Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P59764

- DOCK4_MOUSE

UniProt

P59764 - DOCK4_MOUSE

Protein

Dedicator of cytokinesis protein 4

Gene

Dock4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (03 Jul 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP By similarity.By similarity

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
    2. Rac GTPase activator activity Source: Ensembl

    GO - Biological processi

    1. cell chemotaxis Source: UniProtKB
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dedicator of cytokinesis protein 4
    Gene namesi
    Name:Dock4
    Synonyms:Kiaa0716
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1918006. Dock4.

    Subcellular locationi

    Endomembrane system By similarity; Peripheral membrane protein By similarity. Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. endomembrane system Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB
    4. stereocilium Source: HGNC
    5. stereocilium bundle Source: HGNC

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Dock4 are involved in the cause of some cancers, which are probably due to lack of Rap1 activation.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19781978Dedicator of cytokinesis protein 4PRO_0000189991Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei167 – 1671Phosphotyrosine1 Publication
    Modified residuei1623 – 16231PhosphoserineBy similarity
    Modified residuei1627 – 16271PhosphoserineBy similarity
    Modified residuei1629 – 16291PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP59764.
    PaxDbiP59764.
    PRIDEiP59764.

    PTM databases

    PhosphoSiteiP59764.

    Expressioni

    Gene expression databases

    BgeeiP59764.
    CleanExiMM_DOCK4.
    GenevestigatoriP59764.

    Interactioni

    Subunit structurei

    Interacts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1. Interacts with FASLG. Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP59764.
    SMRiP59764. Positions 2-164, 401-576, 1187-1593.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 6762SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini401 – 574174DHR-1Add
    BLAST
    Domaini1199 – 1605407DHR-2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1797 – 18037SH3-bindingSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1642 – 1863222Ser-richAdd
    BLAST
    Compositional biasi1875 – 196086Pro-richAdd
    BLAST

    Domaini

    The DHR-2 domain probably mediates the GEF activity.By similarity

    Sequence similaritiesi

    Belongs to the DOCK family.Curated
    Contains 1 DHR-1 domain.Curated
    Contains 1 DHR-2 domain.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain, SH3-binding

    Phylogenomic databases

    eggNOGiNOG289808.
    GeneTreeiENSGT00610000085806.
    HOGENOMiHOG000006631.
    HOVERGENiHBG051389.
    InParanoidiP59764.
    KOiK17697.
    OMAiHLTIIQN.
    OrthoDBiEOG7QNVK8.
    PhylomeDBiP59764.
    TreeFamiTF300423.

    Family and domain databases

    InterProiIPR027007. DHR-1_domain.
    IPR027357. DHR-2.
    IPR026791. DOCK.
    IPR010703. DOCK_C.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR23317. PTHR23317. 1 hit.
    PfamiPF06920. Ded_cyto. 1 hit.
    PF14429. DOCK-C2. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS51650. DHR_1. 1 hit.
    PS51651. DHR_2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59764-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN     50
    PNIKGIFPSS YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW 100
    KQLYVRNEGD LFHRLWHIMN EILDLRRQVL VGHLTHDRMK DVKRHITARL 150
    DWGNEQLGLD LVPRKEYAMV DPEDISITEL YRLMEHRHRK KDTPVQASSH 200
    HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR LNRNGLPKAP 250
    DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP 300
    FGCAVLSIAD LLTGETKDDL VLKVYMCNTE SEWYQIHENI IKKLNARYNL 350
    TGSNAGLAVS LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSDIIMPGEM 400
    RNDLYITVER GEFEKGGKSV ARNVEVTMFI VDSNGQPLKD FISFGSGEPP 450
    ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF RGSHIRFEFR HCSTKEKGEK 500
    KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT RYLKLPFSKV 550
    IFLGNNNQTM KATKESFWIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC 600
    LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ 650
    DSKFHHFKPV MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE 700
    VLKAQEYIFK YIVQSRRLFS LATGGQNEEE FRCCIQELLM SVRFFLSQES 750
    KGTGALSQSQ AVFLSSFPAV YSELLKLFDV REVANLVQDT LGSLPTIMHV 800
    DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI HLQEQKDLIM 850
    CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQAS 900
    SSAMRLQFQD VTGEFVACLL SLLRQMTDRH YQQLLNSFST KEELRDFLLQ 950
    IFTVFRILIR PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD 1000
    YKIWDSYFYL AVIFINQLCL QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS 1050
    MWQNLGEHKL HFIPALIGPF LEVTLIPQPD LRNVMIPIFH DMMDWEQRRS 1100
    GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSIIPLFGP YPSLLKKIER 1150
    ETWRESGVSL IATVTRLMER LLDYRDCMKI GEVDGKKIGC TVSLLNFYKT 1200
    ELNKEEMYIR YIHKLYDLHL KAQNFTEAAY TLLLYDELLE WSDRPLREFL 1250
    TYPMQTEWQR KEHLHLTIIQ NFDRGKCWEN GIILCRKIAE QYESYYDYRN 1300
    LSKMRMMEAS LYDKIMDQQR LEPEFFRVGF YGKKFPFFLR NKEFVCRGHD 1350
    YERLEAFQQR MLNEFPHAIA MQHANQPDET IFQAEAQYLQ IYAVTPIPES 1400
    QEVLQREGVP DNIKSFYKVN HIWKFRYDRP FHKGAKDKEN EFKSLWVERT 1450
    SLYLVQSLPG ISRWFEVEKR EVVEMSPLEN AIEVLENKNQ QLKTLISQCQ 1500
    TRQMQNINPL TMCLNGVIDA AVNGGVSRYQ EAFFVKDYIL SHPEDGEKIA 1550
    RLRELMLEQA QILEFGLAVH EKFVPQDMRP LHKKLVDQFF VMKSSFGIQE 1600
    FPACIQASPV HFPNGSPRVC RNSAPASMSP DGTRVIPRRS PLSYPAVNRY 1650
    SSSSLSSQAS AEVSNITGQS ESSDEVFNMQ PSPSTSSLSS THSASPNVTS 1700
    SAPSSARASP LLSDKHKHSR ENSCLSPRDR PCSAIYPTPV EPSQRMLFNH 1750
    IGDGALPRSD PNLSAPEKAV NPTPSSWSLD SGKEAKNMSD SGKLISPPVP 1800
    PRPTQTASPA RHTTSVSPSP AGRSPLKGSV QSFTPSPVEY NSPGLSSNSP 1850
    VLSGSYSSGI SSLSRCSTSE TSGFENQANE QSVPVPVPVP VPVPVPSFSG 1900
    SEEPVRKESK TPPPYSVYER TLRRPVPLPH SLSIPVTSEP PALPPKPLAA 1950
    RSSHLENGTR RTEPGPRPRP LPRKVSQL 1978
    Length:1,978
    Mass (Da):226,550
    Last modified:July 3, 2003 - v1
    Checksum:i4A1FC9C71C5A5719
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122353 mRNA. Translation: BAC65635.1.
    CCDSiCCDS25895.1.
    RefSeqiNP_766391.2. NM_172803.2.
    UniGeneiMm.341423.

    Genome annotation databases

    EnsembliENSMUST00000037488; ENSMUSP00000047387; ENSMUSG00000035954.
    GeneIDi238130.
    KEGGimmu:238130.
    UCSCiuc007nlh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122353 mRNA. Translation: BAC65635.1 .
    CCDSi CCDS25895.1.
    RefSeqi NP_766391.2. NM_172803.2.
    UniGenei Mm.341423.

    3D structure databases

    ProteinModelPortali P59764.
    SMRi P59764. Positions 2-164, 401-576, 1187-1593.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P59764.

    Proteomic databases

    MaxQBi P59764.
    PaxDbi P59764.
    PRIDEi P59764.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037488 ; ENSMUSP00000047387 ; ENSMUSG00000035954 .
    GeneIDi 238130.
    KEGGi mmu:238130.
    UCSCi uc007nlh.1. mouse.

    Organism-specific databases

    CTDi 9732.
    MGIi MGI:1918006. Dock4.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG289808.
    GeneTreei ENSGT00610000085806.
    HOGENOMi HOG000006631.
    HOVERGENi HBG051389.
    InParanoidi P59764.
    KOi K17697.
    OMAi HLTIIQN.
    OrthoDBi EOG7QNVK8.
    PhylomeDBi P59764.
    TreeFami TF300423.

    Miscellaneous databases

    NextBioi 383672.
    PROi P59764.
    SOURCEi Search...

    Gene expression databases

    Bgeei P59764.
    CleanExi MM_DOCK4.
    Genevestigatori P59764.

    Family and domain databases

    InterProi IPR027007. DHR-1_domain.
    IPR027357. DHR-2.
    IPR026791. DOCK.
    IPR010703. DOCK_C.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR23317. PTHR23317. 1 hit.
    Pfami PF06920. Ded_cyto. 1 hit.
    PF14429. DOCK-C2. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS51650. DHR_1. 1 hit.
    PS51651. DHR_2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Cited for: DISEASE.
    3. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiDOCK4_MOUSE
    AccessioniPrimary (citable) accession number: P59764
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 3, 2003
    Last sequence update: July 3, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3