Reviewed, UniProtKB/Swiss-Prot P59796 (GPX6_HUMAN)

Names and origin

Protein names

Recommended name:
    Glutathione peroxidase 6
    EC=1.11.1.9

Gene names

Name:

GPX6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed in olfactory epithelium and embryos. Ref.1
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism Selenocysteine
Domain	Signal
Ligand	Selenium
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC selenium binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 221	202	Glutathione peroxidase 6		PRO_0000013081
Sites
	Active site	73	1	By similarity
Amino acid modifications
	Non-standard residue	73	1	Selenocysteine
Natural variations
	Natural variant	6	1	Q → L Ref.2		VAR_025249
	Natural variant	13	1	F → L: dbSNP rs406113. Ref.2		VAR_025250
	Natural variant	53	1	Y → H: dbSNP rs34825130. Ref.2		VAR_025251
	Natural variant	58	1	Q → H: dbSNP rs6922986. Ref.2		VAR_025252
	Natural variant	72	1	Y → N: dbSNP rs35062161. Ref.2		VAR_025253
	Natural variant	136	1	E → D: dbSNP rs35394555. Ref.2		VAR_025254
	Natural variant	140	1	V → M Ref.2		VAR_025255
	Natural variant	157	1	P → S Ref.2		VAR_025256
	Natural variant	161	1	D → G Ref.2		VAR_025257
	Natural variant	188	1	V → A: dbSNP rs35701070. Ref.2		VAR_025258

Sequences

	Sequence		Length	Mass (Da)
	P59796-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: E9B48AF5F17C3FDD	FASTA	221	24,971
	10 20 30 40 50 60 MFQQFQASCL VLFFLVGFAQ QTLKPQNRKV DCNKGVTGTI YEYGALTLNG EEYIQFKQFA 70 80 90 100 110 120 GKHVLFVNVA AYUGLAAQYP ELNALQEELK NFGVIVLAFP CNQFGKQEPG TNSEILLGLK 130 140 150 160 170 180 YVCPGSGFVP SFQLFEKGDV NGEKEQKVFT FLKNSCPPTS DLLGSSSQLF WEPMKVHDIR 190 200 210 220 WNFEKFLVGP DGVPVMHWFH QAPVSTVKSD ILEYLKQFNT H

References

[1]	"Characterization of mammalian selenoproteomes." Kryukov G.V., Castellano S., Novoselov S.V., Lobanov A.V., Zehtab O., Guigo R., Gladyshev V.N. Science 300:1439-1443(2003) [PubMed: 12775843] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	NIEHS SNPs program Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-6; LEU-13; HIS-53; HIS-58; ASN-72; ASP-136; MET-140; SER-157; GLY-161 AND ALA-188.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY324826 mRNA. Translation: AAP85543.1. DQ088982 Genomic DNA. Translation: AAY68223.1.
IPI	IPI00335668.
RefSeq	NP_874360.1.
UniGene	Hs.448570
3D structure databases
ModBase	Search...
Protein family/group databases
PeroxiBase	3605. HsGPx06.
Genome annotation databases
Ensembl	ENSG00000198704. Homo sapiens. [Contig view]
GeneID	257202.
KEGG	hsa:257202.
Organism-specific databases
GeneCards	GC06M028579.
H-InvDB	HIX0032860.
HGNC	HGNC:4558. GPX6.
MIM	607913. gene.
PharmGKB	PA28954.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P59796.
HOVERGEN	P59796.
OMA	P59796. VGFAQQT.
Enzyme and pathway databases
BRENDA	1.11.1.9. 247.
Gene expression databases
CleanEx	HS_GPX6.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00143. Glutathione.
NextBio	92965.
SOURCE	Search...

Entry information

Entry name

GPX6_HUMAN

Accession

Primary (citable) accession number: P59796
Secondary accession number(s): Q4PJ17

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 4, 2003
Last sequence update:	February 26, 2008
Last modified:	June 16, 2009
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)