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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Chlamydophila caviae (strain GPIC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54S-adenosyl-L-methionineUniRule annotation1
Binding sitei79S-adenosyl-L-methionineUniRule annotation1
Binding sitei106S-adenosyl-L-methionineUniRule annotation1
Active sitei129By similarity1
Binding sitei129S-adenosyl-L-methionineUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Binding sitei165SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:CCA_00775
OrganismiChlamydophila caviae (strain GPIC)
Taxonomic identifieri227941 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000002193 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001713141 – 224tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST224

Proteomic databases

PRIDEiP59718

Interactioni

Protein-protein interaction databases

STRINGi227941.CCA00775

Structurei

3D structure databases

ProteinModelPortaliP59718
SMRiP59718
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1 Bacteria
COG0220 LUCA
KOiK03439
OMAiGHALEYC
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

P59718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPQNLKVPF FWEERSTEIK DNVLYIPNHY FKHDQFIMPS WEEFFGNNNP
60 70 80 90 100
ISCELCSGNG DWVVSQAQNM PQMNWIAVEK RFDRVRKIWS KMHNFQVSNL
110 120 130 140 150
RIVCGEAQTF FRHYLKNEIL QRIVVNFPDP WPKSRHRKHR LFQDEFMNDV
160 170 180 190 200
VRVLVESGIL VLATDDKNYL VEAIKMMRQC LLPTIEDPYY CKVLDNYGDS
210 220
WFERLWRSKG QEIFYTEFVK KVGI
Length:224
Mass (Da):26,984
Last modified:June 16, 2003 - v1
Checksum:iA7E0546ED3DA82E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015925 Genomic DNA Translation: AAP05516.1

Genome annotation databases

EnsemblBacteriaiAAP05516; AAP05516; CCA_00775
KEGGicca:CCA_00775

Similar proteinsi

Entry informationi

Entry nameiTRMB_CHLCV
AccessioniPrimary (citable) accession number: P59718
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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