UniProtKB - P59747 (PRVB_SCOJP)
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Protein
Parvalbumin beta
Gene
N/A
Organism
Scomber japonicus (Chub mackerel)
Status
Functioni
In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).By similarity
Sites
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Metal bindingi | 52 | Calcium 1By similarity | 1 | |
| Metal bindingi | 54 | Calcium 1By similarity | 1 | |
| Metal bindingi | 56 | Calcium 1By similarity | 1 | |
| Metal bindingi | 58 | Calcium 1; via carbonyl oxygenBy similarity | 1 | |
| Metal bindingi | 60 | Calcium 1By similarity | 1 | |
| Metal bindingi | 63 | Calcium 1By similarity | 1 | |
| Metal bindingi | 91 | Calcium 2By similarity | 1 | |
| Metal bindingi | 93 | Calcium 2By similarity | 1 | |
| Metal bindingi | 95 | Calcium 2By similarity | 1 | |
| Metal bindingi | 102 | Calcium 2By similarity | 1 |
Regions
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Calcium bindingi | 52 – 63 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
| Calcium bindingi | 91 – 102 | 2PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
Keywordsi
| Molecular function | Muscle protein |
| Ligand | Calcium, Metal-binding |
Names & Taxonomyi
| Protein namesi | Recommended name: Parvalbumin betaAlternative name(s): Allergen: Sco j 1 |
| Organismi | Scomber japonicus (Chub mackerel) |
| Taxonomic identifieri | 13676 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Neoteleostei › Acanthomorphata › Pelagiaria › Scombriformes › Scombridae › Scomber |
Pathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human.
Keywords - Diseasei
AllergenProtein family/group databases
| Allergomei | 1097. Sco j 1. |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Initiator methioninei | RemovedBy similarity | |||
| ChainiPRO_0000073621 | 2 – 109 | Parvalbumin betaAdd BLAST | 108 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Modified residuei | 2 | N-acetylalanineBy similarity | 1 |
Keywords - PTMi
AcetylationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Helixi | 3 – 6 | Combined sources | 4 | |
| Helixi | 9 – 17 | Combined sources | 9 | |
| Helixi | 27 – 34 | Combined sources | 8 | |
| Turni | 36 – 38 | Combined sources | 3 | |
| Helixi | 41 – 51 | Combined sources | 11 | |
| Beta strandi | 57 – 60 | Combined sources | 4 | |
| Helixi | 61 – 64 | Combined sources | 4 | |
| Turni | 65 – 68 | Combined sources | 4 | |
| Beta strandi | 69 – 71 | Combined sources | 3 | |
| Helixi | 82 – 88 | Combined sources | 7 | |
| Beta strandi | 95 – 98 | Combined sources | 4 | |
| Helixi | 100 – 103 | Combined sources | 4 | |
| Helixi | 105 – 108 | Combined sources | 4 |
3D structure databases
| Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
| 5XND | NMR | - | A | 1-109 | [»] | |
| ProteinModelPortali | P59747. | |||||
| SMRi | P59747. | |||||
| ModBasei | Search... | |||||
| MobiDBi | Search... | |||||
Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Domaini | 39 – 74 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
| Domaini | 78 – 109 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the parvalbumin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
| HOVERGENi | HBG107490. |
Family and domain databases
| InterProi | View protein in InterPro IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR008080. Parvalbumin. |
| PANTHERi | PTHR11653. PTHR11653. 1 hit. |
| Pfami | View protein in Pfam PF13499. EF-hand_7. 1 hit. |
| SMARTi | View protein in SMART SM00054. EFh. 2 hits. |
| SUPFAMi | SSF47473. SSF47473. 1 hit. |
| PROSITEi | View protein in PROSITE PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. |
Sequencei
Sequence statusi: Complete.
Sequence processingi: The displayed sequence is further processed into a mature form.
P59747-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFASVLKDA EVTAALDGCK AAGSFDHKKF FKACGLSGKS TDEVKKAFAI
60 70 80 90 100
IDQDKSGFIE EEELKLFLQN FKAGARALSD AETKAFLKAG DSDGDGKIGI
DEFAAMIKG
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB091470 mRNA. Translation: BAC66618.1. |
Similar proteinsi
Entry informationi
| Entry namei | PRVB_SCOJP | |
| Accessioni | P59747Primary (citable) accession number: P59747 Secondary accession number(s): Q7ZW61 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2003 |
| Last sequence update: | January 23, 2007 | |
| Last modified: | March 28, 2018 | |
| This is version 70 of the entry and version 2 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |