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Protein

Zinc finger protein 280A

Gene

ZNF280A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a transcription factor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri334 – 35724C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38724C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47424C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 280A
Alternative name(s):
3'OY11.1
Suppressor of hairy wing homolog 1
Zinc finger protein 636
Gene namesi
Name:ZNF280A
Synonyms:SUHW1, ZNF280, ZNF636
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:18597. ZNF280A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38358.

Polymorphism and mutation databases

BioMutaiZNF280A.
DMDMi313104252.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Zinc finger protein 280APRO_0000047055Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei70 – 701PhosphoserineBy similarity
Modified residuei72 – 721PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP59817.
PaxDbiP59817.
PeptideAtlasiP59817.
PRIDEiP59817.

Expressioni

Gene expression databases

BgeeiP59817.
CleanExiHS_ZNF280A.
GenevisibleiP59817. HS.

Organism-specific databases

HPAiHPA044475.

Interactioni

Protein-protein interaction databases

BioGridi126180. 6 interactions.
IntActiP59817. 1 interaction.
MINTiMINT-8417737.
STRINGi9606.ENSP00000302855.

Structurei

3D structure databases

ProteinModelPortaliP59817.
SMRiP59817. Positions 326-454.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri334 – 35724C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38724C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47424C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000013047.
HOVERGENiHBG060885.
InParanoidiP59817.
OrthoDBiEOG7QVM24.
PhylomeDBiP59817.
TreeFamiTF331707.

Family and domain databases

InterProiIPR025243. DUF4195.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13836. DUF4195. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDIFLCKKV ESPKKNLRES KQREEDDEDP DLIYVGVEHV HRDAEVLFVG
60 70 80 90 100
MISNSKPVVS NILNRVTPGS KSRRKKGHFR QYPAHVSQPA NHVTSMAKAI
110 120 130 140 150
MPVSLSEGRS TDSPVTMKSS SEPGYKMSSP QVVSPNYSDS LPPGTQCLVG
160 170 180 190 200
AMVSGGGRNE SSPDSKRLST SDINSRDSKR VKLRDGIPGV PSLAVVPSDM
210 220 230 240 250
SSTISTNTPS QGICNSSNHV QNGVTFPWPD ANGKAHFNLT DPERANESGL
260 270 280 290 300
AMTDISSLAS QNKTFDPKKE NPIVLLSNFY YGQHKGDGQP EQKTHTTFKC
310 320 330 340 350
LSCVKVLKNI KFMNHMKHHL EFEKQRNDSW EDHTTCQHCH RQFPTPFQLQ
360 370 380 390 400
CHIDSVHIAM GPSAVCKICE LSFETDQVLL QHMKDHHKPG EMPYVCQVCH
410 420 430 440 450
YRSSVFADVE THFRTCHENT KNLLCLFCLK LFKTAIPYMN HCWRHSRRRV
460 470 480 490 500
LQCSKCRLQF LTLKEEIEHK TKDHQTFKKP EQLQGFPRET KVIIQTSVQP
510 520 530 540
GSSGMASVIV SNTDPQSSPV KTKKKTAMNT RDSRLPCSKD SS
Length:542
Mass (Da):60,816
Last modified:November 30, 2010 - v3
Checksum:i1FFAB419D32C6433
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711K → N.2 Publications
Corresponds to variant rs361959 [ dbSNP | Ensembl ].
VAR_028218
Natural varianti136 – 1361N → S.2 Publications
Corresponds to variant rs362011 [ dbSNP | Ensembl ].
VAR_028219
Natural varianti137 – 1371Y → S.2 Publications
Corresponds to variant rs361580 [ dbSNP | Ensembl ].
VAR_028220
Natural varianti246 – 2461N → S.2 Publications
Corresponds to variant rs362132 [ dbSNP | Ensembl ].
VAR_028221
Natural varianti249 – 2491G → A.2 Publications
Corresponds to variant rs362124 [ dbSNP | Ensembl ].
VAR_028222
Natural varianti276 – 2761L → F.2 Publications
Corresponds to variant rs16989015 [ dbSNP | Ensembl ].
VAR_028223
Natural varianti278 – 2781N → D.2 Publications
Corresponds to variant rs362003 [ dbSNP | Ensembl ].
VAR_028224
Natural varianti486 – 4861F → L.2 Publications
Corresponds to variant rs361762 [ dbSNP | Ensembl ].
VAR_028225
Natural varianti488 – 4881R → S.2 Publications
Corresponds to variant rs361666 [ dbSNP | Ensembl ].
VAR_028226

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87009 Genomic DNA. Translation: BAA20006.1.
D87011 Genomic DNA. Translation: BAA20008.1.
BC053901 mRNA. Translation: AAH53901.1.
CCDSiCCDS13800.1.
RefSeqiNP_542778.2. NM_080740.4.
UniGeneiHs.178665.

Genome annotation databases

EnsembliENST00000302097; ENSP00000302855; ENSG00000169548.
GeneIDi129025.
KEGGihsa:129025.
UCSCiuc032qhw.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87009 Genomic DNA. Translation: BAA20006.1.
D87011 Genomic DNA. Translation: BAA20008.1.
BC053901 mRNA. Translation: AAH53901.1.
CCDSiCCDS13800.1.
RefSeqiNP_542778.2. NM_080740.4.
UniGeneiHs.178665.

3D structure databases

ProteinModelPortaliP59817.
SMRiP59817. Positions 326-454.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126180. 6 interactions.
IntActiP59817. 1 interaction.
MINTiMINT-8417737.
STRINGi9606.ENSP00000302855.

Polymorphism and mutation databases

BioMutaiZNF280A.
DMDMi313104252.

Proteomic databases

MaxQBiP59817.
PaxDbiP59817.
PeptideAtlasiP59817.
PRIDEiP59817.

Protocols and materials databases

DNASUi129025.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302097; ENSP00000302855; ENSG00000169548.
GeneIDi129025.
KEGGihsa:129025.
UCSCiuc032qhw.1. human.

Organism-specific databases

CTDi129025.
GeneCardsiZNF280A.
HGNCiHGNC:18597. ZNF280A.
HPAiHPA044475.
neXtProtiNX_P59817.
PharmGKBiPA38358.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000013047.
HOVERGENiHBG060885.
InParanoidiP59817.
OrthoDBiEOG7QVM24.
PhylomeDBiP59817.
TreeFamiTF331707.

Miscellaneous databases

GenomeRNAii129025.
PROiP59817.

Gene expression databases

BgeeiP59817.
CleanExiHS_ZNF280A.
GenevisibleiP59817. HS.

Family and domain databases

InterProiIPR025243. DUF4195.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13836. DUF4195. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "One-megabase sequence analysis of the human immunoglobulin lambda gene locus."
    Kawasaki K., Minoshima S., Nakato E., Shibuya K., Shintani A., Schmeits J.L., Wang J., Shimizu N.
    Genome Res. 7:250-261(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-71; SER-136; SER-137; SER-246; ALA-249; PHE-276; ASP-278; LEU-486 AND SER-488.
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-71; SER-136; SER-137; SER-246; ALA-249; PHE-276; ASP-278; LEU-486 AND SER-488.
    Tissue: Melanoma.

Entry informationi

Entry nameiZ280A_HUMAN
AccessioniPrimary (citable) accession number: P59817
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: November 30, 2010
Last modified: July 6, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.