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Protein

BPI fold-containing family B member 3

Gene

BPIFB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).By similarity

GO - Molecular functioni

  1. lipid binding Source: InterPro

GO - Biological processi

  1. innate immune response Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 3
Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3
Gene namesi
Name:BPIFB3
Synonyms:C20orf185, LPLUNC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16178. BPIFB3.

Subcellular locationi

Secreted By similarity. Cytoplasm 1 Publication
Note: According to PubMed:12837268, it is cytoplasmic.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 476456BPI fold-containing family B member 3PRO_0000017170Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi164 ↔ 199By similarity
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP59826.
PRIDEiP59826.

Expressioni

Tissue specificityi

Detected in nasal septal epithelium.1 Publication

Gene expression databases

BgeeiP59826.
CleanExiHS_C20orf185.
GenevestigatoriP59826.

Organism-specific databases

HPAiHPA045741.

Interactioni

Protein-protein interaction databases

BioGridi131704. 1 interaction.
STRINGi9606.ENSP00000364643.

Structurei

3D structure databases

ProteinModelPortaliP59826.
SMRiP59826. Positions 91-451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 237232Leu-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG317196.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231741.
HOVERGENiHBG050718.
InParanoidiP59826.
OMAiPIKVPPK.
OrthoDBiEOG715Q45.
PhylomeDBiP59826.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59826-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPVMLALWS LLLLWGLATP CQELLETVGT LARIDKDELG KAIQNSLVGE
60 70 80 90 100
PILQNVLGSV TAVNRGLLGS GGLLGGGGLL GHGGVFGVVE ELSGLKIEEL
110 120 130 140 150
TLPKVLLKLL PGFGVQLSLH TKVGMHCSGP LGGLLQLAAE VNVTSRVALA
160 170 180 190 200
VSSRGTPILI LKRCSTLLGH ISLFSGLLPT PLFGVVEQML FKVLPGLLCP
210 220 230 240 250
VVDSVLGVVN ELLGAVLGLV SLGALGSVEF SLATLPLISN QYIELDINPI
260 270 280 290 300
VKSVAGDIID FPKSRAPAKV PPKKDHTSQV MVPLYLFNTT FGLLQTNGAL
310 320 330 340 350
DMDITPELVP SDVPLTTTDL AALLPEALGK LPLHQQLLLF LRVREAPTVT
360 370 380 390 400
LHNKKALVSL PANIHVLFYV PKGTPESLFE LNSVMTVRAQ LAPSATKLHI
410 420 430 440 450
SLSLERLSVK VASSFTHAFD GSRLEEWLSH VVGAVYAPKL NVALDVGIPL
460 470
PKVLNINFSN SVLEIVENAV VLTVAS
Length:476
Mass (Da):50,342
Last modified:August 16, 2005 - v2
Checksum:i71C57B13BA5757BF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti228 – 2281V → M.
Corresponds to variant rs4911290 [ dbSNP | Ensembl ].
VAR_049742
Natural varianti290 – 2901T → M.
Corresponds to variant rs2093066 [ dbSNP | Ensembl ].
VAR_049743
Natural varianti334 – 3341H → Q.
Corresponds to variant rs6057717 [ dbSNP | Ensembl ].
VAR_049744
Natural varianti369 – 3691Y → C.
Corresponds to variant rs6059063 [ dbSNP | Ensembl ].
VAR_049745
Natural varianti449 – 4491P → S.
Corresponds to variant rs378098 [ dbSNP | Ensembl ].
VAR_049746

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF549189 mRNA. Translation: AAP84989.1.
AL121756 Genomic DNA. Translation: CAI22531.1.
CCDSiCCDS13212.1.
RefSeqiNP_872599.1. NM_182658.1.
UniGeneiHs.472442.

Genome annotation databases

EnsembliENST00000375494; ENSP00000364643; ENSG00000186190.
GeneIDi359710.
KEGGihsa:359710.
UCSCiuc002wym.1. human.

Polymorphism databases

DMDMi73620973.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF549189 mRNA. Translation: AAP84989.1.
AL121756 Genomic DNA. Translation: CAI22531.1.
CCDSiCCDS13212.1.
RefSeqiNP_872599.1. NM_182658.1.
UniGeneiHs.472442.

3D structure databases

ProteinModelPortaliP59826.
SMRiP59826. Positions 91-451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131704. 1 interaction.
STRINGi9606.ENSP00000364643.

Polymorphism databases

DMDMi73620973.

Proteomic databases

PaxDbiP59826.
PRIDEiP59826.

Protocols and materials databases

DNASUi359710.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375494; ENSP00000364643; ENSG00000186190.
GeneIDi359710.
KEGGihsa:359710.
UCSCiuc002wym.1. human.

Organism-specific databases

CTDi359710.
GeneCardsiGC20P031645.
HGNCiHGNC:16178. BPIFB3.
HPAiHPA045741.
MIMi615717. gene.
neXtProtiNX_P59826.
PharmGKBiPA25727.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG317196.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231741.
HOVERGENiHBG050718.
InParanoidiP59826.
OMAiPIKVPPK.
OrthoDBiEOG715Q45.
PhylomeDBiP59826.
TreeFamiTF315617.

Miscellaneous databases

GenomeRNAii359710.
NextBioi99842.
PROiP59826.
SOURCEiSearch...

Gene expression databases

BgeeiP59826.
CleanExiHS_C20orf185.
GenevestigatoriP59826.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides."
    Andrault J.-B., Gaillard I., Giorgi D., Rouquier S.
    Genomics 82:172-184(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx."
    Bingle C.D., Craven C.J.
    Hum. Mol. Genet. 11:937-943(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiBPIB3_HUMAN
AccessioniPrimary (citable) accession number: P59826
Secondary accession number(s): Q5TDX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 16, 2005
Last modified: January 7, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.