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Protein

Interleukin-1 receptor accessory protein-like 1

Gene

Il1rapl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK (By similarity). Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons.By similarity1 Publication

GO - Molecular functioni

  • receptor binding Source: BHF-UCL
  • voltage-gated calcium channel activity Source: UniProtKB

GO - Biological processi

  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
  • negative regulation of exocytosis Source: UniProtKB
  • neuron differentiation Source: BHF-UCL
  • positive regulation of dendrite morphogenesis Source: BHF-UCL
  • presynaptic membrane assembly Source: BHF-UCL
  • regulation of neuron projection development Source: UniProtKB
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor accessory protein-like 1
Short name:
IL-1-RAPL-1
Short name:
IL-1RAPL-1
Short name:
IL1RAPL-1
Alternative name(s):
X-linked interleukin-1 receptor accessory protein-like 1
Gene namesi
Name:Il1rapl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2687319. Il1rapl1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 357333ExtracellularSequence analysisAdd
BLAST
Transmembranei358 – 37821HelicalSequence analysisAdd
BLAST
Topological domaini379 – 695317CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: UniProtKB-SubCell
  • cell surface Source: BHF-UCL
  • cytoplasm Source: UniProtKB-SubCell
  • dendrite Source: BHF-UCL
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
  • postsynaptic membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 695671Interleukin-1 receptor accessory protein-like 1PRO_0000015455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 118PROSITE-ProRule annotation
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence analysis
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence analysis
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi164 ↔ 216PROSITE-ProRule annotation
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence analysis
Disulfide bondi267 ↔ 334PROSITE-ProRule annotation
Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP59823.
PRIDEiP59823.

PTM databases

iPTMnetiP59823.
PhosphoSiteiP59823.

Expressioni

Tissue specificityi

Detected in total brain extracts, olfactory bulb, hippocampus and striatum (at protein level).1 Publication

Gene expression databases

CleanExiMM_IL1RAPL1.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts (calcium-independent) with NCS1/FREQ (By similarity). Interacts (via extracellular region) with PTPRD; this interaction is required for IL1RAPL1-mediated synapse formation.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PtprdQ644876EBI-5452114,EBI-771834

GO - Molecular functioni

  • receptor binding Source: BHF-UCL

Protein-protein interaction databases

IntActiP59823. 1 interaction.
STRINGi10090.ENSMUSP00000077915.

