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P59768

- GBG2_HUMAN

UniProt

P59768 - GBG2_HUMAN

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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Gene

GNG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).By similarity

GO - Molecular functioni

  1. G-protein beta-subunit binding Source: UniProt
  2. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
  2. blood coagulation Source: Reactome
  3. cell proliferation Source: Ensembl
  4. cellular response to catecholamine stimulus Source: BHF-UCL
  5. cellular response to glucagon stimulus Source: Reactome
  6. cellular response to prostaglandin E stimulus Source: BHF-UCL
  7. energy reserve metabolic process Source: Reactome
  8. platelet activation Source: Reactome
  9. small molecule metabolic process Source: Reactome
  10. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Regulation of water balance by renal Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.
SignaLinkiP59768.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Alternative name(s):
G gamma-I
Gene namesi
Name:GNG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:4404. GNG2.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. heterotrimeric G-protein complex Source: BHF-UCL
  3. membrane Source: BHF-UCL
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28784.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 6867Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2PRO_0000012611Add
BLAST
Propeptidei69 – 713Removed in mature formBy similarityPRO_0000012612

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei68 – 681Cysteine methyl esterBy similarity
Lipidationi68 – 681S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP59768.
PaxDbiP59768.
PeptideAtlasiP59768.
PRIDEiP59768.

PTM databases

PhosphoSiteiP59768.

Expressioni

Tissue specificityi

Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain.1 Publication

Gene expression databases

BgeeiP59768.
CleanExiHS_GNG2.
ExpressionAtlasiP59768. baseline and differential.
GenevestigatoriP59768.

Organism-specific databases

HPAiCAB018380.
HPA003534.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus).By similarity

Protein-protein interaction databases

BioGridi119933. 28 interactions.
DIPiDIP-33949N.
IntActiP59768. 2 interactions.
MINTiMINT-8189453.
STRINGi9606.ENSP00000334448.

Structurei

Secondary structure

1
71
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 2315Combined sources
Helixi30 – 4415Combined sources
Helixi45 – 473Combined sources
Turni49 – 513Combined sources
Turni56 – 583Combined sources
Beta strandi60 – 623Combined sources
Turni63 – 664Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KFMX-ray3.45G1-68[»]
ProteinModelPortaliP59768.
SMRiP59768. Positions 8-64.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP59768.

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG298292.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiP59768.
KOiK07826.
PhylomeDBiP59768.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59768-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL
60 70
LTPVPASENP FREKKFFCAI L
Length:71
Mass (Da):7,850
Last modified:January 23, 2007 - v2
Checksum:iEDB74E4135E7A37A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF493870 mRNA. Translation: AAM12584.1.
AL832878 mRNA. Translation: CAI46198.1.
CH471078 Genomic DNA. Translation: EAW65663.1.
BC020774 mRNA. Translation: AAH20774.1.
BC060856 mRNA. Translation: AAH60856.1.
CCDSiCCDS32082.1.
PIRiJC7290. GNG2.
RefSeqiNP_001230702.1. NM_001243773.1.
NP_001230703.1. NM_001243774.1.
NP_444292.1. NM_053064.4.
XP_006720236.1. XM_006720173.1.
UniGeneiHs.187772.
Hs.709082.
Hs.723399.
Hs.741081.

Genome annotation databases

EnsembliENST00000335281; ENSP00000334448; ENSG00000186469.
ENST00000554736; ENSP00000452014; ENSG00000186469.
ENST00000555472; ENSP00000451102; ENSG00000186469.
ENST00000556752; ENSP00000451576; ENSG00000186469.
ENST00000556766; ENSP00000451231; ENSG00000186469.
ENST00000615906; ENSP00000484021; ENSG00000186469.
GeneIDi54331.
KEGGihsa:54331.
UCSCiuc001wzi.3. human.

Polymorphism databases

DMDMi32699499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF493870 mRNA. Translation: AAM12584.1 .
AL832878 mRNA. Translation: CAI46198.1 .
CH471078 Genomic DNA. Translation: EAW65663.1 .
BC020774 mRNA. Translation: AAH20774.1 .
BC060856 mRNA. Translation: AAH60856.1 .
CCDSi CCDS32082.1.
PIRi JC7290. GNG2.
RefSeqi NP_001230702.1. NM_001243773.1.
NP_001230703.1. NM_001243774.1.
NP_444292.1. NM_053064.4.
XP_006720236.1. XM_006720173.1.
UniGenei Hs.187772.
Hs.709082.
Hs.723399.
Hs.741081.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4KFM X-ray 3.45 G 1-68 [» ]
ProteinModelPortali P59768.
SMRi P59768. Positions 8-64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119933. 28 interactions.
DIPi DIP-33949N.
IntActi P59768. 2 interactions.
MINTi MINT-8189453.
STRINGi 9606.ENSP00000334448.

Chemistry

DrugBanki DB01159. Halothane.

PTM databases

PhosphoSitei P59768.

Polymorphism databases

DMDMi 32699499.

Proteomic databases

MaxQBi P59768.
PaxDbi P59768.
PeptideAtlasi P59768.
PRIDEi P59768.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335281 ; ENSP00000334448 ; ENSG00000186469 .
ENST00000554736 ; ENSP00000452014 ; ENSG00000186469 .
ENST00000555472 ; ENSP00000451102 ; ENSG00000186469 .
ENST00000556752 ; ENSP00000451576 ; ENSG00000186469 .
ENST00000556766 ; ENSP00000451231 ; ENSG00000186469 .
ENST00000615906 ; ENSP00000484021 ; ENSG00000186469 .
GeneIDi 54331.
KEGGi hsa:54331.
UCSCi uc001wzi.3. human.

Organism-specific databases

CTDi 54331.
GeneCardsi GC14P052292.
HGNCi HGNC:4404. GNG2.
HPAi CAB018380.
HPA003534.
MIMi 606981. gene.
neXtProti NX_P59768.
PharmGKBi PA28784.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG298292.
GeneTreei ENSGT00760000119218.
HOVERGENi HBG014983.
InParanoidi P59768.
KOi K07826.
PhylomeDBi P59768.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Regulation of water balance by renal Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.
SignaLinki P59768.

Miscellaneous databases

EvolutionaryTracei P59768.
GeneWikii GNG2.
GenomeRNAii 54331.
NextBioi 56571.
PROi P59768.
SOURCEi Search...

Gene expression databases

Bgeei P59768.
CleanExi HS_GNG2.
ExpressionAtlasi P59768. baseline and differential.
Genevestigatori P59768.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit."
    Modarressi M.H., Taylor K.E., Wolfe J.
    Biochem. Biophys. Res. Commun. 272:610-615(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph node.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2."
    Johnston C.A., Kimple A.J., Giguere P.M., Siderovski D.P.
    Structure 16:1086-1094(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN COMPLEXES WITH GNB1 AND PTH1R.
  9. Cited for: RETRACTION.

Entry informationi

Entry nameiGBG2_HUMAN
AccessioniPrimary (citable) accession number: P59768
Secondary accession number(s): Q5JPE2, Q6P9A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3