P59747 (PRVB_SCOJP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Parvalbumin beta Alternative name(s): Allergen=Sco j 1
Organism	Scomber japonicus (Chub mackerel)
Taxonomic identifier	13676 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Neognathi › Neoteleostei › Eurypterygii › Ctenosquamata › Acanthomorpha › Euacanthomorpha › Holacanthopterygii › Acanthopterygii › Euacanthopterygii › Percomorpha › Perciformes › Scombroidei › Scombridae › Scombrinae › Scombrini › Scomber

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions By similarity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the parvalbumin family. Contains 2 EF-hand domains.

Ontologies

Keywords
Disease	Allergen
Domain	Repeat
Ligand	Calcium Metal-binding
Molecular function	Muscle protein
PTM	Acetylation
Gene Ontology (GO)
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 109	108	Parvalbumin beta		PRO_0000073621
Regions
	Domain	39 – 74	36	EF-hand 1
	Domain	78 – 109	32	EF-hand 2
	Calcium binding	52 – 63	12	1 Potential
	Calcium binding	91 – 102	12	2 Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P59747 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 10869A774DFD6899	FASTA	109	11,545
	10 20 30 40 50 60 MAFASVLKDA EVTAALDGCK AAGSFDHKKF FKACGLSGKS TDEVKKAFAI IDQDKSGFIE 70 80 90 100 EEELKLFLQN FKAGARALSD AETKAFLKAG DSDGDGKIGI DEFAAMIKG

References

[1]

"Purification, reactivity with IgE and cDNA cloning of parvalbumin as the major allergen of mackerels." Hamada Y., Tanaka H., Ishizaki S., Ishida M., Nagashima Y., Shiomi K. Food Chem. Toxicol. 41:1149-1156(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB091470 mRNA. Translation: BAC66618.1.
3D structure databases
ProteinModelPortal	P59747.
SMR	P59747. Positions 2-109.
ModBase	Search...
Protein family/group databases
Allergome	1097. Sco j 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG107490.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR008080. Parvalbumin. [Graphical view]
PANTHER	PTHR11653. PTHR11653. 1 hit.
Pfam	PF13499. EF-hand_7. 1 hit. [Graphical view]
SMART	SM00054. EFh. 2 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PRVB_SCOJP

Accession

Primary (citable) accession number: P59747
Secondary accession number(s): Q7ZW61

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2003
Last sequence update:	January 23, 2007
Last modified:	September 18, 2013
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program