P59670 (TIM17_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial import inner membrane translocase subunit tim-17

Gene names

Name:	tim-17
Synonyms:	tim17
ORF Names:	NCU05623

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane By similarity.
Subunit structure	Component of the TIM23 complex, at least composed of tim-23, tim-17, tim-50 and tim-21. The complex interacts with the tim-44 component of the PAM complex By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the Tim17/Tim22/Tim23 family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 155	155	Mitochondrial import inner membrane translocase subunit tim-17		PRO_0000210294
Regions
	Transmembrane	10 – 30	21	Helical; Potential
	Transmembrane	57 – 77	21	Helical; Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Transmembrane	112 – 132	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P59670 [UniParc]. Last modified May 9, 2003. Version 1. Checksum: 78F48D2F3720E5FB	FASTA	155	16,184
	10 20 30 40 50 60 MDHTRDPCPW VILNDFGGAF AMGAIGGTIW HGIKGFRNSP YGERRIGAIT AIKMRAPALG 70 80 90 100 110 120 GNFGVWGGLF STFDCAIKGL RNHKEDPWNS ILAGFFTGGA LAVRGGYKAA RNGAIGCAVL 130 140 150 LAVIEGVGIG FQKMLAGATK LEAPAPPPSN EKVLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Neurospora crassa TIM23 translocase of mitochondrial inner membrane." Nargang F.E., Tan W.-L., Prokisch H. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY212506 mRNA. Translation: AAO72334.1. AABX02000022 Genomic DNA. Translation: EAA30931.1.
RefSeq	XP_960167.1. XM_955074.1.
UniGene	Ncr.9644.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P59670.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000005534; EFNCRP00000005528; EFNCRG00000005524.
GeneID	3876316.
KEGG	ncr:NCU05623.
NMPDR	fig|5141.1.peg.3411.
Phylogenomic databases
eggNOG	fuNOG08965.
GeneTree	EFGT00050000003785.
OMA	PVLGGNF.
OrthoDB	EOG4ZPJ4N.
Enzyme and pathway databases
BioCyc	NCRA-XX3-01:NCRA-XX3-01-009371-MONOMER.
Family and domain databases
InterPro	IPR003397. Tim17/Tim22/Tim23/PMP24. [Graphical view]
Pfam	PF02466. Tim17. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TIM17_NEUCR

Accession

Primary (citable) accession number: P59670
Secondary accession number(s): Q7S5Y3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
Last sequence update:	May 9, 2003
Last modified:	December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program