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P59764 (DOCK4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dedicator of cytokinesis protein 4
Gene names
Name:Dock4
Synonyms:Kiaa0716
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1978 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP By similarity.

Subunit structure

Interacts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1. Interacts with FASLG. Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2 By similarity.

Subcellular location

Endomembrane system; Peripheral membrane protein By similarity. Cytoplasmcytosol By similarity.

Domain

The DHR-2 domain probably mediates the GEF activity By similarity.

Involvement in disease

Defects in Dock4 are involved in the cause of some cancers, which are probably due to lack of Rap1 activation. Ref.2

Sequence similarities

Belongs to the DOCK family.

Contains 1 DHR-1 domain.

Contains 1 DHR-2 domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19781978Dedicator of cytokinesis protein 4
PRO_0000189991

Regions

Domain6 – 6762SH3
Domain401 – 574174DHR-1
Domain1199 – 1605407DHR-2
Motif1797 – 18037SH3-binding Potential
Compositional bias1642 – 1863222Ser-rich
Compositional bias1875 – 196086Pro-rich

Amino acid modifications

Modified residue1671Phosphotyrosine Ref.3
Modified residue16231Phosphoserine By similarity
Modified residue16271Phosphoserine By similarity
Modified residue16291Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P59764 [UniParc].

Last modified July 3, 2003. Version 1.
Checksum: 4A1FC9C71C5A5719

FASTA1,978226,550
        10         20         30         40         50         60 
MWIPTEHEKY GVVIASFRGT VPYGLSLEIG DTVQILEKCD GWYRGFALKN PNIKGIFPSS 

        70         80         90        100        110        120 
YVHLKNACVK NKGQFEMVIP TEDSVITEMT STLRDWGTMW KQLYVRNEGD LFHRLWHIMN 

       130        140        150        160        170        180 
EILDLRRQVL VGHLTHDRMK DVKRHITARL DWGNEQLGLD LVPRKEYAMV DPEDISITEL 

       190        200        210        220        230        240 
YRLMEHRHRK KDTPVQASSH HLFVQMKSLM CSNLGEELEV IFSLFDSKEN RPISERFFLR 

       250        260        270        280        290        300 
LNRNGLPKAP DKPERHCSLF VDLGSSELRK DIYITVHIIR IGRMGAGEKK NACSVQYRRP 

       310        320        330        340        350        360 
FGCAVLSIAD LLTGETKDDL VLKVYMCNTE SEWYQIHENI IKKLNARYNL TGSNAGLAVS 

       370        380        390        400        410        420 
LQLLHGDIEQ IRREYSSVFS HGVSITRKLG FSDIIMPGEM RNDLYITVER GEFEKGGKSV 

       430        440        450        460        470        480 
ARNVEVTMFI VDSNGQPLKD FISFGSGEPP ASEYHSFVLY HNNSPRWSEL LKLPIPVDKF 

       490        500        510        520        530        540 
RGSHIRFEFR HCSTKEKGEK KLFGFSFVPL MQEDGRTLPD GTHELIVHKC EENTNLQDTT 

       550        560        570        580        590        600 
RYLKLPFSKV IFLGNNNQTM KATKESFWIT SFLCSTKLTQ NGDMLDLLKW RTHPDKITGC 

       610        620        630        640        650        660 
LSKLKEIDGS EIVKFLQDTL DTLFGILDEN SQKYGSKVFD SLVHIINLLQ DSKFHHFKPV 

       670        680        690        700        710        720 
MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE VLKAQEYIFK YIVQSRRLFS 

       730        740        750        760        770        780 
LATGGQNEEE FRCCIQELLM SVRFFLSQES KGTGALSQSQ AVFLSSFPAV YSELLKLFDV 

       790        800        810        820        830        840 
REVANLVQDT LGSLPTIMHV DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI 

       850        860        870        880        890        900 
HLQEQKDLIM CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQAS 

       910        920        930        940        950        960 
SSAMRLQFQD VTGEFVACLL SLLRQMTDRH YQQLLNSFST KEELRDFLLQ IFTVFRILIR 

       970        980        990       1000       1010       1020 
PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD YKIWDSYFYL AVIFINQLCL 

      1030       1040       1050       1060       1070       1080 
QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS MWQNLGEHKL HFIPALIGPF LEVTLIPQPD 

      1090       1100       1110       1120       1130       1140 
LRNVMIPIFH DMMDWEQRRS GNFKQVEAKL IDKLDSLMSE GKGDETYREL FNSIIPLFGP 

      1150       1160       1170       1180       1190       1200 
YPSLLKKIER ETWRESGVSL IATVTRLMER LLDYRDCMKI GEVDGKKIGC TVSLLNFYKT 

