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Protein

BPI fold-containing family B member 4

Gene

BPIFB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 4
Alternative name(s):
Ligand-binding protein RY2G5
Long palate, lung and nasal epithelium carcinoma-associated protein 4
Gene namesi
Name:BPIFB4
Synonyms:C20orf186, LPLUNC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16179. BPIFB4.

Subcellular locationi

  • Secreted By similarity
  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25728.

Polymorphism and mutation databases

BioMutaiBPIFB4.
DMDMi215274098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 614596BPI fold-containing family B member 4PRO_0000089159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence analysis
Disulfide bondi295 ↔ 332By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP59827.
PeptideAtlasiP59827.
PRIDEiP59827.

Expressioni

Tissue specificityi

Expressed in nasal tissue.1 Publication

Gene expression databases

BgeeiP59827.
CleanExiHS_C20orf186.
ExpressionAtlasiP59827. baseline and differential.
GenevisibleiP59827. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364632.

Structurei

3D structure databases

ProteinModelPortaliP59827.
SMRiP59827. Positions 227-614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi131 – 22696Gly-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231741.
HOVERGENiHBG108092.
InParanoidiP59827.
OMAiPLIIRIQ.
OrthoDBiEOG7S21XF.
PhylomeDBiP59827.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P59827-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWMAWCVAAL SVVAVCGTSH ETNTVLRVTK DVLSNAISGM LQQSDALHSA
60 70 80 90 100
LREVPLGVGD IPYNDFHVRG PPPVYTNGKK LDGIYQYGHI ETNDNTAQLG
110 120 130 140 150
GKYRYGEILE SEGSIRDLRN SGYRSAENAY GGHRGLGRYR AAPVGRLHRR
160 170 180 190 200
ELQPGEIPPG VATGAVGPGG LLGTGGMLAA DGILAGQGGL LGGGGLLGDG
210 220 230 240 250
GLLGGGGVLG VLGEGGILST VQGITGLRIV ELTLPRVSVR LLPGVGVYLS
260 270 280 290 300
LYTRVAINGK SLIGFLDIAV EVNITAKVRL TMDRTGYPRL VIERCDTLLG
310 320 330 340 350
GIKVKLLRGL LPNLVDNLVN RVLADVLPDL LCPIVDVVLG LVNDQLGLVD
360 370 380 390 400
SLIPLGILGS VQYTFSSLPL VTGEFLELDL NTLVGEAGGG LIDYPLGWPA
410 420 430 440 450
VSPKPMPELP PMGDNTKSQL AMSANFLGSV LTLLQKQHAL DLDITNGMFE
460 470 480 490 500
ELPPLTTATL GALIPKVFQQ YPESCPLIIR IQVLNPPSVM LQKDKALVKV
510 520 530 540 550
LATAEVMVSQ PKDLETTICL IDVDTEFLAS FSTEGDKLMI DAKLEKTSLN
560 570 580 590 600
LRTSNVGNFD IGLMEVLVEK IFDLAFMPAM NAVLGSGVPL PKILNIDFSN
610
ADIDVLEDLL VLSA
Length:614
Mass (Da):65,055
Last modified:November 25, 2008 - v2
Checksum:iF92C542B75CB97E1
GO
Isoform 2 (identifier: P59827-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Show »
Length:575
Mass (Da):60,951
Checksum:iD4B804F446EF7707
GO

Sequence cautioni

The sequence CAI22532.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671G → W.
Corresponds to variant rs2424943 [ dbSNP | Ensembl ].
VAR_059372
Natural varianti199 – 1991D → G.
Corresponds to variant rs4339026 [ dbSNP | Ensembl ].
VAR_055998
Natural varianti206 – 2061G → W.
Corresponds to variant rs2424943 [ dbSNP | Ensembl ].
VAR_055999
Natural varianti229 – 2291I → V.
Corresponds to variant rs2070325 [ dbSNP | Ensembl ].
VAR_059373
Natural varianti268 – 2681I → V.
Corresponds to variant rs2070325 [ dbSNP | Ensembl ].
VAR_056000
Natural varianti320 – 3201N → T.
Corresponds to variant rs2889732 [ dbSNP | Ensembl ].
VAR_056001
Natural varianti527 – 5271F → L.
Corresponds to variant rs11699009 [ dbSNP | Ensembl ].
VAR_069042
Natural varianti533 – 5331T → I.
Corresponds to variant rs11696307 [ dbSNP | Ensembl ].
VAR_069043

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3939Missing in isoform 2. 1 PublicationVSP_037828Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF549190 mRNA. Translation: AAP84990.1.
AL121756 Genomic DNA. Translation: CAI22532.1. Sequence problems.
CCDSiCCDS13213.2. [P59827-1]
RefSeqiNP_872325.2. NM_182519.2. [P59827-1]
UniGeneiHs.38961.

Genome annotation databases

EnsembliENST00000375483; ENSP00000364632; ENSG00000186191. [P59827-1]
GeneIDi149954.
KEGGihsa:149954.
UCSCiuc010zue.3. human. [P59827-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF549190 mRNA. Translation: AAP84990.1.
AL121756 Genomic DNA. Translation: CAI22532.1. Sequence problems.
CCDSiCCDS13213.2. [P59827-1]
RefSeqiNP_872325.2. NM_182519.2. [P59827-1]
UniGeneiHs.38961.

3D structure databases

ProteinModelPortaliP59827.
SMRiP59827. Positions 227-614.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364632.

Polymorphism and mutation databases

BioMutaiBPIFB4.
DMDMi215274098.

Proteomic databases

PaxDbiP59827.
PeptideAtlasiP59827.
PRIDEiP59827.

Protocols and materials databases

DNASUi149954.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375483; ENSP00000364632; ENSG00000186191. [P59827-1]
GeneIDi149954.
KEGGihsa:149954.
UCSCiuc010zue.3. human. [P59827-1]

Organism-specific databases

CTDi149954.
GeneCardsiBPIFB4.
H-InvDBHIX0040539.
HGNCiHGNC:16179. BPIFB4.
MIMi615718. gene.
neXtProtiNX_P59827.
PharmGKBiPA25728.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231741.
HOVERGENiHBG108092.
InParanoidiP59827.
OMAiPLIIRIQ.
OrthoDBiEOG7S21XF.
PhylomeDBiP59827.
TreeFamiTF315617.

Miscellaneous databases

GenomeRNAii149954.
PROiP59827.
SOURCEiSearch...

Gene expression databases

BgeeiP59827.
CleanExiHS_C20orf186.
ExpressionAtlasiP59827. baseline and differential.
GenevisibleiP59827. HS.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides."
    Andrault J.-B., Gaillard I., Giorgi D., Rouquier S.
    Genomics 82:172-184(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx."
    Bingle C.D., Craven C.J.
    Hum. Mol. Genet. 11:937-943(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  4. "Phylogenetic and evolutionary analysis of the PLUNC gene family."
    Bingle C.D., LeClair E.E., Havard S., Bingle L., Gillingham P., Craven C.J.
    Protein Sci. 13:422-430(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiBPIB4_HUMAN
AccessioniPrimary (citable) accession number: P59827
Secondary accession number(s): Q5TDX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 25, 2008
Last modified: July 6, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.