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Protein

Selenoprotein K

Gene

Selk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for Ca2+ flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein K
Short name:
SelK
Gene namesi
Name:Selk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303129. Selk.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Single-pass membrane protein Sequence analysis
  • Cell membrane By similarity; Single-pass membrane protein Sequence analysis

  • Note: Probably mainly localized in the ER.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4223HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 9493Selenoprotein KPRO_0000097671Add
BLAST

Post-translational modificationi

Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei81 – 822Cleavage; by CAPN2By similarity

Proteomic databases

PaxDbiP59798.
PRIDEiP59798.

Interactioni

Subunit structurei

Interacts with DERL1, DERL2, DERL3 and VIMP/SELS. The SELK-VIMP complex interacts with VCP. Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, VIMP, STT3A AND VCP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020284.

Family & Domainsi

Sequence similaritiesi

Belongs to the selenoprotein K family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0AZ. Eukaryota.
ENOG410XWKI. LUCA.
HOGENOMiHOG000013002.
HOVERGENiHBG108467.
InParanoidiP59798.
OrthoDBiEOG747PN7.
PhylomeDBiP59798.
TreeFamiTF328380.

Family and domain databases

InterProiIPR024491. Se_SelK/SelG.
[Graphical view]
PfamiPF10961. DUF2763. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYISNGQVL DSRNQSPWRL SFITDFFWGI AEFVVFFFKT LLQQDVKKRR
60 70 80 90
GYGGSSDSRY DDGRGPPGNP PRRMGRISHL RGPSPPPMAG GUGR
Length:94
Mass (Da):10,626
Last modified:February 26, 2008 - v2
Checksum:iD10B0C633FEB5607
GO

Sequence cautioni

The sequence AAP73816.1 differs from that shown. Reason: Erroneous termination at position 92. Translated as Sec.Curated

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei92 – 921SelenocysteineBy similarity

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY319924 mRNA. Translation: AAP73816.1. Sequence problems.
BC088086 mRNA. Translation: AAH88086.2.
RefSeqiNP_997472.2. NM_207589.3.
UniGeneiRn.103178.

Genome annotation databases

GeneIDi290549.
KEGGirno:290549.
UCSCiRGD:1303129. rat.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY319924 mRNA. Translation: AAP73816.1. Sequence problems.
BC088086 mRNA. Translation: AAH88086.2.
RefSeqiNP_997472.2. NM_207589.3.
UniGeneiRn.103178.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020284.

Proteomic databases

PaxDbiP59798.
PRIDEiP59798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi290549.
KEGGirno:290549.
UCSCiRGD:1303129. rat.

Organism-specific databases

CTDi58515.
RGDi1303129. Selk.

Phylogenomic databases

eggNOGiENOG410J0AZ. Eukaryota.
ENOG410XWKI. LUCA.
HOGENOMiHOG000013002.
HOVERGENiHBG108467.
InParanoidiP59798.
OrthoDBiEOG747PN7.
PhylomeDBiP59798.
TreeFamiTF328380.

Miscellaneous databases

NextBioi631181.
PROiP59798.

Family and domain databases

InterProiIPR024491. Se_SelK/SelG.
[Graphical view]
PfamiPF10961. DUF2763. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rattus norvegicus heat shock protein."
    Zhou L., Guo J., Ma Y.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain stem.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiSELK_RAT
AccessioniPrimary (citable) accession number: P59798
Secondary accession number(s): Q5I0Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: February 26, 2008
Last modified: January 20, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.