Structurei

Secondary structure

1
695
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi32 – 365Combined sources
Beta strandi41 – 444Combined sources
Beta strandi49 – 524Combined sources
Helixi54 – 574Combined sources
Beta strandi60 – 623Combined sources
Helixi64 – 696Combined sources
Beta strandi73 – 819Combined sources
Beta strandi93 – 975Combined sources
Beta strandi102 – 1076Combined sources
Helixi110 – 1123Combined sources
Beta strandi114 – 1218Combined sources
Beta strandi126 – 1305Combined sources
Beta strandi132 – 1365Combined sources
Beta strandi142 – 1454Combined sources
Beta strandi146 – 1483Combined sources
Beta strandi150 – 1556Combined sources
Beta strandi160 – 1634Combined sources
Turni168 – 1703Combined sources
Beta strandi173 – 1753Combined sources
Beta strandi180 – 1834Combined sources
Beta strandi192 – 1965Combined sources
Beta strandi198 – 2058Combined sources
Helixi208 – 2103Combined sources
Beta strandi212 – 2209Combined sources
Beta strandi223 – 23412Combined sources
Beta strandi243 – 2475Combined sources
Turni249 – 2513Combined sources
Beta strandi253 – 2575Combined sources
Beta strandi263 – 2719Combined sources
Beta strandi280 – 2856Combined sources
Helixi290 – 2923Combined sources
Beta strandi296 – 3005Combined sources
Beta strandi304 – 3085Combined sources
Beta strandi313 – 32311Combined sources
Beta strandi326 – 3283Combined sources
Beta strandi330 – 3389Combined sources
Beta strandi341 – 35111Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4YFCX-ray2.70B19-352[»]
4YH6X-ray3.00A/B19-352[»]
4YH7X-ray4.40B19-352[»]
ProteinModelPortaliP59823.
SMRiP59823. Positions 31-352, 403-560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 134110Ig-like C2-type 1Add
BLAST
Domaini143 – 23290Ig-like C2-type 2Add
BLAST
Domaini242 – 350109Ig-like C2-type 3Add
BLAST
Domaini403 – 561159TIRPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni548 – 64396Interaction with NCS1By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3G. Eukaryota.
ENOG4110Z8K. LUCA.
HOVERGENiHBG052148.
InParanoidiP59823.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAPIPHLIL LYATFTQSLK VVTKRGSADG CTDWSVDIKK YQVLVGEPVR
60 70 80 90 100
IKCALFYGYI RTNYSLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE
110 120 130 140 150
DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY
160 170 180 190 200
FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKAW RPSIVFKRDT
210 220 230 240 250
LLIKEVKEDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES
260 270 280 290 300
KLTVQETQLG GSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE
310 320 330 340 350
SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH
360 370 380 390 400
KRELMYTVEL AGGLGAILLL LICSVTIYKC YKIEIMLFYR NHFGAEELDG
410 420 430 440 450
DNKDYDAYLS YTKVDPDQWN QETGEEERFA LEILPDMLEK HYGYKLFIPD
460 470 480 490 500
RDLIPTGNIE DVARCVDQSK RLIIVMTPNY VVRRGWSIFE LETRLRNMLV
510 520 530 540 550
TGEIKVILIE CSELRGIMNY QEVEALKHTI KLLTVIKWHG PKCNKLNSKF
560 570 580 590 600
WKRLQYEMPF KRIEPITHEQ ALDVSEQGPF GELQTVSAIS MAAATSTALA
610 620 630 640 650
TAHPDLRSTF HNTYHSQMRQ KHYYRSYEYD VPPTGTLPLT SIGNQHTYCN
660 670 680 690
IPMTLINGQR PQTKSNREPN PDEAHTNSAI LPLLPRETSI SSVIW
Length:695
Mass (Da):79,630
Last modified:August 22, 2003 - v1
Checksum:i5FE34F204E5908B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844900 Genomic DNA. No translation available.
AL672059 Genomic DNA. No translation available.
AK081272 mRNA. No translation available.
UniGeneiMm.121680.
Mm.400887.
Mm.426143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844900 Genomic DNA. No translation available.
AL672059 Genomic DNA. No translation available.
AK081272 mRNA. No translation available.
UniGeneiMm.121680.
Mm.400887.
Mm.426143.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4YFCX-ray2.70B19-352[»]
4YH6X-ray3.00A/B19-352[»]
4YH7X-ray4.40B19-352[»]
ProteinModelPortaliP59823.
SMRiP59823. Positions 31-352, 403-560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP59823. 1 interaction.
STRINGi10090.ENSMUSP00000077915.

PTM databases

iPTMnetiP59823.
PhosphoSiteiP59823.

Proteomic databases

PaxDbiP59823.
PRIDEiP59823.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2687319. Il1rapl1.

Phylogenomic databases

eggNOGiENOG410IF3G. Eukaryota.
ENOG4110Z8K. LUCA.
HOVERGENiHBG052148.
InParanoidiP59823.

Miscellaneous databases

ChiTaRSiIl1rapl1. mouse.
PROiP59823.
SOURCEiSearch...

Gene expression databases

CleanExiMM_IL1RAPL1.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. "IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase delta."
    Yoshida T., Yasumura M., Uemura T., Lee S.J., Ra M., Taguchi R., Iwakura Y., Mishina M.
    J. Neurosci. 31:13485-13499(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PTPRD, SUBCELLULAR LOCATION.
  4. "IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis."
    Bahi N., Friocourt G., Carrie A., Graham M.E., Weiss J.L., Chafey P., Fauchereau F., Burgoyne R.D., Chelly J.
    Hum. Mol. Genet. 12:1415-1425(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiIRPL1_MOUSE
AccessioniPrimary (citable) accession number: P59823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.