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P59769 (GRP78_ASPAW) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
78 kDa glucose-regulated protein homolog

Short name=GRP-78
Alternative name(s):
Immunoglobulin heavy chain-binding protein homolog
Short name=BiP
Gene names
Name:bipA
Synonyms:bip
OrganismAspergillus awamori (Black koji mold)
Taxonomic identifier105351 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length672 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Induction

By heat shock and tunicamycin. Not induced by carbon source starvation. Ref.1

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Biological processStress response
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
Gene Ontology (GO)
   Biological_processresponse to unfolded protein

Inferred from direct assay Ref.1. Source: UniProtKB

   Cellular_componentendoplasmic reticulum lumen

Non-traceable author statement Ref.2Ref.1. Source: UniProtKB

   Molecular_functionATP binding

Non-traceable author statement Ref.2. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3838 Potential
Chain39 – 67263478 kDa glucose-regulated protein homolog
PRO_0000013577

Regions

Motif669 – 6724Prevents secretion from ER By similarity

Experimental info

Sequence conflict3161R → G in CAA73106. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P59769 [UniParc].

Last modified July 11, 2003. Version 1.
Checksum: C701807FCE08C175

FASTA67273,459
        10         20         30         40         50         60 
MARISHQGAA KPFTAWTTIF YLLLVFIAPL AFFGTAHAQD ETSPQESYGT VIGIDLGTTY 

        70         80         90        100        110        120 
SCVGVMQNGK VEILVNDQGN RITPSYVAFT DEERLVGDAA KNQYAANPRR TIFDIKRLIG 

       130        140        150        160        170        180 
RKFDDKDVQK DAKHFPYKVV NKDGKPHVKV DVNQTPKTLT PEEVSAMVLG KMKEIAEGYL 

       190        200        210        220        230        240 
GKKVTHAVVT VPAYFNDAQR QATKDAGTIA GLNVLRVVNE PTAAAIAYGL DKTGDERQVI 

       250        260        270        280        290        300 
VYDLGGGTFD VSLLSIDNGV FEVLATAGDT HLGGEDFDQR VMDHFVKLYN KKNNVDVTKD 

       310        320        330        340        350        360 
LKAMGKLKRE VEKAKRTLSS QMSTRIEIEA FHNGEDFSET LTRAKFEELN MDLFKKTLKP 

       370        380        390        400        410        420 
VEQVLKDAKV KKSEVDDIVL VGGSTRIPKV QALLEEFFGG KKASKGINPD EAVAFGAAVQ 

       430        440        450        460        470        480 
GGVLSGEEGT GDVVLMDVNP LTLGIETTGG VMTKLIPRNT VIPTRKSQIF STAADNQPTV 

       490        500        510        520        530        540 
LIQVYEGERS LTKDNNLLGK FELTGIPPAP RGVPQIEVSF DLDANGILKV HASDKGTGKA 

       550        560        570        580        590        600 
ESITITNDKG RLSQEEIDRM VAEAEEFAEE DKAIKAKIEA RNTLENYAFS LKNQVNDENG 

       610        620        630        640        650        660 
LGGQIDEDDK QTILDAVKEV TEWLEDNAAT ATTEDFEEQK EQLSNVAYPI TSKLYGSAPA 

       670 
DEDDEPSGHD EL 

« Hide

References

[1]"The ER chaperone encoding bipA gene of black Aspergilli is induced by heat shock and unfolded proteins."
van Gemeren I.A., Punt P.J., Drint-Kuyvenhoven A., Broekhuijsen M.P., van't Hoog A., Beijersbergen A., Verrips C.T., van den Hondel C.A.M.J.J.
Gene 198:43-52(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
Strain: ATCC 11358 / K-6615 / CBS 115.52.
[2]"Characterization of the bip gene of Aspergillus awamori encoding a protein with an HDEL retention signal homologous to the mammalian BiP involved in polypeptide secretion."
Hijarrubia M.J., Casqueiro J., Gutierrez S., Fernandez F.J., Martin J.F.
Curr. Genet. 32:139-146(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 22342 / NRRL 3112.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08867 Genomic DNA. Translation: CAA70090.1.
Y12504 Genomic DNA. Translation: CAA73106.1.
PIRT43723.

3D structure databases

ProteinModelPortalP59769.
SMRP59769. Positions 49-589.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP59769.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
SUPFAMSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGRP78_ASPAW
AccessionPrimary (citable) accession number: P59769
Secondary accession number(s): O13280, O14453
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families