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P59747 (PRVB_SCOJP) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Parvalbumin beta
Alternative name(s):
Allergen=Sco j 1
OrganismScomber japonicus (Chub mackerel)
Taxonomic identifier13676 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPelagimorphariaScombriformesScombridaeScomber

Protein attributes

Sequence length109 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions By similarity.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the parvalbumin family.

Contains 2 EF-hand domains.

Ontologies

Keywords
   DiseaseAllergen
   DomainRepeat
   LigandCalcium
Metal-binding
   Molecular functionMuscle protein
   PTMAcetylation
Gene Ontology (GO)
   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 109108Parvalbumin beta
PRO_0000073621

Regions

Domain39 – 7436EF-hand 1
Domain78 – 10932EF-hand 2
Calcium binding52 – 63121 Potential
Calcium binding91 – 102122 Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
P59747 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 10869A774DFD6899

FASTA10911,545
        10         20         30         40         50         60 
MAFASVLKDA EVTAALDGCK AAGSFDHKKF FKACGLSGKS TDEVKKAFAI IDQDKSGFIE 

        70         80         90        100 
EEELKLFLQN FKAGARALSD AETKAFLKAG DSDGDGKIGI DEFAAMIKG 

« Hide

References

[1]"Purification, reactivity with IgE and cDNA cloning of parvalbumin as the major allergen of mackerels."
Hamada Y., Tanaka H., Ishizaki S., Ishida M., Nagashima Y., Shiomi K.
Food Chem. Toxicol. 41:1149-1156(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB091470 mRNA. Translation: BAC66618.1.

3D structure databases

ProteinModelPortalP59747.
SMRP59747. Positions 2-109.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome1097. Sco j 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG107490.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERPTHR11653. PTHR11653. 1 hit.
PfamPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePRVB_SCOJP
AccessionPrimary (citable) accession number: P59747
Secondary accession number(s): Q7ZW61
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries