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P59670

- TIM17_NEUCR

UniProt

P59670 - TIM17_NEUCR

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Protein
Mitochondrial import inner membrane translocase subunit tim17
Gene
tim17, NCU05623
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane By similarity.

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit tim17
Gene namesi
Name:tim17
ORF Names:NCU05623
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 5, Linkage Group VI

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021Helical; Reviewed prediction
Add
BLAST
Transmembranei57 – 7721Helical; Reviewed prediction
Add
BLAST
Transmembranei87 – 10721Helical; Reviewed prediction
Add
BLAST
Transmembranei112 – 13221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155Mitochondrial import inner membrane translocase subunit tim17
PRO_0000210294Add
BLAST

Interactioni

Subunit structurei

Component of the TIM23 complex, at least composed of tim23, tim17, tim50 and tim21. The complex interacts with the tim44 component of the PAM complex By similarity.

Protein-protein interaction databases

STRINGi5141.NCU05623.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
HOGENOMiHOG000183190.
KOiK17795.
OMAiMRAPVLG.
OrthoDBiEOG7F7WN2.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59670-1 [UniParc]FASTAAdd to Basket

« Hide

MDHTRDPCPW VILNDFGGAF AMGAIGGTIW HGIKGFRNSP YGERRIGAIT    50
AIKMRAPALG GNFGVWGGLF STFDCAIKGL RNHKEDPWNS ILAGFFTGGA 100
LAVRGGYKAA RNGAIGCAVL LAVIEGVGIG FQKMLAGATK LEAPAPPPSN 150
EKVLA 155
Length:155
Mass (Da):16,184
Last modified:May 9, 2003 - v1
Checksum:i78F48D2F3720E5FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY212506 mRNA. Translation: AAO72334.1.
CM002241 Genomic DNA. Translation: EAA30931.1.
RefSeqiXP_960167.1. XM_955074.1.
UniGeneiNcr.9644.

Genome annotation databases

EnsemblFungiiEFNCRT00000005534; EFNCRP00000005528; EFNCRG00000005524.
GeneIDi3876316.
KEGGincr:NCU05623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY212506 mRNA. Translation: AAO72334.1 .
CM002241 Genomic DNA. Translation: EAA30931.1 .
RefSeqi XP_960167.1. XM_955074.1.
UniGenei Ncr.9644.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 5141.NCU05623.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000005534 ; EFNCRP00000005528 ; EFNCRG00000005524 .
GeneIDi 3876316.
KEGGi ncr:NCU05623.

Phylogenomic databases

eggNOGi COG5596.
HOGENOMi HOG000183190.
KOi K17795.
OMAi MRAPVLG.
OrthoDBi EOG7F7WN2.

Family and domain databases

InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view ]
Pfami PF02466. Tim17. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Neurospora crassa TIM23 translocase of mitochondrial inner membrane."
    Nargang F.E., Tan W.-L., Prokisch H.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiTIM17_NEUCR
AccessioniPrimary (citable) accession number: P59670
Secondary accession number(s): Q7S5Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 9, 2003
Last modified: March 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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