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P59691

- SYE_CHLP6

UniProt

P59691 - SYE_CHLP6

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Chlamydophila psittaci (strain ATCC VR-125 / 6BC) (Chlamydia psittaci)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei256 – 2561ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:CPSIT_0206, G5O_0208
    OrganismiChlamydophila psittaci (strain ATCC VR-125 / 6BC) (Chlamydia psittaci)
    Taxonomic identifieri331636 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000007489: Chromosome, UP000008336: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505Glutamate--tRNA ligasePRO_0000119540Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi12 – 2211"HIGH" regionAdd
    BLAST
    Motifi253 – 2575"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    KOiK01885.
    OMAiWINGYYL.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59691-1 [UniParc]FASTAAdd to Basket

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    MAWENVRVRV APSPTGDPHV GTAYMALFNE IFAKRFNGKM ILRIEDTDQT    50
    RSRDDYEKNI FSALKWCGIQ WDEGPDIGGP YGPYRQSERT EIYREYAELL 100
    LKTDYAYKCF ATPKELEEMR AVATTLGYRG GYDRRYRYLS PEEIEARTRE 150
    GQPYTIRLKV PLTGECVLDD YCKGRVVFPW ADVDDQVLIK SDGFPTYHFA 200
    NVVDDHLMGI THVLRGEEWL SSTPKHLLLY EAFGWEAPTF LHMPLLLNPD 250
    GTKLSKRKNP TSIFYYRDAG YVKEAFMNFL TLMGYSMEGD EEIYSLEKLI 300
    ANFDPRRIGK SGAVFDTRKL DWMNKHYLTH EKSSESLLAK LKDWLINDEF 350
    FLKILPLCQS RITTLAEFIG FTGFFFSVLP EYSKEELLPA TIVEEKAAIL 400
    LYSYVKYLEK ADLWVKDQFY QGSKWLSSAF QVHHKKVVIP LLYVAITGKK 450
    QGLPLFDSME LLGKPRTRAR LVHAQNLLGG VPKKIQTTID KVLKEEDFEN 500
    KIFEF 505
    Length:505
    Mass (Da):58,540
    Last modified:June 28, 2011 - v2
    Checksum:i9D51E741448A9B22
    GO

    Sequence cautioni

    The sequence AAA23122.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002549 Genomic DNA. Translation: ADZ18786.1.
    CP002586 Genomic DNA. Translation: AEB55211.1.
    L13598 Genomic DNA. Translation: AAA23122.1. Different initiation.
    PIRiA36909.
    RefSeqiYP_004422038.1. NC_015470.1.
    YP_005662884.1. NC_017287.1.

    Genome annotation databases

    EnsemblBacteriaiADZ18786; ADZ18786; CPSIT_0206.
    AEB55211; AEB55211; G5O_0208.
    GeneIDi10602476.
    12242467.
    KEGGichb:G5O_0208.
    chp:CPSIT_0206.
    PATRICi47105011. VBIChlPsi52874_0193.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002549 Genomic DNA. Translation: ADZ18786.1 .
    CP002586 Genomic DNA. Translation: AEB55211.1 .
    L13598 Genomic DNA. Translation: AAA23122.1 . Different initiation.
    PIRi A36909.
    RefSeqi YP_004422038.1. NC_015470.1.
    YP_005662884.1. NC_017287.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADZ18786 ; ADZ18786 ; CPSIT_0206 .
    AEB55211 ; AEB55211 ; G5O_0208 .
    GeneIDi 10602476.
    12242467.
    KEGGi chb:G5O_0208.
    chp:CPSIT_0206.
    PATRICi 47105011. VBIChlPsi52874_0193.

    Phylogenomic databases

    KOi K01885.
    OMAi WINGYYL.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Full-length de novo sequence of the Chlamydophila psittaci type strain, 6BC."
      Voigt A., Schofl G., Heidrich A., Sachse K., Saluz H.P.
      J. Bacteriol. 193:2662-2663(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-125 / 6BC.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-125 / 6BC.
    3. "Identification of an early-stage gene of Chlamydia psittaci 6BC."
      Wichlan D.W., Hatch T.P.
      J. Bacteriol. 175:2936-2942(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-368.
      Strain: ATCC VR-125 / 6BC.

    Entry informationi

    Entry nameiSYE_CHLP6
    AccessioniPrimary (citable) accession number: P59691
    Secondary accession number(s): F0T375, P94662, Q06560
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 23, 2003
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3