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Protein

BPI fold-containing family B member 3

Gene

BPIFB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 3
Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3
Gene namesi
Name:BPIFB3
Synonyms:C20orf185, LPLUNC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000186190.7.
HGNCiHGNC:16178. BPIFB3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25727.

Polymorphism and mutation databases

BioMutaiBPIFB3.
DMDMi73620973.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001717021 – 476BPI fold-containing family B member 3Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 199By similarity
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP59826.
PaxDbiP59826.
PRIDEiP59826.
TopDownProteomicsiP59826.

PTM databases

iPTMnetiP59826.
PhosphoSitePlusiP59826.

Expressioni

Tissue specificityi

Detected in nasal septal epithelium.1 Publication

Gene expression databases

BgeeiENSG00000186190.
CleanExiHS_C20orf185.

Organism-specific databases

HPAiHPA045741.

Interactioni

Protein-protein interaction databases

BioGridi131704. 2 interactors.
IntActiP59826. 2 interactors.
STRINGi9606.ENSP00000364643.

Structurei

3D structure databases

ProteinModelPortaliP59826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 237Leu-richAdd BLAST232

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231741.
HOVERGENiHBG050718.
InParanoidiP59826.
OMAiEWLSHVV.
OrthoDBiEOG091G048N.
PhylomeDBiP59826.
TreeFamiTF315617.

Family and domain databases

InterProiView protein in InterPro
IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR032951. BPIFB3.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF121. PTHR10504:SF121. 1 hit.
PfamiView protein in Pfam
PF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
SMARTiView protein in SMART
SM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPVMLALWS LLLLWGLATP CQELLETVGT LARIDKDELG KAIQNSLVGE
60 70 80 90 100
PILQNVLGSV TAVNRGLLGS GGLLGGGGLL GHGGVFGVVE ELSGLKIEEL
110 120 130 140 150
TLPKVLLKLL PGFGVQLSLH TKVGMHCSGP LGGLLQLAAE VNVTSRVALA
160 170 180 190 200
VSSRGTPILI LKRCSTLLGH ISLFSGLLPT PLFGVVEQML FKVLPGLLCP
210 220 230 240 250
VVDSVLGVVN ELLGAVLGLV SLGALGSVEF SLATLPLISN QYIELDINPI
260 270 280 290 300
VKSVAGDIID FPKSRAPAKV PPKKDHTSQV MVPLYLFNTT FGLLQTNGAL
310 320 330 340 350
DMDITPELVP SDVPLTTTDL AALLPEALGK LPLHQQLLLF LRVREAPTVT
360 370 380 390 400
LHNKKALVSL PANIHVLFYV PKGTPESLFE LNSVMTVRAQ LAPSATKLHI
410 420 430 440 450
SLSLERLSVK VASSFTHAFD GSRLEEWLSH VVGAVYAPKL NVALDVGIPL
460 470
PKVLNINFSN SVLEIVENAV VLTVAS
Length:476
Mass (Da):50,342
Last modified:August 16, 2005 - v2
Checksum:i71C57B13BA5757BF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049742228V → M. Corresponds to variant dbSNP:rs4911290Ensembl.1
Natural variantiVAR_049743290T → M. Corresponds to variant dbSNP:rs2093066Ensembl.1
Natural variantiVAR_049744334H → Q. Corresponds to variant dbSNP:rs6057717Ensembl.1
Natural variantiVAR_049745369Y → C. Corresponds to variant dbSNP:rs6059063Ensembl.1
Natural variantiVAR_049746449P → S. Corresponds to variant dbSNP:rs378098Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF549189 mRNA. Translation: AAP84989.1.
AL121756 Genomic DNA. No translation available.
CCDSiCCDS13212.1.
RefSeqiNP_872599.1. NM_182658.2.
UniGeneiHs.472442.

Genome annotation databases

EnsembliENST00000375494; ENSP00000364643; ENSG00000186190.
GeneIDi359710.
KEGGihsa:359710.
UCSCiuc002wym.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBPIB3_HUMAN
AccessioniPrimary (citable) accession number: P59826
Secondary accession number(s): Q5TDX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 16, 2005
Last modified: September 27, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families