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Protein

BPI fold-containing family B member 3

Gene

BPIFB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32685-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 3
Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3
Gene namesi
Name:BPIFB3
Synonyms:C20orf185, LPLUNC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16178. BPIFB3.

Subcellular locationi

  • Secreted By similarity
  • Cytoplasm 1 Publication

  • Note: According to PubMed:12837268, it is cytoplasmic.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186190.
PharmGKBiPA25727.

Polymorphism and mutation databases

BioMutaiBPIFB3.
DMDMi73620973.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001717021 – 476BPI fold-containing family B member 3Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi164 ↔ 199By similarity
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP59826.
PaxDbiP59826.
PRIDEiP59826.
TopDownProteomicsiP59826.

PTM databases

iPTMnetiP59826.
PhosphoSitePlusiP59826.

Expressioni

Tissue specificityi

Detected in nasal septal epithelium.1 Publication

Gene expression databases

BgeeiENSG00000186190.
CleanExiHS_C20orf185.

Organism-specific databases

HPAiHPA045741.

Interactioni

Protein-protein interaction databases

BioGridi131704. 2 interactors.
STRINGi9606.ENSP00000364643.

Structurei

3D structure databases

ProteinModelPortaliP59826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 237Leu-richAdd BLAST232

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231741.
HOVERGENiHBG050718.
InParanoidiP59826.
OMAiVYAPKLN.
OrthoDBiEOG091G048N.
PhylomeDBiP59826.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR032951. BPIFB3.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF42. PTHR10504:SF42. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPVMLALWS LLLLWGLATP CQELLETVGT LARIDKDELG KAIQNSLVGE
60 70 80 90 100
PILQNVLGSV TAVNRGLLGS GGLLGGGGLL GHGGVFGVVE ELSGLKIEEL
110 120 130 140 150
TLPKVLLKLL PGFGVQLSLH TKVGMHCSGP LGGLLQLAAE VNVTSRVALA
160 170 180 190 200
VSSRGTPILI LKRCSTLLGH ISLFSGLLPT PLFGVVEQML FKVLPGLLCP
210 220 230 240 250
VVDSVLGVVN ELLGAVLGLV SLGALGSVEF SLATLPLISN QYIELDINPI
260 270 280 290 300
VKSVAGDIID FPKSRAPAKV PPKKDHTSQV MVPLYLFNTT FGLLQTNGAL
310 320 330 340 350
DMDITPELVP SDVPLTTTDL AALLPEALGK LPLHQQLLLF LRVREAPTVT
360 370 380 390 400
LHNKKALVSL PANIHVLFYV PKGTPESLFE LNSVMTVRAQ LAPSATKLHI
410 420 430 440 450
SLSLERLSVK VASSFTHAFD GSRLEEWLSH VVGAVYAPKL NVALDVGIPL
460 470
PKVLNINFSN SVLEIVENAV VLTVAS
Length:476
Mass (Da):50,342
Last modified:August 16, 2005 - v2
Checksum:i71C57B13BA5757BF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049742228V → M.Corresponds to variant rs4911290dbSNPEnsembl.1
Natural variantiVAR_049743290T → M.Corresponds to variant rs2093066dbSNPEnsembl.1
Natural variantiVAR_049744334H → Q.Corresponds to variant rs6057717dbSNPEnsembl.1
Natural variantiVAR_049745369Y → C.Corresponds to variant rs6059063dbSNPEnsembl.1
Natural variantiVAR_049746449P → S.Corresponds to variant rs378098dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF549189 mRNA. Translation: AAP84989.1.
AL121756 Genomic DNA. Translation: CAI22531.1.
CCDSiCCDS13212.1.
RefSeqiNP_872599.1. NM_182658.2.
UniGeneiHs.472442.

Genome annotation databases

EnsembliENST00000375494; ENSP00000364643; ENSG00000186190.
GeneIDi359710.
KEGGihsa:359710.
UCSCiuc002wym.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF549189 mRNA. Translation: AAP84989.1.
AL121756 Genomic DNA. Translation: CAI22531.1.
CCDSiCCDS13212.1.
RefSeqiNP_872599.1. NM_182658.2.
UniGeneiHs.472442.

3D structure databases

ProteinModelPortaliP59826.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131704. 2 interactors.
STRINGi9606.ENSP00000364643.

PTM databases

iPTMnetiP59826.
PhosphoSitePlusiP59826.

Polymorphism and mutation databases

BioMutaiBPIFB3.
DMDMi73620973.

Proteomic databases

EPDiP59826.
PaxDbiP59826.
PRIDEiP59826.
TopDownProteomicsiP59826.

Protocols and materials databases

DNASUi359710.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375494; ENSP00000364643; ENSG00000186190.
GeneIDi359710.
KEGGihsa:359710.
UCSCiuc002wym.1. human.

Organism-specific databases

CTDi359710.
GeneCardsiBPIFB3.
HGNCiHGNC:16178. BPIFB3.
HPAiHPA045741.
MIMi615717. gene.
neXtProtiNX_P59826.
OpenTargetsiENSG00000186190.
PharmGKBiPA25727.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231741.
HOVERGENiHBG050718.
InParanoidiP59826.
OMAiVYAPKLN.
OrthoDBiEOG091G048N.
PhylomeDBiP59826.
TreeFamiTF315617.

Enzyme and pathway databases

BioCyciZFISH:G66-32685-MONOMER.

Miscellaneous databases

GenomeRNAii359710.
PROiP59826.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186190.
CleanExiHS_C20orf185.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR032951. BPIFB3.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF42. PTHR10504:SF42. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiBPIB3_HUMAN
AccessioniPrimary (citable) accession number: P59826
Secondary accession number(s): Q5TDX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 16, 2005
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.