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P59764

- DOCK4_MOUSE

UniProt

P59764 - DOCK4_MOUSE

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Protein

Dedicator of cytokinesis protein 4

Gene
Dock4, Kiaa0716
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP By similarity.

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
  2. Rac GTPase activator activity Source: Ensembl

GO - Biological processi

  1. cell chemotaxis Source: UniProtKB
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 4
Gene namesi
Name:Dock4
Synonyms:Kiaa0716
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1918006. Dock4.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. endomembrane system Source: UniProtKB-SubCell
  3. membrane Source: UniProtKB
  4. stereocilium Source: HGNC
  5. stereocilium bundle Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Dock4 are involved in the cause of some cancers, which are probably due to lack of Rap1 activation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19781978Dedicator of cytokinesis protein 4PRO_0000189991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei167 – 1671Phosphotyrosine1 Publication
Modified residuei1623 – 16231Phosphoserine By similarity
Modified residuei1627 – 16271Phosphoserine By similarity
Modified residuei1629 – 16291Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP59764.
PaxDbiP59764.
PRIDEiP59764.

PTM databases

PhosphoSiteiP59764.

Expressioni

Gene expression databases

BgeeiP59764.
CleanExiMM_DOCK4.
GenevestigatoriP59764.

Interactioni

Subunit structurei

Interacts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1. Interacts with FASLG. Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP59764.
SMRiP59764. Positions 2-164, 401-576, 1187-1593.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6762SH3Add
BLAST
Domaini401 – 574174DHR-1Add
BLAST
Domaini1199 – 1605407DHR-2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1797 – 18037SH3-binding Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1642 – 1863222Ser-richAdd
BLAST
Compositional biasi1875 – 196086Pro-richAdd
BLAST

Domaini

The DHR-2 domain probably mediates the GEF activity By similarity.

Sequence similaritiesi

Belongs to the DOCK family.
Contains 1 DHR-1 domain.
Contains 1 DHR-2 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain, SH3-binding

Phylogenomic databases

eggNOGiNOG289808.
GeneTreeiENSGT00610000085806.
HOGENOMiHOG000006631.
HOVERGENiHBG051389.
InParanoidiP59764.
KOiK17697.
OMAiHLTIIQN.
OrthoDBiEOG7QNVK8.
PhylomeDBiP59764.
TreeFamiTF300423.

Family and domain databases

InterProiIPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23317. PTHR23317. 1 hit.
PfamiPF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59764-1 [UniParc]FASTAAdd to Basket

