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P59769

- GRP78_ASPAW

UniProt

P59769 - GRP78_ASPAW

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Protein

78 kDa glucose-regulated protein homolog

Gene
bipA, bip
Organism
Aspergillus awamori (Black koji mold)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB

GO - Biological processi

  1. response to unfolded protein Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name:
BiP
Gene namesi
Name:bipA
Synonyms:bip
OrganismiAspergillus awamori (Black koji mold)
Taxonomic identifieri105351 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838 Reviewed predictionAdd
BLAST
Chaini39 – 67263478 kDa glucose-regulated protein homologPRO_0000013577Add
BLAST

Proteomic databases

PRIDEiP59769.

Expressioni

Inductioni

By heat shock and tunicamycin. Not induced by carbon source starvation.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP59769.
SMRiP59769. Positions 49-589.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi669 – 6724Prevents secretion from ER By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59769-1 [UniParc]FASTAAdd to Basket

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MARISHQGAA KPFTAWTTIF YLLLVFIAPL AFFGTAHAQD ETSPQESYGT    50
VIGIDLGTTY SCVGVMQNGK VEILVNDQGN RITPSYVAFT DEERLVGDAA 100
KNQYAANPRR TIFDIKRLIG RKFDDKDVQK DAKHFPYKVV NKDGKPHVKV 150
DVNQTPKTLT PEEVSAMVLG KMKEIAEGYL GKKVTHAVVT VPAYFNDAQR 200
QATKDAGTIA GLNVLRVVNE PTAAAIAYGL DKTGDERQVI VYDLGGGTFD 250
VSLLSIDNGV FEVLATAGDT HLGGEDFDQR VMDHFVKLYN KKNNVDVTKD 300
LKAMGKLKRE VEKAKRTLSS QMSTRIEIEA FHNGEDFSET LTRAKFEELN 350
MDLFKKTLKP VEQVLKDAKV KKSEVDDIVL VGGSTRIPKV QALLEEFFGG 400
KKASKGINPD EAVAFGAAVQ GGVLSGEEGT GDVVLMDVNP LTLGIETTGG 450
VMTKLIPRNT VIPTRKSQIF STAADNQPTV LIQVYEGERS LTKDNNLLGK 500
FELTGIPPAP RGVPQIEVSF DLDANGILKV HASDKGTGKA ESITITNDKG 550
RLSQEEIDRM VAEAEEFAEE DKAIKAKIEA RNTLENYAFS LKNQVNDENG 600
LGGQIDEDDK QTILDAVKEV TEWLEDNAAT ATTEDFEEQK EQLSNVAYPI 650
TSKLYGSAPA DEDDEPSGHD EL 672
Length:672
Mass (Da):73,459
Last modified:July 11, 2003 - v1
Checksum:iC701807FCE08C175
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti316 – 3161R → G in CAA73106. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08867 Genomic DNA. Translation: CAA70090.1.
Y12504 Genomic DNA. Translation: CAA73106.1.
PIRiT43723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08867 Genomic DNA. Translation: CAA70090.1 .
Y12504 Genomic DNA. Translation: CAA73106.1 .
PIRi T43723.

3D structure databases

ProteinModelPortali P59769.
SMRi P59769. Positions 49-589.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P59769.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The ER chaperone encoding bipA gene of black Aspergilli is induced by heat shock and unfolded proteins."
    van Gemeren I.A., Punt P.J., Drint-Kuyvenhoven A., Broekhuijsen M.P., van't Hoog A., Beijersbergen A., Verrips C.T., van den Hondel C.A.M.J.J.
    Gene 198:43-52(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    Strain: ATCC 11358 / K-6615 / CBS 115.52.
  2. "Characterization of the bip gene of Aspergillus awamori encoding a protein with an HDEL retention signal homologous to the mammalian BiP involved in polypeptide secretion."
    Hijarrubia M.J., Casqueiro J., Gutierrez S., Fernandez F.J., Martin J.F.
    Curr. Genet. 32:139-146(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 22342 / NRRL 3112.

Entry informationi

Entry nameiGRP78_ASPAW
AccessioniPrimary (citable) accession number: P59769
Secondary accession number(s): O13280, O14453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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