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P59691

- SYE_CHLP6

UniProt

P59691 - SYE_CHLP6

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Chlamydophila psittaci (strain ATCC VR-125 / 6BC) (Chlamydia psittaci)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei256 – 2561ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:CPSIT_0206, G5O_0208
OrganismiChlamydophila psittaci (strain ATCC VR-125 / 6BC) (Chlamydia psittaci)
Taxonomic identifieri331636 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000007489: Chromosome, UP000008336: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Glutamate--tRNA ligasePRO_0000119540Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi12 – 2211"HIGH" regionAdd
BLAST
Motifi253 – 2575"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

KOiK01885.
OMAiWINGYYL.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59691 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MAWENVRVRV APSPTGDPHV GTAYMALFNE IFAKRFNGKM ILRIEDTDQT
60 70 80 90 100
RSRDDYEKNI FSALKWCGIQ WDEGPDIGGP YGPYRQSERT EIYREYAELL
110 120 130 140 150
LKTDYAYKCF ATPKELEEMR AVATTLGYRG GYDRRYRYLS PEEIEARTRE
160 170 180 190 200
GQPYTIRLKV PLTGECVLDD YCKGRVVFPW ADVDDQVLIK SDGFPTYHFA
210 220 230 240 250
NVVDDHLMGI THVLRGEEWL SSTPKHLLLY EAFGWEAPTF LHMPLLLNPD
260 270 280 290 300
GTKLSKRKNP TSIFYYRDAG YVKEAFMNFL TLMGYSMEGD EEIYSLEKLI
310 320 330 340 350
ANFDPRRIGK SGAVFDTRKL DWMNKHYLTH EKSSESLLAK LKDWLINDEF
360 370 380 390 400
FLKILPLCQS RITTLAEFIG FTGFFFSVLP EYSKEELLPA TIVEEKAAIL
410 420 430 440 450
LYSYVKYLEK ADLWVKDQFY QGSKWLSSAF QVHHKKVVIP LLYVAITGKK
460 470 480 490 500
QGLPLFDSME LLGKPRTRAR LVHAQNLLGG VPKKIQTTID KVLKEEDFEN

KIFEF
Length:505
Mass (Da):58,540
Last modified:June 28, 2011 - v2
Checksum:i9D51E741448A9B22
GO

Sequence cautioni

The sequence AAA23122.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002549 Genomic DNA. Translation: ADZ18786.1.
CP002586 Genomic DNA. Translation: AEB55211.1.
L13598 Genomic DNA. Translation: AAA23122.1. Different initiation.
PIRiA36909.
RefSeqiYP_004422038.1. NC_015470.1.
YP_005662884.1. NC_017287.1.

Genome annotation databases

EnsemblBacteriaiADZ18786; ADZ18786; CPSIT_0206.
AEB55211; AEB55211; G5O_0208.
GeneIDi10602476.
12242467.
KEGGichb:G5O_0208.
chp:CPSIT_0206.
PATRICi47105011. VBIChlPsi52874_0193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002549 Genomic DNA. Translation: ADZ18786.1 .
CP002586 Genomic DNA. Translation: AEB55211.1 .
L13598 Genomic DNA. Translation: AAA23122.1 . Different initiation.
PIRi A36909.
RefSeqi YP_004422038.1. NC_015470.1.
YP_005662884.1. NC_017287.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADZ18786 ; ADZ18786 ; CPSIT_0206 .
AEB55211 ; AEB55211 ; G5O_0208 .
GeneIDi 10602476.
12242467.
KEGGi chb:G5O_0208.
chp:CPSIT_0206.
PATRICi 47105011. VBIChlPsi52874_0193.

Phylogenomic databases

KOi K01885.
OMAi WINGYYL.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Full-length de novo sequence of the Chlamydophila psittaci type strain, 6BC."
    Voigt A., Schofl G., Heidrich A., Sachse K., Saluz H.P.
    J. Bacteriol. 193:2662-2663(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-125 / 6BC.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-125 / 6BC.
  3. "Identification of an early-stage gene of Chlamydia psittaci 6BC."
    Wichlan D.W., Hatch T.P.
    J. Bacteriol. 175:2936-2942(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-368.
    Strain: ATCC VR-125 / 6BC.

Entry informationi

Entry nameiSYE_CHLP6
AccessioniPrimary (citable) accession number: P59691
Secondary accession number(s): F0T375, P94662, Q06560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3