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Protein

Selenoprotein K

Gene

Selenok

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for Ca2+ flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein KBy similarity
Short name:
SelKBy similarity
Gene namesi
Name:SelenokImported
Synonyms:SelkImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303129. Selenok.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Single-pass membrane protein Sequence analysis
  • Cell membrane By similarity; Single-pass membrane protein Sequence analysis

  • Note: Probably mainly localized in the ER.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 42HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000976712 – 94Selenoprotein KAdd BLAST93

Post-translational modificationi

Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei81 – 82Cleavage; by CAPN2By similarity2

Proteomic databases

PaxDbiP59798.
PRIDEiP59798.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014624.

Interactioni

Subunit structurei

Interacts with DERL1, DERL2, DERL3 and SELENOS. The SELENOK-SELENOS complex interacts with VCP. Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELENOK, SELENOS, STT3A AND VCP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020284.

Family & Domainsi

Sequence similaritiesi

Belongs to the selenoprotein K family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0AZ. Eukaryota.
ENOG410XWKI. LUCA.
HOGENOMiHOG000013002.
HOVERGENiHBG108467.
InParanoidiP59798.
PhylomeDBiP59798.
TreeFamiTF328380.

Family and domain databases

InterProiView protein in InterPro
IPR024491. Se_SelK/SelG.
PfamiView protein in Pfam
PF10961. SelK_SelG. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYISNGQVL DSRNQSPWRL SFITDFFWGI AEFVVFFFKT LLQQDVKKRR
60 70 80 90
GYGGSSDSRY DDGRGPPGNP PRRMGRISHL RGPSPPPMAG GUGR
Length:94
Mass (Da):10,626
Last modified:February 26, 2008 - v2
Checksum:iD10B0C633FEB5607
GO

Sequence cautioni

The sequence AAP73816 differs from that shown. Reason: Erroneous termination at position 92. Translated as Sec.Curated

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei92SelenocysteineBy similarity1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY319924 mRNA. Translation: AAP73816.1. Sequence problems.
BC088086 mRNA. Translation: AAH88086.2.
RefSeqiNP_997472.2. NM_207589.3.
UniGeneiRn.103178.

Genome annotation databases

GeneIDi290549.
KEGGirno:290549.
UCSCiRGD:1303129. rat.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY319924 mRNA. Translation: AAP73816.1. Sequence problems.
BC088086 mRNA. Translation: AAH88086.2.
RefSeqiNP_997472.2. NM_207589.3.
UniGeneiRn.103178.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020284.

Proteomic databases

PaxDbiP59798.
PRIDEiP59798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi290549.
KEGGirno:290549.
UCSCiRGD:1303129. rat.

Organism-specific databases

CTDi58515.
RGDi1303129. Selenok.

Phylogenomic databases

eggNOGiENOG410J0AZ. Eukaryota.
ENOG410XWKI. LUCA.
HOGENOMiHOG000013002.
HOVERGENiHBG108467.
InParanoidiP59798.
PhylomeDBiP59798.
TreeFamiTF328380.

Miscellaneous databases

PROiP59798.

Gene expression databases

BgeeiENSRNOG00000014624.

Family and domain databases

InterProiView protein in InterPro
IPR024491. Se_SelK/SelG.
PfamiView protein in Pfam
PF10961. SelK_SelG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSELK_RAT
AccessioniPrimary (citable) accession number: P59798
Secondary accession number(s): Q5I0Q3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: February 26, 2008
Last modified: February 15, 2017
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.