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Protein

Interleukin-1 receptor accessory protein-like 1

Gene

Il1rapl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel (PubMed:17502602). May activate the MAP kinase JNK (By similarity). Plays a role in neurite outgrowth (PubMed:18801879). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei34Essential for interaction with PTPRDBy similarity1

GO - Molecular functioni

  • voltage-gated calcium channel activity Source: UniProtKB

GO - Biological processi

  • negative regulation of exocytosis Source: UniProtKB
  • positive regulation of synapse assembly Source: UniProtKB
  • regulation of neuron projection development Source: UniProtKB
  • signal transduction Source: InterPro

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor accessory protein-like 1
Short name:
IL-1-RAPL-1
Short name:
IL-1RAPL-1
Short name:
IL1RAPL-1
Alternative name(s):
X-linked interleukin-1 receptor accessory protein-like 1
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727891. Il1rapl1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 357ExtracellularSequence analysisAdd BLAST333
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Topological domaini379 – 696CytoplasmicSequence analysisAdd BLAST318

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001545825 – 696Interleukin-1 receptor accessory protein-like 1Add BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 126By similarity
Disulfide bondi53 ↔ 118PROSITE-ProRule annotation
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 185By similarity
Disulfide bondi164 ↔ 216PROSITE-ProRule annotation
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi267 ↔ 334PROSITE-ProRule annotation
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP59824.
PRIDEiP59824.

PTM databases

iPTMnetiP59824.
PhosphoSitePlusiP59824.
SwissPalmiP59824.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts (calcium-independent) with NCS1/FREQ (By similarity). Interacts (via the first immunoglobilin domain) with PTPRD (via the second immunoglobilin domain); this interaction is PTPRD-splicing-dependent and induces pre- and post-synaptic differentiation of neurons and is required for IL1RAPL1-mediated synapse formation (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061591.

Structurei

3D structure databases

ProteinModelPortaliP59824.
SMRiP59824.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 134Ig-like C2-type 1Add BLAST110
Domaini143 – 232Ig-like C2-type 2Add BLAST90
Domaini242 – 350Ig-like C2-type 3Add BLAST109
Domaini403 – 562TIRPROSITE-ProRule annotationAdd BLAST160

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni549 – 644Interaction with NCS1By similarityAdd BLAST96

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3G. Eukaryota.
ENOG4110Z8K. LUCA.
HOGENOMiHOG000092977.
HOVERGENiHBG052148.
InParanoidiP59824.
KOiK05170.
PhylomeDBiP59824.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiView protein in Pfam
PF00047. ig. 1 hit.
PF01582. TIR. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSVDIKK YQVLVGEPVR
60 70 80 90 100
IKCALFYGYI RTNYTLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE
110 120 130 140 150
DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY
160 170 180 190 200
FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKTW RPSIVFKRDT
210 220 230 240 250
LLIKEVKEDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES
260 270 280 290 300
KLTIQETQLG GSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE
310 320 330 340 350
SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH
360 370 380 390 400
KRELMYTVEL AGGLGAILLL LVCSVTIYKC YKIEIMLFYR NHFGAEELDG
410 420 430 440 450
DNKDYDAYLS YTKVDPDQWN QETGEEERFA LEILPDMLEK HYGYKLFIPD
460 470 480 490 500
RDLIPTGTYI EDVARCVDQS KRLIIVMTPN YVVRRGWSIF ELETRLRNML
510 520 530 540 550
VTGEIKVILI ECSELRGIMN YQEVEALKHT IKLLTVIKWH GPKCNKLNSK
560 570 580 590 600
FWKRLQYEMP FKRIEPITHE QALDVSEQGP FGELQTVSAI SMAAATSTAL
610 620 630 640 650
ATAHPDLRST FHNTYHSQMR QKHYYRSYEY DVPPTGTLPL TSIGNQHTYC
660 670 680 690
NIPMTLINGQ RPQTKSSREP NPDEAHTNSA ILPLLARETS ISSVIW
Length:696
Mass (Da):79,771
Last modified:August 22, 2003 - v1
Checksum:i3684FCCD0A0B3FD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY216593 mRNA. Translation: AAO62634.1.
RefSeqiNP_808796.1. NM_177935.2.
UniGeneiRn.214479.

Genome annotation databases

GeneIDi317553.
KEGGirno:317553.

Similar proteinsi

Entry informationi

Entry nameiIRPL1_RAT
AccessioniPrimary (citable) accession number: P59824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: September 27, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families