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P59769

- GRP78_ASPAW

UniProt

P59769 - GRP78_ASPAW

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Protein

78 kDa glucose-regulated protein homolog

Gene

bipA

Organism
Aspergillus awamori (Black koji mold)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB

GO - Biological processi

  1. response to unfolded protein Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name:
BiP
Gene namesi
Name:bipA
Synonyms:bip
OrganismiAspergillus awamori (Black koji mold)
Taxonomic identifieri105351 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence AnalysisAdd
BLAST
Chaini39 – 67263478 kDa glucose-regulated protein homologPRO_0000013577Add
BLAST

Proteomic databases

PRIDEiP59769.

Expressioni

Inductioni

By heat shock and tunicamycin. Not induced by carbon source starvation.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP59769.
SMRiP59769. Positions 49-589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi669 – 6724Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59769-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARISHQGAA KPFTAWTTIF YLLLVFIAPL AFFGTAHAQD ETSPQESYGT
60 70 80 90 100
VIGIDLGTTY SCVGVMQNGK VEILVNDQGN RITPSYVAFT DEERLVGDAA
110 120 130 140 150
KNQYAANPRR TIFDIKRLIG RKFDDKDVQK DAKHFPYKVV NKDGKPHVKV
160 170 180 190 200
DVNQTPKTLT PEEVSAMVLG KMKEIAEGYL GKKVTHAVVT VPAYFNDAQR
210 220 230 240 250
QATKDAGTIA GLNVLRVVNE PTAAAIAYGL DKTGDERQVI VYDLGGGTFD
260 270 280 290 300
VSLLSIDNGV FEVLATAGDT HLGGEDFDQR VMDHFVKLYN KKNNVDVTKD
310 320 330 340 350
LKAMGKLKRE VEKAKRTLSS QMSTRIEIEA FHNGEDFSET LTRAKFEELN
360 370 380 390 400
MDLFKKTLKP VEQVLKDAKV KKSEVDDIVL VGGSTRIPKV QALLEEFFGG
410 420 430 440 450
KKASKGINPD EAVAFGAAVQ GGVLSGEEGT GDVVLMDVNP LTLGIETTGG
460 470 480 490 500
VMTKLIPRNT VIPTRKSQIF STAADNQPTV LIQVYEGERS LTKDNNLLGK
510 520 530 540 550
FELTGIPPAP RGVPQIEVSF DLDANGILKV HASDKGTGKA ESITITNDKG
560 570 580 590 600
RLSQEEIDRM VAEAEEFAEE DKAIKAKIEA RNTLENYAFS LKNQVNDENG
610 620 630 640 650
LGGQIDEDDK QTILDAVKEV TEWLEDNAAT ATTEDFEEQK EQLSNVAYPI
660 670
TSKLYGSAPA DEDDEPSGHD EL
Length:672
Mass (Da):73,459
Last modified:July 11, 2003 - v1
Checksum:iC701807FCE08C175
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti316 – 3161R → G in CAA73106. (PubMed:9294262)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08867 Genomic DNA. Translation: CAA70090.1.
Y12504 Genomic DNA. Translation: CAA73106.1.
PIRiT43723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08867 Genomic DNA. Translation: CAA70090.1 .
Y12504 Genomic DNA. Translation: CAA73106.1 .
PIRi T43723.

3D structure databases

ProteinModelPortali P59769.
SMRi P59769. Positions 49-589.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P59769.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The ER chaperone encoding bipA gene of black Aspergilli is induced by heat shock and unfolded proteins."
    van Gemeren I.A., Punt P.J., Drint-Kuyvenhoven A., Broekhuijsen M.P., van't Hoog A., Beijersbergen A., Verrips C.T., van den Hondel C.A.M.J.J.
    Gene 198:43-52(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    Strain: ATCC 11358 / K-6615 / CBS 115.52.
  2. "Characterization of the bip gene of Aspergillus awamori encoding a protein with an HDEL retention signal homologous to the mammalian BiP involved in polypeptide secretion."
    Hijarrubia M.J., Casqueiro J., Gutierrez S., Fernandez F.J., Martin J.F.
    Curr. Genet. 32:139-146(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 22342 / NRRL 3112.

Entry informationi

Entry nameiGRP78_ASPAW
AccessioniPrimary (citable) accession number: P59769
Secondary accession number(s): O13280, O14453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3