      1210       1220       1230       1240       1250       1260 
ELNKEEMYIR YIHKLYDLHL KAQNFTEAAY TLLLYDELLE WSDRPLREFL TYPMQTEWQR 

      1270       1280       1290       1300       1310       1320 
KEHLHLTIIQ NFDRGKCWEN GIILCRKIAE QYESYYDYRN LSKMRMMEAS LYDKIMDQQR 

      1330       1340       1350       1360       1370       1380 
LEPEFFRVGF YGKKFPFFLR NKEFVCRGHD YERLEAFQQR MLNEFPHAIA MQHANQPDET 

      1390       1400       1410       1420       1430       1440 
IFQAEAQYLQ IYAVTPIPES QEVLQREGVP DNIKSFYKVN HIWKFRYDRP FHKGAKDKEN 

      1450       1460       1470       1480       1490       1500 
EFKSLWVERT SLYLVQSLPG ISRWFEVEKR EVVEMSPLEN AIEVLENKNQ QLKTLISQCQ 

      1510       1520       1530       1540       1550       1560 
TRQMQNINPL TMCLNGVIDA AVNGGVSRYQ EAFFVKDYIL SHPEDGEKIA RLRELMLEQA 

      1570       1580       1590       1600       1610       1620 
QILEFGLAVH EKFVPQDMRP LHKKLVDQFF VMKSSFGIQE FPACIQASPV HFPNGSPRVC 

      1630       1640       1650       1660       1670       1680 
RNSAPASMSP DGTRVIPRRS PLSYPAVNRY SSSSLSSQAS AEVSNITGQS ESSDEVFNMQ 

      1690       1700       1710       1720       1730       1740 
PSPSTSSLSS THSASPNVTS SAPSSARASP LLSDKHKHSR ENSCLSPRDR PCSAIYPTPV 

      1750       1760       1770       1780       1790       1800 
EPSQRMLFNH IGDGALPRSD PNLSAPEKAV NPTPSSWSLD SGKEAKNMSD SGKLISPPVP 

      1810       1820       1830       1840       1850       1860 
PRPTQTASPA RHTTSVSPSP AGRSPLKGSV QSFTPSPVEY NSPGLSSNSP VLSGSYSSGI 

      1870       1880       1890       1900       1910       1920 
SSLSRCSTSE TSGFENQANE QSVPVPVPVP VPVPVPSFSG SEEPVRKESK TPPPYSVYER 

      1930       1940       1950       1960       1970 
TLRRPVPLPH SLSIPVTSEP PALPPKPLAA RSSHLENGTR RTEPGPRPRP LPRKVSQL 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"DOCK4, a GTPase activator, is disrupted during tumorigenesis."
Yajnik V., Paulding C., Sordella R., McClatchey A.I., Saito M., Wahrer D.C.R., Reynolds P., Bell D.W., Lake R., van den Heuvel S., Settleman J., Haber D.A.
Cell 112:673-684(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: DISEASE.
[3]"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK122353 mRNA. Translation: BAC65635.1.
CCDSCCDS25895.1.
RefSeqNP_766391.2. NM_172803.2.
UniGeneMm.341423.

3D structure databases

ProteinModelPortalP59764.
SMRP59764. Positions 2-164, 401-576, 1187-1593.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP59764.

Proteomic databases

MaxQBP59764.
PaxDbP59764.
PRIDEP59764.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000037488; ENSMUSP00000047387; ENSMUSG00000035954.
GeneID238130.
KEGGmmu:238130.
UCSCuc007nlh.1. mouse.

Organism-specific databases

CTD9732.
MGIMGI:1918006. Dock4.
RougeSearch...

Phylogenomic databases

eggNOGNOG289808.
GeneTreeENSGT00610000085806.
HOGENOMHOG000006631.
HOVERGENHBG051389.
InParanoidP59764.
KOK17697.
OMAHLTIIQN.
OrthoDBEOG7QNVK8.
PhylomeDBP59764.
TreeFamTF300423.

Gene expression databases

BgeeP59764.
CleanExMM_DOCK4.
GenevestigatorP59764.

Family and domain databases

InterProIPR027007. DHR-1_domain.
IPR027357. DHR-2.
IPR026791. DOCK.
IPR010703. DOCK_C.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERPTHR23317. PTHR23317. 1 hit.
PfamPF06920. Ded_cyto. 1 hit.
PF14429. DOCK-C2. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS51650. DHR_1. 1 hit.
PS51651. DHR_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio383672.
PROP59764.
SOURCESearch...

Entry information

Entry nameDOCK4_MOUSE
AccessionPrimary (citable) accession number: P59764
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 3, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot