Reviewed, UniProtKB/Swiss-Prot P59739 (CYAA_SHIFL)

Names and origin

Protein names

Recommended name:
    Adenylate cyclase
    EC=4.6.1.1
Alternative name(s):
    ATP pyrophosphate-lyase
    Adenylyl cyclase

Gene names

Name:	cyaA
Ordered Locus Names:	SF3878, S3878

Organism

Shigella flexneri [Complete proteome] [HAMAP]

Taxonomic identifier

623 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	848 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the adenylyl cyclase class-1 family.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Lyase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cAMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 848	848	Adenylate cyclase		PRO_0000195674
Regions
	Region	1 – 535	535	Catalytic
	Region	541 – 848	308	Regulatory
Amino acid modifications
	Modified residue	609	1	Phosphohistidine; by CRR Potential

Sequences

	Sequence		Length	Mass (Da)
	P59739-1 [UniParc]. Last modified June 20, 2003. Version 1. Checksum: D31639F2B050302B	FASTA	848	97,584
	10 20 30 40 50 60 MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQQVYSLLPT LLHYHHPRMP GYLDGNVPKG 70 80 90 100 110 120 ICLYTPDETQ RHYLNELELY RGMSVQDPPK GELPITGVYT MGSTSSVGQS CSSDLDIWVC 130 140 150 160 170 180 HQSWLDSEER QLLQRKCSLL ESWAASLGVE VSFFLIDENR FRHNESGSLG GEDCGSTQHI 190 200 210 220 230 240 LLLDEFYRTA VRLAGKRILW NMVPCDEEEH YDDYVMTLYA QGVLTPNEWL DLGGLSSLSA 250 260 270 280 290 300 EEYFGASLWQ LYKSIDSPYK AVLKTLLLEA YSWEYPNPRL LAKDIKQRLH DGEIVSFGLD 310 320 330 340 350 360 PYCMMLERVT EYLTAIEDFT RLDLVRRCFY LKVCEKLSRE RACVGWRRAV LSQLVSEWGW 370 380 390 400 410 420 DEARLAMLDN RANWKIDQVR EAHNELLDAM MQSYRNLIRF ARRNNLSVSA SPQDIGVLTR 430 440 450 460 470 480 KLYAAFEALP GKVTLVNPQI SPDLSEPNLT FIYVPPGRAN RSGWYLYNRA PNIESIISHQ 490 500 510 520 530 540 PLEYNRYLNK LVAWAWFNGL LTSRTRLYIK GNGIVDLPKL QEMVADVSHH FPLRLPAPTP 550 560 570 580 590 600 KALYSPCEIR HLAIIVNLEY DPTAAFRNQV VHFDFRKLDV FSFGENQNCL VGSVDLLYRN 610 620 630 640 650 660 SWNEVRTLHF NGEQSMIEAL KTILGKMHQD AAPPDSVEVF CYSQHLRGLI RTRVQQLVSE 670 680 690 700 710 720 CIELRLSSTR QETGRFKALR VSGQTWGLFF ERLNVSVQKL ENAIEFYGAI SHNKLHGLSV 730 740 750 760 770 780 QVETNHVKLP AVVDGFASEG IIQFFFEETQ DENGFNIYIL DESNRVEVYH HCEGSKEELV 790 800 810 820 830 840 RDVSRFYSSS HDRFTYGSSF INFNLPQFYQ IVKVDGREQV IPFRTKSIGN LPPANQDHDT PLLQQYFS

References

[1]

"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157." Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J. Nucleic Acids Res. 30:4432-4441(2002) [PubMed: 12384590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 301 / Serotype 2a.

[2]

"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T." Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R. Infect. Immun. 71:2775-2786(2003) [PubMed: 12704152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700930 / 2457T / Serotype 2a.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005674 Genomic DNA. Translation: AAN45315.1. AE014073 Genomic DNA. Translation: AAP18883.1.
RefSeq	NP_709608.1. NP_839072.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1025984. 1080096.
GenomeReviews	Gene locus SF3878 in contig AE005674_GR. Gene locus S3878 in contig AE014073_GR.
KEGG	sfl:SF3878. sfx:S3878.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P59739.
OMA	LWQLYKG.
Enzyme and pathway databases
BioCyc	SFLE198214:AAN45315.1-MON.
BRENDA	4.6.1.1. 189495.
Family and domain databases
InterPro	IPR000274. Adenylt_cyclse_1. [Graphical view]
Pfam	PF01295. Adenylate_cycl. 1 hit. [Graphical view]
PIRSF	PIRSF001444. Adenylate_cycl. 1 hit.
PROSITE	PS01092. ADENYLATE_CYCLASE_1_1. 1 hit. PS01093. ADENYLATE_CYCLASE_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYAA_SHIFL

Accession

Primary (citable) accession number: P59739

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
Last sequence update:	June 20, 2003
Last modified:	November 3, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)