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Reviewed, UniProtKB/Swiss-Prot P59796 (GPX6_HUMAN)

Last modified June 16, 2009. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glutathione peroxidase 6
    EC=1.11.1.9
Gene names
Name: GPX6
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed in olfactory epithelium and embryos. Ref.1

Sequence similarities

Belongs to the glutathione peroxidase family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
Selenocysteine
   DomainSignal
   LigandSelenium
   Molecular functionOxidoreductase
Peroxidase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

response to oxidative stress

Inferred from electronic annotation. Source: InterPro

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglutathione peroxidase activity

Inferred from electronic annotation. Source: EC

selenium binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 221202Glutathione peroxidase 6
PRO_0000013081

Sites

Active site731 By similarity

Amino acid modifications

Non-standard residue731Selenocysteine

Natural variations

Natural variant61Q → L Ref.2
VAR_025249
Natural variant131F → L: dbSNP rs406113. Ref.2
VAR_025250
Natural variant531Y → H: dbSNP rs34825130. Ref.2
VAR_025251
Natural variant581Q → H: dbSNP rs6922986. Ref.2
VAR_025252
Natural variant721Y → N: dbSNP rs35062161. Ref.2
VAR_025253
Natural variant1361E → D: dbSNP rs35394555. Ref.2
VAR_025254
Natural variant1401V → M Ref.2
VAR_025255
Natural variant1571P → S Ref.2
VAR_025256
Natural variant1611D → G Ref.2
VAR_025257
Natural variant1881V → A: dbSNP rs35701070. Ref.2
VAR_025258

Sequences

Sequence LengthMass (Da)Tools
P59796-1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: E9B48AF5F17C3FDD

FASTA22124,971
        10         20         30         40         50         60 
MFQQFQASCL VLFFLVGFAQ QTLKPQNRKV DCNKGVTGTI YEYGALTLNG EEYIQFKQFA 

        70         80         90        100        110        120 
GKHVLFVNVA AYUGLAAQYP ELNALQEELK NFGVIVLAFP CNQFGKQEPG TNSEILLGLK 

       130        140        150        160        170        180 
YVCPGSGFVP SFQLFEKGDV NGEKEQKVFT FLKNSCPPTS DLLGSSSQLF WEPMKVHDIR 

       190        200        210        220 
WNFEKFLVGP DGVPVMHWFH QAPVSTVKSD ILEYLKQFNT H 

« Hide

References

[1]"Characterization of mammalian selenoproteomes."
Kryukov G.V., Castellano S., Novoselov S.V., Lobanov A.V., Zehtab O., Guigo R., Gladyshev V.N.
Science 300:1439-1443(2003) [PubMed: 12775843] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]NIEHS SNPs program
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-6; LEU-13; HIS-53; HIS-58; ASN-72; ASP-136; MET-140; SER-157; GLY-161 AND ALA-188.

Web resources

Cross-references

Sequence databases

AY324826 mRNA. Translation: AAP85543.1.
DQ088982 Genomic DNA. Translation: AAY68223.1.
IPIIPI00335668.
RefSeqNP_874360.1.
UniGeneHs.448570

3D structure databases

ModBaseSearch...

Protein family/group databases

PeroxiBase3605. HsGPx06.

Genome annotation databases

EnsemblENSG00000198704. Homo sapiens. [Contig view]
GeneID257202.
KEGGhsa:257202.

Organism-specific databases

GeneCardsGC06M028579.
H-InvDBHIX0032860.
HGNCHGNC:4558. GPX6.
MIM607913. gene.
PharmGKBPA28954.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP59796.
HOVERGENP59796.
OMAP59796. VGFAQQT.

Enzyme and pathway databases

BRENDA1.11.1.9. 247.

Gene expression databases

CleanExHS_GPX6.

Family and domain databases

InterProIPR000889. Glutathione_peroxidase.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHERPTHR11592. Glut_peroxidase. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00143. Glutathione.
NextBio92965.
SOURCESearch...

Entry information

Entry nameGPX6_HUMAN
AccessionPrimary (citable) accession number: P59796
Secondary accession number(s): Q4PJ17
Entry history
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: February 26, 2008
Last modified: June 16, 2009
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents