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P59826

- BPIB3_HUMAN

UniProt

P59826 - BPIB3_HUMAN

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Protein

BPI fold-containing family B member 3

Gene
BPIFB3, C20orf185, LPLUNC3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received By similarity.

GO - Molecular functioni

  1. lipid binding Source: InterPro

GO - Biological processi

  1. innate immune response Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 3
Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3
Gene namesi
Name:BPIFB3
Synonyms:C20orf185, LPLUNC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16178. BPIFB3.

Subcellular locationi

Secreted By similarity. Cytoplasm
Note: According to 1 Publication, it is cytoplasmic.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 476456BPI fold-containing family B member 3PRO_0000017170Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi142 – 1421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi164 ↔ 199 By similarity
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi457 – 4571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP59826.
PRIDEiP59826.

Expressioni

Tissue specificityi

Detected in nasal septal epithelium.1 Publication

Gene expression databases

BgeeiP59826.
CleanExiHS_C20orf185.
GenevestigatoriP59826.

Organism-specific databases

HPAiHPA045741.

Interactioni

Protein-protein interaction databases

BioGridi131704. 1 interaction.
STRINGi9606.ENSP00000364643.

Structurei

3D structure databases

ProteinModelPortaliP59826.
SMRiP59826. Positions 91-451.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 237232Leu-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG317196.
HOGENOMiHOG000231741.
HOVERGENiHBG050718.
InParanoidiP59826.
OMAiPLISNQY.
OrthoDBiEOG715Q45.
PhylomeDBiP59826.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59826-1 [UniParc]FASTAAdd to Basket

« Hide

MQPVMLALWS LLLLWGLATP CQELLETVGT LARIDKDELG KAIQNSLVGE    50
PILQNVLGSV TAVNRGLLGS GGLLGGGGLL GHGGVFGVVE ELSGLKIEEL 100
TLPKVLLKLL PGFGVQLSLH TKVGMHCSGP LGGLLQLAAE VNVTSRVALA 150
VSSRGTPILI LKRCSTLLGH ISLFSGLLPT PLFGVVEQML FKVLPGLLCP 200
VVDSVLGVVN ELLGAVLGLV SLGALGSVEF SLATLPLISN QYIELDINPI 250
VKSVAGDIID FPKSRAPAKV PPKKDHTSQV MVPLYLFNTT FGLLQTNGAL 300
DMDITPELVP SDVPLTTTDL AALLPEALGK LPLHQQLLLF LRVREAPTVT 350
LHNKKALVSL PANIHVLFYV PKGTPESLFE LNSVMTVRAQ LAPSATKLHI 400
SLSLERLSVK VASSFTHAFD GSRLEEWLSH VVGAVYAPKL NVALDVGIPL 450
PKVLNINFSN SVLEIVENAV VLTVAS 476
Length:476
Mass (Da):50,342
Last modified:August 16, 2005 - v2
Checksum:i71C57B13BA5757BF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti228 – 2281V → M.
Corresponds to variant rs4911290 [ dbSNP | Ensembl ].
VAR_049742
Natural varianti290 – 2901T → M.
Corresponds to variant rs2093066 [ dbSNP | Ensembl ].
VAR_049743
Natural varianti334 – 3341H → Q.
Corresponds to variant rs6057717 [ dbSNP | Ensembl ].
VAR_049744
Natural varianti369 – 3691Y → C.
Corresponds to variant rs6059063 [ dbSNP | Ensembl ].
VAR_049745
Natural varianti449 – 4491P → S.
Corresponds to variant rs378098 [ dbSNP | Ensembl ].
VAR_049746

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF549189 mRNA. Translation: AAP84989.1.
AL121756 Genomic DNA. Translation: CAI22531.1.
CCDSiCCDS13212.1.
RefSeqiNP_872599.1. NM_182658.1.
UniGeneiHs.472442.

Genome annotation databases

EnsembliENST00000375494; ENSP00000364643; ENSG00000186190.
GeneIDi359710.
KEGGihsa:359710.
UCSCiuc002wym.1. human.

Polymorphism databases

DMDMi73620973.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF549189 mRNA. Translation: AAP84989.1 .
AL121756 Genomic DNA. Translation: CAI22531.1 .
CCDSi CCDS13212.1.
RefSeqi NP_872599.1. NM_182658.1.
UniGenei Hs.472442.

3D structure databases

ProteinModelPortali P59826.
SMRi P59826. Positions 91-451.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131704. 1 interaction.
STRINGi 9606.ENSP00000364643.

Polymorphism databases

DMDMi 73620973.

Proteomic databases

PaxDbi P59826.
PRIDEi P59826.

Protocols and materials databases

DNASUi 359710.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375494 ; ENSP00000364643 ; ENSG00000186190 .
GeneIDi 359710.
KEGGi hsa:359710.
UCSCi uc002wym.1. human.

Organism-specific databases

CTDi 359710.
GeneCardsi GC20P031645.
HGNCi HGNC:16178. BPIFB3.
HPAi HPA045741.
MIMi 615717. gene.
neXtProti NX_P59826.
PharmGKBi PA25727.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG317196.
HOGENOMi HOG000231741.
HOVERGENi HBG050718.
InParanoidi P59826.
OMAi PLISNQY.
OrthoDBi EOG715Q45.
PhylomeDBi P59826.
TreeFami TF315617.

Miscellaneous databases

GenomeRNAii 359710.
NextBioi 99842.
PROi P59826.
SOURCEi Search...

Gene expression databases

Bgeei P59826.
CleanExi HS_C20orf185.
Genevestigatori P59826.

Family and domain databases

InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view ]
Pfami PF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view ]
SMARTi SM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view ]
SUPFAMi SSF55394. SSF55394. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides."
    Andrault J.-B., Gaillard I., Giorgi D., Rouquier S.
    Genomics 82:172-184(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx."
    Bingle C.D., Craven C.J.
    Hum. Mol. Genet. 11:937-943(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiBPIB3_HUMAN
AccessioniPrimary (citable) accession number: P59826
Secondary accession number(s): Q5TDX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 16, 2005
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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