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Protein

Ras and Rab interactor 3

Gene

Rin3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras and Rab interactor 3
Alternative name(s):
Ras interaction/interference protein 3
Gene namesi
Name:Rin3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2385708. Rin3.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmic vesicle By similarity
  • Early endosome By similarity

  • Note: Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 980980Ras and Rab interactor 3PRO_0000191323Add
BLAST

Proteomic databases

EPDiP59729.
MaxQBiP59729.
PaxDbiP59729.
PRIDEiP59729.

PTM databases

iPTMnetiP59729.
PhosphoSiteiP59729.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044456.
CleanExiMM_RIN3.
ExpressionAtlasiP59729. baseline and differential.
GenevisibleiP59729. MM.

Interactioni

Subunit structurei

Interacts with CD2AP, RAB5B, RAB31 and BIN1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060771.

Structurei

3D structure databases

ProteinModelPortaliP59729.
SMRiP59729. Positions 670-843.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 15896SH2Add
BLAST
Domaini700 – 843144VPS9PROSITE-ProRule annotationAdd
BLAST
Domaini865 – 96298Ras-associatingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni584 – 729146Interaction with RAB5BBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi242 – 380139Pro-richAdd
BLAST
Compositional biasi719 – 7224Poly-Thr

Sequence similaritiesi

Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.Curated
Contains 1 VPS9 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG2320. Eukaryota.
ENOG410ZZW5. LUCA.
GeneTreeiENSGT00530000063053.
HOGENOMiHOG000060122.
HOVERGENiHBG038998.
InParanoidiP59729.
OMAiRLWFVNP.
OrthoDBiEOG091G02V2.
TreeFamiTF331067.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000159. RA_dom.
IPR000980. SH2.
IPR003123. VPS9.
[Graphical view]
PfamiPF02204. VPS9. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00167. VPS9. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS51205. VPS9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRAEAPSSA HPAGPIPDAG KGEGEEDEEK DGTRLGLSTT PRNCIPRRGI
60 70 80 90 100
SVLEKLVKTC PVWLQLGLGQ AEAAKILQQE MAGMFLVCRD NNLKQLVLCV
110 120 130 140 150
HFPSLKGSSA EVLEYPIKEE KAILYLEGSV LVFEDIFRLI AFYCVSRDLL
160 170 180 190 200
PFTLRLPQAI LEASSFLELE TISNLGLGFW DSSLNSRGSA EPLRSPAPGT
210 220 230 240 250
PASSSLRPTT HYANCSCEIE LSVGNDRLWF VNPIFIEDCI LPADPPPLPT
260 270 280 290 300
GSYPPRPTPA TPDATSPTSK GSPRRPPPPP PLPTVPPTGP ARPLAPPVPP
310 320 330 340 350
AGPLPNSPLT PTSHLAPHAP GPPGHSNQPP MTACESLPRP AVGLGPFGEE
360 370 380 390 400
EMKPGTTPNP LHQAPPPPLP LKKALPAAPP RRRISERVSL ESQNVGTSTD
410 420 430 440 450
RDHSGISRTA SLNLPPQSTV SSLGDRPPRT TEQSQDTEAK ASHADSIPVP
460 470 480 490 500
PGKAKQPPVP PPRKKRVSRQ LASTLLSPLE SPIQEASSEK QATGASWEGL
510 520 530 540 550
SPVRQAGMQH LQVQSSSCPQ SSPEFKGSQA SLSDSLGVPA SAADQDSYST
560 570 580 590 600
SSAEEELEFS SPNVKKKPSM ILDKARHRLS FVSFASVFHA FLSSDRKLYK
610 620 630 640 650
KVVELAQDKS SYFGSLVQDY KVYSLEMMAR QTSSTEMLQE IRTMMTQLKS
660 670 680 690 700
YLLQSTELKA LVEPTLHSEE ELEAIVESAL YKCVLKPLKE AINSSLLEIH
710 720 730 740 750
SRDGSLQQLK ENQLVVLATT TTDLGVTTSV PEVAVMEKIL QKLTSMHKAY
760 770 780 790 800
SPGKKISILL KTCKLIYDSM ALGNPGKPYG ADDFLPVLMY VLARSNLTEM
810 820 830 840 850
LLNVEYMMEL MDPALQLGEG SYYLTTTYGA LEHIKNYDKI TVTRQLSVEV
860 870 880 890 900
QDSIHRWERR RTLNKARASR SSVQDFICVS YLKPEQQSRT LASRADTAAQ
910 920 930 940 950
ALCAQCAEKF EVSQPQDYRL FVLVDGRCFQ LADEALPHRI KGYLLRSEPK
960 970 980
RDFHFVYRPQ DSGKDASSQP CIVVREPNFL
Length:980
Mass (Da):107,220
Last modified:July 27, 2011 - v2
Checksum:iF803A8CFEE17A7B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti288 – 2881T → I in BAC27757 (PubMed:16141072).Curated
Sequence conflicti332 – 3321T → K in BAC27757 (PubMed:16141072).Curated
Sequence conflicti560 – 5601S → T in BAC27757 (PubMed:16141072).Curated
Sequence conflicti563 – 5653NVK → DVE in BAC27757 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032205 mRNA. Translation: BAC27757.1.
BC137907 mRNA. Translation: AAI37908.1.
CCDSiCCDS26118.1.
RefSeqiNP_808288.2. NM_177620.4.
UniGeneiMm.24145.

Genome annotation databases

EnsembliENSMUST00000056950; ENSMUSP00000060771; ENSMUSG00000044456.
GeneIDi217835.
KEGGimmu:217835.
UCSCiuc007ouc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032205 mRNA. Translation: BAC27757.1.
BC137907 mRNA. Translation: AAI37908.1.
CCDSiCCDS26118.1.
RefSeqiNP_808288.2. NM_177620.4.
UniGeneiMm.24145.

3D structure databases

ProteinModelPortaliP59729.
SMRiP59729. Positions 670-843.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060771.

PTM databases

iPTMnetiP59729.
PhosphoSiteiP59729.

Proteomic databases

EPDiP59729.
MaxQBiP59729.
PaxDbiP59729.
PRIDEiP59729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056950; ENSMUSP00000060771; ENSMUSG00000044456.
GeneIDi217835.
KEGGimmu:217835.
UCSCiuc007ouc.2. mouse.

Organism-specific databases

CTDi79890.
MGIiMGI:2385708. Rin3.

Phylogenomic databases

eggNOGiKOG2320. Eukaryota.
ENOG410ZZW5. LUCA.
GeneTreeiENSGT00530000063053.
HOGENOMiHOG000060122.
HOVERGENiHBG038998.
InParanoidiP59729.
OMAiRLWFVNP.
OrthoDBiEOG091G02V2.
TreeFamiTF331067.

Miscellaneous databases

ChiTaRSiRin3. mouse.
PROiP59729.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044456.
CleanExiMM_RIN3.
ExpressionAtlasiP59729. baseline and differential.
GenevisibleiP59729. MM.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000159. RA_dom.
IPR000980. SH2.
IPR003123. VPS9.
[Graphical view]
PfamiPF02204. VPS9. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00167. VPS9. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS51205. VPS9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIN3_MOUSE
AccessioniPrimary (citable) accession number: P59729
Secondary accession number(s): B2RQF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.