410. slc18a3b.

Phylogenomic databases

HOVERGENiHBG055082.
InParanoidiP59845.
PhylomeDBiP59845.

Miscellaneous databases

PROiP59845.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004734. Multidrug-R.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00880. 2_A_01_02. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVACHB_DANRE
AccessioniPrimary (citable) accession number: P59845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: September 19, 2003
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.