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Protein

Membrane protein

Gene

M

Organism
Porcine epidemic diarrhea virus (strain CV777) (PEDV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein
Short name:
M protein
Alternative name(s):
E1 glycoprotein
Matrix glycoprotein
Membrane glycoprotein
Gene namesi
Name:M
ORF Names:5
OrganismiPorcine epidemic diarrhea virus (strain CV777) (PEDV)
Taxonomic identifieri229032 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000008159 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17Virion surfaceSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 41IntravirionSequence analysis3
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 75Virion surfaceSequence analysisAdd BLAST13
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 226IntravirionSequence analysisAdd BLAST130

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001060401 – 226Membrane proteinAdd BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP59771.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the coronaviruses M protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000NM.

Family and domain databases

InterProiView protein in InterPro
IPR002574. Corona_M.
PfamiView protein in Pfam
PF01635. Corona_M. 1 hit.

Sequencei

Sequence statusi: Complete.

P59771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNGSIPVDE VIEHLRNWNF TWNIILTILL VVLQYGHYKY SVFLYGVKMA
60 70 80 90 100
ILWILWPLVL ALSLFDAWAS FQVNWVFFAF SILMACITLM LWIMYFVNSI
110 120 130 140 150
RLWRRTHSWW SFNPETDALL TTSVMGRQVC IPVLGAPTGV TLTLLSGTLF
160 170 180 190 200
VEGYKVATGV QVSQLPNFVT VAKATTTIVY GRVGRSVNAS SGTGWAFYVR
210 220
SKHGDYSAVS NPSAVLTDSE KVLHLV
Length:226
Mass (Da):25,410
Last modified:July 11, 2003 - v1
Checksum:i46B79453DE42F67B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti150F → L. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24733 Genomic RNA. Translation: CAA80857.1.
AF353511 Genomic RNA. Translation: AAK38659.1.
Z14976 Genomic RNA. Translation: CAA78699.1.
PIRiS37434.
RefSeqiNP_598313.1. NC_003436.1.

Genome annotation databases

GeneIDi935182.
KEGGivg:935182.

Similar proteinsi

Entry informationi

Entry nameiVME1_PEDV7
AccessioniPrimary (citable) accession number: P59771
Secondary accession number(s): Q07504, Q91AU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome