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Protein

AP-3 complex subunit sigma-2

Gene

AP3S2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-31962-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit sigma-2
Alternative name(s):
AP-3 complex subunit sigma-3B
Adaptor-related protein complex 3 subunit sigma-2
Sigma-3B-adaptin
Short name:
Sigma3B-adaptin
Sigma-adaptin 3b
Gene namesi
Name:AP3S2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:571. AP3S2.

Subcellular locationi

GO - Cellular componenti

  • AP-3 adaptor complex Source: FlyBase
  • axon cytoplasm Source: GOC
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: ProtInc
  • intracellular membrane-bounded organelle Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10239.
OpenTargetsiENSG00000157823.
PharmGKBiPA24863.

Polymorphism and mutation databases

BioMutaiAP3S2.
DMDMi33112220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938171 – 193AP-3 complex subunit sigma-2Add BLAST193

Proteomic databases

EPDiP59780.
PaxDbiP59780.
PeptideAtlasiP59780.
PRIDEiP59780.

PTM databases

iPTMnetiP59780.
PhosphoSitePlusiP59780.

Expressioni

Tissue specificityi

Present in all adult tissues examined.1 Publication

Gene expression databases

BgeeiENSG00000157823.
CleanExiHS_AP3S2.
ExpressionAtlasiP59780. baseline and differential.
GenevisibleiP59780. HS.

Organism-specific databases

HPAiHPA049270.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi115533. 12 interactors.
IntActiP59780. 2 interactors.
STRINGi9606.ENSP00000338777.

Structurei

3D structure databases

ProteinModelPortaliP59780.
SMRiP59780.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0936. Eukaryota.
COG5030. LUCA.
GeneTreeiENSGT00550000074761.
HOGENOMiHOG000185228.
HOVERGENiHBG050517.
InParanoidiP59780.
KOiK12399.
PhylomeDBiP59780.
TreeFamiTF300189.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P59780-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIQAILVFNN HGKPRLVRFY QRFPEEIQQQ IVRETFHLVL KRDDNICNFL
60 70 80 90 100
EGGSLIGGSD YKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC
110 120 130 140 150
FENVCELDLI FHMDKVHYIL QEVVMGGMVL ETNMNEIVAQ IEAQNRLEKS
160 170 180 190
EGGLSAAPAR AVSAVKNINL PEIPRNINIG DLNIKVPNLS QFV
Length:193
Mass (Da):22,017
Last modified:July 19, 2003 - v1
Checksum:iD219EF4A989316EA
GO
Isoform C15orf38-AP3S2 (identifier: Q7Z6K5-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q7Z6K5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a C15orf38-AP3S2 fusion protein.
Length:394
Mass (Da):43,882
GO
Isoform 3 (identifier: P59780-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-124: VFVETLDKCFENVCELDLIFHMDKVHYILQEVV → LKKRERKKSQCNTLQTGTLALWEQGPDIRTRRL
     125-193: Missing.

Note: No experimental confirmation available.
Show »
Length:124
Mass (Da):14,592
Checksum:i98788985D4597692
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84L → I in BAG35374 (PubMed:14702039).Curated1
Sequence conflicti127G → W in BAD96418 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05367392 – 124VFVET…LQEVV → LKKRERKKSQCNTLQTGTLA LWEQGPDIRTRRL in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_053674125 – 193Missing in isoform 3. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99459 mRNA. Translation: CAA67824.1.
AK294712 mRNA. Translation: BAG57864.1.
AK312467 mRNA. Translation: BAG35374.1.
AK222698 mRNA. Translation: BAD96418.1.
AC018988 Genomic DNA. No translation available.
AC027176 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02074.1.
BC002785 mRNA. Translation: AAH02785.1.
BC010020 mRNA. Translation: AAH10020.1.
CCDSiCCDS10357.1. [P59780-1]
RefSeqiNP_005820.1. NM_005829.4. [P59780-1]
UniGeneiHs.632161.

Genome annotation databases

EnsembliENST00000336418; ENSP00000338777; ENSG00000157823. [P59780-1]
ENST00000423566; ENSP00000394170; ENSG00000157823. [P59780-2]
ENST00000560251; ENSP00000453288; ENSG00000157823. [P59780-2]
GeneIDi10239.
KEGGihsa:10239.
UCSCiuc002boq.5. human. [P59780-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99459 mRNA. Translation: CAA67824.1.
AK294712 mRNA. Translation: BAG57864.1.
AK312467 mRNA. Translation: BAG35374.1.
AK222698 mRNA. Translation: BAD96418.1.
AC018988 Genomic DNA. No translation available.
AC027176 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02074.1.
BC002785 mRNA. Translation: AAH02785.1.
BC010020 mRNA. Translation: AAH10020.1.
CCDSiCCDS10357.1. [P59780-1]
RefSeqiNP_005820.1. NM_005829.4. [P59780-1]
UniGeneiHs.632161.

3D structure databases

ProteinModelPortaliP59780.
SMRiP59780.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115533. 12 interactors.
IntActiP59780. 2 interactors.
STRINGi9606.ENSP00000338777.

PTM databases

iPTMnetiP59780.
PhosphoSitePlusiP59780.

Polymorphism and mutation databases

BioMutaiAP3S2.
DMDMi33112220.

Proteomic databases

EPDiP59780.
PaxDbiP59780.
PeptideAtlasiP59780.
PRIDEiP59780.

Protocols and materials databases

DNASUi10239.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336418; ENSP00000338777; ENSG00000157823. [P59780-1]
ENST00000423566; ENSP00000394170; ENSG00000157823. [P59780-2]
ENST00000560251; ENSP00000453288; ENSG00000157823. [P59780-2]
GeneIDi10239.
KEGGihsa:10239.
UCSCiuc002boq.5. human. [P59780-1]

Organism-specific databases

CTDi10239.
DisGeNETi10239.
GeneCardsiAP3S2.
HGNCiHGNC:571. AP3S2.
HPAiHPA049270.
MIMi602416. gene.
neXtProtiNX_P59780.
OpenTargetsiENSG00000157823.
PharmGKBiPA24863.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0936. Eukaryota.
COG5030. LUCA.
GeneTreeiENSGT00550000074761.
HOGENOMiHOG000185228.
HOVERGENiHBG050517.
InParanoidiP59780.
KOiK12399.
PhylomeDBiP59780.
TreeFamiTF300189.

Enzyme and pathway databases

BioCyciZFISH:G66-31962-MONOMER.

Miscellaneous databases

ChiTaRSiAP3S2. human.
GeneWikiiAP3S2.
GenomeRNAii10239.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157823.
CleanExiHS_AP3S2.
ExpressionAtlasiP59780. baseline and differential.
GenevisibleiP59780. HS.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP3S2_HUMAN
AccessioniPrimary (citable) accession number: P59780
Secondary accession number(s): B2R677
, B4DGQ3, O09077, O09149, Q53H83, Q99589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.