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P59747

- PRVB_SCOJP

UniProt

P59747 - PRVB_SCOJP

Protein

Parvalbumin beta

Gene
N/A
Organism
Scomber japonicus (Chub mackerel)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi52 – 63121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi91 – 102122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parvalbumin beta
    Alternative name(s):
    Allergen: Sco j 1
    OrganismiScomber japonicus (Chub mackerel)
    Taxonomic identifieri13676 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPelagimorphariaScombriformesScombridaeScomber

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei1097. Sco j 1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 109108Parvalbumin betaPRO_0000073621Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Structurei

    3D structure databases

    ProteinModelPortaliP59747.
    SMRiP59747. Positions 2-109.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 7436EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini78 – 10932EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the parvalbumin family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG107490.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR008080. Parvalbumin.
    [Graphical view]
    PANTHERiPTHR11653. PTHR11653. 1 hit.
    PfamiPF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P59747-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFASVLKDA EVTAALDGCK AAGSFDHKKF FKACGLSGKS TDEVKKAFAI    50
    IDQDKSGFIE EEELKLFLQN FKAGARALSD AETKAFLKAG DSDGDGKIGI 100
    DEFAAMIKG 109
    Length:109
    Mass (Da):11,545
    Last modified:January 23, 2007 - v2
    Checksum:i10869A774DFD6899
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB091470 mRNA. Translation: BAC66618.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB091470 mRNA. Translation: BAC66618.1 .

    3D structure databases

    ProteinModelPortali P59747.
    SMRi P59747. Positions 2-109.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 1097. Sco j 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG107490.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR008080. Parvalbumin.
    [Graphical view ]
    PANTHERi PTHR11653. PTHR11653. 1 hit.
    Pfami PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification, reactivity with IgE and cDNA cloning of parvalbumin as the major allergen of mackerels."
      Hamada Y., Tanaka H., Ishizaki S., Ishida M., Nagashima Y., Shiomi K.
      Food Chem. Toxicol. 41:1149-1156(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiPRVB_SCOJP
    AccessioniPrimary (citable) accession number: P59747
    Secondary accession number(s): Q7ZW61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3