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P59826 (BPIB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BPI fold-containing family B member 3
Alternative name(s):
Ligand-binding protein RYA3
Long palate, lung and nasal epithelium carcinoma-associated protein 3
Gene names
Name:BPIFB3
Synonyms:C20orf185, LPLUNC3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received By similarity.

Subcellular location

Secreted By similarity. Cytoplasm. Note: According to Ref.1, it is cytoplasmic. Ref.1

Tissue specificity

Detected in nasal septal epithelium. Ref.3

Sequence similarities

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Ontologies

Keywords
   Cellular componentCytoplasm
Secreted
   Coding sequence diversityPolymorphism
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinnate immune response

Non-traceable author statement Ref.3. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay Ref.1. Source: UniProtKB

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 476456BPI fold-containing family B member 3
PRO_0000017170

Regions

Compositional bias6 – 237232Leu-rich

Amino acid modifications

Glycosylation1421N-linked (GlcNAc...) Potential
Glycosylation2881N-linked (GlcNAc...) Potential
Glycosylation4571N-linked (GlcNAc...) Potential
Disulfide bond164 ↔ 199 By similarity

Natural variations

Natural variant2281V → M.
Corresponds to variant rs4911290 [ dbSNP | Ensembl ].
VAR_049742
Natural variant2901T → M.
Corresponds to variant rs2093066 [ dbSNP | Ensembl ].
VAR_049743
Natural variant3341H → Q.
Corresponds to variant rs6057717 [ dbSNP | Ensembl ].
VAR_049744
Natural variant3691Y → C.
Corresponds to variant rs6059063 [ dbSNP | Ensembl ].
VAR_049745
Natural variant4491P → S.
Corresponds to variant rs378098 [ dbSNP | Ensembl ].
VAR_049746

Sequences

Sequence LengthMass (Da)Tools
P59826 [UniParc].

Last modified August 16, 2005. Version 2.
Checksum: 71C57B13BA5757BF

FASTA47650,342
        10         20         30         40         50         60 
MQPVMLALWS LLLLWGLATP CQELLETVGT LARIDKDELG KAIQNSLVGE PILQNVLGSV 

        70         80         90        100        110        120 
TAVNRGLLGS GGLLGGGGLL GHGGVFGVVE ELSGLKIEEL TLPKVLLKLL PGFGVQLSLH 

       130        140        150        160        170        180 
TKVGMHCSGP LGGLLQLAAE VNVTSRVALA VSSRGTPILI LKRCSTLLGH ISLFSGLLPT 

       190        200        210        220        230        240 
PLFGVVEQML FKVLPGLLCP VVDSVLGVVN ELLGAVLGLV SLGALGSVEF SLATLPLISN 

       250        260        270        280        290        300 
QYIELDINPI VKSVAGDIID FPKSRAPAKV PPKKDHTSQV MVPLYLFNTT FGLLQTNGAL 

       310        320        330        340        350        360 
DMDITPELVP SDVPLTTTDL AALLPEALGK LPLHQQLLLF LRVREAPTVT LHNKKALVSL 

       370        380        390        400        410        420 
PANIHVLFYV PKGTPESLFE LNSVMTVRAQ LAPSATKLHI SLSLERLSVK VASSFTHAFD 

       430        440        450        460        470 
GSRLEEWLSH VVGAVYAPKL NVALDVGIPL PKVLNINFSN SVLEIVENAV VLTVAS 

« Hide

References

« Hide 'large scale' references
[1]"Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides."
Andrault J.-B., Gaillard I., Giorgi D., Rouquier S.
Genomics 82:172-184(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
Tissue: Fetal brain.
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx."
Bingle C.D., Craven C.J.
Hum. Mol. Genet. 11:937-943(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF549189 mRNA. Translation: AAP84989.1.
AL121756 Genomic DNA. Translation: CAI22531.1.
RefSeqNP_872599.1. NM_182658.1.
UniGeneHs.472442.

3D structure databases

ProteinModelPortalP59826.
SMRP59826. Positions 91-451.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131704. 1 interaction.
STRING9606.ENSP00000364643.

Polymorphism databases

DMDM73620973.

Proteomic databases

PaxDbP59826.
PRIDEP59826.

Protocols and materials databases

DNASU359710.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375494; ENSP00000364643; ENSG00000186190.
GeneID359710.
KEGGhsa:359710.
UCSCuc002wym.1. human.

Organism-specific databases

CTD359710.
GeneCardsGC20P031645.
HGNCHGNC:16178. BPIFB3.
HPAHPA045741.
neXtProtNX_P59826.
PharmGKBPA25727.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG317196.
HOGENOMHOG000231741.
HOVERGENHBG050718.
InParanoidP59826.
OMAPLISNQY.
OrthoDBEOG715Q45.
PhylomeDBP59826.
TreeFamTF315617.

Gene expression databases

BgeeP59826.
CleanExHS_C20orf185.
GenevestigatorP59826.

Family and domain databases

InterProIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMSSF55394. SSF55394. 2 hits.
ProtoNetSearch...

Other

GenomeRNAi359710.
NextBio99842.
PROP59826.

Entry information

Entry nameBPIB3_HUMAN
AccessionPrimary (citable) accession number: P59826
Secondary accession number(s): Q5TDX7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 16, 2005
Last modified: March 19, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM