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Protein

Interleukin-1 receptor accessory protein-like 1

Gene

Il1rapl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK (By similarity). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed:25908590, PubMed:21940441).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei34Essential for interaction with PTPRD1 Publication1

GO - Molecular functioni

  • receptor binding Source: BHF-UCL
  • voltage-gated calcium channel activity Source: UniProtKB

GO - Biological processi

  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
  • negative regulation of exocytosis Source: UniProtKB
  • neuron differentiation Source: BHF-UCL
  • positive regulation of dendrite morphogenesis Source: BHF-UCL
  • positive regulation of synapse assembly Source: UniProtKB
  • presynaptic membrane assembly Source: BHF-UCL
  • regulation of neuron projection development Source: UniProtKB
  • signal transduction Source: InterPro

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor accessory protein-like 1
Short name:
IL-1-RAPL-1
Short name:
IL-1RAPL-1
Short name:
IL1RAPL-1
Alternative name(s):
X-linked interleukin-1 receptor accessory protein-like 1
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2687319. Il1rapl1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 357ExtracellularSequence analysisAdd BLAST333
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Topological domaini379 – 695CytoplasmicSequence analysisAdd BLAST317

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi34W → A: Abolishes Interaction with PTPRD. Abolishes synaptogenesis. 1 Publication1
Mutagenesisi37D → A: Decreases affinity for PTPRD. Significantly decreases synaptogenesis. 1 Publication1
Mutagenesisi75 – 77MWY → AWA: Decreases affinity for PTPRD; when associated with 88-A--A-91. Significantly decreases synaptogenesis; when associated with 88-A--A-91. 1 Publication3
Mutagenesisi88 – 91PIAF → AIAA: Decreases affinity for PTPRD; when associated with 75-A--A-77. Significantly decreases synaptogenesis; when associated with 88-A--A-91. 1 Publication4
Mutagenesisi292D → A: Decreases affinity for PTPRD. Significantly decreases synaptogenesis. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001545525 – 695Interleukin-1 receptor accessory protein-like 1Add BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 126Combined sources1 Publication
Disulfide bondi53 ↔ 118PROSITE-ProRule annotationCombined sources1 Publication
Glycosylationi63N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi122N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi138N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi143 ↔ 185Combined sources1 Publication
Disulfide bondi164 ↔ 216PROSITE-ProRule annotationCombined sources1 Publication
Glycosylationi213N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi264N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi267 ↔ 334PROSITE-ProRule annotationCombined sources1 Publication
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP59823.
PRIDEiP59823.

PTM databases

iPTMnetiP59823.
PhosphoSitePlusiP59823.

Expressioni

Tissue specificityi

Detected in total brain extracts, olfactory bulb, hippocampus and striatum (at protein level).1 Publication

Gene expression databases

CleanExiMM_IL1RAPL1.

Interactioni

Subunit structurei

Homodimer (PubMed:25908590). Interacts (calcium-independent) with NCS1/FREQ (By similarity). Interacts (via the first immunoglobilin domain) with PTPRD (via the second immunoglobilin domain); this interaction is PTPRD-splicing-dependent and induces pre- and post-synaptic differentiation of neurons and is required for IL1RAPL1-mediated synapse formation (PubMed:25908590, PubMed:21940441).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PtprdQ644876EBI-5452114,EBI-771834

GO - Molecular functioni

  • receptor binding Source: BHF-UCL

Protein-protein interaction databases

IntActiP59823. 1 interactor.
STRINGi10090.ENSMUSP00000077915.

Structurei

Secondary structure

1695
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 36Combined sources5
Beta strandi41 – 44Combined sources4
Beta strandi49 – 52Combined sources4
Helixi54 – 57Combined sources4
Beta strandi60 – 62Combined sources3
Helixi64 – 69Combined sources6
Beta strandi73 – 81Combined sources9
Beta strandi93 – 97Combined sources5
Beta strandi102 – 107Combined sources6
Helixi110 – 112Combined sources3
Beta strandi114 – 121Combined sources8
Beta strandi126 – 130Combined sources5
Beta strandi132 – 136Combined sources5
Beta strandi142 – 145Combined sources4
Beta strandi146 – 148Combined sources3
Beta strandi150 – 155Combined sources6
Beta strandi160 – 163Combined sources4
Turni168 – 170Combined sources3
Beta strandi173 – 175Combined sources3
Beta strandi180 – 183Combined sources4
Beta strandi192 – 196Combined sources5
Beta strandi198 – 205Combined sources8
Helixi208 – 210Combined sources3
Beta strandi212 – 220Combined sources9
Beta strandi223 – 234Combined sources12
Beta strandi243 – 247Combined sources5
Turni249 – 251Combined sources3
Beta strandi253 – 257Combined sources5
Beta strandi263 – 271Combined sources9
Beta strandi280 – 285Combined sources6
Helixi290 – 292Combined sources3
Beta strandi296 – 300Combined sources5
Beta strandi304 – 308Combined sources5
Beta strandi313 – 323Combined sources11
Beta strandi326 – 328Combined sources3
Beta strandi330 – 338Combined sources9
Beta strandi341 – 351Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YFCX-ray2.70B19-352[»]
4YH6X-ray3.00A/B19-352[»]
4YH7X-ray4.40B19-352[»]
ProteinModelPortaliP59823.
SMRiP59823.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 134Ig-like C2-type 1Add BLAST110
Domaini143 – 232Ig-like C2-type 2Add BLAST90
Domaini242 – 350Ig-like C2-type 3Add BLAST109
Domaini403 – 561TIRPROSITE-ProRule annotationAdd BLAST159

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni548 – 643Interaction with NCS1By similarityAdd BLAST96

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3G. Eukaryota.
ENOG4110Z8K. LUCA.
HOVERGENiHBG052148.
InParanoidiP59823.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiView protein in Pfam
PF00047. ig. 1 hit.
PF01582. TIR. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSVDIKK YQVLVGEPVR
60 70 80 90 100
IKCALFYGYI RTNYSLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE
110 120 130 140 150
DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY
160 170 180 190 200
FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKAW RPSIVFKRDT
210 220 230 240 250
LLIKEVKEDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES
260 270 280 290 300
KLTVQETQLG GSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE
310 320 330 340 350
SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH
360 370 380 390 400
KRELMYTVEL AGGLGAILLL LICSVTIYKC YKIEIMLFYR NHFGAEELDG
410 420 430 440 450
DNKDYDAYLS YTKVDPDQWN QETGEEERFA LEILPDMLEK HYGYKLFIPD
460 470 480 490 500
RDLIPTGNIE DVARCVDQSK RLIIVMTPNY VVRRGWSIFE LETRLRNMLV
510 520 530 540 550
TGEIKVILIE CSELRGIMNY QEVEALKHTI KLLTVIKWHG PKCNKLNSKF
560 570 580 590 600
WKRLQYEMPF KRIEPITHEQ ALDVSEQGPF GELQTVSAIS MAAATSTALA
610 620 630 640 650
TAHPDLRSTF HNTYHSQMRQ KHYYRSYEYD VPPTGTLPLT SIGNQHTYCN
660 670 680 690
IPMTLINGQR PQTKSNREPN PDEAHTNSAI LPLLPRETSI SSVIW
Length:695
Mass (Da):79,630
Last modified:August 22, 2003 - v1
Checksum:i5FE34F204E5908B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844900 Genomic DNA. No translation available.
AL672059 Genomic DNA. No translation available.
AK081272 mRNA. No translation available.
UniGeneiMm.121680.
Mm.400887.
Mm.426143.

Similar proteinsi

Entry informationi

Entry nameiIRPL1_MOUSE
AccessioniPrimary (citable) accession number: P59823
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: August 30, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families