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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Gene

GNG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).By similarity

GO - Molecular functioni

  • G-protein beta-subunit binding Source: UniProtKB
  • signal transducer activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-202040. G-protein activation.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-392170. ADP signalling through P2Y purinoceptor 12.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-500657. Presynaptic function of Kainate receptors.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
SignaLinkiP59768.
SIGNORiP59768.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Alternative name(s):
G gamma-I
Gene namesi
Name:GNG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:4404. GNG2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28784.

Chemistry

DrugBankiDB01159. Halothane.

Polymorphism and mutation databases

BioMutaiGNG2.
DMDMi32699499.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 6867Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2PRO_0000012611Add
BLAST
Propeptidei69 – 713Removed in mature formBy similarityPRO_0000012612

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei68 – 681Cysteine methyl esterBy similarity
Lipidationi68 – 681S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP59768.
MaxQBiP59768.
PaxDbiP59768.
PeptideAtlasiP59768.
PRIDEiP59768.

PTM databases

iPTMnetiP59768.
PhosphoSiteiP59768.

Expressioni

Tissue specificityi

Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain.1 Publication

Gene expression databases

BgeeiENSG00000186469.
CleanExiHS_GNG2.
ExpressionAtlasiP59768. baseline and differential.
GenevisibleiP59768. HS.

Organism-specific databases

HPAiCAB018380.
HPA003534.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (PubMed:19713215).By similarity1 Publication

GO - Molecular functioni

  • G-protein beta-subunit binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119933. 31 interactions.
DIPiDIP-33949N.
IntActiP59768. 4 interactions.
MINTiMINT-8189453.
STRINGi9606.ENSP00000334448.

Structurei

Secondary structure

1
71
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 2315Combined sources
Helixi30 – 4415Combined sources
Helixi45 – 473Combined sources
Turni49 – 513Combined sources
Turni56 – 583Combined sources
Beta strandi60 – 623Combined sources
Turni63 – 664Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KFMX-ray3.45G1-68[»]
5HE0X-ray2.56G1-71[»]
5HE1X-ray3.15G1-71[»]
5HE2X-ray2.79G1-71[»]
5HE3X-ray2.74G1-71[»]
ProteinModelPortaliP59768.
SMRiP59768. Positions 8-64.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP59768.

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP59768.
KOiK07826.
PhylomeDBiP59768.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL
60 70
LTPVPASENP FREKKFFCAI L
Length:71
Mass (Da):7,850
Last modified:January 23, 2007 - v2
Checksum:iEDB74E4135E7A37A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493870 mRNA. Translation: AAM12584.1.
AL832878 mRNA. Translation: CAI46198.1.
CH471078 Genomic DNA. Translation: EAW65663.1.
BC020774 mRNA. Translation: AAH20774.1.
BC060856 mRNA. Translation: AAH60856.1.
CCDSiCCDS32082.1.
PIRiJC7290. GNG2.
RefSeqiNP_001230702.1. NM_001243773.1.
NP_001230703.1. NM_001243774.1.
NP_444292.1. NM_053064.4.
XP_006720236.1. XM_006720173.2.
XP_011535148.1. XM_011536846.2.
UniGeneiHs.187772.
Hs.709082.
Hs.723399.
Hs.741081.

Genome annotation databases

EnsembliENST00000335281; ENSP00000334448; ENSG00000186469.
ENST00000554736; ENSP00000452014; ENSG00000186469.
ENST00000555472; ENSP00000451102; ENSG00000186469.
ENST00000556752; ENSP00000451576; ENSG00000186469.
ENST00000556766; ENSP00000451231; ENSG00000186469.
ENST00000615906; ENSP00000484021; ENSG00000186469.
GeneIDi54331.
KEGGihsa:54331.
UCSCiuc001wzi.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF493870 mRNA. Translation: AAM12584.1.
AL832878 mRNA. Translation: CAI46198.1.
CH471078 Genomic DNA. Translation: EAW65663.1.
BC020774 mRNA. Translation: AAH20774.1.
BC060856 mRNA. Translation: AAH60856.1.
CCDSiCCDS32082.1.
PIRiJC7290. GNG2.
RefSeqiNP_001230702.1. NM_001243773.1.
NP_001230703.1. NM_001243774.1.
NP_444292.1. NM_053064.4.
XP_006720236.1. XM_006720173.2.
XP_011535148.1. XM_011536846.2.
UniGeneiHs.187772.
Hs.709082.
Hs.723399.
Hs.741081.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KFMX-ray3.45G1-68[»]
5HE0X-ray2.56G1-71[»]
5HE1X-ray3.15G1-71[»]
5HE2X-ray2.79G1-71[»]
5HE3X-ray2.74G1-71[»]
ProteinModelPortaliP59768.
SMRiP59768. Positions 8-64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119933. 31 interactions.
DIPiDIP-33949N.
IntActiP59768. 4 interactions.
MINTiMINT-8189453.
STRINGi9606.ENSP00000334448.

Chemistry

DrugBankiDB01159. Halothane.

PTM databases

iPTMnetiP59768.
PhosphoSiteiP59768.

Polymorphism and mutation databases

BioMutaiGNG2.
DMDMi32699499.

Proteomic databases

EPDiP59768.
MaxQBiP59768.
PaxDbiP59768.
PeptideAtlasiP59768.
PRIDEiP59768.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335281; ENSP00000334448; ENSG00000186469.
ENST00000554736; ENSP00000452014; ENSG00000186469.
ENST00000555472; ENSP00000451102; ENSG00000186469.
ENST00000556752; ENSP00000451576; ENSG00000186469.
ENST00000556766; ENSP00000451231; ENSG00000186469.
ENST00000615906; ENSP00000484021; ENSG00000186469.
GeneIDi54331.
KEGGihsa:54331.
UCSCiuc001wzi.4. human.

Organism-specific databases

CTDi54331.
GeneCardsiGNG2.
HGNCiHGNC:4404. GNG2.
HPAiCAB018380.
HPA003534.
MIMi606981. gene.
neXtProtiNX_P59768.
PharmGKBiPA28784.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP59768.
KOiK07826.
PhylomeDBiP59768.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-202040. G-protein activation.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-392170. ADP signalling through P2Y purinoceptor 12.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-500657. Presynaptic function of Kainate receptors.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
SignaLinkiP59768.
SIGNORiP59768.

Miscellaneous databases

ChiTaRSiGNG2. human.
EvolutionaryTraceiP59768.
GeneWikiiGNG2.
GenomeRNAii54331.
PROiP59768.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186469.
CleanExiHS_GNG2.
ExpressionAtlasiP59768. baseline and differential.
GenevisibleiP59768. HS.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG2_HUMAN
AccessioniPrimary (citable) accession number: P59768
Secondary accession number(s): Q5JPE2, Q6P9A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.