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P59718

- TRMB_CHLCV

UniProt

P59718 - TRMB_CHLCV

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, CCA_00775
Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541S-adenosyl-L-methionine By similarity
Binding sitei79 – 791S-adenosyl-L-methionine By similarity
Binding sitei106 – 1061S-adenosyl-L-methionine By similarity
Active sitei129 – 1291 By similarity
Binding sitei129 – 1291S-adenosyl-L-methionine By similarity
Binding sitei133 – 1331Substrate By similarity
Binding sitei165 – 1651Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCCAV227941:GH8L-807-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:CCA_00775
    OrganismiChlamydophila caviae (strain GPIC)
    Taxonomic identifieri227941 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000002193: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000171314Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi227941.CCA00775.

    Structurei

    3D structure databases

    ProteinModelPortaliP59718.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    KOiK03439.
    OMAiIVELAMN.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59718-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPQNLKVPF FWEERSTEIK DNVLYIPNHY FKHDQFIMPS WEEFFGNNNP    50
    ISCELCSGNG DWVVSQAQNM PQMNWIAVEK RFDRVRKIWS KMHNFQVSNL 100
    RIVCGEAQTF FRHYLKNEIL QRIVVNFPDP WPKSRHRKHR LFQDEFMNDV 150
    VRVLVESGIL VLATDDKNYL VEAIKMMRQC LLPTIEDPYY CKVLDNYGDS 200
    WFERLWRSKG QEIFYTEFVK KVGI 224
    Length:224
    Mass (Da):26,984
    Last modified:June 16, 2003 - v1
    Checksum:iA7E0546ED3DA82E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015925 Genomic DNA. Translation: AAP05516.1.
    RefSeqiNP_829638.1. NC_003361.3.
    WP_011006730.1. NC_003361.3.

    Genome annotation databases

    EnsemblBacteriaiAAP05516; AAP05516; CCA_00775.
    GeneIDi1218460.
    KEGGicca:CCA00775.
    PATRICi20270683. VBIChlCav107360_0822.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015925 Genomic DNA. Translation: AAP05516.1 .
    RefSeqi NP_829638.1. NC_003361.3.
    WP_011006730.1. NC_003361.3.

    3D structure databases

    ProteinModelPortali P59718.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 227941.CCA00775.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAP05516 ; AAP05516 ; CCA_00775 .
    GeneIDi 1218460.
    KEGGi cca:CCA00775.
    PATRICi 20270683. VBIChlCav107360_0822.

    Phylogenomic databases

    eggNOGi COG0220.
    KOi K03439.
    OMAi IVELAMN.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CCAV227941:GH8L-807-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
      Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G.
      , Rank R.G., Bavoil P.M., Fraser C.M.
      Nucleic Acids Res. 31:2134-2147(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GPIC.

    Entry informationi

    Entry nameiTRMB_CHLCV
    AccessioniPrimary (citable) accession number: P59718
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: June 16, 2003
    Last modified: September 3, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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