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P59720

- TRMB_NITEU

UniProt

P59720 - TRMB_NITEU

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, NE0283
Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561S-adenosyl-L-methionine By similarity
Binding sitei81 – 811S-adenosyl-L-methionine By similarity
Binding sitei108 – 1081S-adenosyl-L-methionine By similarity
Active sitei131 – 1311 By similarity
Binding sitei131 – 1311S-adenosyl-L-methionine By similarity
Binding sitei135 – 1351Substrate By similarity
Binding sitei167 – 1671Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-292-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:NE0283
OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000171364Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228410.NE0283.

Structurei

3D structure databases

ProteinModelPortaliP59720.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni202 – 2054Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiAEWIASH.
OrthoDBiEOG6K6VBC.
PhylomeDBiP59720.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59720-1 [UniParc]FASTAAdd to Basket

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MSSHPPIRSY VLRQGYFSNA QRHAYESLLP RYGIPLTEEP VDLDSIFGRT    50
APGILEIGSG MGETTAEIAR QHPEKDFIAI EVHAPGIGSL LGQIEKHRLT 100
NLRIIPHDAK LVLQQMFTSE SLDGIHIFFP DPWPKARHHK RRLIQPDFVS 150
LLCDRLKPGG YLHIATDWED YATHILHVLR SEERFVNTAV DYAARPAYRP 200
LTKFEQRGMK LGHTIRDIIF TRTA 224
Length:224
Mass (Da):25,579
Last modified:June 16, 2003 - v1
Checksum:iDB0AC10EADCED31A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954747 Genomic DNA. Translation: CAD84194.1.
RefSeqiNP_840372.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD84194; CAD84194; NE0283.
GeneIDi1081211.
KEGGineu:NE0283.
PATRICi22711393. VBINitEur56163_0312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954747 Genomic DNA. Translation: CAD84194.1 .
RefSeqi NP_840372.1. NC_004757.1.

3D structure databases

ProteinModelPortali P59720.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228410.NE0283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD84194 ; CAD84194 ; NE0283 .
GeneIDi 1081211.
KEGGi neu:NE0283.
PATRICi 22711393. VBINitEur56163_0312.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi AEWIASH.
OrthoDBi EOG6K6VBC.
PhylomeDBi P59720.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci NEUR228410:GJNO-292-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
    Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
    J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19718 / NBRC 14298.

Entry informationi

Entry nameiTRMB_NITEU
AccessioniPrimary (citable) accession number: P59720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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