P59780 (AP3S2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
AP-3 complex subunit sigma-2

Alternative name(s):
AP-3 complex subunit sigma-3B
Adapter-related protein complex 3 sigma-2 subunit
Sigma-3B-adaptin
Short name=Sigma3B-adaptin
Sigma-adaptin 3b

Gene names

Name:

AP3S2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subunit structure	Adapter protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex By similarity.
Subcellular location	Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex By similarity.
Tissue specificity	Present in all adult tissues examined. Ref.1
Sequence similarities	Belongs to the adaptor complexes small subunit family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasmic vesicle Golgi apparatus Membrane
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterograde axon cargo transport Inferred from sequence or structural similarity. Source: UniProtKB anterograde synaptic vesicle transport Inferred from sequence or structural similarity. Source: UniProtKB intracellular protein transport Traceable author statement Ref.1. Source: ProtInc
Cellular_component	AP-3 adaptor complex Inferred from direct assay Ref.1. Source: FlyBase Golgi apparatus Traceable author statement Ref.1. Source: ProtInc cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	AP-3 complex subunit sigma-2		PRO_0000193817

Sequences

	Sequence		Length	Mass (Da)
	P59780 [UniParc]. Last modified July 19, 2003. Version 1. Checksum: D219EF4A989316EA	FASTA	193	22,017
	10 20 30 40 50 60 MIQAILVFNN HGKPRLVRFY QRFPEEIQQQ IVRETFHLVL KRDDNICNFL EGGSLIGGSD 70 80 90 100 110 120 YKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHMDKVHYIL 130 140 150 160 170 180 QEVVMGGMVL ETNMNEIVAQ IEAQNRLEKS EGGLSAAPAR AVSAVKNINL PEIPRNINIG 190 DLNIKVPNLS QFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"AP-3: an adaptor-like protein complex with ubiquitous expression." Dell'Angelica E.C., Ohno H., Ooi C.E., Rabinovich E., Roche K.W., Bonifacino J.S. EMBO J. 16:917-928(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X99459 mRNA. Translation: CAA67824.1. BC002785 mRNA. Translation: AAH02785.1. BC010020 mRNA. Translation: AAH10020.1.
IPI	IPI00025115.
RefSeq	NP_005820.1. NM_005829.4.
UniGene	Hs.632161.
3D structure databases
ProteinModelPortal	P59780.
ModBase	Search...
Protein-protein interaction databases
IntAct	P59780. 1 interaction.
STRING	9606.ENSP00000338777.
PTM databases
PhosphoSite	P59780.
Polymorphism databases
DMDM	33112220.
Proteomic databases
PaxDb	P59780.
PRIDE	P59780.
Protocols and materials databases
DNASU	10239.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000336418; ENSP00000338777; ENSG00000157823.
GeneID	10239.
KEGG	hsa:10239.
UCSC	uc002boq.4. human.
Organism-specific databases
CTD	10239.
GeneCards	GC15M090373.
HGNC	HGNC:571. AP3S2.
MIM	602416. gene.
neXtProt	NX_P59780.
PharmGKB	PA24863.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5030.
HOGENOM	HOG000185228.
HOVERGEN	HBG050517.
InParanoid	P59780.
KO	K12399.
OMA	IFHADAV.
OrthoDB	EOG4GF3G5.
PhylomeDB	P59780.
Gene expression databases
ArrayExpress	P59780.
Bgee	P59780.
CleanEx	HS_AP3S2.
Genevestigator	P59780.
GermOnline	ENSG00000157823. Homo sapiens.
Family and domain databases
InterPro	IPR016635. AP_complex_ssu. IPR022775. AP_mu_sigma_su. IPR027155. APS3. IPR000804. Clathrin_sm-chain_CS. IPR011012. Longin-like_dom. [Graphical view]
PANTHER	PTHR11753. PTHR11753. 1 hit. PTHR11753:SF2. PTHR11753:SF2. 1 hit.
Pfam	PF01217. Clat_adaptor_s. 1 hit. [Graphical view]
PIRSF	PIRSF015588. AP_complex_sigma. 1 hit.
SUPFAM	SSF64356. Longin_like. 1 hit.
PROSITE	PS00989. CLAT_ADAPTOR_S. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	AP3S2. human.
GenomeRNAi	10239.
NextBio	38788.
SOURCE	Search...

Entry information

Entry name

AP3S2_HUMAN

Accession

Primary (citable) accession number: P59780
Secondary accession number(s): O09077, O09149, Q99589

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	July 19, 2003
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.