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Protein

Selenoprotein V

Gene

SELV

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in a redox-related process.Curated

Enzyme and pathway databases

BioCyciZFISH:G66-31074-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein V
Short name:
SelV
Gene namesi
Name:SELV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186838.

Polymorphism and mutation databases

BioMutaiSELV.
DMDMi190358771.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976751 – 346Selenoprotein VAdd BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki270 ↔ 273Cysteinyl-selenocysteine (Cys-Sec); redox-activeBy similarity

Proteomic databases

PaxDbiP59797.
PRIDEiP59797.

PTM databases

iPTMnetiP59797.
PhosphoSitePlusiP59797.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSG00000186838.

Organism-specific databases

HPAiHPA059274.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-10216195,EBI-743771
GOLGA2Q083793EBI-10216195,EBI-618309
PRR20CP864793EBI-10216195,EBI-10172814
ZMIZ2Q8NF64-23EBI-10216195,EBI-10182121
ZMYND19Q96E355EBI-10216195,EBI-746595

Protein-protein interaction databases

BioGridi131519. 6 interactors.
IntActiP59797. 5 interactors.
STRINGi9606.ENSP00000333956.

Structurei

3D structure databases

ProteinModelPortaliP59797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SelWTH family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG410JC16. Eukaryota.
ENOG410XZD9. LUCA.
GeneTreeiENSGT00530000064138.
HOGENOMiHOG000169734.
HOVERGENiHBG108471.
InParanoidiP59797.
OMAiDFTFRAD.
PhylomeDBiP59797.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10262. Rdx. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.

Sequencei

Sequence statusi: Complete.

P59797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNQARTPAP SSARTSTSVR ASTPTRTPTP LRTPTPVRTR TPIRTLTPVL
60 70 80 90 100
TPSPAGTSPL VLTPAPAQIP TLVPTPALAR IPRLVPPPAP AWIPTPVPTP
110 120 130 140 150
VPVRNPTPVP TPARTLTPPV RVPAPAPAQL LAGIRAALPV LDSYLAPALP
160 170 180 190 200
LDPPPEPAPE LPLLPEEDPE PAPSLKLIPS VSSEAGPAPG PLPTRTPLAA
210 220 230 240 250
NSPGPTLDFT FRADPSAIGL ADPPIPSPVP SPILGTIPSA ISLQNCTETF
260 270 280 290 300
PSSSENFALD KRVLIRVTYC GLUSYSLRYI LLKKSLEQQF PNHLLFEEDR
310 320 330 340
AAQATGEFEV FVNGRLVHSK KRGDGFVNES RLQKIVSVID EEIKKR
Length:346
Mass (Da):36,800
Last modified:February 26, 2008 - v2
Checksum:iE11FEC8A4E232A28
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061790284K → R.Corresponds to variant rs56149652dbSNPEnsembl.1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei273Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324825 mRNA. Translation: AAP85542.1.
BC117331 mRNA. Translation: AAI17332.1.
CCDSiCCDS54266.1.
RefSeqiNP_874363.1. NM_182704.1.
UniGeneiHs.319284.

Genome annotation databases

GeneIDi348303.
KEGGihsa:348303.

Keywords - Coding sequence diversityi

Polymorphism, Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324825 mRNA. Translation: AAP85542.1.
BC117331 mRNA. Translation: AAI17332.1.
CCDSiCCDS54266.1.
RefSeqiNP_874363.1. NM_182704.1.
UniGeneiHs.319284.

3D structure databases

ProteinModelPortaliP59797.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131519. 6 interactors.
IntActiP59797. 5 interactors.
STRINGi9606.ENSP00000333956.

PTM databases

iPTMnetiP59797.
PhosphoSitePlusiP59797.

Polymorphism and mutation databases

BioMutaiSELV.
DMDMi190358771.

Proteomic databases

PaxDbiP59797.
PRIDEiP59797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi348303.
KEGGihsa:348303.

Organism-specific databases

CTDi348303.
GeneCardsiSELV.
H-InvDBHIX0202931.
HPAiHPA059274.
MIMi607919. gene.
neXtProtiNX_P59797.
OpenTargetsiENSG00000186838.

Phylogenomic databases

eggNOGiENOG410JC16. Eukaryota.
ENOG410XZD9. LUCA.
GeneTreeiENSGT00530000064138.
HOGENOMiHOG000169734.
HOVERGENiHBG108471.
InParanoidiP59797.
OMAiDFTFRAD.
PhylomeDBiP59797.

Enzyme and pathway databases

BioCyciZFISH:G66-31074-MONOMER.

Miscellaneous databases

GenomeRNAii348303.
PROiP59797.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186838.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10262. Rdx. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSELV_HUMAN
AccessioniPrimary (citable) accession number: P59797
Secondary accession number(s): Q17RG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.