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P59720

- TRMB_NITEU

UniProt

P59720 - TRMB_NITEU

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561S-adenosyl-L-methionineUniRule annotation
Binding sitei81 – 811S-adenosyl-L-methionineUniRule annotation
Binding sitei108 – 1081S-adenosyl-L-methionineUniRule annotation
Active sitei131 – 1311By similarity
Binding sitei131 – 1311S-adenosyl-L-methionineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Binding sitei167 – 1671SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-292-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:NE0283
OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferasePRO_0000171364Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228410.NE0283.

Structurei

3D structure databases

ProteinModelPortaliP59720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni202 – 2054Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiAEWIASH.
OrthoDBiEOG6K6VBC.
PhylomeDBiP59720.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59720-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSHPPIRSY VLRQGYFSNA QRHAYESLLP RYGIPLTEEP VDLDSIFGRT
60 70 80 90 100
APGILEIGSG MGETTAEIAR QHPEKDFIAI EVHAPGIGSL LGQIEKHRLT
110 120 130 140 150
NLRIIPHDAK LVLQQMFTSE SLDGIHIFFP DPWPKARHHK RRLIQPDFVS
160 170 180 190 200
LLCDRLKPGG YLHIATDWED YATHILHVLR SEERFVNTAV DYAARPAYRP
210 220
LTKFEQRGMK LGHTIRDIIF TRTA
Length:224
Mass (Da):25,579
Last modified:June 16, 2003 - v1
Checksum:iDB0AC10EADCED31A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD84194.1.
RefSeqiNP_840372.1. NC_004757.1.
WP_011110920.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD84194; CAD84194; NE0283.
GeneIDi1081211.
KEGGineu:NE0283.
PATRICi22711393. VBINitEur56163_0312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD84194.1 .
RefSeqi NP_840372.1. NC_004757.1.
WP_011110920.1. NC_004757.1.

3D structure databases

ProteinModelPortali P59720.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228410.NE0283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD84194 ; CAD84194 ; NE0283 .
GeneIDi 1081211.
KEGGi neu:NE0283.
PATRICi 22711393. VBINitEur56163_0312.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi AEWIASH.
OrthoDBi EOG6K6VBC.
PhylomeDBi P59720.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci NEUR228410:GJNO-292-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
    Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
    J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19718 / NBRC 14298.

Entry informationi

Entry nameiTRMB_NITEU
AccessioniPrimary (citable) accession number: P59720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3