« Hide

MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN     50
PNIKGIFPSS YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW 100
KQLYVRNEGD LFHRLWHIMN EILDLRRQVL VGHLTHDRMK DVKRHITARL 150
DWGNEQLGLD LVPRKEYAMV DPEDISITEL YRLMEHRHRK KDTPVQASSH 200
HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR LNRNGLPKAP 250
DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP 300
FGCAVLSIAD LLTGETKDDL VLKVYMCNTE SEWYQIHENI IKKLNARYNL 350
TGSNAGLAVS LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSDIIMPGEM 400
RNDLYITVER GEFEKGGKSV ARNVEVTMFI VDSNGQPLKD FISFGSGEPP 450
ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF RGSHIRFEFR HCSTKEKGEK 500
KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT RYLKLPFSKV 550
IFLGNNNQTM KATKESFWIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC 600
LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ 650
DSKFHHFKPV MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE 700
VLKAQEYIFK YIVQSRRLFS LATGGQNEEE FRCCIQELLM SVRFFLSQES 750
KGTGALSQSQ AVFLSSFPAV YSELLKLFDV REVANLVQDT LGSLPTIMHV 800
DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI HLQEQKDLIM 850
CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQAS 900
SSAMRLQFQD VTGEFVACLL SLLRQMTDRH YQQLLNSFST KEELRDFLLQ 950
IFTVFRILIR PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD 1000
YKIWDSYFYL AVIFINQLCL QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS 1050
MWQNLGEHKL HFIPALIGPF LEVTLIPQPD LRNVMIPIFH DMMDWEQRRS 1100
GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSIIPLFGP YPSLLKKIER 1150
ETWRESGVSL IATVTRLMER LLDYRDCMKI GEVDGKKIGC TVSLLNFYKT 1200
ELNKEEMYIR YIHKLYDLHL KAQNFTEAAY TLLLYDELLE WSDRPLREFL 1250
TYPMQTEWQR KEHLHLTIIQ NFDRGKCWEN GIILCRKIAE QYESYYDYRN 1300
LSKMRMMEAS LYDKIMDQQR LEPEFFRVGF YGKKFPFFLR NKEFVCRGHD 1350
YERLEAFQQR MLNEFPHAIA MQHANQPDET IFQAEAQYLQ IYAVTPIPES 1400
QEVLQREGVP DNIKSFYKVN HIWKFRYDRP FHKGAKDKEN EFKSLWVERT 1450
SLYLVQSLPG ISRWFEVEKR EVVEMSPLEN AIEVLENKNQ QLKTLISQCQ 1500
TRQMQNINPL TMCLNGVIDA AVNGGVSRYQ EAFFVKDYIL SHPEDGEKIA 1550
RLRELMLEQA QILEFGLAVH EKFVPQDMRP LHKKLVDQFF VMKSSFGIQE 1600
FPACIQASPV HFPNGSPRVC RNSAPASMSP DGTRVIPRRS PLSYPAVNRY 1650
SSSSLSSQAS AEVSNITGQS ESSDEVFNMQ PSPSTSSLSS THSASPNVTS 1700
SAPSSARASP LLSDKHKHSR ENSCLSPRDR PCSAIYPTPV EPSQRMLFNH 1750
IGDGALPRSD PNLSAPEKAV NPTPSSWSLD SGKEAKNMSD SGKLISPPVP 1800
PRPTQTASPA RHTTSVSPSP AGRSPLKGSV QSFTPSPVEY NSPGLSSNSP 1850
VLSGSYSSGI SSLSRCSTSE TSGFENQANE QSVPVPVPVP VPVPVPSFSG 1900
SEEPVRKESK TPPPYSVYER TLRRPVPLPH SLSIPVTSEP PALPPKPLAA 1950
RSSHLENGTR RTEPGPRPRP LPRKVSQL 1978
Length:1,978
Mass (Da):226,550
Last modified:July 3, 2003 - v1
Checksum:i4A1FC9C71C5A5719
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122353 mRNA. Translation: BAC65635.1.
CCDSiCCDS25895.1.
RefSeqiNP_766391.2. NM_172803.2.
UniGeneiMm.341423.

Genome annotation databases

EnsembliENSMUST00000037488; ENSMUSP00000047387; ENSMUSG00000035954.
GeneIDi238130.
KEGGimmu:238130.
UCSCiuc007nlh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122353 mRNA. Translation: BAC65635.1 .
CCDSi CCDS25895.1.
RefSeqi NP_766391.2. NM_172803.2.
UniGenei Mm.341423.

3D structure databases

ProteinModelPortali P59764.
SMRi P59764. Positions 2-164, 401-576, 1187-1593.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P59764.

Proteomic databases

MaxQBi P59764.
PaxDbi P59764.
PRIDEi P59764.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037488 ; ENSMUSP00000047387 ; ENSMUSG00000035954 .
GeneIDi 238130.
KEGGi mmu:238130.
UCSCi uc007nlh.1. mouse.

Organism-specific databases

CTDi 9732.
MGIi MGI:1918006. Dock4.
Rougei Search...

Phylogenomic databases

eggNOGi NOG289808.
GeneTreei ENSGT00610000085806.
HOGENOMi HOG000006631.
HOVERGENi HBG051389.
InParanoidi P59764.
KOi K17697.
OMAi HLTIIQN.
OrthoDBi EOG7QNVK8.
PhylomeDBi P59764.
TreeFami TF300423.

Miscellaneous databases

NextBioi 383672.
PROi P59764.
SOURCEi Search...

Gene expression databases

Bgeei P59764.
CleanExi MM_DOCK4.
Genevestigatori P59764.

Family and domain databases

InterProi IPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR23317. PTHR23317. 1 hit.
Pfami PF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: DISEASE.
  3. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiDOCK4_MOUSE
AccessioniPrimary (citable) accession number: P59764
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 3, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi